Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations
Publication Date
January 02, 2018
Authors
Simon Lévy, Marie Claude Guertin, Ali Khatibi, Aviv Mezer, et al
Volume
13
Issue
1
Pages
e0189944
DOI
https://dx.plos.org/10.1371/journal.pone.0189944
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189944
Scopus
85039975847
Mendeley
http://www.mendeley.com/research/testretest-reliability-myelin-imaging-human-spinal-cord-measurement-errors-versus-region-aginginduce
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Mendeley | Further Information

{"title"=>"Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations", "type"=>"journal", "authors"=>[{"first_name"=>"Simon", "last_name"=>"Lévy", "scopus_author_id"=>"57189389450"}, {"first_name"=>"Marie Claude", "last_name"=>"Guertin", "scopus_author_id"=>"7003637525"}, {"first_name"=>"Ali", "last_name"=>"Khatibi", "scopus_author_id"=>"57200585447"}, {"first_name"=>"Aviv", "last_name"=>"Mezer", "scopus_author_id"=>"8615256200"}, {"first_name"=>"Kristina", "last_name"=>"Martinu", "scopus_author_id"=>"26321773600"}, {"first_name"=>"Jen I.", "last_name"=>"Chen", "scopus_author_id"=>"8421398400"}, {"first_name"=>"Nikola", "last_name"=>"Stikov", "scopus_author_id"=>"36505070800"}, {"first_name"=>"Pierre", "last_name"=>"Rainville", "scopus_author_id"=>"6603719897"}, {"first_name"=>"Julien", "last_name"=>"Cohen-Adad", "scopus_author_id"=>"24777793300"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"620020607", "sgr"=>"85039975847", "issn"=>"19326203", "scopus"=>"2-s2.0-85039975847", "doi"=>"10.1371/journal.pone.0189944", "isbn"=>"1111111111"}, "id"=>"f0de2d50-4496-36b6-ba49-b2e6f072e84f", "abstract"=>"© 2018 Lévy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Purpose To implement a statistical framework for assessing the precision of several quantitative MRI metrics sensitive to myelin in the human spinal cord: T 1 , Magnetization Transfer Ratio (MTR), saturation imposed by an off-resonance pulse (MT sat ) and Macromolecular Tissue Volume (MTV). Methods Thirty-three healthy subjects within two age groups (young, elderly) were scanned at 3T. Among them, 16 underwent the protocol twice to assess repeatability. Statistical reliability indexes such as the Minimal Detectable Change (MDC) were compared across metrics quantified within different cervical levels and white matter (WM) sub-regions. The differences between pathways and age groups were quantified and interpreted in context of the test-retest repeatability of the measurements. Results The M DC was respectively 105.7ms, 2.77%, 0.37% and 4.08% for T 1 , MTR, MT sat and MTV when quantified over all WM, while the standard-deviation across subjects was 70.5ms, 1.34%, 0.20% and 2.44%. Even though particular WM regions did exhibit significant differences, these differences were on the same order as test-retest errors. No significant difference was found between age groups for all metrics. Conclusion While T 1 -based metrics (T 1 and MTV) exhibited better reliability than MT-based measurements (MTR and MT sat ), the observed differences between subjects or WM regions were comparable to (and often smaller than) the MDC. This makes it difficult to determine if observed changes are due to variations in myelin content, or simply due to measurement error. Measurement error remains a challenge in spinal cord myelin imaging, but this study provides statistical guidelines to standardize the field and make it possible to conduct large-scale multi-center studies.", "link"=>"http://www.mendeley.com/research/testretest-reliability-myelin-imaging-human-spinal-cord-measurement-errors-versus-region-aginginduce", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>3, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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