Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner
Publication Date
January 02, 2018
Authors
Jocelyn T. Kim, Emery Chang, Alex Sigal & David Baltimore
Volume
13
Issue
1
Pages
e0189945
DOI
https://dx.plos.org/10.1371/journal.pone.0189945
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189945
Scopus
85039933874
Mendeley
http://www.mendeley.com/research/dendritic-cells-efficiently-transmit-hiv-t-cells-tenofovir-raltegravir-insensitive-manner
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Mendeley | Further Information

{"title"=>"Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner", "type"=>"journal", "authors"=>[{"first_name"=>"Jocelyn T.", "last_name"=>"Kim", "scopus_author_id"=>"51665156900"}, {"first_name"=>"Emery", "last_name"=>"Chang", "scopus_author_id"=>"57200149634"}, {"first_name"=>"Alex", "last_name"=>"Sigal", "scopus_author_id"=>"6701513762"}, {"first_name"=>"David", "last_name"=>"Baltimore", "scopus_author_id"=>"7201722548"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"620020604", "doi"=>"10.1371/journal.pone.0189945", "sgr"=>"85039933874", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85039933874"}, "id"=>"d2a3193e-af32-38ae-a81b-ffe8c7e46964", "abstract"=>"Dendritic cell (DC)-to-T cell transmission is an example of infection in trans, in which the cell transmitting the virus is itself uninfected. During this mode of DC-to-T cell transmission, uninfected DCs concentrate infectious virions, contact T cells and transmit these virions to target cells. Here, we investigated the efficiency of DC-to-T cell transmission on the number of cells infected and the sensitivity of this type of transmission to the antiretroviral drugs tenofovir (TFV) and raltegravir (RAL). We observed activated monocyte-derived and myeloid DCs amplified T cell infection, which resulted in drug insensitivity. This drug insensitivity was dependent on cell-to-cell contact and ratio of DCs to T cells in coculture. DC-mediated amplification of HIV-1 infection was efficient regardless of virus tropism or origin. The DC-toT cell transmission of the T/F strain CH077.t/2627 was relatively insensitive to TFV compared to DC-free T cell infection. The input of virus modulated the drug sensitivity of DC-to-T cell infection, but not T cell infection by cell-free virus. At high viral inputs, DC-to-T cell transmission reduced the sensitivity of infection to TFV. Transmission of HIV by DCs in trans may have important implications for viral persistence in vivo in environments, where residual replication may persist in the face of antiretroviral therapy. © 2018 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "link"=>"http://www.mendeley.com/research/dendritic-cells-efficiently-transmit-hiv-t-cells-tenofovir-raltegravir-insensitive-manner", "reader_count"=>3, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Arts and Humanities"=>1}, "reader_count_by_subdiscipline"=>{"Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>1}

Scopus | Further Information

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