Contributions of direct versus indirect mechanisms for regulatory dendritic cell suppression of asthmatic allergen-specific IgG1 antibody responses
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{"title"=>"Contributions of direct versus indirect mechanisms for regulatory dendritic cell suppression of asthmatic allergen-specific IgG1 antibody responses", "type"=>"journal", "authors"=>[{"first_name"=>"Yanna", "last_name"=>"Ma", "scopus_author_id"=>"55803282000"}, {"first_name"=>"Wojciech", "last_name"=>"Dawicki", "scopus_author_id"=>"6506472110"}, {"first_name"=>"Xiaobei", "last_name"=>"Zhang", "scopus_author_id"=>"57200127349"}, {"first_name"=>"John R.", "last_name"=>"Gordon", "scopus_author_id"=>"7404625068"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"620020550", "sgr"=>"85039854190", "issn"=>"19326203", "pmid"=>"29293622", "scopus"=>"2-s2.0-85039854190", "doi"=>"10.1371/journal.pone.0190414"}, "id"=>"088129ec-4e79-3688-bbf8-d9f68069af83", "abstract"=>"IL-10-differentiated dendritic cells (DC10) can reverse the asthma phenotype in mice, but how they suppress the asthmatic B cell response is unclear. Herein we assessed the mechanism(s) by which DC10 and DC10-induced Treg affect IgG1 production in asthma. We observed a rapid decline in lung-resident OVA-specific IgG1-secreting B cells on cessation of airway allergen challenge, and intraperitoneal DC10 therapy did not amplify that (p>0.05). It did however increase the loss of IgG1-B cells from the bone marrow (by 45+/-7.2%; p≤0.01) and spleen (by 65+/-17.8%; p≤0.05) over 2 wk. Delivery of OVA-loaded DC10 directly into the airways of asthmatic mice decreased the lung IgG1 B cell response assessed 2 dy later by 33+/-9.7% (p≤0.01), while their co-culture with asthmatic lung cell suspensions reduced the numbers of IgG1-secreting cells by 56.5+/-9.7% (p≤0.01). This effect was dependent on the DC10 carrying intact allergen on their cell surface; DC10 that had phagocytosed and fully processed their allergen were unable to suppress B cell responses, although they did suppress asthmatic Th2 cell responses. We had shown that therapeutic delivery of DC10-induced Treg can effectively suppress asthmatic T and B cell (IgE and IgG1) responses; herein CD4+ cells or Treg from the lungs of DC10-treated OVA-asthmatic mice suppressed in vitro B cell IgG1 production by 52.2+/-8.7% (p≤0.001) or 44.6+/-12.2% (p≤0.05), respectively, but delivery of DC10-induced Treg directly into the airways of asthmatic mice had no discernible impact over 2 dy on the numbers of lung IgG1-secreting cells (p≥0.05). In summary, DC10 treatment down-regulates OVA-specific B cell responses of asthmatic mice. While DC10 that carry intact allergen on their cell surface can dampen this response, DC10-induced Treg are critical for full realization of this outcome. This suggests that infectious tolerance is an essential element in regulatory DC control of the B cell response in allergic asthma.", "link"=>"http://www.mendeley.com/research/contributions-direct-versus-indirect-mechanisms-regulatory-dendritic-cell-suppression-asthmatic-alle", "reader_count"=>2, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Immunology and Microbiology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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