Population-based estimate of hepatitis C virus prevalence in Ontario, Canada
Publication Date
January 23, 2018
Authors
Shelly Bolotin, Jordan J. Feld, Gary Garber, William W. L. Wong, et al
Volume
13
Issue
1
Pages
e0191184
DOI
https://dx.plos.org/10.1371/journal.pone.0191184
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0191184
Scopus
85040986318
Mendeley
http://www.mendeley.com/research/populationbased-estimate-hepatitis-c-virus-prevalence-ontario-canada-1
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Mendeley | Further Information

{"title"=>"Population-based estimate of hepatitis C virus prevalence in Ontario, Canada", "type"=>"journal", "authors"=>[{"first_name"=>"Shelly", "last_name"=>"Bolotin"}, {"first_name"=>"Jordan J.", "last_name"=>"Feld"}, {"first_name"=>"Gary", "last_name"=>"Garber"}, {"first_name"=>"William W. L.", "last_name"=>"Wong"}, {"first_name"=>"Fiona M.", "last_name"=>"Guerra"}, {"first_name"=>"Tony", "last_name"=>"Mazzulli"}], "year"=>2018, "source"=>"PLOS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85040986318", "sgr"=>"85040986318", "issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0191184", "pmid"=>"29360823", "isbn"=>"1111111111", "pui"=>"620299316"}, "id"=>"6c4283dd-79ff-3a12-88e6-2bae2c547d2a", "abstract"=>"BACKGROUND: Hepatitis C virus (HCV) is the most burdensome infectious illness in Canada. Current screening strategies miss a significant proportion of cases, leaving many undiagnosed. Elevated HCV prevalence in those born between 1945 and 1965 has prompted calls for birth-cohort screening in this group. However, Canada lacks population-level data to support this recommendation. We performed a serosurvey to obtain population-based HCV prevalence estimates in Ontario residents born between 1945-1974, to generate evidence for birth-cohort screening recommendations. METHODS: We tested anonymized residual sera in five-year age-sex bands from Ontario for anti-HCV antibody. We performed descriptive epidemiological analysis and used a logistic regression model to determine HCV risk-factors. RESULTS: Of 10,006 sera analyzed, 155 (1.55%, 95% confidence interval (CI) 1.32, 1.81) were positive for HCV antibody. Individuals born between 1950-1964 had a significantly higher combined prevalence of 1.92% (95% CI 1.56, 2.34) compared to 1.14% (95% CI 0.69, 1.77) (p = 0.04) for those born between 1970-1974. For males, comprising 107/155 (69.03%) of positive samples, the highest prevalence was 3.00% (95% CI 1.95, 4.39) for the 1960-1964 birth-cohort. For females, the highest prevalence was 1.56% (95% CI 0.83, 2.65) for those born between 1955-1959. Male sex was significantly associated with positive HCV serostatus. INTERPRETATION: HCV prevalence in Ontario is highest among those in this birth cohort, and higher than previous estimates. The prevalence estimates presented in our study provide important data to underpin birth-cohort screening recommendations.", "link"=>"http://www.mendeley.com/research/populationbased-estimate-hepatitis-c-virus-prevalence-ontario-canada-1", "reader_count"=>3, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Other"=>1, "Researcher"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Other"=>1, "Researcher"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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