Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection
Publication Date
January 23, 2018
Authors
Tasson C. Rodrigues, Maria Leonor S. Oliveira, Alessandra Soares Schanoski, Stefanni L. Chavez Rico, et al
Volume
13
Issue
1
Pages
e0191692
DOI
https://dx.plos.org/10.1371/journal.pone.0191692
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0191692
Scopus
85040981281
Mendeley
http://www.mendeley.com/research/mucosal-immunization-pspa-pneumococcal-surface-protein-aadsorbed-nanoparticles-targeting-lungs-prote
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Mendeley | Further Information

{"title"=>"Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection", "type"=>"journal", "authors"=>[{"first_name"=>"Tasson C.", "last_name"=>"Rodrigues", "scopus_author_id"=>"57193016772"}, {"first_name"=>"Maria Leonor S.", "last_name"=>"Oliveira", "scopus_author_id"=>"7402586601"}, {"first_name"=>"Alessandra", "last_name"=>"Soares-Schanoski", "scopus_author_id"=>"17344601800"}, {"first_name"=>"Stefanni L.", "last_name"=>"Chavez-Rico", "scopus_author_id"=>"57200375343"}, {"first_name"=>"Douglas B.", "last_name"=>"Figueiredo", "scopus_author_id"=>"54790954200"}, {"first_name"=>"Viviane M.", "last_name"=>"Gonçalves", "scopus_author_id"=>"35883103800"}, {"first_name"=>"Daniela M.", "last_name"=>"Ferreira", "scopus_author_id"=>"7102490856"}, {"first_name"=>"Nitesh K.", "last_name"=>"Kunda", "scopus_author_id"=>"55371908400"}, {"first_name"=>"Imran Y.", "last_name"=>"Saleem", "scopus_author_id"=>"24831973500"}, {"first_name"=>"Eliane N.", "last_name"=>"Miyaji", "scopus_author_id"=>"6603824505"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"29360883", "scopus"=>"2-s2.0-85040981281", "pui"=>"620299232", "issn"=>"19326203", "isbn"=>"1111111111", "doi"=>"10.1371/journal.pone.0191692", "sgr"=>"85040981281"}, "id"=>"3d84245b-a556-36bb-b94e-1a5baa4b1ad3", "abstract"=>"Burden of pneumonia caused by Streptococcus pneumoniae remains high despite the availability of conjugate vaccines. Mucosal immunization targeting the lungs is an attractive alternative for the induction of local immune responses to improve protection against pneumonia. Our group had previously described the development of poly(glycerol adipate-co-ω-pentadecalactone) (PGA-co-PDL) polymeric nanoparticles (NPs) adsorbed with Pneumococcal surface protein A from clade 4 (PspA4Pro) within L-leucine microcarriers (nanocomposite microparticles—NCMPs) for mucosal delivery targeting the lungs (NP/NCMP PspA4Pro). NP/NCMP PspA4Pro was now used for immunization of mice. Inoculation of this formulation induced anti-PspA4Pro IgG antibodies in serum and lungs. Analysis of binding of serum IgG to intact bacteria showed efficient binding to bacteria expressing PspA from clades 3, 4 and 5 (family 2), but no binding to bacteria expressing PspA from clades 1 and 2 (family 1) was observed. Both mucosal immunization with NP/NCMP PspA4Pro and subcutaneous injection of the protein elicited partial protection against intranasal lethal pneumococcal challenge with a serotype 3 strain expressing PspA from clade 5 (PspA5). Although similar survival levels were observed for mucosal immunization with NP/NCMP PspA4Pro and subcutaneous immunization with purified protein, NP/NCMP PspA4Pro induced earlier control of the infection. Conversely, neither immunization with NP/NCMP PspA4Pro nor subcutaneous immunization with purified protein reduced bacterial burden in the lungs after challenge with a serotype 19F strain expressing PspA from clade 1 (PspA1). Mucosal immunization with NP/NCMP PspA4Pro targeting the lungs is thus able to induce local and systemic antibodies, conferring protection only against a strain expressing PspA from the homologous family 2.", "link"=>"http://www.mendeley.com/research/mucosal-immunization-pspa-pneumococcal-surface-protein-aadsorbed-nanoparticles-targeting-lungs-prote", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Chemistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "group_count"=>0}

Scopus | Further Information

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Source
Scopus
Time
2019-09-07 18:15:16 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0191692)
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