Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis
Publication Date
February 01, 2018
Authors
Nikolai Dyrberg Loft, Lone Skov, Mads Kirchheiner Rasmussen, Robert Gniadecki, et al
Volume
13
Issue
2
Pages
e0192010
DOI
https://dx.plos.org/10.1371/journal.pone.0192010
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192010
Scopus
85041357741
Mendeley
http://www.mendeley.com/research/genetic-polymorphisms-associated-psoriasis-development-psoriatic-arthritis-patients-psoriasis
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Mendeley | Further Information

{"title"=>"Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis", "type"=>"journal", "authors"=>[{"first_name"=>"Nikolai Dyrberg", "last_name"=>"Loft", "scopus_author_id"=>"57193425330"}, {"first_name"=>"Lone", "last_name"=>"Skov", "scopus_author_id"=>"7005922600"}, {"first_name"=>"Mads Kirchheiner", "last_name"=>"Rasmussen", "scopus_author_id"=>"56236590600"}, {"first_name"=>"Robert", "last_name"=>"Gniadecki", "scopus_author_id"=>"7005836029"}, {"first_name"=>"Tomas Norman", "last_name"=>"Dam", "scopus_author_id"=>"7006371996"}, {"first_name"=>"Ivan", "last_name"=>"Brandslund", "scopus_author_id"=>"7006777010"}, {"first_name"=>"Hans Jürgen", "last_name"=>"Hoffmann", "scopus_author_id"=>"56799813400"}, {"first_name"=>"Malene Rohr", "last_name"=>"Andersen", "scopus_author_id"=>"7403198434"}, {"first_name"=>"Ram Benny", "last_name"=>"Dessau", "scopus_author_id"=>"6603866036"}, {"first_name"=>"Ann Christina", "last_name"=>"Bergmann", "scopus_author_id"=>"57200447977"}, {"first_name"=>"Niels Møller", "last_name"=>"Andersen", "scopus_author_id"=>"57200449580"}, {"first_name"=>"Mikkel Kramme", "last_name"=>"Abildtoft", "scopus_author_id"=>"57200445569"}, {"first_name"=>"Paal Skytt", "last_name"=>"Andersen", "scopus_author_id"=>"55663542600"}, {"first_name"=>"Merete Lund", "last_name"=>"Hetland", "scopus_author_id"=>"6603809586"}, {"first_name"=>"Bente", "last_name"=>"Glintborg", "scopus_author_id"=>"6602440311"}, {"first_name"=>"Steffen", "last_name"=>"Bank", "scopus_author_id"=>"35298712600"}, {"first_name"=>"Ulla", "last_name"=>"Vogel", "scopus_author_id"=>"7102692493"}, {"first_name"=>"Vibeke", "last_name"=>"Andersen", "scopus_author_id"=>"56969625200"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"620406648", "doi"=>"10.1371/journal.pone.0192010", "sgr"=>"85041357741", "isbn"=>"1111111111", "pmid"=>"29389950", "scopus"=>"2-s2.0-85041357741"}, "id"=>"77c43b47-0547-3299-af51-51052e5a3892", "abstract"=>"BACKGROUND Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables. METHODS Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO. RESULTS Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO. CONCLUSION Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis.", "link"=>"http://www.mendeley.com/research/genetic-polymorphisms-associated-psoriasis-development-psoriatic-arthritis-patients-psoriasis", "reader_count"=>5, "reader_count_by_academic_status"=>{"Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>1}

Scopus | Further Information

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