Euglena extract suppresses adipocyte-differentiation in human adipose-derived stem cells
Publication Date
February 15, 2018
Authors
Ryota Sugimoto, Naoko Ishibashi Ohgo, Kohei Atsuji, Yuko Miwa, et al
Volume
13
Issue
2
Pages
e0192404
DOI
https://dx.plos.org/10.1371/journal.pone.0192404
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192404
Scopus
85042189213
Mendeley
http://www.mendeley.com/research/euglena-extract-suppresses-adipocytedifferentiation-human-adiposederived-stem-cells
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Mendeley | Further Information

{"title"=>"Euglena extract suppresses adipocyte-differentiation in human adipose-derived stem cells", "type"=>"journal", "authors"=>[{"first_name"=>"Ryota", "last_name"=>"Sugimoto", "scopus_author_id"=>"57200691865"}, {"first_name"=>"Naoko", "last_name"=>"Ishibashi-Ohgo", "scopus_author_id"=>"57200691443"}, {"first_name"=>"Kohei", "last_name"=>"Atsuji", "scopus_author_id"=>"57200685694"}, {"first_name"=>"Yuko", "last_name"=>"Miwa", "scopus_author_id"=>"57200691542"}, {"first_name"=>"Osamu", "last_name"=>"Iwata", "scopus_author_id"=>"57147448200"}, {"first_name"=>"Ayaka", "last_name"=>"Nakashima", "scopus_author_id"=>"57190880498"}, {"first_name"=>"Kengo", "last_name"=>"Suzuki", "scopus_author_id"=>"57020201800"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85042189213", "scopus"=>"2-s2.0-85042189213", "pui"=>"620727321", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0192404"}, "id"=>"89c3e69a-8d19-3853-8533-1b6834aeb5bc", "abstract"=>"© 2018 Sugimoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Euglena gracilis Z (Euglena) is a unicellular, photosynthesizing, microscopic green alga. It contains several nutrients such as vitamins, minerals, and unsaturated fatty acids. In this study, to verify the potential role of Euglena consumption on human health and obesity, we evaluated the effect of Euglena on human adipose-derived stem cells. We prepared a Euglena extract and evaluated its effect on cell growth and lipid accumulation, and found that cell growth was promoted by the addition of the Euglena extract. Interestingly, intracellular lipid accumulation was inhibited in a concentration-dependent manner. Quantitative real-time PCR analysis and western blotting analysis indicated that the Euglena extract suppressed adipocyte differentiation by inhibiting the gene expression of the master regulators peroxisome proliferator-activated receptor-γ (PPARγ) and one of three CCAAT-enhancer-binding proteins (C/EBPα). Further Oil Red O staining experiments indicated that the Euglena extract inhibited the early stage of adipocyte-differentiation. Consistent with these results, we observed that down-regulation of gene expression was involved in the early stage of adipogenesis represented by the sterol regulatory element binding protein 1 c (SREBP1c), two of three CCAAT-enhancer-binding proteins (C/EBPβ, C/EBPδ), and the cAMP regulatory element-binding protein (CREB). Taken together, these data suggest that Euglena extract is a promising candidate for the development of a new therapeutic treatment for obesity.", "link"=>"http://www.mendeley.com/research/euglena-extract-suppresses-adipocytedifferentiation-human-adiposederived-stem-cells", "reader_count"=>1, "reader_count_by_academic_status"=>{"Researcher"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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