Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer’s disease
Publication Date
February 08, 2018
Authors
Eleonora M. Lad, Dibyendu Mukherjee, Sandra S. Stinnett, Scott W. Cousins, et al
Volume
13
Issue
2
Pages
e0192646
DOI
https://dx.plos.org/10.1371/journal.pone.0192646
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192646
Scopus
85041745160
Mendeley
http://www.mendeley.com/research/evaluation-inner-retinal-layers-biomarkers-mild-cognitive-impairment-moderate-alzheimers-disease
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Mendeley | Further Information

{"title"=>"Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease", "type"=>"journal", "authors"=>[{"first_name"=>"Eleonora M.", "last_name"=>"Lad", "scopus_author_id"=>"16063815400"}, {"first_name"=>"Dibyendu", "last_name"=>"Mukherjee", "scopus_author_id"=>"57201541644"}, {"first_name"=>"Sandra S.", "last_name"=>"Stinnett", "scopus_author_id"=>"7004525827"}, {"first_name"=>"Scott W.", "last_name"=>"Cousins", "scopus_author_id"=>"7004987071"}, {"first_name"=>"Guy G.", "last_name"=>"Potter", "scopus_author_id"=>"8848668800"}, {"first_name"=>"James R.", "last_name"=>"Burke", "scopus_author_id"=>"57200579256"}, {"first_name"=>"Sina", "last_name"=>"Farsiu", "scopus_author_id"=>"6603132896"}, {"first_name"=>"Heather E.", "last_name"=>"Whitson", "scopus_author_id"=>"6506179090"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0192646", "sgr"=>"85041745160", "scopus"=>"2-s2.0-85041745160", "isbn"=>"1111111111", "pmid"=>"29420642", "pui"=>"620567103"}, "id"=>"80910534-da02-32bf-b17a-a1682cda138e", "abstract"=>"Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninvasive biomarkers to diagnose AD. This cross-sectional case-control study enrolled 15 mild cognitive impairment (MCI) patients, 15 mild-moderate AD patients, and 18 cognitively normal adults. NFL and GCIPL thicknesses on optical coherence tomography (OCT) were measured using Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP) and Spectralis software. We demonstrated that regional thicknesses of NFL or GCIPL on macular or nerve OCTs did not differ between groups. However, a multi-variate regression analysis identified macular areas with a significant thickening or thinning in NFL and GCIPL in MCI and AD patients. Our primary findings controvert previous reports of thinner NFL in moderate-to-severe AD. The areas of thickening of GCIPL and NFL in the macula adjacent to areas of thinning, as revealed by a more complex statistical model, suggest that NFL and GCIPL may undergo dynamic changes during AD progression.", "link"=>"http://www.mendeley.com/research/evaluation-inner-retinal-layers-biomarkers-mild-cognitive-impairment-moderate-alzheimers-disease", "reader_count"=>10, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>2, "Psychology"=>4, "Computer Science"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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