RAGE-specific single chain Fv for PET imaging of pancreatic cancer
Publication Date
March 12, 2018
Authors
Hye Yeong Kim, Xiaolei Wang, Rui Kang, Daolin Tang, et al
Volume
13
Issue
3
Pages
e0192821
DOI
https://dx.plos.org/10.1371/journal.pone.0192821
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192821
Scopus
85043765115
Mendeley
http://www.mendeley.com/research/ragespecific-single-chain-fv-pet-imaging-pancreatic-cancer
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Mendeley | Further Information

{"title"=>"RAGE-specific single chain Fv for PET imaging of pancreatic cancer", "type"=>"journal", "authors"=>[{"first_name"=>"H.-Y.", "last_name"=>"Kim"}, {"first_name"=>"X.", "last_name"=>"Wang"}, {"first_name"=>"R.", "last_name"=>"Kang"}, {"first_name"=>"D.", "last_name"=>"Tang"}, {"first_name"=>"B.A.", "last_name"=>"Boone"}, {"first_name"=>"H.J.", "last_name"=>"Zeh"}, {"first_name"=>"M.T.", "last_name"=>"Lotze"}, {"first_name"=>"W.", "last_name"=>"Barry Edwards"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0192821", "sgr"=>"85043765115", "pui"=>"621180855", "scopus"=>"2-s2.0-85043765115", "issn"=>"19326203"}, "id"=>"ef8dca4d-74ee-311c-9ab9-63ae2f072a5b", "abstract"=>"© 2018 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Noninvasive detection of both early pancreatic neoplasia and metastases could enhance strategies to improve patient survival in this disease that is notorious for an extremely poor prognosis. There are almost no identifiable targets for non-invasive diagnosis by positron emission tomography (PET) for patients with pancreatic ductal adenocarcinoma (PDAC). Over-expression of the receptor for advanced glycation end products (RAGE) is found on the cell surface of both pre-neoplastic lesions and invasive PDAC. Here, a RAGE-specific single chain (scFv) was developed, specific for PET imaging in syngeneic mouse models of PDAC. An anti-RAGE scFv conjugated with a sulfo-Cy5 fluorescence molecule showed high affinity and selectivity for RAGE expressing pancreatic tumor cells and genetically engineered KRAS G12D mouse models of PDAC. An in vivo biodistribution study was performed with the 64 Cu-radiolabled scFv in a syngeneic murine pancreatic cancer model, demonstrating both the feasibility and potential of an anti-RAGE scFv for detection of PDAC. These studies hold great promise for translation into the clinic.", "link"=>"http://www.mendeley.com/research/ragespecific-single-chain-fv-pet-imaging-pancreatic-cancer", "reader_count"=>1, "reader_count_by_academic_status"=>{"Unspecified"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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