Association between cognitive function and supplementation with omega-3 PUFAs and other nutrients in ≥ 75 years old patients: A randomized multicenter study
Publication Date
March 26, 2018
Authors
Joaquin Baleztena, Miguel Ruiz Canela, Carmen Sayon Orea, Maria Pardo, et al
Volume
13
Issue
3
Pages
e0193568
DOI
https://dx.plos.org/10.1371/journal.pone.0193568
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0193568
Scopus
85044538624
Mendeley
http://www.mendeley.com/research/association-between-cognitive-function-supplementation-omega3-pufas-other-nutrients-75-years-old-pat-1
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Association between cognitive function and supplementation with omega-3 PUFAs and other nutrients in 75 years old patients: A randomized multicenter study", "type"=>"journal", "authors"=>[{"first_name"=>"J.", "last_name"=>"Baleztena"}, {"first_name"=>"M.", "last_name"=>"Ruiz-Canela"}, {"first_name"=>"C.", "last_name"=>"Sayon-Orea"}, {"first_name"=>"M.", "last_name"=>"Pardo"}, {"first_name"=>"T.", "last_name"=>"Añorbe"}, {"first_name"=>"J.I.", "last_name"=>"Gost"}, {"first_name"=>"C.", "last_name"=>"Gomez"}, {"first_name"=>"B.", "last_name"=>"Ilarregui"}, {"first_name"=>"M.", "last_name"=>"Bes-Rastrollo"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85044538624", "pmid"=>"29579102", "doi"=>"10.1371/journal.pone.0193568", "pui"=>"621384266", "isbn"=>"1111111111", "sgr"=>"85044538624"}, "id"=>"e1738eb0-7fce-365a-a760-f4e8384b4b3a", "abstract"=>"© 2018 Baleztena et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. A few studies have assessed the association between omega-3 polyunsaturated fatty acids (n-3 PUFA) and cognitive impairment (CI) in very old adults. The aim of this study was to evaluate the effect of a multinutrient supplementation rich in n-3 PUFA on the cognitive function in an institutionalized 75-year-old population without CI or with mild cognitive impairment (MCI). A multicenter placebo-controlled double-blind randomized trial was conducted between 2012 and 2013. Cognitive function was assessed at baseline and after one year using 4 neuropsychological tests. Nutritional status was assessed using Mini Nutritional Assessment (MNA). Interaction between Mini-Mental State Examination (MMSE) score and nutritional status were analyzed using linear regression models. A total of 99 participants were randomized to receive placebo or pills rich in n-3 PUFA. After 1-year follow-up, both groups decreased their MMSE score (-1.18, SD:0. 53 and -0.82, SD:0. 63, p = 0.67 for the control and the intervention group respectively). The memory subscale of the MMSE showed an improvement (+0.26, SD:0.18) in the intervention group against a worsening in the control group (-0.11, SD: 0.14; p = 0.09 for differences between groups). Patients at intervention group with normal nutritional status (MNA 24) showed an improvement in the MMSE (+1.03, p = 0.025 for differences between 1-y and baseline measurements) against a worsening in the group with malnutrition (MNA < 24) (-0.4, p = 0.886 for differences between 1-y and baseline; p of interaction p = 0.05). Supplementation with n-3 PUFA did not show an improvement in the global cognitive function in institutionalized elderly people without CI or with MCI. They only suggest an apparent improvement in memory loss if previously they were well nourished.", "link"=>"http://www.mendeley.com/research/association-between-cognitive-function-supplementation-omega3-pufas-other-nutrients-75-years-old-pat-1", "reader_count"=>3, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85044538624"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85044538624?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044538624&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85044538624&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85044538624", "dc:identifier"=>"SCOPUS_ID:85044538624", "eid"=>"2-s2.0-85044538624", "dc:title"=>"Association between cognitive function and supplementation with omega-3 PUFAs and other nutrients in 75 years old patients: A randomized multicenter study", "dc:creator"=>"Baleztena J.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"13", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2018-03-01", "prism:coverDisplayDate"=>"March 2018", "prism:doi"=>"10.1371/journal.pone.0193568", "citedby-count"=>"10", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Universidad de Navarra", "affiliation-city"=>"Pamplona", "affiliation-country"=>"Spain"}], "pubmed-id"=>"29579102", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0193568", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"59", "xml_views"=>"8", "html_views"=>"86"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"90", "xml_views"=>"3", "html_views"=>"167"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"4", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"3", "html_views"=>"101"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"127"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"34", "xml_views"=>"4", "html_views"=>"104"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"54"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"42"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"76"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"26", "xml_views"=>"3", "html_views"=>"49"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}

PMC Usage Stats

  • {"unique-ip"=>"126", "full-text"=>"154", "pdf"=>"26", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"127", "full-text"=>"152", "pdf"=>"21", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"115", "full-text"=>"114", "pdf"=>"40", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"98", "full-text"=>"127", "pdf"=>"44", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"62", "full-text"=>"65", "pdf"=>"25", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"44", "full-text"=>"42", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"50", "full-text"=>"66", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"68", "full-text"=>"74", "pdf"=>"26", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"140", "full-text"=>"165", "pdf"=>"40", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"81", "full-text"=>"98", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"163", "full-text"=>"192", "pdf"=>"24", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"166", "full-text"=>"200", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"180", "full-text"=>"197", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"169", "full-text"=>"190", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"172", "full-text"=>"206", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"181", "full-text"=>"194", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"184", "full-text"=>"216", "pdf"=>"25", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"118", "full-text"=>"160", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"173", "full-text"=>"215", "pdf"=>"20", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"131", "full-text"=>"167", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"106", "full-text"=>"150", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"9", "cited-by"=>"2", "year"=>"2020", "month"=>"4"}
Loading … Spinner
There are currently no alerts