L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice
Publication Date
March 15, 2018
Authors
Laurits J. Holm, Martin Haupt Jorgensen, Jesper Larsen, Jano D. Giacobini, et al
Volume
13
Issue
3
Pages
e0194414
DOI
https://dx.plos.org/10.1371/journal.pone.0194414
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0194414
Scopus
85044070623
Mendeley
http://www.mendeley.com/research/lserine-supplementation-lowers-diabetes-incidence-improves-blood-glucose-homeostasis-nod-mice
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Mendeley | Further Information

{"title"=>"L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice", "type"=>"journal", "authors"=>[{"first_name"=>"Laurits J.", "last_name"=>"Holm", "scopus_author_id"=>"57201250732"}, {"first_name"=>"Martin", "last_name"=>"Haupt-Jorgensen", "scopus_author_id"=>"55765535000"}, {"first_name"=>"Jesper", "last_name"=>"Larsen", "scopus_author_id"=>"56660249900"}, {"first_name"=>"Jano D.", "last_name"=>"Giacobini", "scopus_author_id"=>"57201257826"}, {"first_name"=>"Mesut", "last_name"=>"Bilgin", "scopus_author_id"=>"54583126000"}, {"first_name"=>"Karsten", "last_name"=>"Buschard", "scopus_author_id"=>"7005870659"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85044070623", "doi"=>"10.1371/journal.pone.0194414", "pui"=>"621241453", "scopus"=>"2-s2.0-85044070623", "issn"=>"19326203"}, "id"=>"2b37722a-f8c6-34aa-8874-0e3b485ca80e", "abstract"=>"Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis. ", "link"=>"http://www.mendeley.com/research/lserine-supplementation-lowers-diabetes-incidence-improves-blood-glucose-homeostasis-nod-mice", "reader_count"=>2, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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