Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression
Publication Date
March 28, 2018
Authors
Lindsay M. Reynolds, Timothy D. Howard, Ingo Ruczinski, Kanika Kanchan, et al
Volume
13
Issue
3
Pages
e0194610
DOI
https://dx.plos.org/10.1371/journal.pone.0194610
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0194610
Scopus
85044724488
Mendeley
http://www.mendeley.com/research/tissuespecific-impact-fads-cluster-variants-fads1-fads2-gene-expression
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression", "type"=>"journal", "authors"=>[{"first_name"=>"Lindsay M.", "last_name"=>"Reynolds", "scopus_author_id"=>"55710963900"}, {"first_name"=>"Timothy D.", "last_name"=>"Howard", "scopus_author_id"=>"7202242315"}, {"first_name"=>"Ingo", "last_name"=>"Ruczinski", "scopus_author_id"=>"6602228820"}, {"first_name"=>"Kanika", "last_name"=>"Kanchan", "scopus_author_id"=>"57201434816"}, {"first_name"=>"Michael C.", "last_name"=>"Seeds", "scopus_author_id"=>"6701760661"}, {"first_name"=>"Rasika A.", "last_name"=>"Mathias", "scopus_author_id"=>"57197639036"}, {"first_name"=>"Floyd H.", "last_name"=>"Chilton", "scopus_author_id"=>"7005377008"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85044724488", "pui"=>"621467908", "doi"=>"10.1371/journal.pone.0194610", "sgr"=>"85044724488"}, "id"=>"aaced64c-2da6-3f77-855b-4ab3afe9965c", "abstract"=>"© 2018 Reynolds et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Omega-6 (n-6) and omega-3 (n-3) long ( 20 carbon) chain polyunsaturated fatty acids (LC-PUFAs) play a critical role in human health and disease. Biosynthesis of LC-PUFAs from dietary 18 carbon PUFAs in tissues such as the liver is highly associated with genetic variation within the fatty acid desaturase (FADS) gene cluster, containing FADS1 and FADS2 that encode the rate-limiting desaturation enzymes in the LC-PUFA biosynthesis pathway. However, the molecular mechanisms by which FADS genetic variants affect LC-PUFA biosynthesis, and in which tissues, are unclear. The current study examined associations between common single nucleotide polymorphisms (SNPs) within the FADS gene cluster and FADS1 and FADS2 gene expression in 44 different human tissues (sample sizes ranging 70–361) from the Genotype-Tissue Expression (GTEx) Project. FADS1 and FADS2 expression were detected in all 44 tissues. Significant cis-eQTLs (within 1 megabase of each gene, False Discovery Rate, FDR0.05, as defined by GTEx) were identified in 12 tissues for FADS1 gene expression and 23 tissues for FADS2 gene expression. Six tissues had significant (FDR 0.05) eQTLs associated with both FADS1 and FADS2 (including artery, esophagus, heart, muscle, nerve, and thyroid). Interestingly, the identified eQTLs were consistently found to be associated in opposite directions for FADS1 and FADS2 expression. Taken together, findings from this study suggest common SNPs within the FADS gene cluster impact the transcription of FADS1 and FADS2 in numerous tissues and raise important questions about how the inverse expression of these two genes impact intermediate molecular (such a LC-PUFA and LC-PUFA-containing glycero-lipid levels) and ultimately clinical phenotypes associated with inflammatory diseases and brain health.", "link"=>"http://www.mendeley.com/research/tissuespecific-impact-fads-cluster-variants-fads1-fads2-gene-expression", "reader_count"=>3, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Professor"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Professor"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85044724488"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85044724488?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044724488&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85044724488&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85044724488", "dc:identifier"=>"SCOPUS_ID:85044724488", "eid"=>"2-s2.0-85044724488", "dc:title"=>"Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression", "dc:creator"=>"Reynolds L.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"13", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2018-03-01", "prism:coverDisplayDate"=>"March 2018", "prism:doi"=>"10.1371/journal.pone.0194610", "citedby-count"=>"12", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Wake Forest School of Medicine", "affiliation-city"=>"Winston Salem", "affiliation-country"=>"United States"}], "pubmed-id"=>"29590160", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0194610", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"8", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"2", "html_views"=>"85"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"53"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"52", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"19"}

PMC Usage Stats

  • {"unique-ip"=>"31", "full-text"=>"33", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"3", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"42", "full-text"=>"40", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"52", "full-text"=>"52", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"42", "full-text"=>"41", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"32", "full-text"=>"38", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"36", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"32", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"45", "full-text"=>"48", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"35", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"5", "cited-by"=>"2", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"36", "full-text"=>"39", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"38", "full-text"=>"54", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"25", "full-text"=>"32", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
Loading … Spinner
There are currently no alerts