Delay models for the early embryonic cell cycle oscillator
Publication Date
March 26, 2018
Authors
Jan Rombouts, Alexandra Vandervelde & Lendert Gelens
Volume
13
Issue
3
Pages
e0194769
DOI
https://dx.plos.org/10.1371/journal.pone.0194769
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0194769
Scopus
85044522536
Mendeley
http://www.mendeley.com/research/delay-models-early-embryonic-cell-cycle-oscillator
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Mendeley | Further Information

{"title"=>"Delay models for the early embryonic cell cycle oscillator", "type"=>"journal", "authors"=>[{"first_name"=>"J.", "last_name"=>"Rombouts"}, {"first_name"=>"A.", "last_name"=>"Vandervelde"}, {"first_name"=>"L.", "last_name"=>"Gelens"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85044522536", "doi"=>"10.1371/journal.pone.0194769", "sgr"=>"85044522536", "issn"=>"19326203", "pui"=>"621384300"}, "id"=>"4272d090-d870-3403-930c-03482f34d13f", "abstract"=>"© 2018 Rombouts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Time delays are known to play a crucial role in generating biological oscillations. The early embryonic cell cycle in the frog Xenopus laevis is one such example. Although various mathematical models of this oscillating system exist, it is not clear how to best model the required time delay. Here, we study a simple cell cycle model that produces oscillations due to the presence of an ultrasensitive, time-delayed negative feedback loop. We implement the time delay in three qualitatively different ways, using a fixed time delay, a distribution of time delays, and a delay that is state-dependent. We analyze the dynamics in all cases, and we use experimental observations to interpret our results and put constraints on unknown parameters. In doing so, we find that different implementations of the time delay can have a large impact on the resulting oscillations.", "link"=>"http://www.mendeley.com/research/delay-models-early-embryonic-cell-cycle-oscillator", "reader_count"=>1, "reader_count_by_academic_status"=>{"Researcher"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1}, "reader_count_by_subject_area"=>{"Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Physics and Astronomy"=>{"Physics and Astronomy"=>1}}, "group_count"=>0}

Scopus | Further Information

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