Severe abnormal Heart Rate Turbulence Onset is associated with deterioration of liver cirrhosis
Publication Date
April 10, 2018
Authors
Christian Jansen, Baravan Al Kassou, Jennifer Lehmann, Alessandra Pohlmann, et al
Volume
13
Issue
4
Pages
e0195631
DOI
https://dx.plos.org/10.1371/journal.pone.0195631
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195631
Scopus
85045277564
Mendeley
http://www.mendeley.com/research/severe-abnormal-heart-rate-turbulence-onset-associated-deterioration-liver-cirrhosis
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Mendeley | Further Information

{"title"=>"Severe abnormal heart rate turbulence onset is associated with deterioration of liver cirrhosis", "type"=>"journal", "authors"=>[{"first_name"=>"C.", "last_name"=>"Jansen"}, {"first_name"=>"B.", "last_name"=>"Al-Kassou"}, {"first_name"=>"J.", "last_name"=>"Lehmann"}, {"first_name"=>"A.", "last_name"=>"Pohlmann"}, {"first_name"=>"J.", "last_name"=>"Chang"}, {"first_name"=>"M.", "last_name"=>"Praktiknjo"}, {"first_name"=>"G.", "last_name"=>"Nickenig"}, {"first_name"=>"C.P.", "last_name"=>"Strassburg"}, {"first_name"=>"J.W.", "last_name"=>"Schrickel"}, {"first_name"=>"R.", "last_name"=>"Andrié"}, {"first_name"=>"M.", "last_name"=>"Linhart"}, {"first_name"=>"J.", "last_name"=>"Trebicka"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85045277564", "doi"=>"10.1371/journal.pone.0195631", "issn"=>"19326203", "scopus"=>"2-s2.0-85045277564", "pui"=>"621615988"}, "id"=>"18efa45c-b558-398d-8c8b-6075e48d8ba2", "abstract"=>"© 2018 Jansen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background In patients with liver cirrhosis, cardiac dysfunction is frequent and is associated with increased morbidity and mortality. Cardiac dysfunction in cirrhosis seems to be linked to autonomic dysfunction. This study investigates the role of autonomic dysfunction assessed by Heart Rate Turbulence (HRT) analyses in patients with liver cirrhosis. Methods and patients Inclusion criteria was (1) diagnosis of cirrhosis by clinical, imaging or biopsy and (2) evaluation by standard 12-lead-ECG and 24h holter monitoring and (3) at least 3 premature ventricular contractions. The exclusion criterion was presence of cardiac diseases, independent of liver cirrhosis. Biochemical parameters were analysed using standard methods. HRT was assessed using Turbulence onset (TO) and slope (TS). The endpoint was deterioration of liver cirrhosis defined as increased MELD and readmission for complications of liver cirrhosis. Results Out of 122 cirrhotic patients, 82 patients (63% male) with median Child score of 6 (range 5–12) and median MELD score of 10 (range 6–32) were included. Increasing Child score, INR and decreasing albumin were correlated with TO. In addition, decompensated patients with ascites showed more abnormal TO and TS. During the observation period, patients with more abnormal TO showed significantly higher rate of rising MELD Score at 6 months (p = 0.03). Nevertheless, at least in our collective HRT-parameters were not independent predictors of deterioration of cirrhosis. Conclusion Parameters of HRT are closely associated with deterioration of cirrhosis and might be helpful in its prediction.", "link"=>"http://www.mendeley.com/research/severe-abnormal-heart-rate-turbulence-onset-associated-deterioration-liver-cirrhosis", "reader_count"=>2, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2}, "reader_count_by_subdiscipline"=>{"Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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