Deletion of IL-4Rα on CD4 T Cells Renders BALB/c Mice Resistant to Leishmania major Infection
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection", "type"=>"journal", "authors"=>[{"first_name"=>"Magdalena", "last_name"=>"Radwanska", "scopus_author_id"=>"6701435227"}, {"first_name"=>"Antony J.", "last_name"=>"Cutler", "scopus_author_id"=>"35589255500"}, {"first_name"=>"J. Claire", "last_name"=>"Hoving", "scopus_author_id"=>"16549496000"}, {"first_name"=>"Stefan", "last_name"=>"Magez", "scopus_author_id"=>"6701812588"}, {"first_name"=>"Christoph", "last_name"=>"Holscher", "scopus_author_id"=>"7005742397"}, {"first_name"=>"Andreas", "last_name"=>"Bohms", "scopus_author_id"=>"16400580400"}, {"first_name"=>"Berenice", "last_name"=>"Arendse", "scopus_author_id"=>"6602244084"}, {"first_name"=>"Richard", "last_name"=>"Kirsch", "scopus_author_id"=>"57195716995"}, {"first_name"=>"Thomas", "last_name"=>"Hunig", "scopus_author_id"=>"7006096938"}, {"first_name"=>"James", "last_name"=>"Alexander", "scopus_author_id"=>"7404459076"}, {"first_name"=>"Paul", "last_name"=>"Kaye", "scopus_author_id"=>"7102603431"}, {"first_name"=>"Frank", "last_name"=>"Brombacher", "scopus_author_id"=>"7005215644"}], "year"=>2007, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"46827947", "doi"=>"10.1371/journal.ppat.0030068", "isbn"=>"1553-7374 (Electronic)", "pmid"=>"17500591", "issn"=>"15537366", "scopus"=>"2-s2.0-34249658382", "sgr"=>"34249658382"}, "id"=>"a55913d6-de87-3084-a739-8c1ff35712da", "abstract"=>"Effector responses induced by polarized CD4+ T helper 2 (Th2) cells drive nonhealing responses in BALB/c mice infected with Leishmania major. Th2 cytokines IL-4 and IL-13 are known susceptibility factors for L. major infection in BALB/c mice and induce their biological functions through a common receptor, the IL-4 receptor α chain (IL-4Rα). IL-4Rα–deficient BALB/c mice, however, remain susceptible to L. major infection, indicating that IL-4/IL-13 may induce protective responses. Therefore, the roles of polarized Th2 CD4+ T cells and IL-4/IL-13 responsiveness of non-CD4+ T cells in inducing nonhealer or healer responses have yet to be elucidated. CD4+ T cell–specific IL-4Rα (LckcreIL-4Rα−/lox) deficient BALB/c mice were generated and characterized to elucidate the importance of IL-4Rα signaling during cutaneous leishmaniasis in the absence of IL-4–responsive CD4+ T cells. Efficient deletion was confirmed by loss of IL-4Rα expression on CD4+ T cells and impaired IL-4–induced CD4+ T cell proliferation and Th2 differentiation. CD8+, γδ+, and NK–T cells expressed residual IL-4Rα, and representative non–T cell populations maintained IL-4/IL-13 responsiveness. In contrast to IL-4Rα−/lox BALB/c mice, which developed ulcerating lesions following infection with L. major, LckcreIL-4Rα−/lox mice were resistant and showed protection to rechallenge, similar to healer C57BL/6 mice. Resistance to L. major in LckcreIL-4Rα−/lox mice correlated with reduced numbers of IL-10–secreting cells and early IL-12p35 mRNA induction, leading to increased delayed type hypersensitivity responses, interferon-γ production, and elevated ratios of inducible nitric oxide synthase mRNA/parasite, similar to C57BL/6 mice. These data demonstrate that abrogation of IL-4 signaling in CD4+ T cells is required to transform nonhealer BALB/c mice to a healer phenotype. Furthermore, a beneficial role for IL-4Rα signaling in L. major infection is revealed in which IL-4/IL-13–responsive non-CD4+ T cells induce protective responses.", "link"=>"http://www.mendeley.com/research/deletion-il4r%CE%B1-cd4-t-cells-renders-balbc-mice-resistant-leishmania-major-infection", "reader_count"=>28, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "Germany"=>1}, "group_count"=>2}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/34249658382"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/34249658382?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34249658382&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=34249658382&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/34249658382", "dc:identifier"=>"SCOPUS_ID:34249658382", "eid"=>"2-s2.0-34249658382", "dc:title"=>"Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection", "dc:creator"=>"Radwanska M.", "prism:publicationName"=>"PLoS Pathogens", "prism:issn"=>"15537366", "prism:eIssn"=>"15537374", "prism:volume"=>"3", "prism:issueIdentifier"=>"5", "prism:pageRange"=>"0619-0629", "prism:coverDate"=>"2007-06-01", "prism:coverDisplayDate"=>"2007", "prism:doi"=>"10.1371/journal.ppat.0030068", "citedby-count"=>"46", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Cape Town", "affiliation-city"=>"Cape Town", "affiliation-country"=>"South Africa"}], "pubmed-id"=>"17500591", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "source-id"=>"4000151809", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplospathogens%2Farticle%3Fid%3D10.1371%252Fjournal.ppat.0030068", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"5", "year"=>"2007", "pdf_views"=>"136", "xml_views"=>"5", "html_views"=>"223"}
  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"45", "xml_views"=>"2", "html_views"=>"107"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"55"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"4", "html_views"=>"34"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"5", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"191"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"56"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"8"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"7", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/950045"], "description"=>"<div><p>(A) Mouse breeding strategy. IL-4Rα<sup>lox/lox</sup> BALB/c mice were intercrossed with transgenic BALB/c mice expressing Cre-recombinase under control of the Lck promoter and IL-4Rα<sup>−/−</sup> BALB/c mice to generate Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> mice. The “loxed” IL-4Rα allele, gray arrows; deleted allele, black arrows.</p><p>(B) Genotyping of Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> mice. The deleted IL-4Rα PCR yields a product of 471 bp, LoxP, 188 bp (loxed), and 94 bp (WT), and Cre-specific a 450-bp product.</p><p>(C) Phenotypic analysis. WT (solid line), IL-4Rα<sup>−/−</sup> (gray line), and Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> BALB/c mice (dashed line) LN cells were stained for expression of IL-4Rα. T cell subsets were identified using anti-CD3, anti-CD4/CD8, or δ-TCR. B cells, anti-CD19. DCs, CD11<sup>c</sup>/I-A<sup>d</sup>. Macrophages, F4/80/I-A<sup>d</sup>.</p><p>(D) Efficiency of IL-4Rα deletion. The ratio of IL-4Rα exon 5 and exon 8 alleles was determined by real-time PCR from genomic DNA purified from CD4<sup>+</sup> or CD19<sup>+</sup> cells. PCR products of amplified genomic DNA from real-time PCR reactions (75 cycles) were visualized on agarose gel. Data is representative of 2 independent experiments with triplicate values ± SD.</p></div>", "links"=>[], "tags"=>["immunology", "Infectious diseases"], "article_id"=>620352, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Magdalena Radwanska", "Antony J Cutler", "J. Claire Hoving", "Stefan Magez", "Christoph Holscher", "Andreas Bohms", "Berenice Arendse", "Richard Kirsch", "Thomas Hunig", "James Alexander", "Paul Kaye", "Frank Brombacher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030068.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Generation_of_Lck_cre_IL_4R_945_8722_lox_Mice_/620352", "title"=>"Generation of Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> Mice", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-05-11 00:05:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/950395"], "description"=>"<div><p>(A) Lesion development. Footpad swelling was measured at weekly intervals in mice (five per group) infected with 2 × 10<sup>6</sup> stationary phase L. major LV39 (MRHO/SV/59/P) metacyclic promastigotes into the hind footpad. Asterisk indicates ulceration or necrosis/mouse. A representative of one of five experiments is shown with mean values ± SD.</p><p>(B) Week six footpad parasite load. Parasite load was determined by limiting dilution of single-cell suspensions from homogenized footpads at 6 wk after infection.</p><p>(C) Week six LN parasite load. Parasite load was determined by limiting dilution of single-cell suspensions from the draining LNs at 6 wk after infection.</p><p>(D) L. major parasite detection using real-time PCR at 36 wk after infection. Kinetoplast DNA was quantified from footpads at week 36 after infection. One of two representative experiments is shown, with values representing mean parasite number ± SD.</p><p>(E) Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> BALB/c mice are resistant to reinfection. At 6 wk after infection with <i>L. major,</i> mice were reinfected in the contralateral hind footpad, and footpad swelling was monitored for 18 wk. Data are representative of two independent experiments.</p><p>(F) Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> BALB/c mice are resistant to L. major (MHOM/IL/81/FEBNI). Lesion development: mice (four per group) were infected with 2 × 10<sup>6</sup> stationary phase L. major (MHOM/IL/81/FEBNI) metacyclic promastigotes into the hind footpad. Asterisk indicates ulceration or necrosis per mouse. Footpad swelling was measured at weekly intervals up to week 14 and every 2 wk thereafter. A representative of one of two experiments is shown with mean values ± SD.</p></div>", "links"=>[], "tags"=>["mice", "footpad", "swelling", "parasite", "acute"], "article_id"=>620702, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Magdalena Radwanska", "Antony J Cutler", "J. Claire Hoving", "Stefan Magez", "Christoph Holscher", "Andreas Bohms", "Berenice Arendse", "Richard Kirsch", "Thomas Hunig", "James Alexander", "Paul Kaye", "Frank Brombacher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030068.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lck_cre_IL_4R_945_8722_lox_Mice_Control_Footpad_Swelling_and_Parasite_Burden_during_Acute_and_Chronic_L_major_Infection_/620702", "title"=>"Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> Mice Control Footpad Swelling and Parasite Burden during Acute and Chronic L. major Infection", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-05-11 00:11:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/950632"], "description"=>"<div><p>(A and B) IL-12p35 mRNA expression is increased in resistant mice. IL-12p35 expression was determined by real-time RT-PCR from RNA prepared from pooled popliteal LN cells from week 3 L. major–infected mice (eight mice per group). Data are expressed as IL-12p35 copy numbers relative to <i>GAPDH</i> (A) or as fold increase in IL-12p35 mRNA from 3 wk versus 1 wk after infection (B). Mean ± SEM of three runs on the same sample. Data are representative of two independent experiments (*<i>p</i> < 0.05, Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT).</p><p>(C and D) Increased IFN-γ production in resistant mice. (C) IFN-γ secretion by CD4 T cells cultured with fixed APCs and SLA. (**<i>p</i> < 0.01, Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT) and in (D) footpad homogenates (*<i>p</i> < 0.05, Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT) (homogenate data represent the pool of two independent experiments) from week 10 L. major–infected mice.</p><p>(E and F) Maintained IL-4 production in resistant mice. (E) IL-4 secretion by CD4 T cells cultured with fixed APCs and SLA and in (F) footpad homogenates from week-ten L. major–infected mice.</p><p>(G) iNOS production. iNOS mRNA copy number was calculated from footpad mRNA 6 wk after infection with <i>L. major.</i> At the same time, parasite DNA copy number was quantitated by PCR detecting L. major kinetoplast DNA. (*<i>p</i> < 0.05 Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT). The data represent the means of two individual experiments ± SEM.</p></div>", "links"=>[], "tags"=>["immunity", "enhanced", "mice"], "article_id"=>620940, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Magdalena Radwanska", "Antony J Cutler", "J. Claire Hoving", "Stefan Magez", "Christoph Holscher", "Andreas Bohms", "Berenice Arendse", "Richard Kirsch", "Thomas Hunig", "James Alexander", "Paul Kaye", "Frank Brombacher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030068.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Type_1_Immunity_Is_Enhanced_in_Lck_cre_IL_4R_945_8722_lox_Mice_in_Response_to_L_major_Infection_/620940", "title"=>"Type 1 Immunity Is Enhanced in Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> Mice in Response to L. major Infection", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-05-11 00:15:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/950208"], "description"=>"<div><p>(A) Impaired proliferation in response to IL-4. [<sup>3</sup>H] thymidine incorporation by CD4<sup>+</sup> T cells stimulated by serial dilutions of rIL-4 (left panel) or IL-2 (right panel). One of three representative experiments is shown with means of triplicate values ± SD.</p><p>(B) Impaired Th2 differentiation of CD4<sup>+</sup> T cells. CD4<sup>+</sup> T cells were cultured in Th1 or Th2 polarizing conditions and IL-4 or IFN-γ secretion was measured by ELISA. A representative of one of three experiments is shown with means of triplicate values ± SD.</p><p>(C) IL-4 and IL-13 suppress macrophage NO secretion in Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> mice. Peritoneal exudate cells were incubated with IL-4, IL-13, or IL-10 in combination with LPS/IFN-γ, LPS/IFN-γ alone, or medium alone. Nitrite levels were measured by Griess reaction. One of three experiments is shown with means of triplicate values ± SD. (**<i>p</i> < 0.01 or ***<i>p</i> < 0.001, LPS/IFN-γ versus LPS/IFN-γ + IL-4 or IL-13)</p><p>(D) IgE production. Total IgE was measured in sera taken at 3 wk after infection and boosted with OVA (three mice per group). One representative experiment of two is shown.</p></div>", "links"=>[], "tags"=>["immunology", "Infectious diseases"], "article_id"=>620522, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Magdalena Radwanska", "Antony J Cutler", "J. Claire Hoving", "Stefan Magez", "Christoph Holscher", "Andreas Bohms", "Berenice Arendse", "Richard Kirsch", "Thomas Hunig", "James Alexander", "Paul Kaye", "Frank Brombacher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030068.g002", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_Analysis_of_Lck_cre_IL_4R_945_8722_lox_Mice_/620522", "title"=>"Functional Analysis of Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> Mice", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-05-11 00:08:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/468422"], "description"=>"<div><p>Effector responses induced by polarized CD4<sup>+</sup> T helper 2 (Th2) cells drive nonhealing responses in BALB/c mice infected with <em>Leishmania major.</em> Th2 cytokines IL-4 and IL-13 are known susceptibility factors for L. major infection in BALB/c mice and induce their biological functions through a common receptor, the IL-4 receptor α chain (IL-4Rα). IL-4Rα–deficient BALB/c mice, however, remain susceptible to L. major infection, indicating that IL-4/IL-13 may induce protective responses. Therefore, the roles of polarized Th2 CD4<sup>+</sup> T cells and IL-4/IL-13 responsiveness of non-CD4<sup>+</sup> T cells in inducing nonhealer or healer responses have yet to be elucidated. CD4<sup>+</sup> T cell–specific IL-4Rα (Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup>) deficient BALB/c mice were generated and characterized to elucidate the importance of IL-4Rα signaling during cutaneous leishmaniasis in the absence of IL-4–responsive CD4<sup>+</sup> T cells. Efficient deletion was confirmed by loss of IL-4Rα expression on CD4<sup>+</sup> T cells and impaired IL-4–induced CD4<sup>+</sup> T cell proliferation and Th2 differentiation. CD8<sup>+</sup>, γδ<sup>+</sup>, and NK–T cells expressed residual IL-4Rα, and representative non–T cell populations maintained IL-4/IL-13 responsiveness. In contrast to IL-4Rα<sup>−/lox</sup> BALB/c mice, which developed ulcerating lesions following infection with <em>L. major,</em> Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> mice were resistant and showed protection to rechallenge, similar to healer C57BL/6 mice. Resistance to L. major in Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> mice correlated with reduced numbers of IL-10–secreting cells and early IL-12p35 mRNA induction, leading to increased delayed type hypersensitivity responses, interferon-γ production, and elevated ratios of inducible nitric oxide synthase mRNA/parasite, similar to C57BL/6 mice. These data demonstrate that abrogation of IL-4 signaling in CD4<sup>+</sup> T cells is required to transform nonhealer BALB/c mice to a healer phenotype. Furthermore, a beneficial role for IL-4Rα signaling in L. major infection is revealed in which IL-4/IL-13–responsive non-CD4<sup>+</sup> T cells induce protective responses.</p></div>", "links"=>[], "tags"=>["deletion", "cd4", "cells", "renders", "mice", "resistant"], "article_id"=>152357, "categories"=>["Cancer", "Immunology"], "users"=>["Magdalena Radwanska", "Antony J Cutler", "J. Claire Hoving", "Stefan Magez", "Christoph Holscher", "Andreas Bohms", "Berenice Arendse", "Richard Kirsch", "Thomas Hunig", "James Alexander", "Paul Kaye", "Frank Brombacher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030068", "stats"=>{"downloads"=>1, "page_views"=>45, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Deletion_of_IL_4R_on_CD4_T_Cells_Renders_BALB_c_Mice_Resistant_to_Leishmania_major_Infection/152357", "title"=>"Deletion of IL-4Rα on CD4 T Cells Renders BALB/c Mice Resistant to Leishmania major Infection", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2007-05-11 00:39:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/950540"], "description"=>"<div><p>(A and B) Increased numbers of IL-10–secreting cells in IL-4Rα<sup>−/lox</sup> mice. (A) CD4<sup>+</sup> IL-10–secreting cells were identified by intracellular FACS in LN cells restimulated with SLA for 24 h in vitro from L. major–infected mice 6 wk after infection. Data represent one of two independent experiments (pool of eight popliteal LNs/group). (B) Total numbers of CD4<sup>+</sup> IL-10–secreting cells per draining LN.</p><p>(C–E) Susceptible mice exhibit poor DTH responses controlled by IL-10. At 6–8 wk after infection with <i>L. major,</i> mice (five mice per group) were injected in the contralateral hind footpad with (C) 10 μg SLA subcutaneously, (D) 10 μg SLA and 0.5 μg IL-10 subcutaneously, and (E) 10 μg SLA and 1.5 μg anti–IL-10R subcutaneously. Footpad swelling was monitored every 24 h for 5 d. (***<i>p</i> < 0.001, **<i>p</i> < 0.01 Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT). The data represent one of two independent experiments.</p><p>(F) Increased IL-12p70 in DTH footpads of resistant mice. Lysates of footpads (four per group) taken 24 h after induction of DTH responses were analyzed for IL-12p70. The data represent the pool of two independent experiments (*<i>p</i> < 0.05, Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT).</p><p>(G) Increased IFN-γ in DTH footpads of resistant mice. Lysates of footpads (four per group) taken 24 h after induction of DTH responses were analyzed for IFN-γ. The data represent the pool of two independent experiments (**<i>p</i> < 0.01, Lck<sup>cre</sup>IL-4Rα<sup>−/lox</sup> versus WT).</p></div>", "links"=>[], "tags"=>["inhibits"], "article_id"=>620854, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Magdalena Radwanska", "Antony J Cutler", "J. Claire Hoving", "Stefan Magez", "Christoph Holscher", "Andreas Bohms", "Berenice Arendse", "Richard Kirsch", "Thomas Hunig", "James Alexander", "Paul Kaye", "Frank Brombacher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030068.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IL_10_Inhibits_Protective_Responses_/620854", "title"=>"IL-10 Inhibits Protective Responses", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-05-11 00:14:14"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "unique-ip"=>"21", "pdf"=>"7", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"13", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "unique-ip"=>"16", "pdf"=>"6", "year"=>"2010", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2010", "pdf"=>"8", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"14", "unique-ip"=>"14", "pdf"=>"6", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"9", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"11", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "unique-ip"=>"13", "pdf"=>"7", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"11", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"13", "unique-ip"=>"19", "pdf"=>"15", "year"=>"2010", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"11", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"14", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"6", "pdf"=>"0", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2010", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"3", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"15", "unique-ip"=>"13", "pdf"=>"6", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"12", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"3", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"13", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "unique-ip"=>"5", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"13", "unique-ip"=>"11", "pdf"=>"5", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"2", "abstract"=>"3", "full-text"=>"20", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"16", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"4", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"4", "pdf"=>"2", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"6", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"10", "pdf"=>"2", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2012", "pdf"=>"0", "unique-ip"=>"5", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"55", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"5", "figure"=>"139", "scanned-summary"=>"76", "supp-data"=>"77"}
  • {"scanned-page-browse"=>"61", "month"=>"6", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2007", "figure"=>"165", "scanned-summary"=>"93", "supp-data"=>"82"}
  • {"month"=>"7", "scanned-page-browse"=>"33", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"1", "unique-ip"=>"7", "figure"=>"126", "scanned-summary"=>"85", "supp-data"=>"82"}
  • {"scanned-page-browse"=>"56", "month"=>"8", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"15", "pdf"=>"0", "year"=>"2007", "figure"=>"135", "scanned-summary"=>"63", "supp-data"=>"66"}
  • {"month"=>"9", "scanned-page-browse"=>"35", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"93", "scanned-summary"=>"51", "supp-data"=>"47"}
  • {"scanned-page-browse"=>"22", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"9", "pdf"=>"0", "year"=>"2007", "figure"=>"80", "scanned-summary"=>"48", "supp-data"=>"50"}
  • {"month"=>"11", "scanned-page-browse"=>"26", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"2", "year"=>"2007", "pdf"=>"1", "unique-ip"=>"16", "figure"=>"103", "scanned-summary"=>"58", "supp-data"=>"59"}
  • {"scanned-page-browse"=>"11", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"34", "scanned-summary"=>"23", "supp-data"=>"22"}
  • {"month"=>"1", "scanned-page-browse"=>"23", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"1", "unique-ip"=>"8", "figure"=>"71", "scanned-summary"=>"38", "supp-data"=>"38"}
  • {"scanned-page-browse"=>"26", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2008", "figure"=>"66", "scanned-summary"=>"31", "supp-data"=>"31"}
  • {"month"=>"3", "scanned-page-browse"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"2", "unique-ip"=>"9", "figure"=>"54", "scanned-summary"=>"31", "supp-data"=>"30"}
  • {"scanned-page-browse"=>"29", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2008", "figure"=>"61", "scanned-summary"=>"32", "supp-data"=>"33"}
  • {"month"=>"5", "scanned-page-browse"=>"29", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"1", "unique-ip"=>"9", "figure"=>"90", "scanned-summary"=>"51", "supp-data"=>"48"}
  • {"scanned-page-browse"=>"13", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2008", "figure"=>"39", "scanned-summary"=>"25", "supp-data"=>"19"}
  • {"month"=>"7", "scanned-page-browse"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"30", "scanned-summary"=>"16", "supp-data"=>"21"}
  • {"scanned-page-browse"=>"13", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2008", "figure"=>"40", "scanned-summary"=>"26", "supp-data"=>"24"}
  • {"month"=>"9", "scanned-page-browse"=>"17", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2008", "pdf"=>"1", "unique-ip"=>"3", "figure"=>"45", "scanned-summary"=>"19", "supp-data"=>"23"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"21", "pdf"=>"15", "year"=>"2008", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "year"=>"2008", "pdf"=>"13", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "unique-ip"=>"17", "pdf"=>"12", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"45", "year"=>"2009", "pdf"=>"19", "unique-ip"=>"28", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"14", "unique-ip"=>"16", "pdf"=>"8", "year"=>"2009", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"30", "year"=>"2009", "pdf"=>"11", "unique-ip"=>"27", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"19", "unique-ip"=>"21", "pdf"=>"10", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"22", "year"=>"2009", "pdf"=>"10", "unique-ip"=>"26", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"21", "unique-ip"=>"22", "pdf"=>"8", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"13", "year"=>"2009", "pdf"=>"7", "unique-ip"=>"17", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"16", "unique-ip"=>"16", "pdf"=>"8", "year"=>"2009", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2009", "pdf"=>"8", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"1", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "year"=>"2009", "pdf"=>"14", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "unique-ip"=>"9", "pdf"=>"6", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2007-01-01T00:00:00Z", "end_date"=>"2007-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[294, 602, 790, 928, 1026, 1123, 1208, 1254, 1347, 1459, 1519, 1591, 1654, 1704, 1770, 1840, 1939, 2022, 2086, 2140, 2211, 2280, 2335, 2385, 2424, 2470, 2546, 2582, 2630, 2688, 2749, 2788, 2860, 2902, 2950, 3006, 3067, 3116, 3182, 3235, 3292, 3340, 3390, 3472, 3517, 3570, 3628, 3682, 3719, 3751, 3829, 3869, 3911, 3941, 3977, 4038, 4082, 4155, 4206, 4267, 4320, 4385, 4445, 4518, 4590, 4621, 4671, 4715, 4755, 4792, 4897, 4993, 5153, 5223, 5279, 5344, 5411, 5460, 5549, 5657, 5744, 5789, 5836, 5892, 5953]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[276, 596, 751, 882, 965, 1035, 1106, 1191, 1278, 1330, 1469, 1512, 1616, 1678, 1728, 1809, 1898, 1979, 2044, 2114, 2191, 2237, 2315, 2379, 2451, 2517, 2570, 2624, 2667, 2744, 2767, 2827, 2911, 2977, 3024, 3095, 3152, 3209, 3272, 3345, 3391, 3432, 3501, 3532, 3578, 3618, 3666, 3704, 3740, 3773, 3833, 3941, 3958, 4006, 4078, 4166, 4209, 4271, 4323, 4380, 4428, 4473, 4551, 4611, 4659, 4713, 4786, 4876, 4909, 4998, 5051, 5110, 5169, 5254, 5312, 5361, 5414, 5448, 5504, 5560, 5610, 5644, 5709, 5796, 5864]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[250, 558, 775, 924, 1023, 1116, 1215, 1294, 1389, 1453, 1537, 1631, 1692, 1764, 1835, 1918, 1988, 2036, 2082, 2154, 2239, 2301, 2366, 2410, 2465, 2539, 2591, 2660, 2714, 2756, 2814, 2863, 2911, 2957, 3022, 3074, 3122, 3179, 3232, 3298, 3385, 3438, 3485, 3524, 3560, 3605, 3658, 3698, 3743, 3804, 3845, 3882, 3933, 3970, 4003, 4055, 4107, 4183, 4247, 4302, 4351, 4403, 4444, 4498, 4569, 4642, 4699, 4751, 4849, 4916, 4964, 5012, 5176, 5243, 5305, 5362, 5421, 5537, 5600, 5654, 5701, 5749, 5813, 5898, 5973]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[266, 571, 722, 831, 929, 1003, 1095, 1191, 1281, 1390, 1469, 1545, 1605, 1677, 1767, 1834, 1901, 1973, 2066, 2135, 2178, 2219, 2261, 2316, 2363, 2430, 2487, 2541, 2587, 2636, 2705, 2768, 2821, 2888, 2941, 2979, 3048, 3097, 3145, 3189, 3249, 3295, 3355, 3396, 3432, 3465, 3503, 3563, 3628, 3673, 3707, 3748, 3808, 3856, 3917, 3979, 4015, 4066, 4140, 4188, 4237, 4278, 4329, 4382, 4442, 4521, 4597, 4666, 4713, 4770, 4841, 4908, 4960, 5006, 5067, 5163, 5231, 5317, 5400, 5467, 5576, 5673, 5730, 5785, 5839]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[269, 563, 725, 821, 917, 991, 1059, 1145, 1204, 1280, 1347, 1408, 1490, 1564, 1668, 1755, 1823, 1894, 1996, 2043, 2108, 2165, 2244, 2292, 2316, 2344, 2414, 2492, 2548, 2608, 2693, 2736, 2776, 2855, 2928, 2983, 3053, 3116, 3168, 3212, 3252, 3289, 3323, 3356, 3414, 3462, 3510, 3555, 3594, 3633, 3694, 3733, 3786, 3836, 3906, 3979, 4056, 4113, 4171, 4203, 4249, 4311, 4375, 4432, 4500, 4538, 4615, 4640, 4690, 4760, 4876, 4933, 4980, 5011, 5070, 5145, 5191, 5238, 5289, 5391, 5479, 5563, 5633, 5689, 5724]}]}
Loading … Spinner
There are currently no alerts