Nod1 Signaling Overcomes Resistance of S. pneumoniae to Opsonophagocytic Killing
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{"title"=>"Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing", "type"=>"journal", "authors"=>[{"first_name"=>"Elena S.", "last_name"=>"Lysenko", "scopus_author_id"=>"7005617690"}, {"first_name"=>"Thomas B.", "last_name"=>"Clarke", "scopus_author_id"=>"21742071900"}, {"first_name"=>"Mikhail", "last_name"=>"Shchepetov", "scopus_author_id"=>"6603149053"}, {"first_name"=>"Adam J.", "last_name"=>"Ratner", "scopus_author_id"=>"7103141291"}, {"first_name"=>"David I.", "last_name"=>"Roper", "scopus_author_id"=>"7006317297"}, {"first_name"=>"Christopher G.", "last_name"=>"Dowson", "scopus_author_id"=>"7004517413"}, {"first_name"=>"Jeffrey N.", "last_name"=>"Weiser", "scopus_author_id"=>"7102321730"}], "year"=>2007, "source"=>"PLoS Pathogens", "identifiers"=>{"sgr"=>"34548441212", "doi"=>"10.1371/journal.ppat.0030118", "pui"=>"47359085", "pmid"=>"17722978", "scopus"=>"2-s2.0-34548441212", "issn"=>"15537366", "isbn"=>"1553-7374 (Electronic)"}, "id"=>"145c1ddd-581c-3077-823d-9239838bbc11", "abstract"=>"Airway infection by the Gram-positive pathogen Streptococcus pneumoniae (Sp) leads to recruitment of neutrophils but limited bacterial killing by these cells. Co-colonization by Sp and a Gram-negative species, Haemophilus influenzae (Hi), provides sufficient stimulus to induce neutrophil and complement-mediated clearance of Sp from the mucosal surface in a murine model. Products from Hi, but not Sp, also promote killing of Sp by ex vivo neutrophil-enriched peritoneal exudate cells. Here we identify the stimulus from Hi as its peptidoglycan. Enhancement of opsonophagocytic killing was facilitated by signaling through nucleotide-binding oligomerization domain-1 (Nod1), which is involved in recognition of gamma-D-glutamyl-meso-diaminopimelic acid (meso-DAP) contained in cell walls of Hi but not Sp. Neutrophils from mice treated with Hi or compounds containing meso-DAP, including synthetic peptidoglycan fragments, showed increased Sp killing in a Nod1-dependent manner. Moreover, Nod1(-/-) mice showed reduced Hi-induced clearance of Sp during co-colonization. These observations offer insight into mechanisms of microbial competition and demonstrate the importance of Nod1 in neutrophil-mediated clearance of bacteria in vivo.", "link"=>"http://www.mendeley.com/research/nod1-signaling-overcomes-resistance-s-pneumoniae-opsonophagocytic-killing", "reader_count"=>39, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>4, "Student > Master"=>7, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>4, "Student > Master"=>7, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>21, "Medicine and Dentistry"=>10, "Chemistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Argentina"=>1, "Japan"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/946242"], "description"=>"<div><p>(A) The effect of Nod1 on stimulation of macrophage inhibitory protein (MIP-2) in upper respiratory tract lavage fluid in response to <i>Sp</i> and co-colonization with <i>Hi</i> in Nod1<sup>−/−</sup> or parental C57Bl/6 mice (WT). Box-and-whiskers plot indicates high and low values, median and interquartile ranges; <i>n</i> ≥ 13 mice from two independent experiments for each co-infected group. *<i>p</i> < 0.02 compared to PBS control.</p><p>(B) Effect of Nod1 on the neutrophil influx in response to bacteria following co-colonization. Immunofluorescence showing co-localization of <i>Hi</i> and <i>Sp</i> with neutrophils in the murine nasal spaces. Parental (i) or Nod1<sup>−/−</sup> (ii) mice were co-colonized with <i>Hi</i>636 and <i>Sp</i>1121, and at 24 h post-inoculation, adjacent 5-μm frozen parasagittal tissue sections through the lateral nasal spaces of the same animal were stained with anti-capsular polysaccharide serum specific to type b <i>Hi</i> (αHib), type 23F <i>Sp</i> (α23F), or αLy6.G antibody to mouse neutrophils. Hematoxylin and eosin–stained parasagittal sections (H&E) show the neutrophil influx into the lumen between adjacent nasal turbinates. DAPI nuclear staining (blue). Magnification 200×.</p><p>(C) FACS analysis of the effect of Nod1 of the influx of activated neutrophils. Administration (i.p.) of casein with 10<sup>6</sup> heat-inactivated <i>Hi</i> or FK-156 (1.0 μg/animal) was compared to casein alone for the effect on PECs expressing Ly6.G and the activation marker CD11b/CD18. Values represent the percent of total PECs expressing both markers and are means of three independent determinations ± SD.</p><p>(D) Killing of <i>Sp</i> by neutrophil-enriched PECs at a ratio of one bacterium to 25 effector cells obtained from C57Bl/6 (black bars) or congenic Nod1<sup>−/−</sup> (grey bars) mice pretreated by i.p. administration of heat-inactivated whole <i>Hi</i>636 (HK<i>Hi</i>). Where indicated, activated neutrophils were treated <i>ex vivo</i> with cytochalasin D, an inhibitor of actin polymerization, or DPI, an inhibitor of NADPH oxidase and the oxidative burst. Survival of intracellular <i>Sp</i> was based on bacterial counts following treatment with gentamicin sulfate. Values represent ≥ three independent determinations in duplicate ± SD.</p></div>", "links"=>[], "tags"=>["nod1", "chemokine", "neutrophil"], "article_id"=>616597, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Elena S Lysenko", "Thomas B Clarke", "Mikhail Shchepetov", "Adam J Ratner", "David I Roper", "Christopher G Dowson", "Jeffrey N Weiser"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030118.g006", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contribution_of_Nod1_to_Chemokine_Production_Neutrophil_Recruitment_and_Phagocytosis_/616597", "title"=>"Contribution of Nod1 to Chemokine Production, Neutrophil Recruitment, and Phagocytosis", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-08-24 01:49:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/945984"], "description"=>"<div><p>(A) Neutrophil-enriched PECs were obtained from C57Bl/6 (black bars) or congenic Nod1<sup>−/−</sup> (grey bars) mice pretreated by i.p. administration of casein containing heat-inactivated whole <i>Hi</i>636 (HK<i>Hi</i>), murNAcTRI<sub>DAP</sub> (DAP, 10 μg/animal), or its synthetic analog, FK-156 (10 μg/animal). Survival of <i>Sp</i>1121 is shown relative to controls where neutrophil-enriched PECs were elicited by casein administration alone. Values represent ≥ three independent determinations in duplicate ± SD. *<i>p</i> < 0.01 compared to the same treatment in parental mice.</p><p>(B) Neutrophil-enriched PECs were obtained from C57Bl/6 mice pretreated by i.p. administration without casein of heat-inactivated whole <i>Hi</i>636 (HK<i>Hi</i>), murNAcTRI<sub>DAP</sub> (DAP, 10 μg/animal), or murNAcTRI<sub>LYS</sub> (LYS, 10 μg/animal).</p><p>Values represent ≥ three independent determinations in duplicate ± SD. *<i>p</i> < 0.01 compared to other groups.</p></div>", "links"=>[], "tags"=>["synthetic", "peptidoglycan", "fragments", "opsonophagocytic"], "article_id"=>616344, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Elena S Lysenko", "Thomas B Clarke", "Mikhail Shchepetov", "Adam J Ratner", "David I Roper", "Christopher G Dowson", "Jeffrey N Weiser"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030118.g004", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Ability_of_Synthetic_Peptidoglycan_Fragments_to_Stimulate_Opsonophagocytic_Killing_of_Sp_/616344", "title"=>"The Ability of Synthetic Peptidoglycan Fragments to Stimulate Opsonophagocytic Killing of <i>Sp</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-08-24 01:45:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/945836"], "description"=>"<p>Neutrophil-enriched PECs were obtained from C57Bl/6 mice (WT) or congenic mice lacking TLR2 or Nod1. C3H mice with functional or non-functional TLR4 were also compared. The effect of i.p. administration of heat-inactivated whole <i>Hi</i>636 in casein on the ability of neutrophil-enriched PECs to kill <i>Sp</i>1121 is shown relative to controls where neutrophil-enriched PECs were elicited by casein administration alone. Values represent ≥ three independent determinations in duplicate ± SD. *<i>p</i> < 0.05 compared to other groups of the same genetic background.</p>", "links"=>[], "tags"=>["opsonophagocytic", "requires"], "article_id"=>616202, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Elena S Lysenko", "Thomas B Clarke", "Mikhail Shchepetov", "Adam J Ratner", "David I Roper", "Christopher G Dowson", "Jeffrey N Weiser"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030118.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hi_Enhanced_Opsonophagocytic_Killing_of_Sp_Requires_Nod1_/616202", "title"=>"<i>Hi</i>-Enhanced Opsonophagocytic Killing of <i>Sp</i> Requires Nod1", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-08-24 01:43:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/945913"], "description"=>"<p>Neutrophil-enriched PECs were obtained from C57Bl/6 mice pretreated by i.p. administration of casein containing heat-inactivated whole <i>Hi</i>636 (HK<i>Hi, n</i> = 6), E. coli LPS (50 μg/animal, <i>n</i> = 3), <i>Hi</i> LPS (50 μg/animal, <i>n</i> = 4), <i>Sp</i> peptidoglycan (PGN, 10 μg/animal, <i>n</i> = 5), <i>Hi</i> peptidoglycan (PGN, 1.0 or 10 μg/animal, <i>n</i> = 4 and 3, respectively), FK-156 (1.0 μg/animal, <i>n</i> = 6), or MDP (10 μg/animal, <i>n</i> = 3). Survival of <i>Sp</i>1121 is shown relative to controls where neutrophil-enriched PECs were elicited by casein administration alone. Values represent duplicate determinations of the number of independent experiments indicated above for each condition ± SD. *<i>p</i> < 0.01 compared to casein alone control.</p>", "links"=>[], "tags"=>["bacterial", "components", "opsonophagocytic"], "article_id"=>616280, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Elena S Lysenko", "Thomas B Clarke", "Mikhail Shchepetov", "Adam J Ratner", "David I Roper", "Christopher G Dowson", "Jeffrey N Weiser"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030118.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Ability_of_Bacterial_Components_to_Stimulate_Opsonophagocytic_Killing_of_Sp_/616280", "title"=>"The Ability of Bacterial Components to Stimulate Opsonophagocytic Killing of <i>Sp</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-08-24 01:44:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/946041"], "description"=>"<p>The density of <i>Sp</i>1121 (<i>Sp</i>) in upper respiratory tract lavage was determined at 24 h post-intranasal inoculation with <i>Sp</i> alone or together with <i>Hi</i>636 (<i>Hi</i>) in Nod1<sup>−/−</sup> or parental C57Bl/6 mice (WT). Box-and-whiskers plot indicates high and low values, median and interquartile ranges; <i>n</i> ≥ 10 mice from three independent experiments in each group. Co-inoculated species shown in parentheses. The lower limit of detection for bacteria in lavage culture was 10<sup>2</sup> CFU/ml (indicated by a dashed line).</p>", "links"=>[], "tags"=>["nod1"], "article_id"=>616406, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Elena S Lysenko", "Thomas B Clarke", "Mikhail Shchepetov", "Adam J Ratner", "David I Roper", "Christopher G Dowson", "Jeffrey N Weiser"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030118.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Nod1_on_Competition_between_Species_during_Co_Colonization_/616406", "title"=>"Effect of Nod1 on Competition between Species during Co-Colonization", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-08-24 01:46:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/945761"], "description"=>"<p>Neutrophil-enriched PECs were obtained from mice following i.p. administration of heat-inactivated whole <i>Hi</i>636 in casein. The effect of HK<i>Hi</i> on the ability of neutrophil-enriched PECs to kill <i>Sp</i>1121 is shown relative to controls where neutrophil-enriched PECs were elicited by casein administration alone. Survival of <i>Sp</i>1121 was assessed over a 45-min incubation with complement in serum from wild-type mice (WT), C3-deficient mice (C3<sup>−/−</sup>), or factor B–deficient mice (fB<sup>−/−</sup>) as indicated. Neutrophil-enriched PECs were obtained from Mac1<sup>−/−</sup> (grey bar) or control C57Bl/6 (black bars) mice. No stimulation of killing was observed in controls using heat-inactivated complement or cells from animals pretreated with monoclonal antibody RB6-8C5 to deplete neutrophils. Values represent ≥ three independent determinations in duplicate ± SD. *<i>p</i> < 0. 01 compared to other conditions.</p>", "links"=>[], "tags"=>["requires", "opsonization", "involving", "pathway", "complement", "mac-1"], "article_id"=>616127, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Elena S Lysenko", "Thomas B Clarke", "Mikhail Shchepetov", "Adam J Ratner", "David I Roper", "Christopher G Dowson", "Jeffrey N Weiser"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030118.g001", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hi_Enhanced_Killing_of_Sp_Requires_Opsonization_Involving_the_Alternative_Pathway_of_Complement_and_Recognition_by_Mac_1_CD11b_CD18_/616127", "title"=>"<i>Hi</i>-Enhanced Killing of <i>Sp</i> Requires Opsonization Involving the Alternative Pathway of Complement and Recognition by Mac-1 (CD11b/CD18)", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-08-24 01:42:07"}

PMC Usage Stats | Further Information

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Relative Metric

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