Pathogenesis, Virulence, and Infective Dose
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{"title"=>"Pathogenesis, virulence, and infective dose", "type"=>"generic", "authors"=>[{"first_name"=>"Paul", "last_name"=>"Schmid-Hempel", "scopus_author_id"=>"7005822595"}, {"first_name"=>"Steven A.", "last_name"=>"Frank", "scopus_author_id"=>"35614051000"}], "year"=>2007, "source"=>"PLoS Pathogens", "identifiers"=>{"sgr"=>"36049001735", "doi"=>"10.1371/journal.ppat.0030147", "pui"=>"350085600", "pmid"=>"17967057", "scopus"=>"2-s2.0-36049001735", "issn"=>"15537366", "isbn"=>"1553-7366"}, "id"=>"fd8c8708-8c37-31d7-b452-05ca308fe25b", "abstract"=>"Some pathogens can begin an infection with only a small number of cells in the initial inoculum. For example, enterohemorrhagic strains of Escherichia coli require an infective dose of only about ten cells. By contrast, other pathogens, such as Vibrio cholerae, require a large number of cells (103 to 108 cells) in the inoculum to successfully infect a host", "link"=>"http://www.mendeley.com/research/pathogenesis-virulence-infective-dose", "reader_count"=>207, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>13, "Researcher"=>49, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>45, "Student > Postgraduate"=>6, "Other"=>4, "Student > Master"=>31, "Student > Bachelor"=>17, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>4, "Professor"=>17}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>13, "Researcher"=>49, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>45, "Student > Postgraduate"=>6, "Other"=>4, "Student > Master"=>31, "Student > Bachelor"=>17, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>4, "Professor"=>17}, "reader_count_by_subject_area"=>{"Unspecified"=>14, "Agricultural and Biological Sciences"=>117, "Veterinary Science and Veterinary Medicine"=>2, "Chemistry"=>3, "Computer Science"=>2, "Engineering"=>11, "Environmental Science"=>9, "Biochemistry, Genetics and Molecular Biology"=>10, "Nursing and Health Professions"=>2, "Materials Science"=>4, "Mathematics"=>3, "Medicine and Dentistry"=>16, "Physics and Astronomy"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>9, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>14}, "Environmental Science"=>{"Environmental Science"=>9}, "Engineering"=>{"Engineering"=>11}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>117}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Reunion"=>1, "Colombia"=>1, "United States"=>10, "United Kingdom"=>2, "Malaysia"=>1, "Switzerland"=>2, "India"=>1, "Spain"=>1, "Saudi Arabia"=>1, "Canada"=>1, "Austria"=>2, "Brazil"=>2, "Italy"=>1, "Mexico"=>1, "South Africa"=>1, "Chile"=>1, "Germany"=>3}, "group_count"=>10}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/942804"], "description"=>"<p>Upper panel: bacteria with pathogenic mechanisms that depend on direct contact (local action). Lower panel: bacteria with pathogenic mechanisms that depend on secreted molecules (distant action). Dose information is from the US Food and Drug Administration [<a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030147#ppat-0030147-b002\" target=\"_blank\">2</a>] and Health Canada [<a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030147#ppat-0030147-b003\" target=\"_blank\">3</a>]. Various sources include references [<a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030147#ppat-0030147-b012\" target=\"_blank\">12</a>–<a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030147#ppat-0030147-b014\" target=\"_blank\">14</a>]. Values for <i>Yersinia</i> are considered low by the US Food and Drug Administration, while Health Canada refers to LD50 in mice.</p>", "links"=>[], "tags"=>["pathogenic"], "article_id"=>613211, "categories"=>["Microbiology", "Immunology", "Cell Biology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Paul Schmid-Hempel", "Steven A Frank"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.0030147.g001", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dose_and_Mode_of_Pathogenic_Mechanism_/613211", "title"=>"Dose and Mode of Pathogenic Mechanism", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-10-26 00:53:31"}

PMC Usage Stats | Further Information

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Relative Metric

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