Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes
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{"title"=>"Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes", "type"=>"journal", "authors"=>[{"first_name"=>"Paul D.", "last_name"=>"Cotter", "scopus_author_id"=>"7006716039"}, {"first_name"=>"Lorraine A.", "last_name"=>"Draper", "scopus_author_id"=>"10340009700"}, {"first_name"=>"Elaine M.", "last_name"=>"Lawton", "scopus_author_id"=>"10340404400"}, {"first_name"=>"Karen M.", "last_name"=>"Daly", "scopus_author_id"=>"25121470000"}, {"first_name"=>"David S.", "last_name"=>"Groeger", "scopus_author_id"=>"25121326300"}, {"first_name"=>"Pat G.", "last_name"=>"Casey", "scopus_author_id"=>"7102742190"}, {"first_name"=>"R. Paul", "last_name"=>"Ross", "scopus_author_id"=>"55664948500"}, {"first_name"=>"Colin", "last_name"=>"Hill", "scopus_author_id"=>"7403558967"}], "year"=>2008, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"352447252", "sgr"=>"53049084310", "issn"=>"15537366", "pmid"=>"18787690", "scopus"=>"2-s2.0-53049084310", "doi"=>"10.1371/journal.ppat.1000144", "isbn"=>"1553-7366 (Print)\\n1553-7374 (Electronic)"}, "id"=>"a51c4637-6d22-396a-a431-74ae1a6fafd7", "abstract"=>"Author Summary\nListeria monocytogenes is known to produce only one haemolytic factor that plays an important role in its pathogenic cycle—that is, the cholesterol-dependent Listeriolysin O. However, here we identify a second haemolysin, which is present in a subset of strains of lineage I, the evolutionary lineage of L. monocytogenes that contributes to the majority of spontaneous and epidemic outbreaks of listeriosis. This second haemolysin is only induced under oxidative stress conditions and contributes to murine virulence and in survival in polymorphonuclear neutrophils. Bioinformatic analysis suggests that the haemolysin Listeriolysin S (LLS) is post-translationally modified and belongs to a family of modified virulence peptides, including the potent virulence factor Streptolysin S (SLS), a peptide cytolysin produced by Streptococcus pyogenes , and several as-yet uncharacterised members of the same family in other pathogens. Therefore, en route to establishing that some L. monocytogenes produce more than one haemolysin, we have uncovered a virulence factor that is exclusively associated with a subset of the lineage I evolutionary line and that is also the first non-streptococcal representative of a potentially extended family of SLS-like peptides.", "link"=>"http://www.mendeley.com/research/listeriolysin-s-novel-peptide-haemolysin-associated-subset-lineage-i-listeria-monocytogenes", "reader_count"=>99, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>26, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>6, "Student > Bachelor"=>8, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>26, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>6, "Student > Bachelor"=>8, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>62, "Veterinary Science and Veterinary Medicine"=>1, "Business, Management and Accounting"=>1, "Chemical Engineering"=>1, "Chemistry"=>2, "Computer Science"=>2, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>9, "Medicine and Dentistry"=>8, "Psychology"=>1, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>62}, "Computer Science"=>{"Computer Science"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Brazil"=>1, "Israel"=>1, "Portugal"=>1}, "group_count"=>5}

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  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/921284"], "description"=>"<p>(A) Haemolysis of Columbia blood agar (5% Sheep's blood) by F2365, F2365Δ<i>hly</i> and F2365Δ<i>hly</i>Δ<i>llsB</i> when the <i>lls</i> genes is under the control of the natural PllsA or constitutive P<sub>HELP</sub> promoters (F2365LLS<sup>C</sup>, F2365Lls<sup>C</sup>Δ<i>hly</i> and F2365LLS<sup>C</sup>Δ<i>hly</i>Δ<i>llsB</i>). In situations where haemolytic activity was quantified, the corresponding haemolytic unit (H.U.) values are presented. (B) Cytotoxicity relative to F2365 (100%) with respect to the J774, C2-Bbe and CT26 cell lines; F2365Δhly-black, F2365LLS<sup>C</sup>Δ<i>hly</i>-white. *-significantly different (P<0.05), **-extremely significantly different (P<0.005) different. Error bars represent standard error of the mean. (C) Assessment of the haemolytic activity of cell free supernatant (CFS) of F2365LLS<sup>C</sup>Δ<i>hly</i> and F2365LLS<sup>C</sup>Δ<i>hly</i>Δ<i>llsB</i>, of the cell free supernatant of induction buffer washed F2365LLS<sup>C</sup>Δ<i>hly</i> and F2365LLS<sup>C</sup>Δ<i>hly</i>Δ<i>llsB</i> (IBS), and of IBS from the strains combined with RNA core (RNA<sup>C</sup>; inducer) and ammonium acetate (AmmAc; stabilizer) aliquoted into 4.6 mm wells in Columbia blood agar (5% Sheep's blood). NB. IB, RNA<sup>C</sup> and AmmAc, both individually and in combination, are non-haemolytic (data not shown).</p>", "links"=>[], "tags"=>["cytolytic", "activities"], "article_id"=>591725, "categories"=>["Infectious Diseases", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000144.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Haemolytic_and_cytolytic_activities_of_LLS_/591725", "title"=>"Haemolytic and cytolytic activities of LLS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-12 00:28:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/454492", "https://ndownloader.figshare.com/files/454561", "https://ndownloader.figshare.com/files/454675"], "description"=>"<div><p>Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A <em>Streptococcus</em> (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including <em>Listeria monocytogenes</em>, <em>Clostridium botulinum</em> and <em>Staphylococcus aureus</em>, produce related peptides. The distribution of the <em>L. monocytogenes</em> cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil–based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I <em>L. monocytogenes</em> may have been revealed.</p></div>", "links"=>[], "tags"=>["listeriolysin", "peptide", "haemolysin", "subset", "lineage"], "article_id"=>149548, "categories"=>["Cancer", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1000144.s001", "https://dx.doi.org/10.1371/journal.ppat.1000144.s002", "https://dx.doi.org/10.1371/journal.ppat.1000144.s003"], "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Listeriolysin_S_a_Novel_Peptide_Haemolysin_Associated_with_a_Subset_of_Lineage_I_Listeria_monocytogenes_/149548", "title"=>"Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I <em>Listeria monocytogenes</em>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-09-12 02:39:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/921412"], "description"=>"<p>(A) Levels (cfu–colony forming units) of wild-type (F2365) and mutant (F2365Δ<i>llsB</i>; LLS<sup>−</sup>) F2365 in livers and spleens of Balb/C mice 3 days post-intraperitoneal infection. (B) Survival in human PMNs after 2 hr. * - significantly different (P<0.05), ** - extremely significantly different (P<0.005) different. Error bars represent standard error of the mean.</p>", "links"=>[], "tags"=>["virulence", "wildtype", "f2365"], "article_id"=>591853, "categories"=>["Infectious Diseases", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000144.g006", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_virulence_of_wildtype_F2365_and_a_LLS_8722_derivative_/591853", "title"=>"Comparison of the virulence of wildtype F2365 and a LLS<sup>−</sup> derivative.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-12 00:30:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/921099"], "description"=>"<p>Comparison of the LIPI-3-containing region (bottom) with the corresponding region of LLS<sup>− </sup><i>L. monocytogenes</i> (middle), <i>L. innocua</i> and <i>L. welshimeri </i><a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000144#ppat.1000144-Gajic1\" target=\"_blank\">[49]</a>. For <i>L. monocytognes</i> strains, the strain name and serotype (in brackets) is presented and the designation of the first and last gene in each case is that designated in the corresponding genome sequence. Homologous genes (or in the case of the <i>llsA-P</i>, clusters of genes) are presented by matching colours.</p>", "links"=>[], "tags"=>["corresponding", "regions", "lipi-3", "minus"], "article_id"=>591540, "categories"=>["Infectious Diseases", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000144.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LIPI_3_and_corresponding_regions_in_LIPI_3_minus_Listeria_/591540", "title"=>"LIPI-3 and corresponding regions in LIPI-3 minus <i>Listeria</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-12 00:25:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/921039"], "description"=>"<p>Arrangement of the Stapholysin S (<i>sts</i>), Listeriolysin S (<i>lls</i>), Streptolysin S (<i>sag</i>) and Botulysin (<i>bts</i>) associated genes in <i>S. aureus</i> ET3-1, <i>L. monocytogenes</i> F2365, <i>S. pyogenes</i> MGAS 8232 and <i>C. botulinum</i> ATCC3502 respectively. Homology between the predicted <i>lls</i> gene products and their <i>sag</i> and <i>sts</i> equivalents is indicated by a line and dashed line, respectively, with an associated % identity value. % identity values with respect to the predicted Sag and Bts gene products are also indicated. The amino acid sequence of the predicted unmodified structural peptides, StsA, LlsA, SagA and BtsA is presented (boxed) with italicized letters indicating amino acids likely to constitute the leader region. Residues within the structural propeptide that are potentially modified are underlined. The location of oligonucleotide pairs used to investigate strain variation are indicated (i) llsAint-llsAsoeD, (ii) 1118degf–1118degr and (iii) 1118f–1118r.</p>", "links"=>[], "tags"=>["mvp-associated"], "article_id"=>591485, "categories"=>["Infectious Diseases", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000144.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_MVP_associated_operons_/591485", "title"=>"Comparison of MVP-associated operons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-12 00:24:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/921213"], "description"=>"<p>LIPI-3 status (positive, + or negative, −) mapped onto a maximum parsimony tree inferred from sequence data of lineage I strains (adapted from <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000144#ppat.1000144-Ducey1\" target=\"_blank\">[24]</a>). The individual sequence types (1–19), representatives tested (strain number in brackets) and associated epidemic outbreaks (in red). Strains of serotype 4b and 1/2b are also distinguished.</p>", "links"=>[], "tags"=>["lipi-3", "lineage"], "article_id"=>591659, "categories"=>["Infectious Diseases", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000144.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_LIPI_3_among_lineage_I_L_monocytogenes_/591659", "title"=>"Distribution of LIPI-3 among lineage I <i>L. monocytogenes</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-12 00:27:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/921352"], "description"=>"<p>Induction of PllsA by 13 mM cumene hydroperoxide and 22 and 50 mM hydrogen peroxide. Data are presented as (A) mean relative light units (RLU; photons s<sup>−1</sup>)/well±standard deviations for three replicates, and (B) one representative of three independent experiments is shown. The colour bar indicates bioluminescence signal intensity (in photons s<sup>−1</sup> cm<sup>−2</sup>).</p>", "links"=>[], "tags"=>["pllsa"], "article_id"=>591799, "categories"=>["Infectious Diseases", "Microbiology", "Genetics"], "users"=>["Paul D. Cotter", "Lorraine A. Draper", "Elaine M. Lawton", "Karen M. Daly", "David S. Groeger", "Pat G. Casey", "R. Paul Ross", "Colin Hill"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000144.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Induction_of_the_PllsA_promoter_/591799", "title"=>"Induction of the PllsA promoter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-12 00:29:59"}

PMC Usage Stats | Further Information

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Relative Metric

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