A New Perspective on Listeria monocytogenes Evolution
Publication Date
September 05, 2008
Journal
PLOS Pathogens
Authors
Marie Ragon, Thierry Wirth, Florian Hollandt, Rachel Lavenir, et al
Volume
4
Issue
9
Pages
e1000146
DOI
https://dx.plos.org/10.1371/journal.ppat.1000146
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1000146
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/18773117
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518857
Europe PMC
http://europepmc.org/abstract/MED/18773117
Web of Science
000259783300004
Scopus
53049109498
Mendeley
http://www.mendeley.com/research/new-perspective-listeria-monocytogenes-evolution
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"A new perspective on Listeria monocytogenes evolution", "type"=>"journal", "authors"=>[{"first_name"=>"Marie", "last_name"=>"Ragon", "scopus_author_id"=>"25226473000"}, {"first_name"=>"Thierry", "last_name"=>"Wirth", "scopus_author_id"=>"56256893400"}, {"first_name"=>"Florian", "last_name"=>"Hollandt", "scopus_author_id"=>"25121500100"}, {"first_name"=>"Rachel", "last_name"=>"Lavenir", "scopus_author_id"=>"14050534100"}, {"first_name"=>"Marc", "last_name"=>"Lecuit", "scopus_author_id"=>"17735328200"}, {"first_name"=>"Alban Le", "last_name"=>"Monnier", "scopus_author_id"=>"25121689400"}, {"first_name"=>"Sylvain", "last_name"=>"Brisse", "scopus_author_id"=>"7003389142"}], "year"=>2008, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"352447260", "sgr"=>"53049109498", "issn"=>"15537366", "pmid"=>"18773117", "scopus"=>"2-s2.0-53049109498", "doi"=>"10.1371/journal.ppat.1000146", "isbn"=>"1553-7374 (Electronic)"}, "id"=>"29e0ff7e-b48d-3ff7-b588-c3a7f4aaf57c", "abstract"=>"Listeria monocytogenes is a model organism for cellular microbiology and host-pathogen interaction studies and an important food-borne pathogen widespread in the environment, thus representing an attractive model to study the evolution of virulence. The phylogenetic structure of L. monocytogenes was determined by sequencing internal portions of seven housekeeping genes (3,288 nucleotides) in 360 representative isolates. Fifty-eight of the 126 disclosed sequence types were grouped into seven well-demarcated clonal complexes (clones) that comprised almost 75% of clinical isolates. Each clone had a unique or dominant serotype (4b for clones 1, 2 and 4, 1/2b for clones 3 and 5, 1/2a for clone 7, and 1/2c for clone 9), with no association of clones with clinical forms of human listeriosis. Homologous recombination was extremely limited (r/m<1 for nucleotides), implying long-term genetic stability of multilocus genotypes over time. Bayesian analysis based on 438 SNPs recovered the three previously defined lineages, plus one unclassified isolate of mixed ancestry. The phylogenetic distribution of serotypes indicated that serotype 4b evolved once from 1/2b, the likely ancestral serotype of lineage I. Serotype 1/2c derived once from 1/2a, with reference strain EGDe (1/2a) likely representing an intermediate evolutionary state. In contrast to housekeeping genes, the virulence factor internalin (InlA) evolved by localized recombination resulting in a mosaic pattern, with convergent evolution indicative of natural selection towards a truncation of InlA protein. This work provides a reference evolutionary framework for future studies on L. monocytogenes epidemiology, ecology, and virulence.", "link"=>"http://www.mendeley.com/research/new-perspective-listeria-monocytogenes-evolution", "reader_count"=>185, "reader_count_by_academic_status"=>{"Unspecified"=>6, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>48, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>52, "Student > Postgraduate"=>5, "Student > Master"=>25, "Other"=>5, "Student > Bachelor"=>15, "Lecturer"=>3, "Professor"=>12}, "reader_count_by_user_role"=>{"Unspecified"=>6, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>48, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>52, "Student > Postgraduate"=>5, "Student > Master"=>25, "Other"=>5, "Student > Bachelor"=>15, "Lecturer"=>3, "Professor"=>12}, "reader_count_by_subject_area"=>{"Unspecified"=>14, "Agricultural and Biological Sciences"=>109, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>5, "Chemistry"=>3, "Computer Science"=>5, "Engineering"=>4, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>18, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>15, "Immunology and Microbiology"=>7}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Unspecified"=>{"Unspecified"=>14}, "Environmental Science"=>{"Environmental Science"=>2}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>109}, "Computer Science"=>{"Computer Science"=>5}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>18}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>5}}, "reader_count_by_country"=>{"Greece"=>1, "Sweden"=>1, "United States"=>2, "Denmark"=>2, "Brazil"=>2, "United Kingdom"=>2, "South Africa"=>1, "France"=>3, "Portugal"=>1, "Germany"=>1, "Spain"=>2}, "group_count"=>9}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/53049109498"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/53049109498?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=53049109498&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=53049109498&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/53049109498", "dc:identifier"=>"SCOPUS_ID:53049109498", "eid"=>"2-s2.0-53049109498", "dc:title"=>"A new perspective on Listeria monocytogenes evolution", "dc:creator"=>"Ragon M.", "prism:publicationName"=>"PLoS Pathogens", "prism:issn"=>"15537366", "prism:eIssn"=>"15537374", "prism:volume"=>"4", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2008-09-01", "prism:coverDisplayDate"=>"September 2008", "prism:doi"=>"10.1371/journal.ppat.1000146", "citedby-count"=>"274", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Organisation Mondiale de la Santé", "affiliation-city"=>"Geneva", "affiliation-country"=>"Switzerland"}, {"@_fa"=>"true", "affilname"=>"Institut Pasteur, Paris", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}], "pubmed-id"=>"18773117", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1000146", "source-id"=>"4000151809", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplospathogens%2Farticle%3Fid%3D10.1371%252Fjournal.ppat.1000146", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"112", "xml_views"=>"0", "html_views"=>"946"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"60", "xml_views"=>"0", "html_views"=>"217"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"110"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"40", "xml_views"=>"4", "html_views"=>"83"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"83"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"23", "xml_views"=>"3", "html_views"=>"77"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"70"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"5", "html_views"=>"63"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"185"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"133"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"123"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"149"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"3", "html_views"=>"96"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"3", "html_views"=>"96"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"31", "xml_views"=>"2", "html_views"=>"90"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"34", "xml_views"=>"5", "html_views"=>"79"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"58", "xml_views"=>"0", "html_views"=>"214"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"71", "xml_views"=>"0", "html_views"=>"238"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"130"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"267"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"355"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"218"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"185"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"167"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"168"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"130"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"184"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"4", "html_views"=>"188"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"3", "html_views"=>"113"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"201"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"182"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"179"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"220"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"289"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"306"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"215"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"116"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"139"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"3", "html_views"=>"220"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"215"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"159"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"152"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"135"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"129"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"101"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"8", "html_views"=>"96"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"138"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"2", "html_views"=>"123"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"118"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"61"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"87"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"92"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"138"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"73"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"60"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/921874"], "description"=>"<p>A) 50% consensus tree obtained after 100,000 iterations (after 50,000 burn-in) for the 130 distinct <i>Listeria</i> STs. <i>L. monocytogenes</i> appears monophyletic, with three distinct lineages and one strain (CLIP98) considered as a fourth lineage. Note the close association of CLIP85 with other lineage III strains. B) Detailed view of the inferred relationships within lineage I. Note the monophyly of serotype 4b. C) Detailed view of the inferred relationships within lineage II. Note that all strains of serotype 1/2c (CC9) are nested inside the diversity of 1/2a, and that serotype 1/2c seems to have evolved from 1/2a just after the split from strain EDGe. D) Detailed view of the inferred relationships within lineage III. E) Events on the branch that separates CLIP85 (ST157) from the rest of lineage III. Note the high number of nucleotide changes in <i>lhkA</i> (seventh gene), inferred by clonalFrame to correspond to a single recombination event.</p>", "links"=>[], "tags"=>["clonalframe", "serotype"], "article_id"=>592315, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogeny_obtained_with_ClonalFrame_and_serotype_relationships_/592315", "title"=>"Phylogeny obtained with ClonalFrame and serotype relationships.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-05 00:38:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/922049"], "description"=>"a<p>Concat., concatenated data set. Values for rho (ρ) were obtained by dividing the per-locus recombination rate estimate from LDhat by the sequence length.</p>**<p>Estimates that are significant at the 5% level. Θ and <i>ρ</i> correspond to the population estimates of mutation and recombination rates, respectively.</p>", "links"=>[], "tags"=>["mutation", "rates", "recombination"], "article_id"=>592492, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_mutation_rates_956_and_recombination_rates_r_per_base_/592492", "title"=>"Comparison of mutation rates (<i>μ</i>) and recombination rates (r) per base.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-05 00:41:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/921796"], "description"=>"<p>A) Proportions of ancestry in seven housekeeping genes of <i>L. monocytogenes</i> strains from three ancestral populations as inferred by the linkage model of structure. This plot shows one vertical line for each isolate in which the proportions of ancestry from the three sources are color-coded. For example, strain CLIP85 was inferred as having mixed ancestry, with approximately 75% of nucleotides originated from lineage III (blue), whereas 25% of them were inferred to have an origin in lineage II (green). A number of strains from lineage I have a small proportion of nucleotides with ancestry in lineage III, while strains of lineage II had some nucleotides from lineages I (red) or III (blue). The case of CLIP98 is particular, as it was inferred as deriving from lineage II by imports mainly from <i>L. innocua</i> (see text). B) Neighbor-joining phylogenetic analysis of concatenated housekeeping gene sequences, using the Tamura-Nei+G+I model. The three major <i>L. monocytogenes</i> lineages are recognized. Together, they included all strains except CLIP85 and CLIP98. Bootstrap support of lineages is given at corresponding branches. An asterisk (*) marks strains that were recognized by structure to contain a fraction of nucleotides imported from another ancestral population, with corresponding branches colored according to the source of the recombined nucleotides. Recombination events detected independently using with RDP3 are numbered from 1 to 7 (referring to <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000146#ppat.1000146.s003\" target=\"_blank\">Table S2</a>), and the involved genes are indicated.</p>", "links"=>[], "tags"=>["recombination", "distorts", "phylogenetic"], "article_id"=>592241, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Homologous_recombination_is_rare_but_distorts_phylogenetic_reconstruction_/592241", "title"=>"Homologous recombination is rare, but distorts phylogenetic reconstruction.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-05 00:37:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/922149"], "description"=>"<p>ST: sequence type; CC: clonal complex; pos.: position; Id.: identical; nt: nucleotide; del. Deleted; SNP: single nucleotide polymorphism.</p>", "links"=>[], "tags"=>["codons", "internalin"], "article_id"=>592592, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Premature_stop_codons_identified_in_internalin_gene_inlA_of_Listeria_monocytogenes_isolates_/592592", "title"=>"Premature stop codons identified in internalin gene <i>inlA</i> of <i>Listeria monocytogenes</i> isolates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-05 00:43:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/922084"], "description"=>"<p>Ks: No. of synonymous changes per synonymous site. Ka: No. of non-synonymous changes per non-synonymous site.</p><p>π: nucleotide diversity.</p>", "links"=>[], "tags"=>["housekeeping", "protein-coding", "genes"], "article_id"=>592526, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Polymorphism_of_seven_housekeeping_protein_coding_genes_among_L_monocytogenes_isolates_/592526", "title"=>"Polymorphism of seven housekeeping protein-coding genes among <i>L. monocytogenes</i> isolates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-05 00:42:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/921696"], "description"=>"<p>Each circle corresponds to a sequence type (ST). Grey zones surround STs that belong to the same clonal complex (CC; 24 CCs are visible in total). ST numbers are given inside the circles and are enlarged for the central genotypes that define the major CCs (e.g., ST9 defines the central genotype of CC9). The three major lineages are highlighted by polygons. Four <i>L. innocua</i> sequence types are also represented (black circles). The lines between STs indicate inferred phylogenetic relationships and are represented as bold, plain, discontinuous and light discontinuous depending on the number of allelic mismatches between profiles (1, 2, 3 and 4 or more, respectively); note that discontinuous links are only indicative, as alternative links with equal weight may exist. There were no common alleles between the three major lineages, <i>L. innocua</i>, ST161 (CLIP98) and ST157 (CLIP85); they are arbitrarily linked through ST7 by default. Circles and sectors were colored based on serotyping data according to the provided legend; in addition, rare serotypes (3a, 3c, 4d, 4e) are indicated directly on the Figure. Note that for simplicity, the serotype of strains that were serotyped by the PCR method (<a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000146#ppat.1000146.s002\" target=\"_blank\">Table S1</a>) was equated to the most frequent serotype of each PCR group (e.g., 1/2a for PCR group IIA). STs in which truncated forms of InlA were found are indicated by a black triangle, with the position of the premature stop codons given after letter Δ. The ST of reference genome strains is indicated. The positioning of H7858 (ECII) is based on 6 genes only, as gene <i>dat</i> is incomplete. Inset A. Crosslinks corresponding to one or two allelic mismatches are indicated. Note the absence of links among major clonal complexes, indicative of their neat demarcation. Circles were colored by grey levels according to the number of isolates. Inset B. Correlation between the number of allelic mismatches (number of distinct alleles between MLST profiles) and the average number of nucleotide differences at distinct alleles. Note the regular positive trend, which indicates that <i>L. monocytogenes</i> genotypes diverge predominantly by a mutational process <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000146#ppat.1000146-Feil5\" target=\"_blank\">[81]</a>. Allelic mismatch values of 7 correspond mostly to inter-lineages comparisons.</p>", "links"=>[], "tags"=>["spanning", "360", "strains", "mlst"], "article_id"=>592139, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Minimum_spanning_tree_analysis_of_360_L_monocytogenes_and_four_L_innocua_strains_based_on_MLST_data_/592139", "title"=>"Minimum spanning tree analysis of 360 <i>L. monocytogenes</i> and four <i>L. innocua</i> strains based on MLST data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-05 00:35:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/921959"], "description"=>"<p>A) Distribution of the polymorphisms along the 2,400 nt of gene <i>inlA</i> in the 33 distinct <i>inlA</i> alleles encountered. The scale above the graph is in amino-acids (AA). InlA functional domains are represented as distinct blocks: signal peptide (SP), alpha-domain linker, leucine-rich repeats (LRR), Ig-like, B-repeat, Pre-anchor (PA) and cell wall anchor (CWA). Vertical bars above these blocks, correspond to synonymous nucleotide polymorphisms; below these blocks, non-synonymous polymorphisms resulting in amino-acid changes. Note that the LRR domain, especially repeats 7 to 15, is highly conserved. Triangles indicate the position of premature stop codons (PMSC) observed in this study and previous reports; black triangles: PMSCs observed in clonal complex CC9; red: PMSCs in other clones; see <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000146#ppat-1000146-t004\" target=\"_blank\">Table 4</a> for details. B) Deduced amino-acid polymorphisms in InlA. Lineages in which the <i>inlA</i> alleles were found are indicated on the left (1, 2 or 3). Blocks of amino-acids that are identical to the sequence in reference strain EGDe (allele 8) are color-shaded. Note the mosaic pattern, with blocks of polymorphisms shared between distinct groups of alleles when scrolling along the sequence.</p>", "links"=>[], "tags"=>["microbiology/microbial evolution and genomics"], "article_id"=>592408, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_InlA_polymorphisms_/592408", "title"=>"InlA polymorphisms.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-05 00:40:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/922112"], "description"=>"a<p>Positions correspond to complete genome sequence of strain EGDe (NC003210).</p>", "links"=>[], "tags"=>["sequencing", "primers"], "article_id"=>592556, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000146.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PCR_and_sequencing_primers_used_/592556", "title"=>"PCR and sequencing primers used.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-05 00:42:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/454487", "https://ndownloader.figshare.com/files/454743", "https://ndownloader.figshare.com/files/454777"], "description"=>"<div><p><em>Listeria monocytogenes</em> is a model organism for cellular microbiology and host–pathogen interaction studies and an important food-borne pathogen widespread in the environment, thus representing an attractive model to study the evolution of virulence. The phylogenetic structure of <em>L. monocytogenes</em> was determined by sequencing internal portions of seven housekeeping genes (3,288 nucleotides) in 360 representative isolates. Fifty-eight of the 126 disclosed sequence types were grouped into seven well-demarcated clonal complexes (clones) that comprised almost 75% of clinical isolates. Each clone had a unique or dominant serotype (4b for clones 1, 2 and 4, 1/2b for clones 3 and 5, 1/2a for clone 7, and 1/2c for clone 9), with no association of clones with clinical forms of human listeriosis. Homologous recombination was extremely limited (r/m<1 for nucleotides), implying long-term genetic stability of multilocus genotypes over time. Bayesian analysis based on 438 SNPs recovered the three previously defined lineages, plus one unclassified isolate of mixed ancestry. The phylogenetic distribution of serotypes indicated that serotype 4b evolved once from 1/2b, the likely ancestral serotype of lineage I. Serotype 1/2c derived once from 1/2a, with reference strain EGDe (1/2a) likely representing an intermediate evolutionary state. In contrast to housekeeping genes, the virulence factor internalin (InlA) evolved by localized recombination resulting in a mosaic pattern, with convergent evolution indicative of natural selection towards a truncation of InlA protein. This work provides a reference evolutionary framework for future studies on <em>L. monocytogenes</em> epidemiology, ecology, and virulence.</p></div>", "links"=>[], "tags"=>[], "article_id"=>149554, "categories"=>["Microbiology"], "users"=>["Marie Ragon", "Thierry Wirth", "Florian Hollandt", "Rachel Lavenir", "Marc Lecuit", "Alban Le Monnier", "Sylvain Brisse"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1000146.s001", "https://dx.doi.org/10.1371/journal.ppat.1000146.s002", "https://dx.doi.org/10.1371/journal.ppat.1000146.s003"], "stats"=>{"downloads"=>12, "page_views"=>36, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_New_Perspective_on_Listeria_monocytogenes_Evolution/149554", "title"=>"A New Perspective on <em>Listeria monocytogenes</em> Evolution", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-09-05 02:39:14"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"31", "unique-ip"=>"30", "pdf"=>"8", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"25", "year"=>"2010", "pdf"=>"12", "unique-ip"=>"25", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"26", "unique-ip"=>"27", "pdf"=>"12", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "year"=>"2010", "pdf"=>"11", "unique-ip"=>"18", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"19", "unique-ip"=>"21", "pdf"=>"12", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"23", "year"=>"2010", "pdf"=>"12", "unique-ip"=>"19", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "unique-ip"=>"25", "pdf"=>"23", "year"=>"2010", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2010", "pdf"=>"9", "unique-ip"=>"13", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"34", "unique-ip"=>"32", "pdf"=>"25", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"33", "year"=>"2010", "pdf"=>"13", "unique-ip"=>"25", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"10", "pdf"=>"3", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2010", "pdf"=>"11", "unique-ip"=>"18", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"11", "pdf"=>"5", "year"=>"2011", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"17", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "unique-ip"=>"15", "pdf"=>"8", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"22", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"25", "unique-ip"=>"25", "pdf"=>"14", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"18", "year"=>"2011", "pdf"=>"11", "unique-ip"=>"21", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "unique-ip"=>"14", "pdf"=>"20", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"12", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "unique-ip"=>"17", "pdf"=>"4", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"18", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"13", "pdf"=>"5", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2011", "pdf"=>"12", "unique-ip"=>"15", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"9", "pdf"=>"6", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"13", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"25", "unique-ip"=>"25", "pdf"=>"19", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"5", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"13", "pdf"=>"6", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"81", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"2", "year"=>"2008", "pdf"=>"11", "unique-ip"=>"16", "figure"=>"214", "scanned-summary"=>"104", "supp-data"=>"101"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"99", "unique-ip"=>"88", "pdf"=>"64", "year"=>"2008", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"65", "year"=>"2008", "pdf"=>"38", "unique-ip"=>"60", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"14"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"63", "unique-ip"=>"57", "pdf"=>"32", "year"=>"2008", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"12"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"35", "year"=>"2009", "pdf"=>"29", "unique-ip"=>"46", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"2", "abstract"=>"4", "full-text"=>"46", "unique-ip"=>"44", "pdf"=>"43", "year"=>"2009", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"51", "year"=>"2009", "pdf"=>"21", "unique-ip"=>"46", "figure"=>"21", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"28", "unique-ip"=>"28", "pdf"=>"31", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "year"=>"2009", "pdf"=>"17", "unique-ip"=>"28", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"26", "pdf"=>"16", "year"=>"2009", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"15", "year"=>"2009", "pdf"=>"11", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"18", "pdf"=>"12", "year"=>"2009", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "year"=>"2009", "pdf"=>"16", "unique-ip"=>"22", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "unique-ip"=>"12", "pdf"=>"5", "year"=>"2009", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"27", "year"=>"2009", "pdf"=>"8", "unique-ip"=>"27", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"26", "unique-ip"=>"26", "pdf"=>"8", "year"=>"2009", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"29", "full-text"=>"35", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"29", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"28", "pdf"=>"12", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"6", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"33", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"43", "pdf"=>"10", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"34", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"34", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"23", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"24", "full-text"=>"20", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"10", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"28", "full-text"=>"39", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"30", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"22", "pdf"=>"4", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"51", "full-text"=>"46", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"11", "cited-by"=>"7", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"50", "full-text"=>"42", "pdf"=>"10", "abstract"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"40", "full-text"=>"38", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"31", "full-text"=>"25", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"49", "full-text"=>"48", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"36", "full-text"=>"46", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"28", "full-text"=>"31", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"27", "full-text"=>"33", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"37", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"50", "full-text"=>"49", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"39", "full-text"=>"39", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"61", "full-text"=>"60", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"4", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"32", "full-text"=>"29", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"4", "cited-by"=>"4", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"27", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"35", "full-text"=>"40", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"33", "full-text"=>"49", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"31", "full-text"=>"67", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"49", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"37", "full-text"=>"58", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"32", "full-text"=>"71", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"55", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"32", "full-text"=>"72", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"27", "full-text"=>"38", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"21", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"39", "full-text"=>"44", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"29", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"36", "full-text"=>"34", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"44", "full-text"=>"42", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"32", "full-text"=>"35", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"45", "full-text"=>"37", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"36", "full-text"=>"36", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"40", "full-text"=>"42", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2008-01-01T00:00:00Z", "end_date"=>"2008-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[324, 674, 863, 1015, 1146, 1259, 1360, 1452, 1540, 1621, 1704, 1776, 1843, 1905, 1968, 2029, 2097, 2162, 2233, 2289, 2352, 2412, 2476, 2538, 2601, 2655, 2714, 2777, 2841, 2894, 2946, 2998, 3047, 3103, 3151, 3201, 3258, 3317, 3369, 3424, 3471, 3521, 3583, 3625, 3687, 3743, 3788, 3838, 3896, 3953, 4015, 4075, 4148, 4201, 4275, 4347, 4420, 4486, 4535, 4592, 4660, 4731, 4792, 4845, 4901, 4971, 5027, 5089, 5148, 5200, 5261, 5318, 5374]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[347, 699, 899, 1072, 1167, 1294, 1377, 1481, 1550, 1618, 1701, 1759, 1827, 1908, 1979, 2041, 2088, 2137, 2199, 2260, 2317, 2372, 2421, 2485, 2554, 2615, 2649, 2721, 2791, 2849, 2897, 2945, 3004, 3057, 3104, 3165, 3216, 3253, 3301, 3347, 3403, 3454, 3514, 3549, 3612, 3668, 3717, 3774, 3838, 3886, 3916, 3993, 4048, 4095, 4161, 4255, 4342, 4391, 4466, 4559, 4618, 4714, 4794, 4868, 4913, 4980, 5030, 5085, 5143, 5207, 5269, 5309, 5364]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[372, 729, 958, 1108, 1266, 1374, 1469, 1569, 1626, 1700, 1806, 1875, 1944, 2012, 2088, 2147, 2206, 2271, 2324, 2393, 2445, 2506, 2574, 2642, 2703, 2777, 2830, 2895, 2951, 2994, 3034, 3071, 3135, 3191, 3255, 3317, 3374, 3422, 3484, 3529, 3584, 3612, 3661, 3710, 3766, 3830, 3876, 3940, 3985, 4048, 4089, 4134, 4182, 4227, 4313, 4369, 4486, 4542, 4603, 4695, 4753, 4811, 4862, 4968, 5017, 5096, 5151, 5214, 5256, 5338, 5421, 5486, 5523]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[329, 686, 873, 1009, 1130, 1239, 1337, 1426, 1509, 1585, 1667, 1746, 1816, 1880, 1937, 1999, 2058, 2120, 2179, 2245, 2311, 2374, 2437, 2511, 2565, 2616, 2671, 2723, 2783, 2844, 2902, 2958, 3017, 3056, 3104, 3169, 3206, 3249, 3298, 3354, 3428, 3479, 3526, 3579, 3628, 3679, 3727, 3771, 3819, 3865, 3927, 4006, 4075, 4116, 4164, 4250, 4323, 4380, 4436, 4492, 4547, 4599, 4652, 4708, 4761, 4811, 4889, 4966, 5025, 5071, 5134, 5186, 5258]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[316, 663, 828, 992, 1103, 1209, 1306, 1400, 1491, 1563, 1640, 1715, 1783, 1851, 1908, 1991, 2061, 2121, 2177, 2237, 2296, 2365, 2422, 2521, 2581, 2639, 2696, 2757, 2822, 2874, 2925, 2977, 3030, 3097, 3156, 3247, 3311, 3355, 3414, 3468, 3531, 3579, 3626, 3677, 3715, 3778, 3846, 3903, 3941, 4005, 4076, 4129, 4189, 4266, 4332, 4385, 4452, 4495, 4583, 4647, 4710, 4771, 4849, 4905, 4971, 5026, 5098, 5160, 5213, 5269, 5329, 5393, 5439]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[328, 663, 852, 1015, 1147, 1265, 1369, 1468, 1557, 1626, 1696, 1763, 1830, 1909, 1970, 2025, 2105, 2189, 2263, 2309, 2368, 2432, 2502, 2569, 2629, 2709, 2780, 2835, 2900, 2949, 2998, 3064, 3110, 3179, 3235, 3286, 3334, 3390, 3447, 3501, 3550, 3606, 3663, 3704, 3751, 3810, 3858, 3929, 3990, 4058, 4112, 4190, 4252, 4322, 4399, 4471, 4539, 4620, 4692, 4750, 4833, 4898, 4945, 5006, 5058, 5114, 5155, 5210, 5262, 5319, 5386, 5445, 5493]}, {"subject_area"=>"/Computer and information sciences/Data management", "average_usage"=>[398, 861, 1090, 1224, 1349, 1476, 1685, 1820, 1922, 2031, 2116, 2192, 2248, 2287, 2330, 2420, 2530, 2659, 2751, 2852, 2953, 3077, 3155, 3255, 3358, 3476, 3581, 3662, 3735, 3793, 3873, 3929, 3971, 4013, 4081, 4159, 4222, 4263, 4298, 4348, 4422, 4483, 4558, 4661, 4770, 4870, 4962, 5042, 5127, 5197, 5262, 5331, 5394, 5463, 5524, 5609, 5669, 5714, 5754, 5816, 5895, 6001, 6077, 6139, 6251, 6373, 6426, 6494, 6553, 6602, 6658, 6712, 6759, 6797]}, {"subject_area"=>"/Ecology and environmental sciences", "average_usage"=>[376, 699, 876, 1017, 1214, 1298, 1422, 1532, 1613, 1702, 1795, 1881, 1953, 2034, 2101, 2153, 2217, 2265, 2337, 2416, 2513, 2581, 2656, 2723, 2785, 2847, 2926, 2995, 3111, 3162, 3202, 3244, 3289, 3341, 3390, 3443, 3497, 3532, 3593, 3661, 3707, 3755, 3834, 3926, 3997, 4048, 4104, 4145, 4195, 4244, 4303, 4392, 4457, 4539, 4613, 4670, 4723, 4794, 4847, 4910, 4962, 5018, 5108, 5162, 5231, 5303, 5389, 5431, 5476, 5518, 5579, 5603, 5652, 5705]}, {"subject_area"=>"/Ecology and environmental sciences/Ecology", "average_usage"=>[373, 829, 1071, 1251, 1374, 1523, 1653, 1748, 1885, 2004, 2092, 2182, 2229, 2298, 2352, 2396, 2439, 2489, 2554, 2640, 2862, 2942, 3008, 3073, 3115, 3209, 3338, 3404, 3444, 3486, 3541, 3597, 3645, 3711, 3772, 3866, 3957, 4040, 4137, 4205, 4248, 4318, 4420, 4504, 4587, 4648, 4715, 4781, 4851, 4938, 5016, 5072, 5124, 5281, 5340, 5423, 5484, 5561, 5646, 5689, 5790, 5883, 5951, 5974, 6016, 6058, 6094, 6136, 6185, 6224, 6250, 6307, 6389, 6490]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 661, 845, 1003, 1135, 1248, 1352, 1439, 1532, 1618, 1691, 1765, 1831, 1902, 1969, 2028, 2098, 2159, 2234, 2294, 2356, 2423, 2483, 2548, 2615, 2682, 2743, 2796, 2853, 2907, 2970, 3025, 3078, 3138, 3197, 3243, 3307, 3351, 3420, 3468, 3519, 3569, 3625, 3688, 3739, 3799, 3850, 3911, 3961, 4009, 4075, 4137, 4194, 4263, 4329, 4393, 4449, 4501, 4566, 4638, 4706, 4761, 4828, 4898, 4948, 4999, 5040, 5107, 5170, 5226, 5292, 5352, 5434]}]}

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts