The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations
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{"title"=>"The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations", "type"=>"journal", "authors"=>[{"first_name"=>"Susanne", "last_name"=>"Häussler", "scopus_author_id"=>"7006416179"}, {"first_name"=>"Tanja", "last_name"=>"Becker", "scopus_author_id"=>"36618640500"}], "year"=>2008, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"18818733", "doi"=>"10.1371/journal.ppat.1000166", "sgr"=>"53049106100", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "scopus"=>"2-s2.0-53049106100", "issn"=>"15537366", "pui"=>"352447246"}, "id"=>"e495c7e0-cef8-3e68-a2c5-1d5bc8de1c2f", "abstract"=>"When environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediates induction of all of these phenotypes. For individual cells, PQS, an interbacterial signaling molecule of Pseudomonas aeruginosa, has both deleterious and beneficial activities: on the one hand, it acts as a pro-oxidant and sensitizes the bacteria towards oxidative and other stresses and, on the other, it efficiently induces a protective anti-oxidative stress response. We propose that this dual function fragments populations into less and more stress tolerant members which respond differentially to developing stresses in deteriorating habitats. This suggests that a little poison may be generically beneficial to populations, in promoting survival of the fittest, and in contributing to bacterial multi-cellular behavior. It further identifies PQS as an essential mediator of the shaping of the population structure of Pseudomonas and of its response to and survival in hostile environmental conditions.", "link"=>"http://www.mendeley.com/research/pseudomonas-quinolone-signal-pqs-balances-life-death-pseudomonas-aeruginosa-populations", "reader_count"=>184, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>9, "Researcher"=>33, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>59, "Student > Postgraduate"=>8, "Student > Master"=>17, "Other"=>4, "Student > Bachelor"=>31, "Lecturer"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>9, "Researcher"=>33, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>59, "Student > Postgraduate"=>8, "Student > Master"=>17, "Other"=>4, "Student > Bachelor"=>31, "Lecturer"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>4, "Unspecified"=>6, "Environmental Science"=>6, "Biochemistry, Genetics and Molecular Biology"=>26, "Agricultural and Biological Sciences"=>106, "Medicine and Dentistry"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Chemistry"=>11, "Computer Science"=>1, "Immunology and Microbiology"=>16}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>11}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>16}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>106}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>26}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "Belgium"=>2, "United States"=>7, "United Kingdom"=>2, "Germany"=>3}, "group_count"=>8}

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  • {"files"=>["https://ndownloader.figshare.com/files/920553"], "description"=>"<p>Proposed mechanism of the primary anti-oxidant effect and the secondary pro-oxidant effect of PQS.</p>", "links"=>[], "tags"=>["anti-oxidant", "pro-oxidant"], "article_id"=>591003, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g007", "stats"=>{"downloads"=>1, "page_views"=>59, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proposed_mechanism_of_the_primary_anti_oxidant_effect_and_the_secondary_pro_oxidant_effect_of_PQS_/591003", "title"=>"Proposed mechanism of the primary anti-oxidant effect and the secondary pro-oxidant effect of PQS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:16:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/455174", "https://ndownloader.figshare.com/files/455209"], "description"=>"<div><p>When environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediates induction of all of these phenotypes. For individual cells, PQS, an interbacterial signaling molecule of <em>Pseudomonas aeruginosa</em>, has both deleterious and beneficial activities: on the one hand, it acts as a pro-oxidant and sensitizes the bacteria towards oxidative and other stresses and, on the other, it efficiently induces a protective anti-oxidative stress response. We propose that this dual function fragments populations into less and more stress tolerant members which respond differentially to developing stresses in deteriorating habitats. This suggests that a little poison may be generically beneficial to populations, in promoting survival of the fittest, and in contributing to bacterial multi-cellular behavior. It further identifies PQS as an essential mediator of the shaping of the population structure of <em>Pseudomonas</em> and of its response to and survival in hostile environmental conditions.</p></div>", "links"=>[], "tags"=>["pseudomonas", "quinolone", "balances", "populations"], "article_id"=>149673, "categories"=>["Cancer", "Microbiology"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1000166.s001", "https://dx.doi.org/10.1371/journal.ppat.1000166.s002"], "stats"=>{"downloads"=>5, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Pseudomonas_Quinolone_Signal_PQS_Balances_Life_and_Death_in_Pseudomonas_aeruginosa_Populations/149673", "title"=>"The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in <em>Pseudomonas aeruginosa</em> Populations", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-09-26 02:41:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/920390"], "description"=>"<p>PQS non-producing strains (<i>pqsA</i> and <i>pqsH</i> mutant) exhibited an increased resistance towards H<sub>2</sub>O<sub>2</sub> as compared to the wild-type (paired t-test; p-value <0.005). The diameter of the inhibition zone is given as the mean+SD of a triplicate.</p>", "links"=>[], "tags"=>["inhibition", "agar", "diffusion"], "article_id"=>590837, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g002", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Growth_inhibition_by_H_2_O_2_as_determined_by_agar_diffusion_assays_/590837", "title"=>"Growth inhibition by H<sub>2</sub>O<sub>2</sub> as determined by agar diffusion assays.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:13:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/920481"], "description"=>"<p>The median of fluorescence intensity (MFI) of 50,000 log phase grown cells treated with 20 µM H<sub>2</sub>DCFDA is given. PQS was added to log phase grown PAO1 wild-type and <i>pqsA</i> mutant cultures at concentrations of 0, 50 and 100 µM PQS, respectively followed by an 1 h incubation period prior to FACS analysis. In contrast to PQS addition, the addition of at least equimolar concentrations of the biologically less active PQS precursor heptyl-4-hydroxy-quinoline (HHQ) or the iron chelator dipyridyl did not show a clear reduction of the ROI levels (data not shown). The assays were performed three times with independent cultures, the addition of PQS reduced the MFI significantly as determined by t-test (p<0.05).</p>", "links"=>[], "tags"=>["intracellular", "roi"], "article_id"=>590929, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g005", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PQS_reduces_the_intracellular_ROI_levels_/590929", "title"=>"PQS reduces the intracellular ROI levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:15:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/920348"], "description"=>"<p>Killing curves of log phase grown <i>P. aeruginosa</i> PAO1 cultures treated with 5 µg/ml ciprofloxacin were recorded. Killing was significantly delayed in the <i>pqsA</i> and <i>pqsH</i> mutant compared to the wild-type and the <i>pqsL</i> mutant as determined by OD<sub>600</sub> determinations (A) and CFU counts after 3 h of exposure (B). Error bars mark the standard deviation of three independent experiments. CFU counts of the PAO1 wild-type and the <i>pqsL</i> mutant were significantly different (p<0.05, as determined by t-test) as compared to the <i>pqsA</i> and <i>pqsH</i> mutants.</p>", "links"=>[], "tags"=>["pqs"], "article_id"=>590801, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibiotic_tolerance_in_the_absence_of_PQS_production_/590801", "title"=>"Antibiotic tolerance in the absence of PQS production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:13:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/920584"], "description"=>"<p>The Fe2<sup>+</sup> mediated DNA fragmentation process is strongly enhanced by the addition of PQS or vitamin C but not by the addition of the biological inactive precursor substance HHQ. Lane 1: chromosomal <i>P. aeruginosa</i> DNA under the addition of vitamin C and Fe2<sup>+</sup>, lane 2: DNA+vitamin C, lane 3: DNA , Fe2<sup>+</sup> and PQS, lane 4: DNA and PQS, lane 5: DNA, Fe2<sup>+</sup> and HHQ, lane 6: DNA and HHQ. The DNA was pre-incubated with PQS, HHQ or vitamin C, respectively, at room temperature for 45 min before exposure of the probes to 2.5 mM Fe2<sup>+</sup> for 15 min and separation on an agarose gel.</p>", "links"=>[], "tags"=>["exhibits", "pro-oxidants"], "article_id"=>591037, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g008", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PQS_exhibits_pro_oxidants_activities_/591037", "title"=>"PQS exhibits pro-oxidants activities.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/920458"], "description"=>"<p>The addition of PQS to bacterial cultures of a <i>pqsA</i> mutant is characterized by a slope reduction in log phase of growth and lower maximum OD<sub>600</sub> values as compared to the cultures grown without added PQS. Bacteriostasis seems to be a PQS-specific effect because both the addition of equimolar concentrations of the biologically less active PQS precursor heptyl-4-hydroxy-quinoline (HHQ) or the iron chelator dipyridyl did not have the same effect. This is a representative experiment for at least three independent measurements.</p>", "links"=>[], "tags"=>["bacteriostasis"], "article_id"=>590908, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PQS_induces_bacteriostasis_in_a_concentration_dependent_manner_/590908", "title"=>"PQS induces bacteriostasis in a concentration dependent manner.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:15:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/920614"], "description"=>"<p>PAO1 wild-type, the <i>pqsA</i>, the <i>pqsH</i> and the <i>pqsL</i> mutant were grown in LB medium. Supernatant samples were collected after 8 h (lane 1, 3, 5, 7, 9) and 36 h (lane 2, 4, 6, 8, 10), respectively. Increasing amounts of fragmented DNA were found in the supernatant of the PAO1 wild-type cultures under prolonged incubation (lanes 1, 2). DNA release and fragmentation was delayed in the PAO1 <i>pqsA</i> and <i>pqsH</i> mutants (lane 3, 4 and lane 7, 8). The DNA release and fragmentation pattern was most pronounced in the <i>pqsL</i> mutant (lanes 5, 6) and the complemented <i>pqsA</i> mutant (<i>pqsA-E</i> operon on plasmid pLG10) (lanes 9, 10).</p>", "links"=>[], "tags"=>["extracellular"], "article_id"=>591062, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g009", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PQS_dependent_release_of_extracellular_DNA_/591062", "title"=>"PQS dependent release of extracellular DNA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:17:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/920422"], "description"=>"<p>Killing of the bacteria by 5 µg/ml ciprofloxacin was significantly enhanced under the addition of PQS as opposed to HHQ (paired t-test; p value <0.05).</p>", "links"=>[], "tags"=>["bioluminescence", "pao1", "wild-type", "antibiotic"], "article_id"=>590870, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Loss_of_bioluminescence_of_P_aeruginosa_PAO1_wild_type_after_exposure_to_the_antibiotic_ciprofloxacin_/590870", "title"=>"Loss of bioluminescence of <i>P. aeruginosa</i> PAO1 wild-type after exposure to the antibiotic ciprofloxacin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:14:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/920512"], "description"=>"<p>The absorbance changes of the stable 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical was measured in three independent experiments at the OD of 517 nm in the presence of PQS, HHQ and ascorbate. Error bars mark the standard deviation of three independent experiments. The decolorization is stoichiometric with respect to the number of electrons captured.</p>", "links"=>[], "tags"=>["Infectious diseases", "microbiology"], "article_id"=>590962, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PQS_is_a_primary_anti_oxidant_/590962", "title"=>"PQS is a primary anti-oxidant.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:16:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/920653"], "description"=>"<p>Wild-type PAO1, the <i>pqsA</i> mutant, the <i>pqsH</i> mutant and the <i>pqsA</i> mutant complemented with pLG10 were grown overnight in LB, and diluted in DeMoss medium <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000166#ppat.1000166-Frank1\" target=\"_blank\">[40]</a>. The cells were UV irradiated while shaking, and aliquots were removed at 10s intervals. The exogenous addition of 100 µM PQS to the <i>pqsA</i> mutant cultures 4 h before exposure to UV radiation restored UV tolerance, whereas PQS addition immediately before the UV stress did not show any effect. Serial dilutions were plated on LB agar to determine the viable cell count. The UV killing assays were performed three times with independent cultures, and the outcome of one representative experiment is shown.</p>", "links"=>[], "tags"=>["curves", "uv"], "article_id"=>591103, "categories"=>["Microbiology", "Infectious Diseases"], "users"=>["Susanne Häussler", "Tanja Becker"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1000166.g010", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Killing_curves_upon_exposure_to_UV_irradiation_/591103", "title"=>"Killing curves upon exposure to UV irradiation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-09-26 00:18:23"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
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Relative Metric

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