Aerosols Transmit Prions to Immunocompetent and Immunodeficient Mice
- Publication Date
- January 13, 2011
- Journal
- PLOS Pathogens
- Authors
- Johannes Haybaeck, Mathias Heikenwalder, Britta Klevenz, Petra Schwarz, et al
- Volume
- 7
- Issue
- 1
- Pages
- e1001257
- DOI
- https://dx.plos.org/10.1371/journal.ppat.1001257
- Publisher URL
- http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1001257
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/21249178
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020930
- Europe PMC
- http://europepmc.org/abstract/MED/21249178
- Web of Science
- 000286654100014
- Scopus
- 79551523008
- Mendeley
- http://www.mendeley.com/research/aerosols-transmit-prions-immunocompetent-immunodeficient-mice
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CiteULike | Further Information
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Mendeley | Further Information
{"title"=>"Aerosols transmit prions to immunocompetent and immunodeficient mice", "type"=>"journal", "authors"=>[{"first_name"=>"Johannes", "last_name"=>"Haybaeck", "scopus_author_id"=>"23027287200"}, {"first_name"=>"Mathias", "last_name"=>"Heikenwalder", "scopus_author_id"=>"6602267435"}, {"first_name"=>"Britta", "last_name"=>"Klevenz", "scopus_author_id"=>"57199642327"}, {"first_name"=>"Petra", "last_name"=>"Schwarz", "scopus_author_id"=>"35771535000"}, {"first_name"=>"Ilan", "last_name"=>"Margalith", "scopus_author_id"=>"23985714100"}, {"first_name"=>"Claire", "last_name"=>"Bridel", "scopus_author_id"=>"6508071655"}, {"first_name"=>"Kirsten", "last_name"=>"Mertz", "scopus_author_id"=>"9943211500"}, {"first_name"=>"Elizabeta", "last_name"=>"Zirdum", "scopus_author_id"=>"36919670000"}, {"first_name"=>"Benjamin", "last_name"=>"Petsch", "scopus_author_id"=>"25626519700"}, {"first_name"=>"Thomas J.", "last_name"=>"Fuchs", "scopus_author_id"=>"56454885300"}, {"first_name"=>"Lothar", "last_name"=>"Stitz", "scopus_author_id"=>"7005446991"}, {"first_name"=>"Adriano", "last_name"=>"Aguzzi", "scopus_author_id"=>"7102605630"}], "year"=>2011, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"21249178", "doi"=>"10.1371/journal.ppat.1001257", "sgr"=>"79551523008", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "scopus"=>"2-s2.0-79551523008", "issn"=>"15537366", "pui"=>"361204777"}, "id"=>"080b0805-0e10-33f0-a0b7-30b2d04d8cd6", "abstract"=>"Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 transgenic mice overexpressing PrP(C), efficiently develop scrapie upon exposure to aerosolized prions. NSE-PrP transgenic mice, which express PrP(C) selectively in neurons, were also susceptible to airborne prions. Aerogenic infection occurred also in mice lacking B- and T-lymphocytes, NK-cells, follicular dendritic cells or complement components. Brains of diseased mice contained PrP(Sc) and transmitted scrapie when inoculated into further mice. We conclude that aerogenic exposure to prions is very efficacious and can lead to direct invasion of neural pathways without an obligatory replicative phase in lymphoid organs. This previously unappreciated risk for airborne prion transmission may warrant re-thinking on prion biosafety guidelines in research and diagnostic laboratories.", "link"=>"http://www.mendeley.com/research/aerosols-transmit-prions-immunocompetent-immunodeficient-mice", "reader_count"=>96, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>5, "Researcher"=>28, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>4, "Other"=>9, "Student > Master"=>9, "Student > Bachelor"=>11, "Professor"=>9}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>5, "Researcher"=>28, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>4, "Other"=>9, "Student > Master"=>9, "Student > Bachelor"=>11, "Professor"=>9}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>62, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Earth and Planetary Sciences"=>1, "Engineering"=>1, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>7, "Medicine and Dentistry"=>13, "Neuroscience"=>1, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>62}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>1, "Brazil"=>1, "United Kingdom"=>2, "Germany"=>1, "Spain"=>1}, "group_count"=>2}CrossRef
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- http://doi.org/10.1111/tbed.12671
Scopus | Further Information
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Journal Comments | Further Information
- {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/63a850bc-47ac-4256-a70f-963a3baf7633", "title"=>"dual-use", "body"=>"I don't suppose this result surprised anyone in the scientific community. A pathogen that is stable in extreme environments and can be transmitted orally is undoubtedly transmissible via aerosol. I believe the people most interested in this report are terrorists, and I won't be surprised to learn that the next suicide bomber has loaded his explosive vest with CJD brains instead of nails. \"Dual-use\" research should be thoughtfully censored by investigators and editors, and not exploited for sensationalism.", "isRemoved"=>false, "created"=>"2011-02-02T00:07:15Z", "lastModified"=>"2011-02-02T00:07:15Z", "creator"=>{"userId"=>"153611"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.ppat.1001257", "state"=>"published", "journals"=>{"PLoSPathogens"=>{"journalKey"=>"PLoSPathogens", "eIssn"=>"1553-7374", "title"=>"PLOS Pathogens"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2011-02-02T00:07:15Z", "replies"=>[]}
- {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/5e4413fb-2c8b-436b-80fc-12471c8acf06", "title"=>"Authors' individual contributions", "body"=>"I am the corresponding author of this paper. I was made aware that some readers felt that the individual contributions of the authors should be specified with more precision. Here is a more granular description of the contributions of each author. Conceived and designed the experiments: JH MH BK LS AA. Performed the aerosol experiments/applications: BK EZ BP. Performed the intranasal experiments/injections: JH MH BK PS CB. Performed the Western Blot experiments: JH BK IM CB KM. Performed the histological and immunohistochemical analyses and the analysis of the dot blots: JH MH. Generated the dot blots: PS. Performed the statistical analysis: TJF. Contributed reagents/materials/analysis tools: LS AA. Analyzed the data: JH MH BK AA. Wrote the paper: JH MH LS AA. ", "isRemoved"=>false, "created"=>"2015-11-20T09:14:24Z", "lastModified"=>"2015-11-20T09:14:24Z", "creator"=>{"userId"=>"85133"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.ppat.1001257", "state"=>"published", "journals"=>{"PLoSPathogens"=>{"journalKey"=>"PLoSPathogens", "eIssn"=>"1553-7374", "title"=>"PLOS Pathogens"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-11-20T09:14:24Z", "replies"=>[]}
- {"id"=>"214306721416491008", "text"=>"Aerosols Transmit Prions to Immunocompetent and Immunodeficient Mice http://t.co/GZu3AOgn #thelastdefense", "created_at"=>"2012-06-17T10:41:18Z", "user"=>"thelastdefense", "user_name"=>"The Last Defense", "user_profile_image"=>"http://a0.twimg.com/profile_images/2051172513/Jefferson_ETF1_normal.jpg"}
- {"id"=>"405783836925370368", "text"=>"http://t.co/J07KIXYi4x Aerosols Transmit #Prions to Immunocompetent and Immunodeficient Mice #cambiandoesquemas", "created_at"=>"2013-11-27T19:43:00Z", "user"=>"cientounero", "user_name"=>"Javier Casas Ciria", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2418268096/b8cj69kdep6niz99fyre_normal.jpeg"}
- {"id"=>"413738867888369664", "text"=>"Once upon a time it was the ricin umbrella, then dioxin soup, then the polonium tea... and now, prion Binaca...\nhttp://t.co/kxm2RgbNor", "created_at"=>"2013-12-19T18:33:27Z", "user"=>"seancostigan", "user_name"=>"sean costigan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000724353896/6e8e67a79335dbc96784a9ee1050468c_normal.jpeg"}
Wikipedia | Further Information
- {"title"=>"Transmissible spongiform encephalopathy", "url"=>"http://en.wikipedia.org/wiki/Transmissible_spongiform_encephalopathy", "timestamp"=>"2019-03-14T06:18:35Z"}
- {"title"=>"Prion", "url"=>"http://en.wikipedia.org/wiki/Prion", "timestamp"=>"2019-03-12T09:25:39Z"}
- {"title"=>"Bovine spongiforme Enzephalopathie", "url"=>"http://de.wikipedia.org/wiki/Bovine_spongiforme_Enzephalopathie", "timestamp"=>"2019-01-05T16:48:35Z"}
- {"title"=>"Prion", "url"=>"http://de.wikipedia.org/wiki/Prion", "timestamp"=>"2019-02-23T09:34:57Z"}
- {"title"=>"Creutzfeldt-Jakob-Krankheit", "url"=>"http://de.wikipedia.org/wiki/Creutzfeldt-Jakob-Krankheit", "timestamp"=>"2019-03-11T06:53:04Z"}
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- {"month"=>"9", "year"=>"2015", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"113"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"107"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"165"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"128"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"113"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"52", "xml_views"=>"0", "html_views"=>"164"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"115"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"149"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"80"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"85"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"84"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"105"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"155"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"168"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"119"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"144"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"112"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"93"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"114"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"102"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"157"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"84"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"88"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"82"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"68"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"90"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"99"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"63"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"76"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"43"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"86"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"55"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"41"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"64"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"32"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"50"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"57"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"4", "html_views"=>"68"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"4", "html_views"=>"64"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"83"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"41"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"10", "html_views"=>"43"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"13", "html_views"=>"63"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"18", "html_views"=>"25"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"12", "html_views"=>"40"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"15", "html_views"=>"74"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"20", "html_views"=>"43"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"19", "html_views"=>"63"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"14", "html_views"=>"51"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"11", "html_views"=>"41"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"21", "html_views"=>"58"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"24", "html_views"=>"64"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"26", "xml_views"=>"16", "html_views"=>"53"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"25", "html_views"=>"54"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"15", "html_views"=>"41"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"125", "xml_views"=>"3", "html_views"=>"87"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"156", "xml_views"=>"14", "html_views"=>"85"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"12", "html_views"=>"35"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"17", "html_views"=>"36"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"6", "html_views"=>"40"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"21", "html_views"=>"52"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"24", "xml_views"=>"11", "html_views"=>"37"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"11", "html_views"=>"25"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"8", "xml_views"=>"6", "html_views"=>"103"}
PMC Usage Stats | Further Information
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"87", "unique-ip"=>"82", "pdf"=>"79", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"8", "full-text"=>"96", "year"=>"2011", "pdf"=>"79", "unique-ip"=>"85", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"10", "full-text"=>"81", "unique-ip"=>"85", "pdf"=>"69", "year"=>"2011", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"15"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"11", "full-text"=>"43", "year"=>"2011", "pdf"=>"30", "unique-ip"=>"47", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"8"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"45", "unique-ip"=>"41", "pdf"=>"15", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"13"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "year"=>"2011", "pdf"=>"12", "unique-ip"=>"31", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"33", "unique-ip"=>"31", "pdf"=>"14", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"29", "year"=>"2011", "pdf"=>"19", "unique-ip"=>"34", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"42", "unique-ip"=>"39", "pdf"=>"25", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"32", "year"=>"2011", "pdf"=>"25", "unique-ip"=>"36", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "unique-ip"=>"25", "pdf"=>"12", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"16", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"18", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"30", "unique-ip"=>"55", "pdf"=>"45", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"28", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"25", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "unique-ip"=>"27", "pdf"=>"20", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "year"=>"2012", "pdf"=>"13", "unique-ip"=>"22", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"1"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"17", "pdf"=>"7", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"21", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"4"}
- {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"8", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"15", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"19", "full-text"=>"62", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
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