Sexual Development in Plasmodium: Lessons from Functional Analyses
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{"title"=>"Sexual development in plasmodium: Lessons from functional analyses", "type"=>"journal", "authors"=>[{"first_name"=>"David S.", "last_name"=>"Guttery", "scopus_author_id"=>"31267552700"}, {"first_name"=>"Anthony A.", "last_name"=>"Holder", "scopus_author_id"=>"16215359300"}, {"first_name"=>"Rita", "last_name"=>"Tewari", "scopus_author_id"=>"8343732400"}], "year"=>2012, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537366", "scopus"=>"2-s2.0-84857493589", "pui"=>"364329977", "doi"=>"10.1371/journal.ppat.1002404", "sgr"=>"84857493589", "pmid"=>"22275863"}, "id"=>"0c7534ae-68e5-399b-b165-5a7eca7f9417", "abstract"=>"(http://www.mrc.ac.uk), (G0900109 to RT; U117532067 to AAH), a MRC programme grant (G0900278 to RT and AAH), and also the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement (N° 242095 to AAH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist. Malaria is a devastating global disease with several hundred million clinical cases and just under 1 million deaths each year (http://www.who.int/topics/malaria/). It is caused by protozoan parasites of the genus Plasmodium, which have a complex life cycle in a vertebrate host and a mosquito vector. Malaria parasites are haploid throughout most of this life cycle, replicating by asexual multiplication twice in a mammalian host: in liver hepatocytes (pre-erythrocytic schizogony) and within red blood cells (blood stage schizogony), and once in the mosquito (sporogony). The essential sexual stage occurs at the transmission from vertebrate to insect. Some asexual blood stage parasites develop into either male or female gametocytes (the precursor sex cells) and following ingestion in a mosquito blood meal differentiate further into gametes in the lumen of the mosquito's gut, where fertilization takes place. The core processes of gametocytogenesis, gamete activation, exflagellation, fertilization, and zygote formation are conserved across the species from the human parasite Plasmodium falciparum to the rodent parasite Plasmodium berghei, which is an attractive laboratory model, in part because of its ease of genetic manipulation and the shorter time for the maturation and differentiation of the sexual stages. Here, we focus largely on recent functional studies using reverse genetics that have uncovered many aspects of the parasite's sexual development.", "link"=>"http://www.mendeley.com/research/sexual-development-plasmodium-lessons-functional-analyses", "reader_count"=>83, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>20, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>7, "Student > Master"=>12, "Other"=>3, "Student > Bachelor"=>11, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>20, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>7, "Student > Master"=>12, "Other"=>3, "Student > Bachelor"=>11, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>17, "Materials Science"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>52, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>52}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>17}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>3, "United Kingdom"=>2, "France"=>1, "India"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/690186"], "description"=>"<p>Differentiation of asexual blood stage parasites into gametocytes occurs in the vertebrate host. Ingestion in a mosquito blood meal results in activation of the gametocytes in the lumen of the gut, stimulated by an increase in Ca<sup>2+</sup>, a drop in temperature, and the presence of the mosquito-derived xanthurenic acid, leading to the production of male and female gametes. Fertilization and fusion of these gametes results in zygote formation. Eventual elongation of the zygote leads to the final stage of the sexual cycle, a highly motile ookinete. Genes involved at each stage of the process (as suggested by a number of functional analyses) and time spans for each stage are indicated.</p>", "links"=>[], "tags"=>["gametocytogenesis"], "article_id"=>360677, "categories"=>["Developmental Biology"], "users"=>["David S. Guttery", "Anthony A. Holder", "Rita Tewari"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1002404.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regulators_of_gametocytogenesis_and_the_sexual_stage_of_the_life_cycle_/360677", "title"=>"Regulators of gametocytogenesis and the sexual stage of the life cycle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:42:48"}

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Relative Metric

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