Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)", "type"=>"journal", "authors"=>[{"first_name"=>"Katarzyna J.", "last_name"=>"Maresz", "scopus_author_id"=>"57188924118"}, {"first_name"=>"Annelie", "last_name"=>"Hellvard", "scopus_author_id"=>"36127333300"}, {"first_name"=>"Aneta", "last_name"=>"Sroka", "scopus_author_id"=>"6602868009"}, {"first_name"=>"Karina", "last_name"=>"Adamowicz", "scopus_author_id"=>"55507302200"}, {"first_name"=>"Ewa", "last_name"=>"Bielecka", "scopus_author_id"=>"55782879500"}, {"first_name"=>"Joanna", "last_name"=>"Koziel", "scopus_author_id"=>"23492241200"}, {"first_name"=>"Katarzyna", "last_name"=>"Gawron", "scopus_author_id"=>"56418207100"}, {"first_name"=>"Danuta", "last_name"=>"Mizgalska", "scopus_author_id"=>"26531688700"}, {"first_name"=>"Katarzyna A.", "last_name"=>"Marcinska", "scopus_author_id"=>"37032824300"}, {"first_name"=>"Malgorzata", "last_name"=>"Benedyk", "scopus_author_id"=>"8211689600"}, {"first_name"=>"Krzysztof", "last_name"=>"Pyrc", "scopus_author_id"=>"8869026100"}, {"first_name"=>"Anne Marie", "last_name"=>"Quirke", "scopus_author_id"=>"8764238200"}, {"first_name"=>"Roland", "last_name"=>"Jonsson", "scopus_author_id"=>"7103084634"}, {"first_name"=>"Saba", "last_name"=>"Alzabin", "scopus_author_id"=>"8346308000"}, {"first_name"=>"Patrick J.", "last_name"=>"Venables", "scopus_author_id"=>"35249843200"}, {"first_name"=>"Ky Anh", "last_name"=>"Nguyen", "scopus_author_id"=>"7202572469"}, {"first_name"=>"Piotr", "last_name"=>"Mydel", "scopus_author_id"=>"6504332971"}, {"first_name"=>"Jan", "last_name"=>"Potempa", "scopus_author_id"=>"7102884964"}], "year"=>2013, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"24068934", "doi"=>"10.1371/journal.ppat.1003627", "sgr"=>"84884677299", "isbn"=>"10.1371/journal.ppat.1003627", "scopus"=>"2-s2.0-84884677299", "issn"=>"15537366", "pui"=>"369904129"}, "id"=>"0173c595-1ff6-344f-8be2-8051e7dda6ee", "abstract"=>"Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with viable periodontal pathogen Porphyromonas gingivalis strain W83 exacerbated collagen-induced arthritis (CIA) in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction. The ability of P. gingivalis to augment CIA was dependent on the expression of a unique P. gingivalis peptidylarginine deiminase (PPAD), which converts arginine residues in proteins to citrulline. Infection with wild type P. gingivalis was responsible for significantly increased levels of autoantibodies to collagen type II and citrullinated epitopes as a PPAD-null mutant did not elicit similar host response. High level of citrullinated proteins was also detected at the site of infection with wild-type P. gingivalis. Together, these results suggest bacterial PAD as the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis.", "link"=>"http://www.mendeley.com/research/porphyromonas-gingivalis-facilitates-development-progression-destructive-arthritis-through-unique-ba", "reader_count"=>74, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>18, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>8, "Student > Master"=>15, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>18, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>8, "Student > Master"=>15, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>29, "Medicine and Dentistry"=>27, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>29}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Turkey"=>1, "United States"=>1, "United Kingdom"=>1, "Germany"=>2}, "group_count"=>12}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84884677299"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84884677299?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884677299&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84884677299&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84884677299", "dc:identifier"=>"SCOPUS_ID:84884677299", "eid"=>"2-s2.0-84884677299", "dc:title"=>"Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)", "dc:creator"=>"Maresz K.", "prism:publicationName"=>"PLoS Pathogens", "prism:issn"=>"15537366", "prism:eIssn"=>"15537374", "prism:volume"=>"9", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-09-01", "prism:coverDisplayDate"=>"September 2013", "prism:doi"=>"10.1371/journal.ppat.1003627", "citedby-count"=>"123", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Uniwersytet Jagielloński w Krakowie", "affiliation-city"=>"Krakow", "affiliation-country"=>"Poland"}], "pubmed-id"=>"24068934", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1003627", "source-id"=>"4000151809", "openaccess"=>"1", "openaccessFlag"=>true}

Article Coverage

Article Coverage Curated

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplospathogens%2Farticle%3Fid%3D10.1371%252Fjournal.ppat.1003627", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Twitter

Counter

  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"244", "xml_views"=>"21", "html_views"=>"1907"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"132", "xml_views"=>"9", "html_views"=>"1290"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"84", "xml_views"=>"1", "html_views"=>"778"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"53", "xml_views"=>"1", "html_views"=>"411"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"401"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"69", "xml_views"=>"3", "html_views"=>"491"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"71", "xml_views"=>"3", "html_views"=>"413"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"61", "xml_views"=>"2", "html_views"=>"400"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"263"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"339"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"307"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"3", "html_views"=>"282"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"220"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"266"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"246"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"222"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"168"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"332"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"163"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"131"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"106"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"121"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"68", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"189"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"220"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"208"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"6", "html_views"=>"173"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"222"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"247"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"216"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"69"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"118"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"216"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"5", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"58", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"5", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"53"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"20", "html_views"=>"29"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"32", "xml_views"=>"3", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"10"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1201878"], "description"=>"<p>(A) Kaplan-Meier plots showing differences in the clinical onset of arthritis (log-rank test, p<0.001) (n = 7). (B) Mean severity of arthritis in mice followed for 5–6 weeks after immunization. Two-way ANOVA with Bonferroni's post-test was used for the statistical evaluation. (n = 7). (C) H&E staining of the representative inflamed tarsal joints from CII- immunized DBA/1, and (F) mice infected with wild-type <i>P. gingivalis</i> strain W83 (D) Representative picture of the inflamed lower paw in CIA and (E) CIA after infection with wild type <i>P. gingivalis</i>. (G) Scatter dot plot showing MPO activity in 1 g of joint tissue extract prepared at day 45 after CII immunization. Horizontal bar and error bars represent the mean and SEM, respectively. Differences between groups were analyzed using Mann-Whitney U test (n = 20). *** denotes p<0.001.</p>", "links"=>[], "tags"=>["exacerbation", "cia", "mice", "inoculated", "w83", "cells", "subsequently", "immunized"], "article_id"=>797570, "categories"=>["Biological Sciences"], "users"=>["Katarzyna J. Maresz", "Annelie Hellvard", "Aneta Sroka", "Karina Adamowicz", "Ewa Bielecka", "Joanna Koziel", "Katarzyna Gawron", "Danuta Mizgalska", "Katarzyna A. Marcinska", "Malgorzata Benedyk", "Krzysztof Pyrc", "Anne-Marie Quirke", "Roland Jonsson", "Saba Alzabin", "Patrick J. Venables", "Ky-Anh Nguyen", "Piotr Mydel", "Jan Potempa"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003627.g001", "stats"=>{"downloads"=>5, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_gingivalis_exacerbation_of_CIA_in_DBA_1_mice_Mice_n_7_were_inoculated_with_1_10_8_P_gingivalis_strain_W83_cells_and_subsequently_immunized_with_CII_/797570", "title"=>"<i>P. gingivalis</i> exacerbation of CIA in DBA/1 mice. Mice (n = 7) were inoculated with 1×10<sup>8</sup><i>P. gingivalis</i> strain W83 cells and subsequently immunized with CII.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 01:34:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1201879"], "description"=>"<p>(A) Development of CIA at 5–6 weeks in DBA/1 mice (n = 7) were compared after exposure to viable <i>P. gingivalis</i> and heat-killed <i>P. gingivalis</i>; (B) Mice were immunized with <i>P. gingivalis</i> cell-envelope fractions (n = 10) 3 weeks prior to CII challenge and the development CIA were monitored at the 5–6 weeks period. (C) Mice were challenged with the periodontal pathogen <i>P. intermedia</i> strain 17 as compared to wild-type <i>P. gingivalis</i>. Points represent mean ± SEM. Two-way ANOVA with Bonferroni's post-test was used for the statistical evaluation (*** p<0.001, **** p<0.0001).</p>", "links"=>[], "tags"=>["collagen-induced", "arthritis", "viable"], "article_id"=>797571, "categories"=>["Biological Sciences"], "users"=>["Katarzyna J. Maresz", "Annelie Hellvard", "Aneta Sroka", "Karina Adamowicz", "Ewa Bielecka", "Joanna Koziel", "Katarzyna Gawron", "Danuta Mizgalska", "Katarzyna A. Marcinska", "Malgorzata Benedyk", "Krzysztof Pyrc", "Anne-Marie Quirke", "Roland Jonsson", "Saba Alzabin", "Patrick J. Venables", "Ky-Anh Nguyen", "Piotr Mydel", "Jan Potempa"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003627.g002", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aggravation_of_collagen_induced_arthritis_was_specific_to_exposure_to_viable_P_gingivalis_/797571", "title"=>"Aggravation of collagen-induced arthritis was specific to exposure to viable <i>P. gingivalis</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 01:34:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1201882"], "description"=>"<p><b><i> </i></b> Mice (n = 7) were inoculated with 1×10<sup>8</sup> CFU <i>P. gingivalis</i> wild-type strain W83 or PPAD-knockout strain (dPAD) and subsequently immunized with CII. (A) Kaplan-Meier plots displaying the clinical onset of arthritis (log-rank test, p = 0.002). (B) Mean severity of arthritis in mice followed for 5–6 weeks after immunization. (C) Histological signs of synovitis and (D) erosion on day 45 after CII immunization. (E) Scatter dot plot showing MPO activity in 1 g of joint tissue extract at day 45 after CII immunization. H&E staining of the representative inflamed tarsal joints from (F) CII- immunized DBA/1, (G) mice infected with wild-type <i>P. gingivalis</i> strain W83, and (H) isogenic dPAD mutant. Horizontal bar and error bars represent the mean and SEM, respectively. Statistical evaluation using two-way ANOVA with Bonferroni's post-test were employed for data in (B) and statistical differences between groups were analyzed using Mann-Whitney U test (C) or one way ANOVA (D). ** denotes p<0.01; ***, p<0.001; ****, p<0.0001.</p>", "links"=>[], "tags"=>["collagen-induced", "arthritis", "mice", "peptidylarginine", "deiminase"], "article_id"=>797574, "categories"=>["Biological Sciences"], "users"=>["Katarzyna J. Maresz", "Annelie Hellvard", "Aneta Sroka", "Karina Adamowicz", "Ewa Bielecka", "Joanna Koziel", "Katarzyna Gawron", "Danuta Mizgalska", "Katarzyna A. Marcinska", "Malgorzata Benedyk", "Krzysztof Pyrc", "Anne-Marie Quirke", "Roland Jonsson", "Saba Alzabin", "Patrick J. Venables", "Ky-Anh Nguyen", "Piotr Mydel", "Jan Potempa"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003627.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aggravation_of_collagen_induced_arthritis_in_DBA_1_mice_was_dependent_on_the_production_of_P_gingivalis_peptidylarginine_deiminase_PPAD_/797574", "title"=>"Aggravation of collagen-induced arthritis in DBA/1 mice was dependent on the production of <i>P. gingivalis</i> peptidylarginine deiminase (PPAD).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 01:34:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1201883"], "description"=>"<p>(A) Development of arthritis in DBA/1 mice (n = 7) inoculated with <i>P. gingivalis</i> wild-type W83 strain or a PPAD-complemented mutant (dPAD<sup>+</sup>). Mean severity of arthritis in mice followed for 5–6 weeks after immunization. B) Serum levels of IgG antibodies against CII were determined by ELISA on day 45 after immunization. Horizontal bar and error bars represent the mean and SEM, respectively. Statistical evaluation using two-way ANOVA with Bonferroni's post-test (* p<0.05, ** p<0.01).</p>", "links"=>[], "tags"=>["collagen-induced", "arthritis", "mice", "peptidylarginine", "deiminase"], "article_id"=>797575, "categories"=>["Biological Sciences"], "users"=>["Katarzyna J. Maresz", "Annelie Hellvard", "Aneta Sroka", "Karina Adamowicz", "Ewa Bielecka", "Joanna Koziel", "Katarzyna Gawron", "Danuta Mizgalska", "Katarzyna A. Marcinska", "Malgorzata Benedyk", "Krzysztof Pyrc", "Anne-Marie Quirke", "Roland Jonsson", "Saba Alzabin", "Patrick J. Venables", "Ky-Anh Nguyen", "Piotr Mydel", "Jan Potempa"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003627.g004", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aggravation_of_collagen_induced_arthritis_in_DBA_1_mice_was_dependent_on_the_production_of_P_gingivalis_peptidylarginine_deiminase_PPAD_/797575", "title"=>"Aggravation of collagen-induced arthritis in DBA/1 mice was dependent on the production of <i>P. gingivalis</i> peptidylarginine deiminase (PPAD).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 01:34:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1201884"], "description"=>"<p>(A) Subcutaneously implanted titanium chambers were inoculated with: 1) 1×10<sup>8 </sup><i>P. gingivalis</i>, 2) PBS, 3) 5×10<sup>7</sup> and 4) 1×10<sup>7 </sup><i>P. gingivalis</i>. After 24 h, 20 µl of chamber fluid was collected and assayed for citrullinated proteins by immunoblotting with anti-modified citrulline antibody. B) Level of citrullinated proteins in chamber fluid 7 days post-inoculation. Pooled chamber fluid from 2 independent experiments was used. Horizontal bar and error bars represent the mean and SEM, respectively. C) Serum titers of aCCP IgG and D) IgG antibodies against CEP-1 were determined using an ELISA 45 days post-immunization with CII. Error bars represent the SEM. Statistical evaluation was carried out using one way ANOVA. * denotes p<0.05.</p>", "links"=>[], "tags"=>["w83", "leads", "citrullination", "antibody", "citrullinated", "proteins"], "article_id"=>797576, "categories"=>["Biological Sciences"], "users"=>["Katarzyna J. Maresz", "Annelie Hellvard", "Aneta Sroka", "Karina Adamowicz", "Ewa Bielecka", "Joanna Koziel", "Katarzyna Gawron", "Danuta Mizgalska", "Katarzyna A. Marcinska", "Malgorzata Benedyk", "Krzysztof Pyrc", "Anne-Marie Quirke", "Roland Jonsson", "Saba Alzabin", "Patrick J. Venables", "Ky-Anh Nguyen", "Piotr Mydel", "Jan Potempa"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003627.g005", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inoculation_with_P_gingivalis_strain_W83_leads_to_citrullination_in_vivo_and_in_turn_production_of_antibody_against_citrullinated_proteins_aCCP_/797576", "title"=>"Inoculation with <i>P. gingivalis</i> strain W83 leads to citrullination <i>in vivo</i> and, in turn, production of antibody against citrullinated proteins (aCCP).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 01:34:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/1201885", "https://ndownloader.figshare.com/files/1201886"], "description"=>"<div><p>Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with viable periodontal pathogen <i>Porphyromonas gingivalis</i> strain W83 exacerbated collagen-induced arthritis (CIA) in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction. The ability of <i>P. gingivalis</i> to augment CIA was dependent on the expression of a unique <i>P. gingivalis</i> peptidylarginine deiminase (PPAD), which converts arginine residues in proteins to citrulline. Infection with wild type <i>P. gingivalis</i> was responsible for significantly increased levels of autoantibodies to collagen type II and citrullinated epitopes as a PPAD-null mutant did not elicit similar host response. High level of citrullinated proteins was also detected at the site of infection with wild-type <i>P. gingivalis</i>. Together, these results suggest bacterial PAD as the mechanistic link between <i>P. gingivalis</i> periodontal infection and rheumatoid arthritis.</p></div>", "links"=>[], "tags"=>["facilitates", "progression", "destructive", "arthritis", "bacterial", "peptidylarginine", "deiminase"], "article_id"=>797577, "categories"=>["Biological Sciences"], "users"=>["Katarzyna J. Maresz", "Annelie Hellvard", "Aneta Sroka", "Karina Adamowicz", "Ewa Bielecka", "Joanna Koziel", "Katarzyna Gawron", "Danuta Mizgalska", "Katarzyna A. Marcinska", "Malgorzata Benedyk", "Krzysztof Pyrc", "Anne-Marie Quirke", "Roland Jonsson", "Saba Alzabin", "Patrick J. Venables", "Ky-Anh Nguyen", "Piotr Mydel", "Jan Potempa"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1003627.s001", "https://dx.doi.org/10.1371/journal.ppat.1003627.s002"], "stats"=>{"downloads"=>4, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Porphyromonas_gingivalis_Facilitates_the_Development_and_Progression_of_Destructive_Arthritis_through_Its_Unique_Bacterial_Peptidylarginine_Deiminase_PAD_/797577", "title"=>"<i>Porphyromonas gingivalis</i> Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-09-12 01:34:50"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"116", "full-text"=>"137", "pdf"=>"75", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"28", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"72", "full-text"=>"81", "pdf"=>"37", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"57", "full-text"=>"59", "pdf"=>"181", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"47", "full-text"=>"45", "pdf"=>"268", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"57", "full-text"=>"66", "pdf"=>"103", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"36", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"73", "full-text"=>"103", "pdf"=>"39", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"42", "full-text"=>"39", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"28", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"35", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"41", "full-text"=>"47", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"27", "pdf"=>"15", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"33", "full-text"=>"36", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"30", "full-text"=>"35", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"32", "full-text"=>"41", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"42", "full-text"=>"47", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"45", "full-text"=>"54", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"39", "full-text"=>"59", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"26", "full-text"=>"33", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"29", "full-text"=>"28", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"41", "full-text"=>"40", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"30", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"27", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"36", "full-text"=>"39", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"28", "full-text"=>"32", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"30", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"36", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"28", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"22", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"32", "full-text"=>"31", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"4", "cited-by"=>"2", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"21", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"28", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[293, 503, 638, 755, 861, 960, 1056, 1146, 1239, 1323, 1403, 1491, 1568]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[256, 449, 572, 676, 775, 866, 955, 1041, 1127, 1213, 1290, 1370, 1437]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}, {"subject_area"=>"/Medicine and health sciences/Inflammatory diseases", "average_usage"=>[255, 445, 583, 697, 792, 882, 971, 1045, 1128, 1221, 1291, 1409, 1462, 1534]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[267, 466, 592, 709, 806, 901, 989, 1075, 1162, 1254, 1342, 1424, 1486]}, {"subject_area"=>"/Medicine and health sciences/Public and occupational health", "average_usage"=>[291, 491, 610, 723, 817, 906, 991, 1071, 1153, 1238, 1324, 1411, 1478]}, {"subject_area"=>"/Medicine and health sciences/Rheumatology", "average_usage"=>[245, 445, 573, 702, 807, 913, 1011, 1132, 1217, 1305, 1387, 1488, 1537]}]}
Loading … Spinner
There are currently no alerts