Gambiense Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity
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{"title"=>"Gambiense Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity", "type"=>"journal", "authors"=>[{"first_name"=>"Veerle", "last_name"=>"Lejon", "scopus_author_id"=>"6603690455"}, {"first_name"=>"Dieudonné", "last_name"=>"Mumba Ngoyi", "scopus_author_id"=>"26325686700"}, {"first_name"=>"Luc", "last_name"=>"Kestens", "scopus_author_id"=>"7005196537"}, {"first_name"=>"Luc", "last_name"=>"Boel", "scopus_author_id"=>"6507974963"}, {"first_name"=>"Barbara", "last_name"=>"Barbé", "scopus_author_id"=>"55355250400"}, {"first_name"=>"Victor", "last_name"=>"Kande Betu", "scopus_author_id"=>"56094457700"}, {"first_name"=>"Johan", "last_name"=>"van Griensven", "scopus_author_id"=>"16644465400"}, {"first_name"=>"Emmanuel", "last_name"=>"Bottieau", "scopus_author_id"=>"6602194146"}, {"first_name"=>"Jean Jacques", "last_name"=>"Muyembe Tamfum", "scopus_author_id"=>"6603743560"}, {"first_name"=>"Jan", "last_name"=>"Jacobs", "scopus_author_id"=>"16435235900"}, {"first_name"=>"Philippe", "last_name"=>"Büscher", "scopus_author_id"=>"55943912400"}], "year"=>2014, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "scopus"=>"2-s2.0-84897398530", "pui"=>"372738349", "doi"=>"10.1371/journal.ppat.1003947", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "sgr"=>"84897398530", "pmid"=>"24603894"}, "id"=>"71f17352-0fbf-327a-b69f-3f1dca58124c", "abstract"=>"In mice, experimental infection with Trypanosoma brucei causes decreased bone marrow B-cell development, abolished splenic B-cell maturation and loss of antibody mediated protection including vaccine induced memory responses. Nothing is known about this phenomenon in human African trypanosomiasis (HAT), but if occurring, it would imply the need of revaccination of HAT patients after therapy and abolish hope for a HAT vaccine. The effect of gambiense HAT on peripheral blood memory T- and B-cells and on innate and vaccine induced antibody levels was examined. The percentage of memory B- and T-cells was quantified in peripheral blood, prospectively collected in DR Congo from 117 Trypanosoma brucei gambiense infected HAT patients before and six months after treatment and 117 controls at the same time points. Antibodies against carbohydrate antigens on red blood cells and against measles were quantified. Before treatment, significantly higher percentages of memory B-cells, mainly T-independent memory B-cells, were observed in HAT patients compared to controls (CD20+CD27+IgM+, 13.0% versus 2.0%, p<0.001). The percentage of memory T-cells, mainly early effector/memory T-cells, was higher in HAT (CD3+CD45RO+CD27+, 19.4% versus 16.7%, p = 0.003). After treatment, the percentage of memory T-cells normalized, the percentage of memory B-cells did not. The median anti-red blood cell carbohydrate IgM level was one titer lower in HAT patients than in controls (p<0.004), and partially normalized after treatment. Anti-measles antibody concentrations were lower in HAT patients than in controls (medians of 1500 versus 2250 mIU/ml, p = 0.02), and remained so after treatment, but were above the cut-off level assumed to provide protection in 94.8% of HAT patients, before and after treatment (versus 98.3% of controls, p = 0.3). Although functionality of the B-cells was not verified, the results suggest that immunity was conserved in T.b. gambiense infected HAT patients and that B-cell dysfunction might not be that severe as in mouse models.", "link"=>"http://www.mendeley.com/research/gambiense-human-african-trypanosomiasis-immunological-memory-effect-phenotypic-lymphocyte-profiles-h", "reader_count"=>27, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>7, "Student > Ph. D. Student"=>8, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>7, "Student > Ph. D. Student"=>8, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>10, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Czech Republic"=>1, "United Kingdom"=>2}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1410231"], "description"=>"<p>Blood was taken from HAT patients and non-HAT controls at inclusion (T = 0 months) and after treatment or at the same time point (T = 7 months). All comparisons were performed with the Wilcoxon Signed Rank Test. T-cells expressed as percentage of all lymphocytes. All the T-cell subsets are expressed as percentages of T-cells. Q1–4 refers to the corresponding quarters in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003947#ppat-1003947-g002\" target=\"_blank\">Figure 2</a>. Individual data are shown in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003947#ppat.1003947.s002\" target=\"_blank\">Fig. S2</a>, and can be obtained from the authors upon request.</p>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "t-cell", "subsets"], "article_id"=>954080, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003947.t002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Peripheral_blood_T_cell_subsets_in_HAT_and_in_controls_/954080", "title"=>"Peripheral blood T-cell subsets in HAT and in controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:49:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410229"], "description"=>"<p>Blood was taken from HAT patients and non-HAT controls before treatment (T = 0 months, n = 116), and after treatment or at the same time point (T = 7 months, n = 99). The cut-off value for protective immunity of ≥200 mIU/ml is indicated by the dashed line. Full data can be obtained from the authors upon request.</p>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "measles", "antibody", "concentrations"], "article_id"=>954078, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003947.g003", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Box_plot_of_measles_antibody_concentrations_in_HAT_and_controls_/954078", "title"=>"Box plot of measles antibody concentrations in HAT and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:49:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410241", "https://ndownloader.figshare.com/files/1410242", "https://ndownloader.figshare.com/files/1410243"], "description"=>"<div><p>In mice, experimental infection with <i>Trypanosoma brucei</i> causes decreased bone marrow B-cell development, abolished splenic B-cell maturation and loss of antibody mediated protection including vaccine induced memory responses. Nothing is known about this phenomenon in human African trypanosomiasis (HAT), but if occurring, it would imply the need of revaccination of HAT patients after therapy and abolish hope for a HAT vaccine. The effect of <i>gambiense</i> HAT on peripheral blood memory T- and B-cells and on innate and vaccine induced antibody levels was examined. The percentage of memory B- and T-cells was quantified in peripheral blood, prospectively collected in DR Congo from 117 <i>Trypanosoma brucei gambiense</i> infected HAT patients before and six months after treatment and 117 controls at the same time points. Antibodies against carbohydrate antigens on red blood cells and against measles were quantified. Before treatment, significantly higher percentages of memory B-cells, mainly T-independent memory B-cells, were observed in HAT patients compared to controls (CD20+CD27+IgM+, 13.0% versus 2.0%, <i>p</i><0.001). The percentage of memory T-cells, mainly early effector/memory T-cells, was higher in HAT (CD3+CD45RO+CD27+, 19.4% versus 16.7%, <i>p</i> = 0.003). After treatment, the percentage of memory T-cells normalized, the percentage of memory B-cells did not. The median anti-red blood cell carbohydrate IgM level was one titer lower in HAT patients than in controls (<i>p</i><0.004), and partially normalized after treatment. Anti-measles antibody concentrations were lower in HAT patients than in controls (medians of 1500 versus 2250 mIU/ml, <i>p</i> = 0.02), and remained so after treatment, but were above the cut-off level assumed to provide protection in 94.8% of HAT patients, before and after treatment (versus 98.3% of controls, <i>p</i> = 0.3). Although functionality of the B-cells was not verified, the results suggest that immunity was conserved in <i>T.b. gambiense</i> infected HAT patients and that B-cell dysfunction might not be that severe as in mouse models.</p></div>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "african", "trypanosomiasis", "immunological", "phenotypic", "lymphocyte", "profiles", "humoral", "immunity"], "article_id"=>954083, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1003947.s001", "https://dx.doi.org/10.1371/journal.ppat.1003947.s002", "https://dx.doi.org/10.1371/journal.ppat.1003947.s003"], "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gambiense_Human_African_Trypanosomiasis_and_Immunological_Memory_Effect_on_Phenotypic_Lymphocyte_Profiles_and_Humoral_Immunity/954083", "title"=>"<i>Gambiense</i> Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-03-06 03:49:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410228"], "description"=>"<p>T-cell subsets were based on the CD27 and CD45RO cell surface markers. A HAT patient before and after treatment (T = 0 and 7 months), and a control at the same time points are shown. Cut-offs for considering a cell surface marker positive or negative are shown as solid lines, and subdivide the graph into 4 quadrants (Q1–Q4). T-cell subsets in each quadrant are expressed as percentages of CD3+ T cells.</p>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "cytometry", "t-cell"], "article_id"=>954077, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003947.g002", "stats"=>{"downloads"=>2, "page_views"=>32, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_cytometry_dot_plot_of_the_CD3_T_cell_population_in_HAT_and_in_a_control_/954077", "title"=>"Flow cytometry dot plot of the CD3+ T-cell population in HAT and in a control.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:49:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410227"], "description"=>"<p>B-cell subsets were based on the CD27 and IgM cell surface markers. A HAT patient before and after treatment (T = 0 and 7 months), and a healthy control subject at the same time points are shown. Cut-offs for considering a cell surface marker positive or negative were based on isotype controls and are shown as solid lines, and subdivide the graph into 4 quadrants (Q1–Q4). B-cell subsets in each quadrant are expressed as percentages of CD20+ B-cells.</p>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "cytometry", "B-cell"], "article_id"=>954076, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003947.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_cytometry_dot_plot_of_the_CD20_B_cell_population_in_HAT_and_in_a_control_/954076", "title"=>"Flow cytometry dot plot of the CD20+ B-cell population in HAT and in a control.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-06 03:49:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410232"], "description"=>"<p>Blood was taken from HAT patients and from non-HAT controls before treatment (T = 0 months) and after treatment or at the corresponding time point (T = 7 months). All comparisons were performed with the Wilcoxon Signed Rank Test. B-cells are expressed as percentage of all lymphocytes and all the B-cell subsets are expressed as percentages of B-cells. Q1–4 refers to the corresponding quarters in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003947#ppat-1003947-g001\" target=\"_blank\">Figure 1</a>. Individual data are shown in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003947#ppat.1003947.s001\" target=\"_blank\">Fig. S1</a>, and can be obtained from the authors upon request.</p>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "B-cell", "subsets"], "article_id"=>954081, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003947.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Peripheral_blood_B_cell_subsets_in_HAT_and_in_controls_/954081", "title"=>"Peripheral blood B-cell subsets in HAT and in controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:49:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1410230"], "description"=>"<p>Blood was taken from HAT patients before and after treatment (T = 0 and T = 7 months) and from non-HAT controls at the same time points. n: number of matched pairs used for comparison.</p>a<p>Not calculated due to data loss. Full data can be obtained from the authors upon request.</p>", "links"=>[], "tags"=>["Clinical immunology", "Immune response", "Infectious diseases", "neglected tropical diseases", "African trypanosomiasis", "end-titres"], "article_id"=>954079, "categories"=>["Medicine"], "users"=>["Veerle Lejon", "Dieudonné Mumba Ngoyi", "Luc Kestens", "Luc Boel", "Barbara Barbé", "Victor Kande Betu", "Johan van Griensven", "Emmanuel Bottieau", "Jean-Jacques Muyembe Tamfum", "Jan Jacobs", "Philippe Büscher"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003947.t003", "stats"=>{"downloads"=>2, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iso_agglutinin_end_titres_in_HAT_and_in_controls_/954079", "title"=>"Iso-agglutinin end-titres in HAT and in controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-06 03:49:20"}

PMC Usage Stats | Further Information

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Relative Metric

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