CiteULike | Further Information

• {"link"=>{"url"=>"http://www.citeulike.org/group/15097/article/13113930"}, "post_time"=>"2014-03-21 20:12:14", "tag"=>["hiv", "microbiome", "oral"], "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.ppat.1003996"}, "group"=>"The human microbiome", "group_id"=>"15097", "article_id"=>"13113930"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/djkt/article/13113930"}, "post_time"=>"2014-03-21 20:11:57", "tag"=>["hiv", "microbiome", "oral"], "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.ppat.1003996"}, "username"=>"djkt", "article_id"=>"13113930"}

Mendeley | Further Information

{"title"=>"Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi", "type"=>"journal", "authors"=>[{"first_name"=>"Pranab K.", "last_name"=>"Mukherjee", "scopus_author_id"=>"7201661793"}, {"first_name"=>"Jyotsna", "last_name"=>"Chandra", "scopus_author_id"=>"7004474544"}, {"first_name"=>"Mauricio", "last_name"=>"Retuerto", "scopus_author_id"=>"55083970100"}, {"first_name"=>"Masoumeh", "last_name"=>"Sikaroodi", "scopus_author_id"=>"6506423671"}, {"first_name"=>"Robert E.", "last_name"=>"Brown", "scopus_author_id"=>"55574210357"}, {"first_name"=>"Richard", "last_name"=>"Jurevic", "scopus_author_id"=>"6507570442"}, {"first_name"=>"Robert A.", "last_name"=>"Salata", "scopus_author_id"=>"7004523736"}, {"first_name"=>"Michael M.", "last_name"=>"Lederman", "scopus_author_id"=>"35227594000"}, {"first_name"=>"Patrick M.", "last_name"=>"Gillevet", "scopus_author_id"=>"6603773928"}, {"first_name"=>"Mahmoud A.", "last_name"=>"Ghannoum", "scopus_author_id"=>"35379746400"}], "year"=>2014, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"372738338", "issn"=>"15537374", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "doi"=>"10.1371/journal.ppat.1003996", "scopus"=>"2-s2.0-84897392010", "pmid"=>"24626467", "sgr"=>"84897392010"}, "id"=>"732d7539-b133-3898-9e6f-9ee9bff2de49", "abstract"=>"Oral microbiota contribute to health and disease, and their disruption may influence the course of oral diseases. Here, we used pyrosequencing to characterize the oral bacteriome and mycobiome of 12 HIV-infected patients and matched 12 uninfected controls. The number of bacterial and fungal genera in individuals ranged between 8-14 and 1-9, among uninfected and HIV-infected participants, respectively. The core oral bacteriome (COB) comprised 14 genera, of which 13 were common between the two groups. In contrast, the core oral mycobiome (COM) differed between HIV-infected and uninfected individuals, with Candida being the predominant fungus in both groups. Among Candida species, C. albicans was the most common (58% in uninfected and 83% in HIV-infected participants). Furthermore, 15 and 12 bacteria-fungi pairs were correlated significantly within uninfected and HIV-infected groups, respectively. Increase in Candida colonization was associated with a concomitant decrease in the abundance of Pichia, suggesting antagonism. We found that Pichia spent medium (PSM) inhibited growth of Candida, Aspergillus and Fusarium. Moreover, Pichia cells and PSM inhibited Candida biofilms (P = .002 and .02, respectively, compared to untreated controls). The mechanism by which Pichia inhibited Candida involved nutrient limitation, and modulation of growth and virulence factors. Finally, in an experimental murine model of oral candidiasis, we demonstrated that mice treated with PSM exhibited significantly lower infection score (P = .011) and fungal burden (P = .04) compared to untreated mice. Moreover, tongues of PSM-treated mice had few hyphae and intact epithelium, while vehicle- and nystatin-treated mice exhibited extensive fungal invasion of tissue with epithelial disruption. These results showed that PSM was efficacious against oral candidiasis in vitro and in vivo. The inhibitory activity of PSM was associated with secretory protein/s. Our findings provide the first evidence of interaction among members of the oral mycobiota, and identifies a potential novel antifungal.", "link"=>"http://www.mendeley.com/research/oral-mycobiome-analysis-hivinfected-patients-identification-pichia-antagonist-opportunistic-fungi", "reader_count"=>114, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>2, "Researcher"=>25, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>9, "Student > Master"=>17, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>2, "Researcher"=>25, "Student > Doctoral Student"=>6, "Student > Ph. D. 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Scopus | Further Information

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Web of Science® | Further Information

Article Coverage

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Article Coverage Curated

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• {"referral"=>"https://blogs.plos.org/speakingofmedicine/?p=20094", "language"=>"English", "title"=>"Sweetening their own deal", "type"=>"Blog", "publication"=>"blogs.plos.org", "published_on"=>"", "link_state"=>"APPROVED", "id"=>97976, "created"=>"2020-05-04T09:13:39.000Z", "crowdsourced"=>false, "article"=>{"id"=>4351, "doi"=>"10.1371/journal.ppat.1003996", "title"=>"Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi", "published_on"=>"2014-03-13T00:00:00.000Z"}}

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplospathogens%2Farticle%3Fid%3D10.1371%252Fjournal.ppat.1003996", "share_count"=>1, "like_count"=>0, "comment_count"=>1, "click_count"=>0, "total_count"=>2}

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• {"id"=>"444554864178114560", "text"=>"Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi http://t.co/Qi56tB0PCq", "created_at"=>"2014-03-14T19:25:13Z", "user"=>"DanielSprockett", "user_name"=>"Daniel Sprockett", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000432851504/2fadb6299b4a4e41c850c2e71ae8d782_normal.jpeg"}
• {"id"=>"444603405739106304", "text"=>"Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/aaCypJSEMo", "created_at"=>"2014-03-14T22:38:07Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000667021417/07dfff3f593fc108308ded3df8c96892_normal.jpeg"}
• {"id"=>"444604006275747840", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T22:40:30Z", "user"=>"ProfCharlesHaas", "user_name"=>"Charles Haas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1520530828/Charles_Haas-High_Res_DSC_0760_normal.jpg"}
• {"id"=>"444604035681644544", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T22:40:37Z", "user"=>"MarcelGutCo", "user_name"=>"M. Gutiérrez-Correa", "user_profile_image"=>"http://pbs.twimg.com/profile_images/424606088764207104/9iV5kBWd_normal.jpeg"}
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• {"id"=>"444604504231931904", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T22:42:28Z", "user"=>"JATetro", "user_name"=>"Jason Anthony Tetro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/439481567963283456/IHSg4784_normal.png"}
• {"id"=>"444604511903297536", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T22:42:30Z", "user"=>"RaitzaDE", "user_name"=>"Raitza", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000523655392/41d32ffbe2586563193b1175db868a29_normal.jpeg"}
• {"id"=>"444607603109548033", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T22:54:47Z", "user"=>"chitinette", "user_name"=>"Carol Munro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2151632989/Carol_Munro_2_normal.jpg"}
• {"id"=>"444612773964967937", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T23:15:20Z", "user"=>"dmrmay", "user_name"=>"Mr. D. ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/441964699425312769/_twajTdy_normal.jpeg"}
• {"id"=>"444619581726810112", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-14T23:42:23Z", "user"=>"aadaudi", "user_name"=>"Arsalan Daudi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000521228757/62660a4a03e2b062d784ce6f1bc46991_normal.jpeg"}
• {"id"=>"444622259685433344", "text"=>"Pichia \"@PLOSPathogens: Good fungi keep bad ones in check in healthy mouths @PLOSPathogens http://t.co/O5JYfJb8ok http://t.co/sOzHE9hfKx\"", "created_at"=>"2014-03-14T23:53:02Z", "user"=>"djeanspringer", "user_name"=>"Deborah Springer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/438029788821733376/TVx0lHY5_normal.jpeg"}
• {"id"=>"444630916057792512", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-15T00:27:25Z", "user"=>"Mira_Casti", "user_name"=>"Mira Demasié", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000429093361/045ef5f211104b0cd0ff88371f70b322_normal.jpeg"}
• {"id"=>"444639725119614976", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-15T01:02:26Z", "user"=>"Stewart_Barker", "user_name"=>"Stewart Barker", "user_profile_image"=>"http://pbs.twimg.com/profile_images/416015196915007489/vMzWZfhQ_normal.jpeg"}
• {"id"=>"444648955205255169", "text"=>"\"@PLOSPathogens: Good fungi keep bad ones in check in.. @PLOSPathogens http://t.co/iH5YMVXuug http://t.co/lGO39VCog6\"cc @Julyadharma", "created_at"=>"2014-03-15T01:39:06Z", "user"=>"dr_dimas_seto", "user_name"=>"Dimas Seto Prasetyo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1750107767/100_4822-resize_normal.jpg"}
• {"id"=>"444663308646612992", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-15T02:36:08Z", "user"=>"rodrigues_bio", "user_name"=>"Anderson Rodrigues", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1296659308/Anderson_1_normal.jpg"}
• {"id"=>"444707729178132480", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-15T05:32:39Z", "user"=>"jsaringe", "user_name"=>"Jeremiah Saringe", "user_profile_image"=>"http://pbs.twimg.com/profile_images/441439919785775104/fEL04AL1_normal.jpeg"}
• {"id"=>"445174159958872066", "text"=>"Oral microbiota contribute to health; their disruption influences the course of oral diseases http://t.co/1xiY9rUjzA http://t.co/Ik7yzDaxQF", "created_at"=>"2014-03-16T12:26:05Z", "user"=>"erlesen", "user_name"=>"Reiner Grißhammer ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/125495921/Reiner19.Nov.Z_normal.jpg"}
• {"id"=>"445323092936912896", "text"=>"RT @PLOSPathogens: Good fungi keep bad ones in check in healthy mouths: see the results @PLOSPathogens http://t.co/AREIBjrgnt http://t.co/a…", "created_at"=>"2014-03-16T22:17:53Z", "user"=>"dolovidal1", "user_name"=>"Dolo Vidal", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000434655949/535faddcd66a1598c862aca5f3185648_normal.jpeg"}
• {"id"=>"445536402156310530", "text"=>"Why oral candidiasis is a common complication of #HIV infection, via @PLOSPathogens: http://t.co/Ux8Ue8RgQN (free)", "created_at"=>"2014-03-17T12:25:30Z", "user"=>"The_BDJ", "user_name"=>"British Dental Jnl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1817204981/Twit_BDJ_normal.jpg"}
• {"id"=>"445538031114543105", "text"=>"Increase in oral Candida colonization associated with decrease in abundance of Pichia, suggesting antagonism http://t.co/zhh0RUHwZ8", "created_at"=>"2014-03-17T12:31:58Z", "user"=>"Eukaryotes", "user_name"=>"Chr. Rune Stensvold", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2361527970/tn8w4ukyc83d9k94l8uz_normal.jpeg"}
• {"id"=>"445542743239294976", "text"=>"RT @Eukaryotes: Increase in oral Candida colonization associated with decrease in abundance of Pichia, suggesting antagonism http://t.co/zh…", "created_at"=>"2014-03-17T12:50:42Z", "user"=>"Sandflyman", "user_name"=>"Rod Dillon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3599825344/1e5c8b3a49ad876b17199960ce3ae902_normal.jpeg"}
• {"id"=>"445547170502938624", "text"=>"RT @The_BDJ: Why oral candidiasis is a common complication of #HIV infection, via @PLOSPathogens: http://t.co/Ux8Ue8RgQN (free)", "created_at"=>"2014-03-17T13:08:17Z", "user"=>"Kent_Express", "user_name"=>"Kent Express Dental ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1638730029/Kent_Express_Dental_Supplies_normal.jpg"}
• {"id"=>"445548421311496192", "text"=>"RT @The_BDJ: Why oral candidiasis is a common complication of #HIV infection, via @PLOSPathogens: http://t.co/Ux8Ue8RgQN (free)", "created_at"=>"2014-03-17T13:13:16Z", "user"=>"gary_takacs", "user_name"=>"Gary Takacs", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1358452235/GaryTakacs_smallest_normal.jpg"}
• {"id"=>"445616237180387329", "text"=>"Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi http://t.co/vKYwr9s7iV", "created_at"=>"2014-03-17T17:42:44Z", "user"=>"pathogenomenick", "user_name"=>"Nick Loman", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1370766780/215282_10150165068141692_502431691_6652059_5392675_n_normal.jpg"}
• {"id"=>"445622805162254336", "text"=>"RT @The_BDJ: Why oral candidiasis is a common complication of #HIV infection, via @PLOSPathogens: http://t.co/Ux8Ue8RgQN (free)", "created_at"=>"2014-03-17T18:08:50Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000667021417/07dfff3f593fc108308ded3df8c96892_normal.jpeg"}
• {"id"=>"445627698128642048", "text"=>"RT @The_BDJ: Why oral candidiasis is a common complication of #HIV infection, via @PLOSPathogens: http://t.co/Ux8Ue8RgQN (free)", "created_at"=>"2014-03-17T18:28:17Z", "user"=>"RPMESP", "user_name"=>"RPMESP", "user_profile_image"=>"http://pbs.twimg.com/profile_images/444565078386286592/2pjwvHcc_normal.jpeg"}
• {"id"=>"445659554471104512", "text"=>"RT @The_BDJ: Why oral candidiasis is a common complication of #HIV infection, via @PLOSPathogens: http://t.co/Ux8Ue8RgQN (free)", "created_at"=>"2014-03-17T20:34:52Z", "user"=>"AngryByChoice1", "user_name"=>"AngryByChoice", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1622910722/Candida_albicans_fig4_normal.jpg"}
• {"id"=>"445674534696656896", "text"=>"RT @pathogenomenick: Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi htt…", "created_at"=>"2014-03-17T21:34:23Z", "user"=>"hostmicrobe", "user_name"=>"daniel beiting", "user_profile_image"=>"http://pbs.twimg.com/profile_images/441774600544735233/f6Qgn0TV_normal.jpeg"}
• {"id"=>"445746272558120960", "text"=>"Reading great article in @PLOSPathogens on how good fungi (Pichia) can keep opportunistic fungal pathogens in check http://t.co/c2R2AMiaal", "created_at"=>"2014-03-18T02:19:27Z", "user"=>"sdoublie", "user_name"=>"Sylvie Doublie", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2781868507/ad4da9f2d64302088bb9dd1f45ce7436_normal.jpeg"}
• {"id"=>"446430261593788417", "text"=>"For some reason, HIV-infected individuals seem to have a different set of fungi in their mouths:\nhttp://t.co/q5kPOxHz0m", "created_at"=>"2014-03-19T23:37:23Z", "user"=>"bykriscampbell", "user_name"=>"Kristina Campbell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1603683817/Kristina_Campbell__11_of_202__normal.jpg"}
• {"id"=>"446784543438041088", "text"=>"Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine http://t.co/5COCow8O36", "created_at"=>"2014-03-20T23:05:10Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000667021417/07dfff3f593fc108308ded3df8c96892_normal.jpeg"}
• {"id"=>"446785137888358400", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-20T23:07:32Z", "user"=>"anthroetc", "user_name"=>"Heather Battles", "user_profile_image"=>"http://pbs.twimg.com/profile_images/435988889023430657/W_oq-r5H_normal.jpeg"}
• {"id"=>"446785470597693440", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-20T23:08:51Z", "user"=>"EpiEvo", "user_name"=>"Yongzhong Zhao", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_0_normal.png"}
• {"id"=>"446785797052973056", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-20T23:10:09Z", "user"=>"djcomerci", "user_name"=>"DJ Comerci", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1819579827/IMG081_normal.jpg"}
• {"id"=>"446786022169264128", "text"=>"Also @chicagotribune on @PLOSPathogens http://t.co/AREIBjrgnt: friendly fungus protects mouth from harmful cousins http://t.co/quVpQ2FaWx", "created_at"=>"2014-03-20T23:11:03Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000667021417/07dfff3f593fc108308ded3df8c96892_normal.jpeg"}
• {"id"=>"446786367180124160", "text"=>"Fungal friends and foes in your mouth. New paper in @PLOSPathogens http://t.co/wTFl556s7k", "created_at"=>"2014-03-20T23:12:25Z", "user"=>"danielcroll", "user_name"=>"Daniel Croll", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000863272824/EPurs_AX_normal.jpeg"}
• {"id"=>"446786710324916224", "text"=>"#PLOSPathogens: Oral Mycobiome Analysis Identifies Pichia as an Antagonist of Opportunistic Fungi http://t.co/8tD1TpQ5tz", "created_at"=>"2014-03-20T23:13:47Z", "user"=>"HelenLouBrown", "user_name"=>"Helen Brown", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3433370150/fa1cc60d4529032a8db3ef1963f087ba_normal.jpeg"}
• {"id"=>"446791254102138880", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-20T23:31:50Z", "user"=>"mjcreid", "user_name"=>"Michael Reid", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000215598697/4edf605313c603b8ec50ef9fcf2a79f5_normal.jpeg"}
• {"id"=>"446816414263816192", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-21T01:11:49Z", "user"=>"Stewart_Barker", "user_name"=>"Stewart Barker", "user_profile_image"=>"http://pbs.twimg.com/profile_images/416015196915007489/vMzWZfhQ_normal.jpeg"}
• {"id"=>"446909134144012288", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-21T07:20:15Z", "user"=>"RecycleInno", "user_name"=>"Recycle Innovation", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3677629338/a76c83e2b6ec3dd6f9cde512dfc838a6_normal.jpeg"}
• {"id"=>"446922934108819456", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-21T08:15:05Z", "user"=>"DavidAnsardi", "user_name"=>"David Ansardi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2071100634/DavidPam_normal.jpg"}
• {"id"=>"446950212071071744", "text"=>"@RT:\n“@PLOSPathogens: Friendly fungus protects our mouths .....\nhttp://t.co/Ns40fHMRmx covered by @sciencemagazine http://t.co/yNPW23BFSN”", "created_at"=>"2014-03-21T10:03:29Z", "user"=>"joeriddick", "user_name"=>"joseph h riddick jr", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1105111920/Joe_cropped_normal.jpg"}
• {"id"=>"446974061546332160", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-21T11:38:15Z", "user"=>"scopedbylarry", "user_name"=>"Larry Lynam", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1157221720/Larry3_normal.jpg"}
• {"id"=>"446993444410765313", "text"=>"Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/8qT1Vn02IV @sciencemagazine http://t.co/g9K11tGIIg", "created_at"=>"2014-03-21T12:55:16Z", "user"=>"Kenzibit", "user_name"=>"Ken Yaw Agyeman-Badu", "user_profile_image"=>"http://pbs.twimg.com/profile_images/441643684375691264/qRvv_Ozz_normal.jpeg"}
• {"id"=>"447002669451055104", "text"=>"Friendly fungi: mouth fungus has role in pathogen homeostasis. http://t.co/JrKO87Lu4V via @Kenzibit", "created_at"=>"2014-03-21T13:31:55Z", "user"=>"luddyka", "user_name"=>"Kim Luddy", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2741230006/1f2267e956ebf85cd3402dd5d9c5f406_normal.jpeg"}
• {"id"=>"447267980653903872", "text"=>"RT @PLOSPathogens: Friendly fungus protects our mouths from invaders: @PLOSPathogens http://t.co/AREIBjrgnt covered by @sciencemagazine htt…", "created_at"=>"2014-03-22T07:06:11Z", "user"=>"D_Busse92", "user_name"=>"David Busse", "user_profile_image"=>"http://pbs.twimg.com/profile_images/418074769590730752/E8hk23f8_normal.jpeg"}
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Wikipedia | Further Information

• {"title"=>"Millerozyma farinosa", "url"=>"http://sv.wikipedia.org/wiki/Millerozyma_farinosa", "timestamp"=>"2019-03-03T05:56:31Z"}

Wordpress.com | Further Information

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1419829"], "description"=>"<p>Assessment of oral candidiasis in mice infected with <i>Candida</i> was performed by (A) clinical score and (B) tongue fungal burden. (A) Median clinical scores of oral candidiasis in mice after treatment with PSM and nystatin. (B) Box-plot of tissue fungal burden (log CFUs/g) in different groups of mice infected with <i>Candida</i> (<i>P</i>-values, compared to PSM treatment). Histology analyses of tissue section of tongue from mouse infected with <i>Candida</i>, followed by (C) no treatment or treated with (D) vehicle control, (E) nystatin, or (F) PSM. Arrows – fungal hyphae.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "spent", "murine", "morel"], "article_id"=>961741, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g009", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Efficacy_of_Pichia_spent_medium_PSM_in_an_experimental_murine_morel_of_oral_candidiasis_/961741", "title"=>"Efficacy of <i>Pichia</i> spent medium (PSM) in an experimental murine morel of oral candidiasis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419828"], "description"=>"<p>(A) Metabolic activity of <i>Candida</i> biofilms exposed to metabolites extracted from spent media of Pichia, Penicillium, or media control. (B) Effect of PSM exposed to proteinase, heat, or alkali on <i>Candida</i> biofilms. Confocal images show architecture of <i>Candida</i> biofilms exposed to (C) no PSM (control), (D) untreated PSM, (E) proteinase-K treated PSM, (F) heat, or (G) alkali.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "characterization", "pichia", "spent"], "article_id"=>961740, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g008", "stats"=>{"downloads"=>0, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biochemical_characterization_of_Pichia_spent_medium_/961740", "title"=>"Biochemical characterization of Pichia spent medium.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419823"], "description"=>"<p>(A) Relative abundance of <i>Pichia</i> and <i>Candida</i> in uninfected individuals. (B) Effect of PSM on growth of <i>Candida</i> was determined by measuring optical density (OD). Effect of PSM on (C) <i>Aspergillus</i>, and (D) <i>Fusarium</i> was determined by measuring dry weight of fungi. <i>Pichia</i> spent (“conditioned”) medium (PSM) was obtained by centrifuging 100-mL culture of <i>Pichia</i> grown in Sabouraud dextrose broth (SDB).</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases"], "article_id"=>961735, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antagonistic_relation_between_Pichia_and_other_fungi_/961735", "title"=>"Antagonistic relation between <i>Pichia</i> and other fungi.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419824"], "description"=>"<p><i>Pichia farinosa</i> was mixed with GFP-tagged <i>C. albicans</i> strain at 10³ cells each in yeast nitrogen base (YNB) growth medium and incubated at 37°C for 54 h. Growth of Candida cells was monitored by phase-contrast and fluorescence microscopy. Panels A, D, G: phase-contrast images of <i>Candida</i> alone, <i>Candida</i>+<i>Pichia</i>, and <i>Pichia</i> alone, respectively. Panels B, E: fluorescence images of <i>Candida</i> alone and <i>Candida</i>+<i>Pichia</i> mixture. Panels C, F: Composite figures with phase-contrast images merged with fluorescence image, for <i>Candida</i> only and <i>Candida</i>+<i>Pichia</i> mixture of cells. Panel H: quantitative measurement of fluorescence (excitation and emission wavelength = 485 and 435 nm, respectively).</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "overgrows"], "article_id"=>961736, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g005", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pichia_overgrows_Candida_in_mixed_cultures_/961736", "title"=>"<i>Pichia</i> overgrows <i>Candida</i> in mixed cultures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419822"], "description"=>"<p>Correlation of bacteriome and mycobiome was determined for (A) uninfected and (B) HIV-infected study participants using R statistical computing software (Spearman's correlation and two-tailed probability of <i>t</i> for each correlation) for the two groups. Interactions among different fungi in the mycobiome of (C) uninfected and (D) HIV-infected study participants was also determined using similar approach. Red: Positive correlation; Blue: negative correlation; diameter of circles represent the absolute value of correlation for each pair of the microbe-microbe matrix.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "coefficients", "abundance", "microbes", "uninfected", "hiv-infected"], "article_id"=>961734, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g003", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_coefficients_of_abundance_of_microbes_in_uninfected_and_HIV_infected_patients_/961734", "title"=>"Correlation coefficients of abundance of microbes in uninfected and HIV-infected patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419833"], "description"=>"<p>For correlation analysis, microbiome abundance data was divided into independent data matrices (disease and no disease) and correlation analyses was conducted using the “psych” package (corr.test function) in R statistical platform (pairwise Spearman's correlation and two-tailed probability of <i>t</i> for each correlation) <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003996#ppat.1003996-R1\" target=\"_blank\">[34]</a>, <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003996#ppat.1003996-Revelle1\" target=\"_blank\">[35]</a>.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "bacteriome", "mycobiome", "uninfected", "hiv-infected"], "article_id"=>961745, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_bacteriome_and_mycobiome_in_uninfected_and_HIV_infected_study_participants_/961745", "title"=>"Correlation between bacteriome and mycobiome in uninfected and HIV-infected study participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419831"], "description"=>"§<p>Gender: M – Male, F – Female.</p><p>*Self-reported ethnicity: W = White; H = Hispanic; C = Caucasian; AA = African-American.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases"], "article_id"=>961743, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.t001", "stats"=>{"downloads"=>14, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_information_of_study_participants_/961743", "title"=>"Demographic information of study participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419832"], "description"=>"<p>Correlation among oral fungi in uninfected study participants.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "fungi", "uninfected"], "article_id"=>961744, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.t003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_among_oral_fungi_in_uninfected_study_participants_/961744", "title"=>"Correlation among oral fungi in uninfected study participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419830"], "description"=>"1<p>Absent: fungi that were not detected in samples with <i>Pichia</i>.</p>2<p>Co-colonizers: fungi detected in samples where <i>Pichia</i> was present.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "fungi", "uninfected"], "article_id"=>961742, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.t004", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_Pichia_and_other_fungi_in_oral_wash_of_uninfected_patients_/961742", "title"=>"Relationship between <i>Pichia</i> and other fungi in oral wash of uninfected patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419827"], "description"=>"<p>Effect of undiluted and diluted (50%) PSM on (A) metabolic activity and (B) thickness of <i>Candida</i> biofilms was assessed. (C) Germination in <i>Candida</i> grown in SDB, exposed to fetal bovine serum, (D) Stunted germ tubes formed by <i>Candida</i> exposed to <i>Pichia</i> supernatant (Magnification 20X), (E) Effect of PSM on the ability of <i>Candida</i> (grown in SDB) to adhere to solid substrates. (SDB - Sabouraud dextrose broth.)</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "germination"], "article_id"=>961739, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g007", "stats"=>{"downloads"=>3, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dose_dependent_activity_of_PSM_and_its_effect_on_Candida_germination_and_adhesion_/961739", "title"=>"Dose dependent activity of PSM, and its effect on <i>Candida</i> germination and adhesion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419826"], "description"=>"<p>(A) Effect of <i>Pichia</i> cells on the ability of <i>Candida</i> to form biofilms. <i>Candida</i> and <i>Pichia</i> were co-incubated [<i>Candida</i>∶<i>Pichia</i> (C∶P) = 3∶1, 1∶1, or 1∶3] and biofilm formation was monitored (*<i>P</i>≤.002, compared to <i>Candida</i> or <i>Pichia</i> controls). (B) Effect of media supernatant obtained from <i>Pichia, Penicillium, or Cladosporium</i> on <i>Candida</i> biofilms. Mean ± SD of ≥3 separate experiments. (C–E) Confocal microscopy images of <i>Candida</i> biofilms formed in presence of (C) no media supernatant, (D) <i>Penicillium</i> supernatant or (E) <i>Pichia</i> supernatant. (F) Thickness of biofilms formed in presence of media supernatant of <i>Pichia</i> or <i>Penicillium</i>.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "spent", "fungal"], "article_id"=>961738, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g006", "stats"=>{"downloads"=>3, "page_views"=>51, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Activity_of_Pichia_spent_medium_PSM_against_fungal_biofilms_/961738", "title"=>"Activity of <i>Pichia</i> spent medium (PSM) against fungal biofilms.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419820"], "description"=>"<p>(A) Relative abundance of fungi in uninfected and HIV-infected patients (N = 12 for each group), (B) Fungi present in the core oral mycobiome of uninfected and HIV-infected individuals.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "microbiome", "hiv-infected", "patients", "uninfected"], "article_id"=>961733, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g002", "stats"=>{"downloads"=>4, "page_views"=>67, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fungal_microbiome_mycobiome_of_HIV_infected_patients_and_uninfected_individuals_/961733", "title"=>"Fungal microbiome (mycobiome) of HIV-infected patients and uninfected individuals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419818"], "description"=>"<p>(A) Relative abundance bacteria in uninfected and HIV-infected patients (N = 11 for each group), (B) Bacteria present in the core oral bacteriome of uninfected and HIV-infected individuals.</p>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "microbiome", "hiv-infected", "patients", "uninfected"], "article_id"=>961732, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1003996.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bacterial_microbiome_bacteriome_of_HIV_infected_patients_and_uninfected_individuals_/961732", "title"=>"Bacterial microbiome (bacteriome) of HIV-infected patients and uninfected individuals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-03-13 10:21:26"}
• {"files"=>["https://ndownloader.figshare.com/files/1419834", "https://ndownloader.figshare.com/files/1419835", "https://ndownloader.figshare.com/files/1419836"], "description"=>"<div><p>Oral microbiota contribute to health and disease, and their disruption may influence the course of oral diseases. Here, we used pyrosequencing to characterize the oral bacteriome and mycobiome of 12 HIV-infected patients and matched 12 uninfected controls. The number of bacterial and fungal genera in individuals ranged between 8–14 and 1–9, among uninfected and HIV-infected participants, respectively. The core oral bacteriome (COB) comprised 14 genera, of which 13 were common between the two groups. In contrast, the core oral mycobiome (COM) differed between HIV-infected and uninfected individuals, with <i>Candida</i> being the predominant fungus in both groups. Among <i>Candida</i> species, <i>C. albicans</i> was the most common (58% in uninfected and 83% in HIV-infected participants). Furthermore, 15 and 12 bacteria-fungi pairs were correlated significantly within uninfected and HIV-infected groups, respectively. Increase in <i>Candida</i> colonization was associated with a concomitant decrease in the abundance of <i>Pichia</i>, suggesting antagonism. We found that <i>Pichia</i> spent medium (PSM) inhibited growth of <i>Candida</i>, <i>Aspergillus</i> and <i>Fusarium</i>. Moreover, <i>Pichia</i> cells and PSM inhibited <i>Candida</i> biofilms (<i>P</i> = .002 and .02, respectively, compared to untreated controls). The mechanism by which <i>Pichia</i> inhibited <i>Candida</i> involved nutrient limitation, and modulation of growth and virulence factors. Finally, in an experimental murine model of oral candidiasis, we demonstrated that mice treated with PSM exhibited significantly lower infection score (<i>P</i> = .011) and fungal burden (<i>P</i> = .04) compared to untreated mice. Moreover, tongues of PSM-treated mice had few hyphae and intact epithelium, while vehicle- and nystatin-treated mice exhibited extensive fungal invasion of tissue with epithelial disruption. These results showed that PSM was efficacious against oral candidiasis <i>in vitro</i> and <i>in vivo</i>. The inhibitory activity of PSM was associated with secretory protein/s. Our findings provide the first evidence of interaction among members of the oral mycobiota, and identifies a potential novel antifungal.</p></div>", "links"=>[], "tags"=>["microbiology", "Bacterial pathogens", "Medical microbiology", "Mycology", "Infectious diseases", "Fungal diseases", "mycobiome", "hiv-infected", "antagonist", "opportunistic", "fungi"], "article_id"=>961746, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Pranab K. Mukherjee", "Jyotsna Chandra", "Mauricio Retuerto", "Masoumeh Sikaroodi", "Robert E. Brown", "Richard Jurevic", "Robert A. Salata", "Michael M. Lederman", "Patrick M. Gillevet", "Mahmoud A. Ghannoum"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1003996.s001", "https://dx.doi.org/10.1371/journal.ppat.1003996.s002", "https://dx.doi.org/10.1371/journal.ppat.1003996.s003"], "stats"=>{"downloads"=>16, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Oral_Mycobiome_Analysis_of_HIV_Infected_Patients_Identification_of_Pichia_as_an_Antagonist_of_Opportunistic_Fungi/961746", "title"=>"Oral Mycobiome Analysis of HIV-Infected Patients: Identification of <i>Pichia</i> as an Antagonist of Opportunistic Fungi", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-03-13 10:21:26"}

PMC Usage Stats | Further Information

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• {"unique-ip"=>"30", "full-text"=>"43", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
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• {"unique-ip"=>"37", "full-text"=>"37", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
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• {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2020", "month"=>"3"}
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• {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
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Relative Metric

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F1000Prime | Further Information

• {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-05-26T08:35:58Z"}
• {"year"=>2014, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-06-30T08:35:51Z"}
• {"year"=>2014, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-07-28T08:36:00Z"}
• {"year"=>2014, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-08-25T08:36:00Z"}
• {"year"=>2014, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-09-29T08:36:04Z"}
• {"year"=>2014, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-10-27T08:35:41Z"}
• {"year"=>2014, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-11-24T09:33:42Z"}
• {"year"=>2014, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2014-12-29T09:43:33Z"}
• {"year"=>2015, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-01-26T09:41:10Z"}
• {"year"=>2015, "month"=>2, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-02-23T09:41:11Z"}
• {"year"=>2015, "month"=>3, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-03-23T08:41:32Z"}
• {"year"=>2015, "month"=>4, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-04-27T08:41:20Z"}
• {"year"=>2015, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-05-25T08:41:09Z"}
• {"year"=>2015, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-06-29T08:41:14Z"}
• {"year"=>2015, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-07-27T08:41:06Z"}
• {"year"=>2015, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-08-31T08:41:18Z"}
• {"year"=>2015, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-09-28T08:41:05Z"}
• {"year"=>2015, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-10-26T08:41:25Z"}
• {"year"=>2015, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-11-30T09:41:25Z"}
• {"year"=>2015, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2015-12-28T09:41:29Z"}
• {"year"=>2016, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-01-25T09:41:27Z"}
• {"year"=>2016, "month"=>2, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-02-29T09:41:02Z"}
• {"year"=>2016, "month"=>3, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-03-28T08:40:58Z"}
• {"year"=>2016, "month"=>4, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-04-25T08:41:10Z"}
• {"year"=>2016, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-05-16T08:41:07Z"}
• {"year"=>2016, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-06-27T08:41:05Z"}
• {"year"=>2016, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-07-25T08:41:01Z"}
• {"year"=>2016, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-08-29T08:40:54Z"}
• {"year"=>2016, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-09-26T08:41:00Z"}
• {"year"=>2016, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-10-31T08:40:59Z"}
• {"year"=>2016, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-11-28T09:41:02Z"}
• {"year"=>2016, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2016-12-26T09:41:16Z"}
• {"year"=>2017, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-01-30T09:41:10Z"}
• {"year"=>2017, "month"=>2, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-02-27T09:41:14Z"}
• {"year"=>2017, "month"=>3, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-03-27T08:41:10Z"}
• {"year"=>2017, "month"=>4, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-04-24T08:41:07Z"}
• {"year"=>2017, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-05-29T08:41:06Z"}
• {"year"=>2017, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"http://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-06-26T08:41:12Z"}
• {"year"=>2017, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-07-31T08:41:06Z"}
• {"year"=>2017, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-08-28T08:41:11Z"}
• {"year"=>2017, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-09-25T08:41:15Z"}
• {"year"=>2017, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-10-30T08:41:35Z"}
• {"year"=>2017, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-11-27T09:41:17Z"}
• {"year"=>2017, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2017-12-25T09:41:11Z"}
• {"year"=>2018, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-01-29T09:40:52Z"}
• {"year"=>2018, "month"=>2, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-02-26T09:40:55Z"}
• {"year"=>2018, "month"=>3, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-03-26T08:40:57Z"}
• {"year"=>2018, "month"=>4, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-04-30T08:40:54Z"}
• {"year"=>2018, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-05-28T08:40:55Z"}
• {"year"=>2018, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-06-25T08:40:55Z"}
• {"year"=>2018, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-07-30T08:41:03Z"}
• {"year"=>2018, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-08-27T08:41:18Z"}
• {"year"=>2018, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-09-24T08:41:04Z"}
• {"year"=>2018, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-10-29T08:41:06Z"}
• {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-11-26T09:41:09Z"}
• {"year"=>2018, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2018-12-31T09:41:14Z"}
• {"year"=>2019, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-01-28T09:41:00Z"}
• {"year"=>2019, "month"=>2, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-02-25T09:41:03Z"}
• {"year"=>2019, "month"=>3, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-03-25T08:40:58Z"}
• {"year"=>2019, "month"=>4, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-04-29T08:41:06Z"}
• {"year"=>2019, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-05-27T08:41:17Z"}
• {"year"=>2019, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-06-24T08:41:06Z"}
• {"year"=>2019, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-07-29T08:41:23Z"}
• {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-08-26T08:41:13Z"}
• {"year"=>2019, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-09-30T08:41:14Z"}
• {"year"=>2019, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-10-28T08:41:12Z"}
• {"year"=>2019, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-11-25T09:41:16Z"}
• {"year"=>2019, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2019-12-30T09:41:33Z"}
• {"year"=>2020, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-01-27T09:41:08Z"}
• {"year"=>2020, "month"=>2, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-02-24T09:41:16Z"}
• {"year"=>2020, "month"=>3, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-03-30T08:41:18Z"}
• {"year"=>2020, "month"=>4, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-04-27T08:41:11Z"}
• {"year"=>2020, "month"=>5, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-05-25T08:41:11Z"}
• {"year"=>2020, "month"=>6, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-06-29T08:41:13Z"}
• {"year"=>2020, "month"=>7, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-07-27T08:41:12Z"}
• {"year"=>2020, "month"=>8, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-08-31T08:41:20Z"}
• {"year"=>2020, "month"=>9, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-09-28T08:41:16Z"}
• {"year"=>2020, "month"=>10, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-10-26T08:41:13Z"}
• {"year"=>2020, "month"=>11, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-11-30T09:41:18Z"}
• {"year"=>2020, "month"=>12, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2020-12-28T09:41:18Z"}
• {"year"=>2021, "month"=>1, "doi"=>"10.1371/journal.ppat.1003996", "f1000_id"=>"718310756", "url"=>"https://f1000.com/prime/718310756", "score"=>3, "classifications"=>["new_finding", "novel_drug_target"], "updated_at"=>"2021-01-11T09:41:17Z"}