HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
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{"title"=>"HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1", "type"=>"generic", "authors"=>[{"first_name"=>"Nuria", "last_name"=>"Izquierdo-Useros", "scopus_author_id"=>"16834791400"}, {"first_name"=>"Maier", "last_name"=>"Lorizate", "scopus_author_id"=>"6507634662"}, {"first_name"=>"Paul J.", "last_name"=>"McLaren", "scopus_author_id"=>"7006020418"}, {"first_name"=>"Amalio", "last_name"=>"Telenti", "scopus_author_id"=>"7006764406"}, {"first_name"=>"Hans Georg", "last_name"=>"Kräusslich", "scopus_author_id"=>"7006112877"}, {"first_name"=>"Javier", "last_name"=>"Martinez-Picado", "scopus_author_id"=>"7004218612"}], "year"=>2014, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-84905386677", "sgr"=>"84905386677", "issn"=>"15537374", "doi"=>"10.1371/journal.ppat.1004146", "pmid"=>"25033082", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "pui"=>"373686536"}, "id"=>"c4a3ee19-9dac-381b-9777-fc6c90150e04", "abstract"=>"Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection.", "link"=>"http://www.mendeley.com/research/hiv1-capture-transmission-dendritic-cells-role-viral-glycolipids-cellular-receptor-siglec1", "reader_count"=>83, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>5, "Researcher"=>15, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>33, "Student > Postgraduate"=>1, "Student > Master"=>12, "Other"=>1, "Student > Bachelor"=>6, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>5, "Researcher"=>15, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>33, "Student > Postgraduate"=>1, "Student > Master"=>12, "Other"=>1, "Student > Bachelor"=>6, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>13, "Agricultural and Biological Sciences"=>42, "Medicine and Dentistry"=>9, "Chemical Engineering"=>2, "Immunology and Microbiology"=>12}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>12}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>42}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>13}, "Unspecified"=>{"Unspecified"=>5}, "Chemical Engineering"=>{"Chemical Engineering"=>2}}, "reader_count_by_country"=>{"Netherlands"=>2, "United States"=>1, "Japan"=>1, "Brazil"=>1, "Italy"=>1, "Germany"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1598181"], "description"=>"<p><b>A.</b> HIV-1 can bind to DC-SIGN via recognition of the viral envelope glycoprotein. <b>B.</b> Several gangliosides in the HIV-1 lipid membrane expose a sialyllactose moiety, while GM4 only carries sialic acid on galactose. <b>C.</b> Siglec-1 can capture HIV-1 through recognition of sialyllactose moieties of viral membrane gangliosides. Abbreviations: Cer (ceramide), Gal (galactose), GalNAc (N-acetylgalactosamine), Glu (glucose), SiA (sialic acid).</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "HIV immunopathogenesis", "microbiology", "Medical microbiology", "Microbial pathogens", "Viral pathogens", "Immunodeficiency viruses", "hiv", "Virology", "Viral transmission and infection", "Viral attachment", "Viral entry", "Viral immune evasion", "Pathology and laboratory medicine", "pathogenesis", "Host-pathogen interactions", "pathogens", "Virulence factors", "Infectious diseases", "Viral diseases", "binding", "dc"], "article_id"=>1108508, "categories"=>["Biological Sciences"], "users"=>["Nuria Izquierdo-Useros", "Maier Lorizate", "Paul J. McLaren", "Amalio Telenti", "Hans-Georg Kräusslich", "Javier Martinez-Picado"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004146.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIV_1_binding_to_DC_receptors_/1108508", "title"=>"HIV-1 binding to DC receptors.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-17 03:05:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1598186"], "description"=>"<p><b>A.</b> HIV-1 binds to Siglec-1 through viral membrane gangliosides. Viral capture is followed by accumulation in a storage compartment until virus is released to infect a contacting CD4<sup>+</sup> T cell via viral envelope glycoprotein and CD4/coreceptor interactions. <b>B.</b> Exosomes bearing processed antigens on MHC II molecules bind to Siglec-1 through recognition of their membrane gangliosides. They accumulate in the same storage compartment as HIV-1 until they are released and recognized by a CD4<sup>+</sup> T cell via the interaction of the antigen-loaded MHC II on the exosome with an antigen-specific T-cell receptor on the target cell.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "HIV immunopathogenesis", "microbiology", "Medical microbiology", "Microbial pathogens", "Viral pathogens", "Immunodeficiency viruses", "hiv", "Virology", "Viral transmission and infection", "Viral attachment", "Viral entry", "Viral immune evasion", "Pathology and laboratory medicine", "pathogenesis", "Host-pathogen interactions", "pathogens", "Virulence factors", "Infectious diseases", "Viral diseases", "exosome", "targeting"], "article_id"=>1108513, "categories"=>["Biological Sciences"], "users"=>["Nuria Izquierdo-Useros", "Maier Lorizate", "Paul J. McLaren", "Amalio Telenti", "Hans-Georg Kräusslich", "Javier Martinez-Picado"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004146.g003", "stats"=>{"downloads"=>6, "page_views"=>264, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIV_1_and_exosome_targeting_to_Siglec_1_/1108513", "title"=>"HIV-1 and exosome targeting to Siglec-1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-17 03:05:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1598184"], "description"=>"<p><b>A.</b> Siglec-1 has 16 C2-type domains that extend the V-set domain from the glycocalix of the cell, allowing for recognition of sialylated molecules on different ligands and pathogens such as HIV-1. <b>B.</b> Other members of the Siglec family display a lower number of C2-type domains and interact only in <i>cis</i>, with sialylated molecules exposed on the membrane of the same cell.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "HIV immunopathogenesis", "microbiology", "Medical microbiology", "Microbial pathogens", "Viral pathogens", "Immunodeficiency viruses", "hiv", "Virology", "Viral transmission and infection", "Viral attachment", "Viral entry", "Viral immune evasion", "Pathology and laboratory medicine", "pathogenesis", "Host-pathogen interactions", "pathogens", "Virulence factors", "Infectious diseases", "Viral diseases", "siglec-1"], "article_id"=>1108511, "categories"=>["Biological Sciences"], "users"=>["Nuria Izquierdo-Useros", "Maier Lorizate", "Paul J. McLaren", "Amalio Telenti", "Hans-Georg Kräusslich", "Javier Martinez-Picado"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004146.g002", "stats"=>{"downloads"=>1, "page_views"=>133, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trans_and_cis_recognition_of_Siglec_1_ligands_/1108511", "title"=>"<i>Trans</i> and <i>cis</i> recognition of Siglec-1 ligands.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-17 03:05:35"}

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