Characterization of Arabidopsis Transcriptional Responses to Different Aphid Species Reveals Genes that Contribute to Host Susceptibility and Non-host Resistance
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{"title"=>"Characterization of Arabidopsis Transcriptional Responses to Different Aphid Species Reveals Genes that Contribute to Host Susceptibility and Non-host Resistance", "type"=>"journal", "authors"=>[{"first_name"=>"Maëlle", "last_name"=>"Jaouannet", "scopus_author_id"=>"36454599500"}, {"first_name"=>"Jenny A.", "last_name"=>"Morris", "scopus_author_id"=>"7405894238"}, {"first_name"=>"Peter E.", "last_name"=>"Hedley", "scopus_author_id"=>"6603361504"}, {"first_name"=>"Jorunn I.B.", "last_name"=>"Bos", "scopus_author_id"=>"7201649149"}], "year"=>2015, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"604704949", "sgr"=>"84930350678", "issn"=>"15537374", "pmid"=>"25993686", "scopus"=>"2-s2.0-84930350678", "doi"=>"10.1371/journal.ppat.1004918", "isbn"=>"1553-7366\\r1553-7374"}, "id"=>"0a0fc194-4a54-33b2-9716-0c4017c8f211", "abstract"=>"Aphids are economically important pests that display exceptional variation in host range. The determinants of diverse aphid host ranges are not well understood, but it is likely that molecular interactions are involved. With significant progress being made towards understanding host responses upon aphid attack, the mechanisms underlying non-host resistance remain to be elucidated. Here, we investigated and compared Arabidopsis thaliana host and non-host responses to aphids at the transcriptional level using three different aphid species, Myzus persicae, Myzus cerasi and Rhopalosiphum pisum. Gene expression analyses revealed a high level of overlap in the overall gene expression changes during the host and non-host interactions with regards to the sets of genes differentially expressed and the direction of expression changes. Despite this overlap in transcriptional responses across interactions, there was a stronger repression of genes involved in metabolism and oxidative responses specifically during the host interaction with M. persicae. In addition, we identified a set of genes with opposite gene expression patterns during the host versus non-host interactions. Aphid performance assays on Arabidopsis mutants that were selected based on our transcriptome analyses identified novel genes contributing to host susceptibility, host defences during interactions with M. persicae as well to non-host resistance against R. padi. Understanding how plants respond to aphid species that differ in their ability to infest plant species, and identifying the genes and signaling pathways involved, is essential for the development of novel and durable aphid control in crop plants.", "link"=>"http://www.mendeley.com/research/characterization-arabidopsis-transcriptional-responses-different-aphid-species-reveals-genes-contrib", "reader_count"=>31, "reader_count_by_academic_status"=>{"Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>27}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>27}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Portugal"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2076067"], "description"=>"<p>Using volcano plot analyses (fold change ≥ 2.0, p-value ≤ 0.05) in GeneSpring, we identified 11 genes with statistically significant opposite gene expression changes during different aphid interactions. Hierarchical gene tree cluster analysis in GeneSpring generated an overview of the expression changes of these 11 genes 3h, 6h and 24h after aphid exposure. Low gene expression levels are indicated by blue color and high gene expression levels are indicated by red color.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420960, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g004", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_profile_of_Arabidopsis_genes_showing_opposite_gene_expression_changes_during_aphid_host_and_non_host_interactions_/1420960", "title"=>"Expression profile of <i>Arabidopsis</i> genes showing opposite gene expression changes during aphid host and non-host interactions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076065"], "description"=>"<p>Using one-way ANOVA in GeneSpring (Bonferroni correction, p-value ≤ 0.05), we identified 874 genes that display significant differential expression across different aphid treatments and timepoints. Hierarchical gene tree cluster analysis of these 874 genes using GeneSpring software identified three main clusters of genes (A, B and C) according to their expression profiles across all treatments and timepoints. Low gene expression levels are indicated by blue colour and high gene expression levels are indicated by red colour. Mc indicates <i>Myzus cerasi</i>, Mp indicates <i>M</i>. <i>persicae</i> and Rp indicates <i>Rhopalosiphum padi</i>.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420958, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clustering_of_874_differentially_expressed_Arabidopsis_genes_during_host_and_non_host_interactions_with_aphids_/1420958", "title"=>"Clustering of 874 differentially expressed <i>Arabidopsis</i> genes during host and non-host interactions with aphids.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076088", "https://ndownloader.figshare.com/files/2076089", "https://ndownloader.figshare.com/files/2076090", "https://ndownloader.figshare.com/files/2076091", "https://ndownloader.figshare.com/files/2076092", "https://ndownloader.figshare.com/files/2076093", "https://ndownloader.figshare.com/files/2076094", "https://ndownloader.figshare.com/files/2076095", "https://ndownloader.figshare.com/files/2076096", "https://ndownloader.figshare.com/files/2076097", "https://ndownloader.figshare.com/files/2076098", "https://ndownloader.figshare.com/files/2076099", "https://ndownloader.figshare.com/files/2076100", "https://ndownloader.figshare.com/files/2076101", "https://ndownloader.figshare.com/files/2076102", "https://ndownloader.figshare.com/files/2076103", "https://ndownloader.figshare.com/files/2076104", "https://ndownloader.figshare.com/files/2076105", "https://ndownloader.figshare.com/files/2076106", "https://ndownloader.figshare.com/files/2076107", "https://ndownloader.figshare.com/files/2076108", "https://ndownloader.figshare.com/files/2076109"], "description"=>"<div><p>Aphids are economically important pests that display exceptional variation in host range. The determinants of diverse aphid host ranges are not well understood, but it is likely that molecular interactions are involved. With significant progress being made towards understanding host responses upon aphid attack, the mechanisms underlying non-host resistance remain to be elucidated. Here, we investigated and compared <i>Arabidopsis thaliana</i> host and non-host responses to aphids at the transcriptional level using three different aphid species, <i>Myzus persicae</i>, <i>Myzus cerasi</i> and <i>Rhopalosiphum pisum</i>. Gene expression analyses revealed a high level of overlap in the overall gene expression changes during the host and non-host interactions with regards to the sets of genes differentially expressed and the direction of expression changes. Despite this overlap in transcriptional responses across interactions, there was a stronger repression of genes involved in metabolism and oxidative responses specifically during the host interaction with <i>M</i>. <i>persicae</i>. In addition, we identified a set of genes with opposite gene expression patterns during the host versus non-host interactions. Aphid performance assays on <i>Arabidopsis</i> mutants that were selected based on our transcriptome analyses identified novel genes contributing to host susceptibility, host defences during interactions with <i>M</i>. <i>persicae</i> as well to non-host resistance against <i>R</i>. <i>padi</i>. Understanding how plants respond to aphid species that differ in their ability to infest plant species, and identifying the genes and signaling pathways involved, is essential for the development of novel and durable aphid control in crop plants.</p></div>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420981, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1004918.s001", "https://dx.doi.org/10.1371/journal.ppat.1004918.s002", "https://dx.doi.org/10.1371/journal.ppat.1004918.s003", "https://dx.doi.org/10.1371/journal.ppat.1004918.s004", "https://dx.doi.org/10.1371/journal.ppat.1004918.s005", "https://dx.doi.org/10.1371/journal.ppat.1004918.s006", "https://dx.doi.org/10.1371/journal.ppat.1004918.s007", "https://dx.doi.org/10.1371/journal.ppat.1004918.s008", "https://dx.doi.org/10.1371/journal.ppat.1004918.s009", "https://dx.doi.org/10.1371/journal.ppat.1004918.s010", "https://dx.doi.org/10.1371/journal.ppat.1004918.s011", "https://dx.doi.org/10.1371/journal.ppat.1004918.s012", "https://dx.doi.org/10.1371/journal.ppat.1004918.s013", "https://dx.doi.org/10.1371/journal.ppat.1004918.s014", "https://dx.doi.org/10.1371/journal.ppat.1004918.s015", "https://dx.doi.org/10.1371/journal.ppat.1004918.s016", "https://dx.doi.org/10.1371/journal.ppat.1004918.s017", "https://dx.doi.org/10.1371/journal.ppat.1004918.s018", "https://dx.doi.org/10.1371/journal.ppat.1004918.s019", "https://dx.doi.org/10.1371/journal.ppat.1004918.s020", "https://dx.doi.org/10.1371/journal.ppat.1004918.s021", "https://dx.doi.org/10.1371/journal.ppat.1004918.s022"], "stats"=>{"downloads"=>28, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characterization_of_Arabidopsis_Transcriptional_Responses_to_Different_Aphid_Species_Reveals_Genes_that_Contribute_to_Host_Susceptibility_and_Non_host_Resistance/1420981", "title"=>"Characterization of <i>Arabidopsis</i> Transcriptional Responses to Different Aphid Species Reveals Genes that Contribute to Host Susceptibility and Non-host Resistance", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076070"], "description"=>"<p>Leaves exposed to different aphid species were incubated with the dye DCFH-DA (dichlorodihydro-fluorescein diacetate) to compare reactive oxygen species (ROS) levels during host and non-host interactions. Images were taken 3, 6, 12 and 24 hours after aphid exposure using a laser confocal microscope and processed in ImageJ to generate graph bars representing relative fluorescence to the control treatment (no aphids). Graph indicates fluorescence ratios of leaf samples exposed to aphids compared to a no-aphid control (C). Average relative ratios are based on 5 different leaf samples per treatment. Three independent replicated experiments, with 5 leaf samples per treatment per replicate, were performed with similar results. Graph shows results of one of the two replicates. The additional replicate is shown in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004918#ppat.1004918.s009\" target=\"_blank\">S9 Fig</a>.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420963, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g007", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROS_levels_during_host_and_non_host_interactions_with_aphids_/1420963", "title"=>"ROS levels during host and non-host interactions with aphids.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076069"], "description"=>"<p>(A) Graph showing <i>R</i>. <i>padi</i> aphid survival on the control (Col-0) and a <i>vsp1</i> mutant line over 6 days. Five adult aphids were placed on four-week old plants and survival was monitored the following 6 days. Three independent biological replicates were carried out, with 10 plants per replicate. Error bars indicate standard error. (B) Graph shows the percentage of <i>R</i>. <i>padi</i> survival between day 3 and 4 on a <i>vsp1</i> mutant line and Col-0 wild-type plants. Data is from the same experiment as described in (A). The two-tailed Student's <i>t</i>-test was used for statistical analyses (*** indicates p-value<0.001). Error bars indicate standard error. (C) <i>M</i>. <i>persicae</i> and <i>M</i>. <i>cerasi</i> performance on an <i>Arabidopsis vsp1</i> knock-out line and Col-0 wild-type plants. Four-week old plants were exposed to two adult aphids and nymph production was counted after 10 days. Average nymph was calculated from three independent replicated experiments, with 10 plants per replicate per treatment. The two-tailed Student's <i>t</i>-test was used for statistical analyses (* indicates p-value<0.05). (D) Graph showing <i>R</i>. <i>padi</i> aphid survival on the control (Col-0) and a mutant line for an <i>Arabidopsis</i> gene predicted to encode an ABA-responsive protein over 6 days. Same experimental set-up and analyses as described in A. Error bars indicate standard error. (E) Graph showing the percentage of R. padi survival between day 3 and 4 on a mutant line for an <i>Arabidopsis</i> gene predicted to encode an ABA-responsive protein and Col-0 wild-type plants. Data are from the same experiment as described in D. The two-tailed Student's <i>t</i>-test was used for statistical analyses (*** indicates p<0.001). Error bars indicate standard error. (F) <i>M</i>. <i>persicae</i> and <i>M</i>. <i>cerasi</i> performance on a mutant line for an <i>Arabidopsis</i> gene predicted to encode an ABA-responsive protein and Col-0 wild-type plants. Same experimental set-up as described in (C). The two-tailed Student's <i>t</i>-test was used for statistical analyses (* indicates p-value < 0.05).</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420962, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Arabidopsis_knock_out_mutants_show_altered_susceptibility_to_Myzus_persicae_Myzus_cerasi_and_Rhopalosiphum_padi_/1420962", "title"=>"<i>Arabidopsis</i> knock-out mutants show altered susceptibility to <i>Myzus persicae</i>, <i>Myzus cerasi</i> and <i>Rhopalosiphum padi</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076064"], "description"=>"<p>(A) Autofluorescence around aphid probe sites, indicated by white arrows, was visualized using laser confocal microscopy. Scale bars 100μm. (B) Aphid colonization of <i>Arabidopsis</i> by <i>Myzus persicae</i>, <i>M</i>. <i>cerasi</i> and <i>Rhopalosiphum padi</i>. Graph shows the mean number of nymphs produced after two weeks on wild type Col-0 plants. Error bars indicate standard error. A Student’s <i>t</i>-test was used for statistical analysis of <i>M</i>. <i>persicae</i> versus <i>M</i>. <i>cerasi</i> progeny (*** indicates p-value < 0.001). Three independent biological replicates were carried out, with 10 plants per treatment per replicate.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420957, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g001", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aphid_probing_during_host_and_non_host_interactions_/1420957", "title"=>"Aphid probing during host and non-host interactions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076072"], "description"=>"<p>(A) <i>Myzus persicae</i> (Mp) <i>and M</i>. <i>cerasi</i> (Mc) performance on <i>Arabidopsis atrbohD-3</i> and <i>atrbohF-3</i> knock-out lines. Four-week old plants were exposed to two adult aphids and nymph production was counted after 10 days. Average nymph production for <i>M</i>. <i>persicae</i> and <i>M</i>. <i>cerasi</i> was calculated from three independent replicated experiments, with 10 plants per replicate per treatment. (B) Graph shows <i>R</i>. <i>padi</i> aphid survival on control (Col-0) and <i>Arabidopsis atrbohD-3</i> and <i>atrbohF-3</i> knock-out lines over 6 days. Three independent biological replicates were carried out, with 10 plants per replicate. Error bars indicate standard error. (C) <i>Rhopalosiphum padi</i> (Rp) survival on <i>Arabidopsis atrbohD-3</i> and <i>atrbohF-3</i> mutants and Col-0 wild-type plants between 3 and 4 days of the experiment. The two-tailed Student's <i>t</i>-test was used for statistical analyses (*** indicates p-value<0.001). Error bars indicate standard error. (D) ROS levels in <i>atrbohD-3</i> and <i>atrbohF-3</i> mutants during host and non-host interactions with aphids. Images were taken 3 and 24 hours after aphid exposure using a laser confocal microscope and processed in ImageJ to generate graph bars representing relative fluorescence to the control treatment (no aphids). Graph indicates fluorescence the relative fluorescence of leaf samples exposed to aphids compared to a no aphid control (indicated by C). Average relative ratios are based on 5 different leaf samples per treatment. Three independent replicated experiments, with 5 leaf samples per treatment per replicate, were performed with similar results. Graph shows results of one of the three replicates. Additional replicates are shown in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004918#ppat.1004918.s010\" target=\"_blank\">S10 Fig</a>.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420965, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g008", "stats"=>{"downloads"=>2, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Arabidopsis_atrbohD_3_and_atrbohF_3_knock_out_mutants_show_reduced_non_host_resistance_and_enhanced_susceptibility_to_aphids_/1420965", "title"=>"<i>Arabidopsis atrbohD-3</i> and <i>atrbohF-3</i> knock-out mutants show reduced non-host resistance and enhanced susceptibility to aphids.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076068"], "description"=>"<p>Four-week old plants were exposed to two adult aphids and nymph production was counted after 10 days. Average nymph production was calculated from three independent replicated experiments, with 10 plants per replicate per treatment. Error bars indicate standard error. The two-tailed Student's <i>t</i>-test was used for statistical analyses (*** indicates p-value < 0.001, ** indicates p-value < 0.01, * indicates p-value < 0.05). Mc indicates <i>Myzus cerasi</i>, Mp indicates <i>M</i>. <i>persicae</i>.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420961, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g005", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Arabidopsis_knock_out_mutants_show_altered_susceptibility_to_Myzus_persicae_and_Myzus_cerasi_/1420961", "title"=>"<i>Arabidopsis</i> knock-out mutants show altered susceptibility to <i>Myzus persicae</i> and <i>Myzus cerasi</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2076066"], "description"=>"<p>Venn diagram analyses of 874 differentially expressed as determined by one-way ANOVA (Bonferroni correction, p-value ≤ 0.05) across different aphid interactions and timepoints. (A) Venn diagrams showing the numbers of genes that are down-regulated during different aphid interactions at 3h, 6h and 24h post aphid exposure. (B) Venn diagrams showing the numbers of genes that are up-regulated during different aphid interactions at 3h, 6h and 24h post aphid exposure. Mc indicates <i>Myzus cerasi</i>, Mp indicates <i>M</i>. <i>persicae</i> and Rp indicates <i>Rhopalosiphum padi</i>.</p>", "links"=>[], "tags"=>["Arabidopsis thaliana host", "understanding host responses", "Aphid performance assays", "aphid species", "Different Aphid Species", "gene expression changes", "interaction", "gene expression patterns", "Arabidopsis Transcriptional Responses", "gene expression analyses", "aphid host ranges"], "article_id"=>1420959, "categories"=>["Biological Sciences"], "users"=>["Maëlle Jaouannet", "Jenny A. Morris", "Peter E. Hedley", "Jorunn I. B. Bos"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1004918.g003", "stats"=>{"downloads"=>4, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overlap_of_Arabidopsis_differentially_expressed_genes_across_different_aphid_interactions_/1420959", "title"=>"Overlap of <i>Arabidopsis</i> differentially expressed genes across different aphid interactions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 03:14:43"}

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  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"19", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"4", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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