Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle
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{"title"=>"Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle", "type"=>"journal", "authors"=>[{"first_name"=>"Aurore", "last_name"=>"Dubuffet", "scopus_author_id"=>"13409745200"}, {"first_name"=>"Caroline", "last_name"=>"Zanchi", "scopus_author_id"=>"38962387300"}, {"first_name"=>"Gwendoline", "last_name"=>"Boutet", "scopus_author_id"=>"56940524900"}, {"first_name"=>"Jérôme", "last_name"=>"Moreau", "scopus_author_id"=>"55131984000"}, {"first_name"=>"Maria", "last_name"=>"Teixeira", "scopus_author_id"=>"56555875400"}, {"first_name"=>"Yannick", "last_name"=>"Moret", "scopus_author_id"=>"6602738234"}], "year"=>2015, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "scopus"=>"2-s2.0-84946013521", "sgr"=>"84946013521", "pui"=>"606740859", "pmid"=>"26430786", "doi"=>"10.1371/journal.ppat.1005178"}, "id"=>"d8500a6c-dfed-3bad-a82d-34cc8c032692", "abstract"=>"In many vertebrates and invertebrates, offspring whose mothers have been exposed to pathogens can exhibit increased levels of immune activity and/or increased survival to infection. Such phenomena, called \"Trans-generational immune priming\" (TGIP) are expected to provide immune protection to the offspring. As the offspring and their mother may share the same environment, and consequently similar microbial threats, we expect the immune molecules present in the progeny to be specific to the microbes that immune challenged the mother. We provide evidence in the mealworm beetle Tenebrio molitor that the antimicrobial activity found in the eggs is only active against Gram-positive bacteria, even when females were exposed to Gram-negative bacteria or fungi. Fungi were weak inducers of TGIP while we obtained similar levels of anti-Gram-positive activity using different bacteria for the maternal challenge. Furthermore, we have identified an antibacterial peptide from the defensin family, the tenecin 1, which spectrum of activity is exclusively directed toward Gram-positive bacteria as potential contributor to this antimicrobial activity. We conclude that maternal transfer of antimicrobial activity in the eggs of T. molitor might have evolved from persistent Gram-positive bacterial pathogens between insect generations.", "link"=>"http://www.mendeley.com/research/transgenerational-immune-priming-protects-eggs-only-against-grampositive-bacteria-mealworm-beetle", "reader_count"=>63, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>1, "Student > Bachelor"=>8, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>1, "Student > Bachelor"=>8, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>46, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>46}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Bolivia"=>1, "France"=>1, "Germany"=>1}, "group_count"=>4}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2297958"], "description"=>"<p>Identification of proteins contained in the protein bands specifically found in egg extracts from bacteria-challenged females (N1: from native AU-PAGE gel, D1: from Tricine-SDS-gel).</p>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563591, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1005178.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_mass_spectrometry_analysis_/1563591", "title"=>"Results of mass spectrometry analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-02 04:14:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297959", "https://ndownloader.figshare.com/files/2297960", "https://ndownloader.figshare.com/files/2297961", "https://ndownloader.figshare.com/files/2297962", "https://ndownloader.figshare.com/files/2297963", "https://ndownloader.figshare.com/files/2297964", "https://ndownloader.figshare.com/files/2297965", "https://ndownloader.figshare.com/files/2297966", "https://ndownloader.figshare.com/files/2297967", "https://ndownloader.figshare.com/files/2297968"], "description"=>"<div><p>In many vertebrates and invertebrates, offspring whose mothers have been exposed to pathogens can exhibit increased levels of immune activity and/or increased survival to infection. Such phenomena, called “Trans-generational immune priming” (TGIP) are expected to provide immune protection to the offspring. As the offspring and their mother may share the same environment, and consequently similar microbial threats, we expect the immune molecules present in the progeny to be specific to the microbes that immune challenged the mother. We provide evidence in the mealworm beetle <i>Tenebrio molitor</i> that the antimicrobial activity found in the eggs is only active against Gram-positive bacteria, even when females were exposed to Gram-negative bacteria or fungi. Fungi were weak inducers of TGIP while we obtained similar levels of anti-Gram-positive activity using different bacteria for the maternal challenge. Furthermore, we have identified an antibacterial peptide from the defensin family, the tenecin 1, which spectrum of activity is exclusively directed toward Gram-positive bacteria as potential contributor to this antimicrobial activity. We conclude that maternal transfer of antimicrobial activity in the eggs of <i>T</i>. <i>molitor</i> might have evolved from persistent Gram-positive bacterial pathogens between insect generations.</p></div>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563592, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1005178.s001", "https://dx.doi.org/10.1371/journal.ppat.1005178.s002", "https://dx.doi.org/10.1371/journal.ppat.1005178.s003", "https://dx.doi.org/10.1371/journal.ppat.1005178.s004", "https://dx.doi.org/10.1371/journal.ppat.1005178.s005", "https://dx.doi.org/10.1371/journal.ppat.1005178.s006", "https://dx.doi.org/10.1371/journal.ppat.1005178.s007", "https://dx.doi.org/10.1371/journal.ppat.1005178.s008", "https://dx.doi.org/10.1371/journal.ppat.1005178.s009", "https://dx.doi.org/10.1371/journal.ppat.1005178.s010"], "stats"=>{"downloads"=>14, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trans_generational_Immune_Priming_Protects_the_Eggs_Only_against_Gram_Positive_Bacteria_in_the_Mealworm_Beetle_/1563592", "title"=>"Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-10-02 04:14:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297957"], "description"=>"<p>Protein profiles of eggs from females injected with inactivated bacteria (Se: <i>S</i>. <i>entomophila</i>, Ec: <i>E</i>. <i>coli</i>, Ag: <i>A</i>. <i>globiformis</i>) and eggs from sham control females (injected with PBS), resolved on an AU-PAGE gel. The N1 band, only detected in egg extracts from bacteria-injected females, is shown in the rectangle.</p>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563590, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1005178.g005", "stats"=>{"downloads"=>17, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detection_of_the_N1_band_in_egg_extracts_from_females_injected_with_bacteria_/1563590", "title"=>"Detection of the N1 band in egg extracts from females injected with bacteria.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 04:14:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297954"], "description"=>"<p>The vertical bars represent the confidence intervals at 95% (95CI). The sample size of each treatment is stated between brackets under the egg assay. Different letters above the bars indicate significant differences according to the degree of overlap of the 95CI (p < 0.05) across female treatments. Treatments: PBS = sham-injected females, Ag = <i>A</i>. <i>globiformis</i>, Bs = <i>B</i>. <i>subtilis</i>, Ec = <i>E</i>. <i>coli</i>, Sm = <i>S</i>. <i>marcescens</i>, Ca = <i>C</i>. <i>albicans</i>, Ma = <i>M</i>. <i>anisopliae</i>.</p>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563587, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1005178.g003", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Barplot_showing_the_mean_proportion_of_egg_extracts_showing_a_zone_of_inhibition_according_to_the_microorganism_on_which_they_were_tested_egg_assay_and_the_maternal_microbial_treatment_/1563587", "title"=>"Barplot showing the mean proportion of egg extracts showing a zone of inhibition according to the microorganism on which they were tested (egg assay) and the maternal microbial treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 04:14:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297953"], "description"=>"<p>The boxes extend from the first to the third quartiles, the band inside the box represents the median. The bars outside the boxes indicate the 1.5 interquartile of the lower and upper quartiles. Each dot represents a data point, and the biggest dot represents the median. The sample size of each treatment is stated between brackets under the egg assay. Different letters above the bars indicate significant differences according to the degree of overlap of the 95CI (p < 0.05, see <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005178#ppat.1005178.s003\" target=\"_blank\">S2 Fig</a>) across female treatments. Treatments: naïve = unmanipulated females, PBS = sham-injected females, Ag = <i>A</i>. <i>globiformis</i>, Bs = <i>B</i>. <i>subtilis</i>, Bt = <i>B</i>. <i>thuringiensis</i>, Ec = <i>E</i>. <i>coli</i>, Se = <i>S</i>. <i>entomophila</i>, Sm = S. <i>marsescens</i>. Were only represented, for all the maternal treatments, the clutch treatments on which a ZI could be detected.</p>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563586, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1005178.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Boxplot_showing_the_mean_diameter_of_the_zone_of_inhibitions_in_mm_of_protected_egg_extracts_according_to_the_microorganism_on_which_they_were_tested_egg_assay_and_the_maternal_bacterial_treatment_/1563586", "title"=>"Boxplot showing the mean diameter of the zone of inhibitions (in mm) of protected egg extracts according to the microorganism on which they were tested (egg assay) and the maternal bacterial treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 04:14:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297956"], "description"=>"<p>The boxes extend from the first to the third quartiles, the band inside the box represents the median. The bars outside the boxes indicate the 1.5 interquartile of the lower and upper quartiles. Each dot represents a data point, and the biggest dot represents the median. The sample size of each treatment is stated between brackets under the egg assay. Different letters above the bars indicate significant differences according to the degree of overlap of the 95CI (p < 0.05, see <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005178#ppat.1005178.s004\" target=\"_blank\">S3 Fig</a>) across female treatments. Treatments: PBS = sham-injected females, Ag = <i>A</i>. <i>globiformis</i>, Bs = <i>B</i>. <i>subtilis</i>, Ca = <i>C</i>. <i>albicans</i>, Ma = <i>M</i>. <i>anisopliae</i>. Were only represented, for all the maternal treatments, the clutch treatments on which a ZI could be detected.</p>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563589, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1005178.g004", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Boxplot_showing_the_mean_diameter_of_the_zone_of_inhibitions_in_mm_of_protected_egg_extracts_according_to_the_microorganism_on_which_they_were_tested_egg_assay_and_the_maternal_microbial_treatment_/1563589", "title"=>"Boxplot showing the mean diameter of the zone of inhibitions (in mm) of protected egg extracts according to the microorganism on which they were tested (egg assay) and the maternal microbial treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 04:14:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297952"], "description"=>"<p>The vertical bars represent the confidence intervals at 95% (95 CI). The sample size of each treatment is stated between brackets under the egg assay. Different letters above the bars indicate significant differences according to the degree of overlap of the 95CI (p < 0.05) across female treatments. Treatments: naïve = unmanipulated females, PBS = sham-injected females, Ag = <i>A</i>. <i>globiformis</i>, Bs = <i>B</i>. <i>subtilis</i>, Bt = <i>B</i>. <i>thuringiensis</i>, Ec = <i>E</i>. <i>coli</i>, Se = <i>S</i>. <i>entomophila</i>, Sm = <i>S</i>. <i>marsescens</i>.</p>", "links"=>[], "tags"=>["offspring", "antimicrobial activity", "TGIP", "mealworm beetle Tenebrio molitor", "bacteria"], "article_id"=>1563585, "categories"=>["Biological Sciences"], "users"=>["Aurore Dubuffet", "Caroline Zanchi", "Gwendoline Boutet", "Jérôme Moreau", "Maria Teixeira", "Yannick Moret"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1005178.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Barplot_showing_the_mean_proportion_of_egg_extracts_showing_a_zone_of_inhibition_according_to_the_microorganism_on_which_they_were_tested_egg_assay_and_the_maternal_bacterial_treatment_/1563585", "title"=>"Barplot showing the mean proportion of egg extracts showing a zone of inhibition according to the microorganism on which they were tested (egg assay) and the maternal bacterial treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 04:14:31"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

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