Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection
Publication Date
July 14, 2016
Journal
PLOS Pathogens
Authors
Ines Anderl, Laura Vesala, Teemu O. Ihalainen, Leena Maija Vanha Aho, et al
Volume
12
Issue
7
Pages
e1005746
DOI
https://dx.plos.org/10.1371/journal.ppat.1005746
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005746
Web of Science
000383366400030
Scopus
84980576901
Mendeley
http://www.mendeley.com/research/transdifferentiation-proliferation-two-distinct-hemocyte-lineages-drosophila-melanogaster-larvae-aft
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Mendeley | Further Information

{"title"=>"Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection", "type"=>"journal", "authors"=>[{"first_name"=>"Ines", "last_name"=>"Anderl", "scopus_author_id"=>"6504640779"}, {"first_name"=>"Laura", "last_name"=>"Vesala", "scopus_author_id"=>"35744053200"}, {"first_name"=>"Teemu O.", "last_name"=>"Ihalainen", "scopus_author_id"=>"14060136000"}, {"first_name"=>"Leena Maija", "last_name"=>"Vanha-aho", "scopus_author_id"=>"24402987600"}, {"first_name"=>"István", "last_name"=>"Andó", "scopus_author_id"=>"7103146796"}, {"first_name"=>"Mika", "last_name"=>"Rämet", "scopus_author_id"=>"7004090465"}, {"first_name"=>"Dan", "last_name"=>"Hultmark", "scopus_author_id"=>"7004353324"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"27414410", "sgr"=>"84982899656", "doi"=>"10.1371/journal.ppat.1005746", "scopus"=>"2-s2.0-84982899656", "pui"=>"611582085", "issn"=>"15537374"}, "id"=>"d22256c9-4cf5-34ce-a1ff-37bd3d1873e8", "abstract"=>"Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generation remains controversial. To study the cellular immune system, we developed a flow cytometry approach using in vivo reporters for lamellocytes as well as for plasmatocytes, the main hemocyte type in healthy larvae. We found that two different blood cell lineages, the plasmatocyte and lamellocyte lineages, contribute to the generation of lamellocytes in a demand-adapted hematopoietic process. Plasmatocytes transdifferentiate into lamellocyte-like cells in situ directly on the wasp egg. In parallel, a novel population of infection-induced cells, which we named lamelloblasts, appears in the circulation. Lamelloblasts proliferate vigorously and develop into the major class of circulating lamellocytes. Our data indicate that lamellocyte differentiation upon wasp parasitism is a plastic and dynamic process. Flow cytometry with in vivo hemocyte reporters can be used to study this phenomenon in detail.", "link"=>"http://www.mendeley.com/research/transdifferentiation-proliferation-two-distinct-hemocyte-lineages-drosophila-melanogaster-larvae-aft", "reader_count"=>37, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>10, "Agricultural and Biological Sciences"=>22, "Neuroscience"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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