RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection
Publication Date
July 20, 2016
Journal
PLOS Pathogens
Authors
Matheswaran Kandasamy, Amol Suryawanshi, Smanla Tundup, Jasmine T. Perez, et al
Volume
12
Issue
7
Pages
e1005754
DOI
https://dx.plos.org/10.1371/journal.ppat.1005754
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005754
Scopus
84980603568
Mendeley
http://www.mendeley.com/research/rigi-signaling-critical-efficient-polyfunctional-t-cell-responses-during-influenza-virus-infection
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection", "type"=>"journal", "authors"=>[{"first_name"=>"Matheswaran", "last_name"=>"Kandasamy", "scopus_author_id"=>"55624970100"}, {"first_name"=>"Amol", "last_name"=>"Suryawanshi", "scopus_author_id"=>"24465799300"}, {"first_name"=>"Smanla", "last_name"=>"Tundup", "scopus_author_id"=>"12241283900"}, {"first_name"=>"Jasmine T.", "last_name"=>"Perez", "scopus_author_id"=>"35094427200"}, {"first_name"=>"Mirco", "last_name"=>"Schmolke", "scopus_author_id"=>"9732716900"}, {"first_name"=>"Santhakumar", "last_name"=>"Manicassamy", "scopus_author_id"=>"9939651400"}, {"first_name"=>"Balaji", "last_name"=>"Manicassamy", "scopus_author_id"=>"6506285821"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "pui"=>"611582026", "doi"=>"10.1371/journal.ppat.1005754", "sgr"=>"84982987890", "pmid"=>"27438481", "scopus"=>"2-s2.0-84982987890"}, "id"=>"7f55acc9-f312-330b-ab73-d3773b69e13e", "abstract"=>"Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism and regulating host immune responses. Mice deficient in the RIG-I-MAVS pathway show defects in migratory dendritic cell (DC) activation, viral antigen presentation, and priming of CD8+ and CD4+ T cell responses during IAV infection. These defects result in decreased frequency of polyfunctional effector T cells and lowered protection against heterologous IAV challenge. In addition, our data show that RIG-I activation is essential for protecting epithelial cells and hematopoietic cells from IAV infection. These diverse effects of RIG-I signaling are likely imparted by the actions of type I interferon (IFN), as addition of exogenous type I IFN is sufficient to overcome the defects in antigen presentation by RIG-I deficient BMDC. Moreover, the in vivo T cell defects in RIG-I deficient mice can be overcome by the activation of MDA5 -MAVS via poly I:C treatment. Taken together, these findings demonstrate that RIG-I signaling through MAVS is critical for determining the quality of polyfunctional T cell responses against IAV and for providing protection against subsequent infection from heterologous or novel pandemic IAV strains.", "link"=>"http://www.mendeley.com/research/rigi-signaling-critical-efficient-polyfunctional-t-cell-responses-during-influenza-virus-infection", "reader_count"=>29, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>5, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>5, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Brazil"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84982987890"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84982987890?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84982987890&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84982987890&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84982987890", "dc:identifier"=>"SCOPUS_ID:84982987890", "eid"=>"2-s2.0-84982987890", "dc:title"=>"RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection", "dc:creator"=>"Kandasamy M.", "prism:publicationName"=>"PLoS Pathogens", "prism:issn"=>"15537366", "prism:eIssn"=>"15537374", "prism:volume"=>"12", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2016-07-01", "prism:coverDisplayDate"=>"July 2016", "prism:doi"=>"10.1371/journal.ppat.1005754", "citedby-count"=>"10", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Chicago", "affiliation-city"=>"Chicago", "affiliation-country"=>"United States"}], "pubmed-id"=>"27438481", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1005754", "source-id"=>"4000151809", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplospathogens%2Farticle%3Fid%3D10.1371%252Fjournal.ppat.1005754", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"156", "xml_views"=>"0", "html_views"=>"887"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"106", "xml_views"=>"0", "html_views"=>"405"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"91"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"88"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"118"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"81"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"69"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}

PMC Usage Stats

  • {"unique-ip"=>"48", "full-text"=>"51", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"38", "full-text"=>"33", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"38", "full-text"=>"35", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"35", "full-text"=>"38", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"29", "full-text"=>"34", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"28", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"31", "full-text"=>"34", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"12", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"28", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
Loading … Spinner
There are currently no alerts