Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response
Publication Date
July 25, 2016
Journal
PLOS Pathogens
Authors
Nicolas Tremblay, Martin Baril, Laurent Chatel Chaix, Salwa Es Saad, et al
Volume
12
Issue
7
Pages
e1005772
DOI
https://dx.plos.org/10.1371/journal.ppat.1005772
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005772
Web of Science
000383366400047
Scopus
84980569549
Mendeley
http://www.mendeley.com/research/spliceosome-snrnp200-promotes-viral-rna-sensing-irf3-activation-antiviral-response
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Mendeley | Further Information

{"title"=>"Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response", "type"=>"journal", "authors"=>[{"first_name"=>"Nicolas", "last_name"=>"Tremblay", "scopus_author_id"=>"57201015270"}, {"first_name"=>"Martin", "last_name"=>"Baril", "scopus_author_id"=>"35997767800"}, {"first_name"=>"Laurent", "last_name"=>"Chatel-Chaix", "scopus_author_id"=>"8872935200"}, {"first_name"=>"Salwa", "last_name"=>"Es-Saad", "scopus_author_id"=>"55362426500"}, {"first_name"=>"Alex Young", "last_name"=>"Park", "scopus_author_id"=>"57190748201"}, {"first_name"=>"Robert K.", "last_name"=>"Koenekoop", "scopus_author_id"=>"7004058713"}, {"first_name"=>"Daniel", "last_name"=>"Lamarre", "scopus_author_id"=>"7003847589"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"doi"=>"10.1371/journal.ppat.1005772", "sgr"=>"84982949470", "pui"=>"611582001", "scopus"=>"2-s2.0-84982949470", "issn"=>"15537374", "pmid"=>"27454487", "isbn"=>"1111111111"}, "id"=>"17fa63a9-c22b-3dac-9bbc-c7595e3242a1", "abstract"=>"Spliceosomal SNRNP200 is a Ski2-like RNA helicase that is associated with retinitis pigmentosa 33 (RP33). Here we found that SNRNP200 promotes viral RNA sensing and IRF3 activation through the ability of its amino-terminal Sec63 domain (Sec63-1) to bind RNA and to interact with TBK1. We show that SNRNP200 relocalizes into TBK1-containing cytoplasmic structures upon infection, in contrast to the RP33-associated S1087L mutant, which is also unable to rescue antiviral response of SNRNP200 knockdown cells. This functional rescue correlates with the Sec63-1-mediated binding of viral RNA. The hindered IFN-beta production of knockdown cells was further confirmed in peripheral blood cells of RP33 patients bearing missense mutation in SNRNP200 upon infection with Sendai virus (SeV). This work identifies a novel immunoregulatory role of the spliceosomal SNRNP200 helicase as an RNA sensor and TBK1 adaptor for the activation of IRF3-mediated antiviral innate response.", "link"=>"http://www.mendeley.com/research/spliceosome-snrnp200-promotes-viral-rna-sensing-irf3-activation-antiviral-response", "reader_count"=>11, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Student > Bachelor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Student > Bachelor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>0}

Scopus | Further Information

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