Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread
Publication Date
September 28, 2016
Journal
PLOS Pathogens
Authors
Farah El Najjar, Nicolás Cifuentes Muñoz, Jing Chen, Haining Zhu, et al
Volume
12
Issue
9
Pages
e1005922
DOI
https://dx.plos.org/10.1371/journal.ppat.1005922
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005922
Web of Science
000385621900061
Scopus
84989920334
Mendeley
http://www.mendeley.com/research/human-metapneumovirus-induces-reorganization-actin-cytoskeleton-direct-celltocell-spread
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Mendeley | Further Information

{"title"=>"Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread", "type"=>"journal", "authors"=>[{"first_name"=>"Farah", "last_name"=>"El Najjar", "scopus_author_id"=>"56321109400"}, {"first_name"=>"Nicolás", "last_name"=>"Cifuentes-Muñoz", "scopus_author_id"=>"36550240900"}, {"first_name"=>"Jing", "last_name"=>"Chen", "scopus_author_id"=>"56290731200"}, {"first_name"=>"Haining", "last_name"=>"Zhu", "scopus_author_id"=>"7404663416"}, {"first_name"=>"Ursula J.", "last_name"=>"Buchholz", "scopus_author_id"=>"7004004457"}, {"first_name"=>"Carole L.", "last_name"=>"Moncman", "scopus_author_id"=>"6602614129"}, {"first_name"=>"Rebecca Ellis", "last_name"=>"Dutch", "scopus_author_id"=>"6602168471"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "sgr"=>"84989920334", "doi"=>"10.1371/journal.ppat.1005922", "scopus"=>"2-s2.0-84989920334", "isbn"=>"1553-7374", "pui"=>"612522062"}, "id"=>"2a141c8e-1fcd-3ce3-800f-ed7cba6b161c", "abstract"=>"Paramyxovirus spread generally involves assembly of individual viral particles which then infect target cells. We show that infection of human bronchial airway cells with human metapneumovirus (HMPV), a recently identified paramyxovirus which causes significant respiratory disease, results in formation of intercellular extensions and extensive networks of branched cell-associated filaments. Formation of these structures is dependent on actin, but not microtubule, polymerization. Interestingly, using a co-culture assay we show that conditions which block regular infection by HMPV particles, including addition of neutralizing antibodies or removal of cell surface heparan sulfate, did not prevent viral spread from infected to new target cells. In contrast, inhibition of actin polymerization or alterations to Rho GTPase signaling pathways significantly decreased cell-to-cell spread. Furthermore, viral proteins and viral RNA were detected in intercellular extensions, suggesting direct transfer of viral genetic material to new target cells. While roles for paramyxovirus matrix and fusion proteins in membrane deformation have been previously demonstrated, we show that the HMPV phosphoprotein extensively co-localized with actin and induced formation of cellular extensions when transiently expressed, supporting a new model in which a paramyxovirus phosphoprotein is a key player in assembly and spread. Our results reveal a novel mechanism for HMPV direct cell-to-cell spread and provide insights into dissemination of respiratory viruses.", "link"=>"http://www.mendeley.com/research/human-metapneumovirus-induces-reorganization-actin-cytoskeleton-direct-celltocell-spread", "reader_count"=>17, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}}, "group_count"=>0}

Scopus | Further Information

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