Microbial Community Composition Impacts Pathogen Iron Availability during Polymicrobial Infection
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{"title"=>"Microbial Community Composition Impacts Pathogen Iron Availability during Polymicrobial Infection", "type"=>"journal", "authors"=>[{"first_name"=>"Apollo", "last_name"=>"Stacy", "scopus_author_id"=>"55240546700"}, {"first_name"=>"Nader", "last_name"=>"Abraham", "scopus_author_id"=>"57192709345"}, {"first_name"=>"Peter", "last_name"=>"Jorth", "scopus_author_id"=>"23502043100"}, {"first_name"=>"Marvin", "last_name"=>"Whiteley", "scopus_author_id"=>"7007178295"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"27973608", "doi"=>"10.1371/journal.ppat.1006084", "sgr"=>"85007574571", "scopus"=>"2-s2.0-85007574571", "issn"=>"15537374", "pui"=>"613937834"}, "id"=>"5f633f78-dd43-35e5-a5e0-15a556f64915", "abstract"=>"Iron is an essential nutrient for bacterial pathogenesis, but in the host, iron is tightly sequestered, limiting its availability for bacterial growth. Although this is an important arm of host immunity, most studies examine how bacteria respond to iron restriction in laboratory rather than host settings, where the microbiome can potentially alter pathogen strategies for acquiring iron. One of the most important transcriptional regulators controlling bacterial iron homeostasis is Fur. Here we used a combination of RNA-seq and chromatin immunoprecipitation (ChIP)-seq to characterize the iron-restricted and Fur regulons of the biofilm-forming opportunistic pathogen Aggregatibacter actinomycetemcomitans. We discovered that iron restriction and Fur regulate 4% and 3.5% of the genome, respectively. While most genes in these regulons were related to iron uptake and metabolism, we found that Fur also directly regulates the biofilm-dispersing enzyme Dispersin B, allowing A. actinomycetemcomitans to escape from iron-scarce environments. We then leveraged these datasets to assess the availability of iron to A. actinomycetemcomitans in its primary infection sites, abscesses and the oral cavity. We found that A. actinomycetemcomitans is not restricted for iron in a murine abscess mono-infection, but becomes restricted for iron upon co-infection with the oral commensal Streptococcus gordonii. Furthermore, in the transition from health to disease in human gum infection, A. actinomycetemcomitans also becomes restricted for iron. These results suggest that host iron availability is heterogeneous and dependent on the infecting bacterial community.", "link"=>"http://www.mendeley.com/research/microbial-community-composition-impacts-pathogen-iron-availability-during-polymicrobial-infection", "reader_count"=>24, "reader_count_by_academic_status"=>{"Researcher"=>7, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>7, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>12, "Medicine and Dentistry"=>2, "Physics and Astronomy"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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