L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes
Publication Date
January 23, 2017
Authors
Adi Haber, Sivan Friedman, Lior Lobel, Tamar Burg Golani, et al
Volume
13
Issue
1
Pages
e1006161
DOI
https://dx.plos.org/10.1371/journal.ppat.1006161
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006161
Scopus
85010943933
Mendeley
http://www.mendeley.com/research/lglutamine-induces-expression-listeria-monocytogenes-virulence-genes
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Mendeley | Further Information

{"title"=>"L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes", "type"=>"journal", "authors"=>[{"first_name"=>"Adi", "last_name"=>"Haber", "scopus_author_id"=>"57193124574"}, {"first_name"=>"Sivan", "last_name"=>"Friedman", "scopus_author_id"=>"7403181818"}, {"first_name"=>"Lior", "last_name"=>"Lobel", "scopus_author_id"=>"55370294100"}, {"first_name"=>"Tamar", "last_name"=>"Burg-Golani", "scopus_author_id"=>"55927567600"}, {"first_name"=>"Nadejda", "last_name"=>"Sigal", "scopus_author_id"=>"9242199300"}, {"first_name"=>"Jessica", "last_name"=>"Rose", "scopus_author_id"=>"57193127766"}, {"first_name"=>"Nurit", "last_name"=>"Livnat-Levanon", "scopus_author_id"=>"23992829600"}, {"first_name"=>"Oded", "last_name"=>"Lewinson", "scopus_author_id"=>"6505758328"}, {"first_name"=>"Anat A.", "last_name"=>"Herskovits", "scopus_author_id"=>"7801320566"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"doi"=>"10.1371/journal.ppat.1006161", "issn"=>"15537374", "sgr"=>"85010943933", "pui"=>"614267556", "scopus"=>"2-s2.0-85010943933", "pmid"=>"28114430", "isbn"=>"1111111111"}, "id"=>"b11db87d-4407-3629-b000-defef7a8540b", "abstract"=>"The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human pathogen Listeria monocytogenes flourishes in soil, water and food, and in ~50 different animals, and serves as a model for intracellular infection. L. monocytogenes identifies host entry by sensing both physical (e.g., temperature) and chemical (e.g., metabolite concentrations) factors. We report here that L-glutamine, an abundant nitrogen source in host serum and cells, serves as an environmental indicator and inducer of virulence gene expression. In contrast, ammonia, which is the most abundant nitrogen source in soil and water, fully supports growth, but fails to activate virulence gene transcription. We demonstrate that induction of virulence genes only occurs when the Listerial intracellular concentration of L-glutamine crosses a certain threshold, acting as an on/off switch: off when L-glutamine concentrations are below the threshold, and fully on when the threshold is crossed. To turn on the switch, L-glutamine must be present, and the L-glutamine high affinity ABC transporter, GlnPQ, must be active. Inactivation of GlnPQ led to complete arrest of L-glutamine uptake, reduced type I interferon response in infected macrophages, dramatic reduction in expression of virulence genes, and attenuated virulence in a mouse infection model. These results may explain observation made with other pathogens correlating nitrogen metabolism and virulence, and suggest that gauging of L-glutamine as a means of ascertaining host localization may be a general mechanism.", "link"=>"http://www.mendeley.com/research/lglutamine-induces-expression-listeria-monocytogenes-virulence-genes", "reader_count"=>34, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>15, "Agricultural and Biological Sciences"=>16, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>15}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>2}

Scopus | Further Information

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