Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay
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{"title"=>"Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay", "type"=>"journal", "authors"=>[{"first_name"=>"Mart", "last_name"=>"Toots", "scopus_author_id"=>"36679180000"}, {"first_name"=>"Mart", "last_name"=>"Ustav", "scopus_author_id"=>"7003963913"}, {"first_name"=>"Andres", "last_name"=>"Männik", "scopus_author_id"=>"6602779853"}, {"first_name"=>"Karl", "last_name"=>"Mumm", "scopus_author_id"=>"56215821400"}, {"first_name"=>"Kaido", "last_name"=>"Tämm", "scopus_author_id"=>"6602946902"}, {"first_name"=>"Tarmo", "last_name"=>"Tamm", "scopus_author_id"=>"7003529607"}, {"first_name"=>"Ene", "last_name"=>"Ustav", "scopus_author_id"=>"6602950978"}, {"first_name"=>"Mart", "last_name"=>"Ustav", "scopus_author_id"=>"56660785600"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-85014070673", "sgr"=>"85014070673", "issn"=>"15537374", "doi"=>"10.1371/journal.ppat.1006168", "isbn"=>"1111111111", "pui"=>"614626140"}, "id"=>"ced2782d-ebf1-33de-b94f-d88e8b09e0cc", "abstract"=>"Human papillomaviruses (HPVs) are oncogenic viruses that cause numerous different can-cers as well as benign lesions in the epithelia. To date, there is no effective cure for an ongo-ing HPV infection. Here, we describe the generation process of a platform for the development of anti-HPV drugs. This system consists of engineered full-length HPV genomes that express reporter genes for evaluation of the viral copy number in all three HPV replication stages. We demonstrate the usefulness of this system by conducting high-throughput screens to identify novel high-risk HPV-specific inhibitors. At least five of the inhibitors block the function of Tdp1 and PARP1, which have been identified as essential cellular proteins for HPV replication and promising candidates for the development of antivi-rals against HPV and possibly against HPV-related cancers. Author summary", "link"=>"http://www.mendeley.com/research/identification-several-highrisk-hpv-inhibitors-drug-targets-novel-highthroughput-screening-assay", "reader_count"=>4, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Immunology and Microbiology"=>1, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>0}

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