Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
Publication Date
March 09, 2017
Journal
PLOS Pathogens
Authors
Alec J. Hirsch, Jessica L. Smith, Nicole N. Haese, Rebecca M. Broeckel, et al
Volume
13
Issue
3
Pages
e1006219
DOI
https://dx.plos.org/10.1371/journal.ppat.1006219
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006219
Scopus
85016472486
Mendeley
http://www.mendeley.com/research/zika-virus-infection-rhesus-macaques-leads-viral-persistence-multiple-tissues-1
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{"title"=>"Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues", "type"=>"journal", "authors"=>[{"first_name"=>"Alec J.", "last_name"=>"Hirsch", "scopus_author_id"=>"8727401700"}, {"first_name"=>"Jessica L.", "last_name"=>"Smith", "scopus_author_id"=>"8628716600"}, {"first_name"=>"Nicole N.", "last_name"=>"Haese", "scopus_author_id"=>"56707254200"}, {"first_name"=>"Rebecca M.", "last_name"=>"Broeckel", "scopus_author_id"=>"57039174500"}, {"first_name"=>"Christopher J.", "last_name"=>"Parkins", "scopus_author_id"=>"51161922400"}, {"first_name"=>"Craig", "last_name"=>"Kreklywich", "scopus_author_id"=>"6507926985"}, {"first_name"=>"Victor R.", "last_name"=>"DeFilippis", "scopus_author_id"=>"7801666085"}, {"first_name"=>"Michael", "last_name"=>"Denton", "scopus_author_id"=>"7103033839"}, {"first_name"=>"Patricia P.", "last_name"=>"Smith", "scopus_author_id"=>"7406993121"}, {"first_name"=>"William B.", "last_name"=>"Messer", "scopus_author_id"=>"7004450638"}, {"first_name"=>"Lois M.A.", "last_name"=>"Colgin", "scopus_author_id"=>"35080163600"}, {"first_name"=>"Rebecca M.", "last_name"=>"Ducore", "scopus_author_id"=>"6505738114"}, {"first_name"=>"Peta L.", "last_name"=>"Grigsby", "scopus_author_id"=>"14019456500"}, {"first_name"=>"Jon D.", "last_name"=>"Hennebold", "scopus_author_id"=>"6601961666"}, {"first_name"=>"Tonya", "last_name"=>"Swanson", "scopus_author_id"=>"43761502900"}, {"first_name"=>"Alfred W.", "last_name"=>"Legasse", "scopus_author_id"=>"14018193800"}, {"first_name"=>"Michael K.", "last_name"=>"Axthelm", "scopus_author_id"=>"7004004818"}, {"first_name"=>"Rhonda", "last_name"=>"MacAllister", "scopus_author_id"=>"47761413900"}, {"first_name"=>"Clayton A.", "last_name"=>"Wiley", "scopus_author_id"=>"35395102700"}, {"first_name"=>"Jay A.", "last_name"=>"Nelson", "scopus_author_id"=>"35461231000"}, {"first_name"=>"Daniel N.", "last_name"=>"Streblow", "scopus_author_id"=>"6603615291"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-85016472486", "pmid"=>"28278237", "sgr"=>"85016472486", "issn"=>"15537374", "pui"=>"615118531", "isbn"=>"1111111111", "doi"=>"10.1371/journal.ppat.1006219"}, "id"=>"2f05932f-812d-3a89-a69a-75729ecbc860", "abstract"=>"Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcephaly and other developmental abnormalities in the fetus. We report herein the results of ZIKV infection of adult rhesus macaques. Following subcutaneous infection, animals developed transient plasma viremia and viruria from 1-7 days post infection (dpi) that was accompanied by the development of a rash, fever and conjunctivitis. Animals produced a robust adaptive immune response to ZIKV, although systemic cytokine response was minimal. At 7 dpi, virus was detected in peripheral nervous tissue, multiple lymphoid tissues, joints, and the uterus of the necropsied animals. Notably, viral RNA persisted in neuronal, lymphoid and joint/muscle tissues and the male and female reproductive tissues through 28 to 35 dpi. The tropism and persistence of ZIKV in the peripheral nerves and reproductive tract may provide a mechanism of subsequent neuropathogenesis and sexual transmission.", "link"=>"http://www.mendeley.com/research/zika-virus-infection-rhesus-macaques-leads-viral-persistence-multiple-tissues-1", "reader_count"=>84, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Researcher"=>17, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>4, "Student > Master"=>15, "Other"=>2, "Student > Bachelor"=>14, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Researcher"=>17, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>4, "Student > Master"=>15, "Other"=>2, "Student > Bachelor"=>14, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>11, "Agricultural and Biological Sciences"=>33, "Medicine and Dentistry"=>15, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Veterinary Science and Veterinary Medicine"=>2, "Psychology"=>1, "Immunology and Microbiology"=>13}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>13}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>33}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Germany"=>1}, "group_count"=>7}

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Scopus | Further Information

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