Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation
Publication Date
June 26, 2017
Authors
Jennifer Mesureur, Joana R. Feliciano, Nelly Wagner, Margarida C. Gomes, et al
Volume
13
Issue
6
Pages
e1006437
DOI
https://dx.plos.org/10.1371/journal.ppat.1006437
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006437
Scopus
85021781001
Mendeley
http://www.mendeley.com/research/macrophages-not-neutrophils-critical-proliferation-burkholderia-cenocepacia-ensuing-hostdamaging-inf
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{"title"=>"Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation", "type"=>"journal", "authors"=>[{"first_name"=>"Jennifer", "last_name"=>"Mesureur", "scopus_author_id"=>"56593204600"}, {"first_name"=>"Joana R.", "last_name"=>"Feliciano", "scopus_author_id"=>"44360910000"}, {"first_name"=>"Nelly", "last_name"=>"Wagner", "scopus_author_id"=>"56060300800"}, {"first_name"=>"Margarida C.", "last_name"=>"Gomes", "scopus_author_id"=>"57194527033"}, {"first_name"=>"Lili", "last_name"=>"Zhang", "scopus_author_id"=>"57194729090"}, {"first_name"=>"Monica", "last_name"=>"Blanco-Gonzalez", "scopus_author_id"=>"57194715549"}, {"first_name"=>"Michiel", "last_name"=>"van der Vaart", "scopus_author_id"=>"55933619900"}, {"first_name"=>"David", "last_name"=>"O’Callaghan", "scopus_author_id"=>"57189697979"}, {"first_name"=>"Annemarie H.", "last_name"=>"Meijer", "scopus_author_id"=>"55892485800"}, {"first_name"=>"Annette C.", "last_name"=>"Vergunst", "scopus_author_id"=>"6603387233"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"617190842", "sgr"=>"85021781001", "issn"=>"15537374", "pmid"=>"28651010", "scopus"=>"2-s2.0-85021781001", "doi"=>"10.1371/journal.ppat.1006437", "isbn"=>"1111111111"}, "id"=>"568dbf67-d2f9-3b18-9de1-dc8c3275e8c3", "abstract"=>"Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known. Bcc bacteria are generally believed to have a predominant extracellular biofilm life style in infected CF lungs, similar to Pseudomonas aeruginosa, but this has been challenged by clinical observations which show Bcc bacteria predominantly in macrophages. More recently, Bcc bacteria have emerged in nosocomial infections of patients hospitalized for reasons unrelated to CF. Research has abundantly shown that Bcc bacteria can survive and replicate in mammalian cells in vitro, yet the importance of an intracellular life style during infection in humans is unknown. Here we studied the contribution of innate immune cell types to fatal pro-inflammatory infection caused by B. cenocepacia using zebrafish larvae. In strong contrast to the usual protective role for macrophages against microbes, our results show that these phagocytes significantly worsen disease outcome. We provide new insight that macrophages are critical for multiplication of B. cenocepacia in the host and for development of a fatal, pro-inflammatory response that partially depends on Il1-signalling. In contrast, neutrophils did not significantly contribute to disease outcome. In subcutaneous infections that are dominated by neutrophil-driven phagocytosis, the absence of a functional NADPH oxidase complex resulted in a small but measurably higher increase in bacterial growth suggesting the oxidative burst helps limit bacterial multiplication; however, neutrophils were unable to clear the bacteria. We suggest that paradigm-changing approaches are needed for development of novel antimicrobials to efficiently disarm intracellular bacteria of this group of highly persistent, opportunistic pathogens.", "link"=>"http://www.mendeley.com/research/macrophages-not-neutrophils-critical-proliferation-burkholderia-cenocepacia-ensuing-hostdamaging-inf", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>8, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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