T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria
Publication Date
August 17, 2017
Authors
Oanh H. Pham, Hope O’donnell, Aymen Al Shamkhani, Tobias Kerrinnes, et al
Volume
13
Issue
8
Pages
e1006566
DOI
https://dx.plos.org/10.1371/journal.ppat.1006566
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006566
Scopus
85028672191
Mendeley
http://www.mendeley.com/research/t-cell-expression-il18r-dr3-essential-noncognate-stimulation-th1-cells-optimal-clearance-intracellul
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Mendeley | Further Information

{"title"=>"T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria", "type"=>"journal", "authors"=>[{"first_name"=>"Oanh H.", "last_name"=>"Pham", "scopus_author_id"=>"24332338800"}, {"first_name"=>"Hope", "last_name"=>"O’Donnell", "scopus_author_id"=>"57195538349"}, {"first_name"=>"Aymen", "last_name"=>"Al-Shamkhani", "scopus_author_id"=>"6603684074"}, {"first_name"=>"Tobias", "last_name"=>"Kerrinnes", "scopus_author_id"=>"26658100000"}, {"first_name"=>"Renée M.", "last_name"=>"Tsolis", "scopus_author_id"=>"7003616130"}, {"first_name"=>"Stephen J.", "last_name"=>"McSorley", "scopus_author_id"=>"6603810635"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "scopus"=>"2-s2.0-85028672191", "pui"=>"618120832", "doi"=>"10.1371/journal.ppat.1006566", "isbn"=>"1111111111", "sgr"=>"85028672191"}, "id"=>"55210104-c954-3830-9ff2-ef6db8bf836f", "abstract"=>"© 2017 Pham et al. Th1 cells can be activated by TCR-independent stimuli, but the importance of this pathway in vivo and the precise mechanisms involved require further investigation. Here, we used a simple model of non-cognate Th1 cell stimulation in Salmonella-infected mice to examine these issues. CD4 Th1 cell expression of both IL-18R and DR3 was required for optimal IFN-γ induction in response to non-cognate stimulation, while IL-15R expression was dispensable. Interestingly, effector Th1 cells generated by immunization rather than live infection had lower non-cognate activity despite comparable IL-18R and DR3 expression. Mice lacking T cell intrinsic expression of MyD88, an important adapter molecule in non-cognate T cell stimulation, exhibited higher bacterial burdens upon infection with Salmonella, Chlamydia or Brucella, suggesting that non-cognate Th1 stimulation is a critical element of efficient bacterial clearance. Thus, IL-18R and DR3 are critical players in non-cognate stimulation of Th1 cells and this response plays an important role in protection against intracellular bacteria.", "link"=>"http://www.mendeley.com/research/t-cell-expression-il18r-dr3-essential-noncognate-stimulation-th1-cells-optimal-clearance-intracellul", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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