TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses
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{"title"=>"TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses", "type"=>"journal", "authors"=>[{"first_name"=>"Qing", "last_name"=>"Yang", "scopus_author_id"=>"57189713137"}, {"first_name"=>"Tian Tian", "last_name"=>"Liu", "scopus_author_id"=>"56131833000"}, {"first_name"=>"Heng", "last_name"=>"Lin", "scopus_author_id"=>"55544827400"}, {"first_name"=>"Man", "last_name"=>"Zhang", "scopus_author_id"=>"56716951600"}, {"first_name"=>"Jin", "last_name"=>"Wei", "scopus_author_id"=>"57188640763"}, {"first_name"=>"Wei Wei", "last_name"=>"Luo", "scopus_author_id"=>"57054771000"}, {"first_name"=>"Yun Hong", "last_name"=>"Hu", "scopus_author_id"=>"55589596800"}, {"first_name"=>"Bo", "last_name"=>"Zhong", "scopus_author_id"=>"57197711343"}, {"first_name"=>"Ming Ming", "last_name"=>"Hu", "scopus_author_id"=>"55341129400"}, {"first_name"=>"Hong Bing", "last_name"=>"Shu", "scopus_author_id"=>"7203086832"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-85030461542", "sgr"=>"85030461542", "issn"=>"15537374", "doi"=>"10.1371/journal.ppat.1006600", "pmid"=>"28898289", "isbn"=>"1111111111", "pui"=>"618568032"}, "id"=>"a22c3c01-9e43-3671-87e1-72021c63c79d", "abstract"=>"Toll-like receptor (TLR)-mediated signaling are critical for host defense against pathogen invasion. However, excessive responses would cause harmful damages to the host. Here we show that deficiency of the E3 ubiquitin ligase TRIM32 increases poly(I:C)- and LPS-induced transcription of downstream genes such as type I interferons (IFNs) and proinflammatory cytokines in both primary mouse immune cells and in mice. Trim32-/- mice produced higher levels of serum inflammatory cytokines and were more sensitive to loss of body weight and inflammatory death upon Salmonella typhimurium infection. TRIM32 interacts with and mediates the degradation of TRIF, a critical adaptor protein for TLR3/4, in an E3 activity-independent manner. TRIM32-mediated as well as poly(I:C)- and LPS-induced degradation of TRIF is inhibited by deficiency of TAX1BP1, a receptor for selective autophagy. Furthermore, TRIM32 links TRIF and TAX1BP1 through distinct domains. These findings suggest that TRIM32 negatively regulates TLR3/4-mediated immune responses by targeting TRIF to TAX1BP1-mediated selective autophagic degradation.", "link"=>"http://www.mendeley.com/research/trim32tax1bp1dependent-selective-autophagic-degradation-trif-negatively-regulates-tlr34mediated-inna", "reader_count"=>9, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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