Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication
Publication Date
October 30, 2017
Authors
Aastha Sindhwani, Subhash B. Arya, Harmeet Kaur, Divya Jagga, et al
Volume
13
Issue
10
Pages
e1006700
DOI
https://dx.plos.org/10.1371/journal.ppat.1006700
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006700
Scopus
85033213274
Mendeley
http://www.mendeley.com/research/salmonella-exploits-host-endolysosomal-tethering-factor-hops-complex-promote-intravacuolar-replicati
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Mendeley | Further Information

{"title"=>"Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication", "type"=>"journal", "authors"=>[{"first_name"=>"Aastha", "last_name"=>"Sindhwani", "scopus_author_id"=>"35280669500"}, {"first_name"=>"Subhash B.", "last_name"=>"Arya", "scopus_author_id"=>"57194738073"}, {"first_name"=>"Harmeet", "last_name"=>"Kaur", "scopus_author_id"=>"57201231114"}, {"first_name"=>"Divya", "last_name"=>"Jagga", "scopus_author_id"=>"56337377200"}, {"first_name"=>"Amit", "last_name"=>"Tuli", "scopus_author_id"=>"23669827400"}, {"first_name"=>"Mahak", "last_name"=>"Sharma", "scopus_author_id"=>"14520628700"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"619157726", "sgr"=>"85033213274", "issn"=>"15537374", "scopus"=>"2-s2.0-85033213274", "doi"=>"10.1371/journal.ppat.1006700", "isbn"=>"1111111111"}, "id"=>"7aae8503-b2e9-356d-adba-395d2ffebaec", "abstract"=>"Salmonella enterica serovar typhimurium extensively remodels the host late endocytic compartments to establish its vacuolar niche within the host cells conducive for its replication, also known as the Salmonella-containing vacuole (SCV). By maintaining a prolonged interaction with late endosomes and lysosomes of the host cells in the form of interconnected network of tubules (Salmonella-induced filaments or SIFs), Salmonella gains access to both membrane and fluid-phase cargo from these compartments. This is essential for maintaining SCV membrane integrity and for bacterial intravacuolar nutrition. Here, we have identified the multisubunit lysosomal tethering factor—HOPS (HOmotypic fusion and Protein Sorting) complex as a crucial host factor facilitating delivery of late endosomal and lysosomal content to SCVs, providing membrane for SIF formation, and nutrients for intravacuolar bacterial replication. Accordingly, depletion of HOPS subunits significantly reduced the bacterial load in non-phagocytic and phagocytic cells as well as in a mouse model of Salmonella infection. We found that Salmonella effector SifA in complex with its binding partner; SKIP, interacts with HOPS subunit Vps39 and mediates recruitment of this tethering factor to SCV compartments. The lysosomal small GTPase Arl8b that binds to, and promotes membrane localization of Vps41 (and other HOPS subunits) was also required for HOPS recruitment to SCVs and SIFs. Our findings suggest that Salmonella recruits the host late endosomal and lysosomal membrane fusion machinery to its vacuolar niche for access to host membrane and nutrients, ensuring its intracellular survival and replication.", "link"=>"http://www.mendeley.com/research/salmonella-exploits-host-endolysosomal-tethering-factor-hops-complex-promote-intravacuolar-replicati", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Materials Science"=>1, "Agricultural and Biological Sciences"=>4, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>1}

Scopus | Further Information

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