Lower temperatures reduce type I interferon activity and promote alphaviral arthritis
Publication Date
December 27, 2017
Journal
PLOS Pathogens
Authors
Natalie A. Prow, Bing Tang, Joy Gardner, Thuy T. Le, et al
Volume
13
Issue
12
Pages
e1006788
DOI
https://dx.plos.org/10.1371/journal.ppat.1006788
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006788
Scopus
85039903542
Mendeley
http://www.mendeley.com/research/lower-temperatures-reduce-type-i-interferon-activity-promote-alphaviral-arthritis
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Mendeley | Further Information

{"title"=>"Lower temperatures reduce type I interferon activity and promote alphaviral arthritis", "type"=>"journal", "authors"=>[{"first_name"=>"Natalie A.", "last_name"=>"Prow", "scopus_author_id"=>"16310418700"}, {"first_name"=>"Bing", "last_name"=>"Tang", "scopus_author_id"=>"57191630160"}, {"first_name"=>"Joy", "last_name"=>"Gardner", "scopus_author_id"=>"7403052748"}, {"first_name"=>"Thuy T.", "last_name"=>"Le", "scopus_author_id"=>"26652059300"}, {"first_name"=>"Adam", "last_name"=>"Taylor", "scopus_author_id"=>"8707130200"}, {"first_name"=>"Yee S.", "last_name"=>"Poo", "scopus_author_id"=>"55440836900"}, {"first_name"=>"Eri", "last_name"=>"Nakayama", "scopus_author_id"=>"57200142704"}, {"first_name"=>"Thiago D.C.", "last_name"=>"Hirata", "scopus_author_id"=>"57200139753"}, {"first_name"=>"Helder I.", "last_name"=>"Nakaya", "scopus_author_id"=>"36843586800"}, {"first_name"=>"Andrii", "last_name"=>"Slonchak", "scopus_author_id"=>"57199513101"}, {"first_name"=>"Pamela", "last_name"=>"Mukhopadhyay", "scopus_author_id"=>"57200142732"}, {"first_name"=>"Suresh", "last_name"=>"Mahalingam", "scopus_author_id"=>"12241751100"}, {"first_name"=>"Wayne A.", "last_name"=>"Schroder", "scopus_author_id"=>"15758055800"}, {"first_name"=>"William", "last_name"=>"Klimstra", "scopus_author_id"=>"6701773087"}, {"first_name"=>"Andreas", "last_name"=>"Suhrbier", "scopus_author_id"=>"7006137200"}], "year"=>2017, "source"=>"PLoS Pathogens", "identifiers"=>{"doi"=>"10.1371/journal.ppat.1006788", "sgr"=>"85039903542", "isbn"=>"1111111111", "pmid"=>"29281739", "issn"=>"15537374", "scopus"=>"2-s2.0-85039903542", "pui"=>"620067286"}, "id"=>"413d9d8e-3945-3655-8444-df460cd294cf", "abstract"=>"Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthropathy were dramatically reduced when mice were housed at 30°C, rather than the conventional 22°C. The effect was not associated with a detectable fever, but was dependent on type I interferon responses. Bioinformatics analyses of RNA-Seq data after injection of poly(I:C)/jetPEI suggested the unfolded protein response and certain type I interferon responses are promoted when feet are slightly warmer. The ambient temperature thus appears able profoundly to effect anti-viral activity in the periphery, with clear consequences for alphaviral replication and the ensuing arthropathy. These observations may provide an explanation for why alphaviral arthropathies are largely restricted to joints of the limbs and the extremities.", "link"=>"http://www.mendeley.com/research/lower-temperatures-reduce-type-i-interferon-activity-promote-alphaviral-arthritis", "reader_count"=>14, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Other"=>3, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Other"=>3, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>4, "Psychology"=>1, "Immunology and Microbiology"=>2, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

Scopus | Further Information

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