Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi
Publication Date
April 12, 2018
Authors
Robert H. Proctor, Susan P. Mc Cormick, Hye Seon Kim, Rosa E. Cardoza, et al
Volume
14
Issue
4
Pages
e1006946
DOI
https://dx.plos.org/10.1371/journal.ppat.1006946
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006946
Scopus
85046493370
Mendeley
http://www.mendeley.com/research/evolution-structural-diversity-trichothecenes-family-toxins-produced-plant-pathogenic-entomopathogen
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Mendeley | Further Information

{"title"=>"Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi", "type"=>"journal", "authors"=>[{"first_name"=>"Robert H.", "last_name"=>"Proctor"}, {"first_name"=>"Susan P.", "last_name"=>"McCormick"}, {"first_name"=>"Hye-Seon", "last_name"=>"Kim"}, {"first_name"=>"Rosa E.", "last_name"=>"Cardoza"}, {"first_name"=>"April M.", "last_name"=>"Stanley"}, {"first_name"=>"Laura", "last_name"=>"Lindo"}, {"first_name"=>"Amy", "last_name"=>"Kelly"}, {"first_name"=>"Daren W.", "last_name"=>"Brown"}, {"first_name"=>"Theresa", "last_name"=>"Lee"}, {"first_name"=>"Martha M.", "last_name"=>"Vaughan"}, {"first_name"=>"Nancy J.", "last_name"=>"Alexander"}, {"first_name"=>"Mark", "last_name"=>"Busman"}, {"first_name"=>"Santiago", "last_name"=>"Gutiérrez"}], "year"=>2018, "source"=>"PLOS Pathogens", "identifiers"=>{"issn"=>"1553-7374", "doi"=>"10.1371/journal.ppat.1006946", "sgr"=>"85046493370", "scopus"=>"2-s2.0-85046493370", "isbn"=>"1111111111", "pui"=>"622016014"}, "id"=>"e8cb1289-2d29-381a-b101-4fdbd1c58c34", "abstract"=>"Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and trichothecene production contributes to pathogenesis of some Fusarium species on plants. Collectively, fungi produce over 150 trichothecene analogs: i.e., molecules that share the same core structure but differ in patterns of substituents attached to the core structure. Here, we carried out genomic, phylogenetic, gene-function, and analytical chemistry studies of strains from nine fungal genera to identify genetic variation responsible for trichothecene structural diversity and to gain insight into evolutionary processes that have contributed to the variation. The results indicate that structural diversity has resulted from gain, loss, and functional changes of trichothecene biosynthetic (TRI) genes. The results also indicate that the presence of some substituents has arisen independently in different fungi by gain of different genes with the same function. Variation in TRI gene duplication and number of TRI loci was also observed among the fungi examined, but there was no evidence that such genetic differences have contributed to trichothecene structural variation. We also inferred ancestral states of the TRI cluster and trichothecene biosynthetic pathway, and proposed scenarios for changes in trichothecene structures during divergence of TRI cluster homologs. Together, our findings provide insight into evolutionary processes responsible for structural diversification of toxins produced by pathogenic fungi.", "link"=>"http://www.mendeley.com/research/evolution-structural-diversity-trichothecenes-family-toxins-produced-plant-pathogenic-entomopathogen", "reader_count"=>7, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>2, "Lecturer > Senior Lecturer"=>1, "Student > Master"=>1, "Researcher"=>1, "Student > Bachelor"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>2, "Lecturer > Senior Lecturer"=>1, "Student > Master"=>1, "Researcher"=>1, "Student > Bachelor"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>6, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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