Host shifts result in parallel genetic changes when viruses evolve in closely related species
Publication Date
April 12, 2018
Authors
Ben Longdon, Jonathan P. Day, Joel M. Alves, Sophia C. L. Smith, et al
Volume
14
Issue
4
Pages
e1006951
DOI
https://dx.plos.org/10.1371/journal.ppat.1006951
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006951
Scopus
85046436375
Mendeley
http://www.mendeley.com/research/host-shifts-result-parallel-genetic-changes-viruses-evolve-closely-related-species
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Mendeley | Further Information

{"title"=>"Host shifts result in parallel genetic changes when viruses evolve in closely related species.", "type"=>"journal", "authors"=>[{"first_name"=>"Ben", "last_name"=>"Longdon"}, {"first_name"=>"Jonathan P", "last_name"=>"Day"}, {"first_name"=>"Joel M", "last_name"=>"Alves"}, {"first_name"=>"Sophia C L", "last_name"=>"Smith"}, {"first_name"=>"Thomas M", "last_name"=>"Houslay"}, {"first_name"=>"John E", "last_name"=>"McGonigle"}, {"first_name"=>"Lucia", "last_name"=>"Tagliaferri"}, {"first_name"=>"Francis M", "last_name"=>"Jiggins"}], "year"=>2018, "source"=>"PLoS pathogens", "identifiers"=>{"scopus"=>"2-s2.0-85046436375", "sgr"=>"85046436375", "doi"=>"10.1371/journal.ppat.1006951", "pui"=>"622015999", "pmid"=>"29649296", "isbn"=>"1111111111", "issn"=>"1553-7374"}, "id"=>"2efb9b30-b52c-3bba-9f20-6e889b9a321e", "abstract"=>"Host shifts, where a pathogen invades and establishes in a new host species, are a major source of emerging infectious diseases. They frequently occur between related host species and often rely on the pathogen evolving adaptations that increase their fitness in the novel host species. To investigate genetic changes in novel hosts, we experimentally evolved replicate lineages of an RNA virus (Drosophila C Virus) in 19 different species of Drosophilidae and deep sequenced the viral genomes. We found a strong pattern of parallel evolution, where viral lineages from the same host were genetically more similar to each other than to lineages from other host species. When we compared viruses that had evolved in different host species, we found that parallel genetic changes were more likely to occur if the two host species were closely related. This suggests that when a virus adapts to one host it might also become better adapted to closely related host species. This may explain in part why host shifts tend to occur between related species, and may mean that when a new pathogen appears in a given species, closely related species may become vulnerable to the new disease.", "link"=>"http://www.mendeley.com/research/host-shifts-result-parallel-genetic-changes-viruses-evolve-closely-related-species", "reader_count"=>9, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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