CiteULike | Further Information

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Mendeley | Further Information

{"title"=>"Evolution at two levels: On genes and form", "type"=>"generic", "authors"=>[{"first_name"=>"Sean B.", "last_name"=>"Carroll", "scopus_author_id"=>"7201476366"}], "year"=>2005, "source"=>"PLoS Biology", "identifiers"=>{"pmid"=>"16000021", "doi"=>"10.1371/journal.pbio.0030245", "sgr"=>"22744439568", "isbn"=>"1544-9173", "scopus"=>"2-s2.0-22744439568", "issn"=>"15449173", "pui"=>"41032181"}, "id"=>"302d30f5-e734-34d5-b2da-86646cf40f12", "abstract"=>"Emerging knowledge about organismal evolution suggests that changes in the regulation of gene expression have played a major role - a thesis proposed 30 years ago by King and Wilson.", "link"=>"http://www.mendeley.com/research/evolution-two-levels-genes-form", "reader_count"=>946, "reader_count_by_academic_status"=>{"Unspecified"=>11, "Professor > Associate Professor"=>79, "Librarian"=>2, "Researcher"=>238, "Student > Doctoral Student"=>37, "Student > Ph. D. Student"=>255, "Student > Postgraduate"=>36, "Student > Master"=>90, "Other"=>25, "Student > Bachelor"=>81, "Lecturer"=>8, "Lecturer > Senior Lecturer"=>2, "Professor"=>82}, "reader_count_by_user_role"=>{"Unspecified"=>11, "Professor > Associate Professor"=>79, "Librarian"=>2, "Researcher"=>238, "Student > Doctoral Student"=>37, "Student > Ph. D. Student"=>255, "Student > Postgraduate"=>36, "Student > Master"=>90, "Other"=>25, "Student > Bachelor"=>81, "Lecturer"=>8, "Lecturer > Senior Lecturer"=>2, "Professor"=>82}, "reader_count_by_subject_area"=>{"Unspecified"=>24, "Agricultural and Biological Sciences"=>713, "Philosophy"=>7, "Arts and Humanities"=>5, "Veterinary Science and Veterinary Medicine"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>4, "Computer Science"=>14, "Earth and Planetary Sciences"=>17, "Engineering"=>3, "Environmental Science"=>11, "Biochemistry, Genetics and Molecular Biology"=>75, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>17, "Neuroscience"=>5, "Sports and Recreations"=>2, "Physics and Astronomy"=>7, "Psychology"=>21, "Social Sciences"=>16, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Social Sciences"=>{"Social Sciences"=>16}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>7}, "Psychology"=>{"Psychology"=>21}, "Unspecified"=>{"Unspecified"=>24}, "Environmental Science"=>{"Environmental Science"=>11}, "Arts and Humanities"=>{"Arts and Humanities"=>5}, "Engineering"=>{"Engineering"=>3}, "Chemistry"=>{"Chemistry"=>4}, "Neuroscience"=>{"Neuroscience"=>5}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>17}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>713}, "Computer Science"=>{"Computer Science"=>14}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>75}, "Philosophy"=>{"Philosophy"=>7}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>42, "Egypt"=>1, "Portugal"=>2, "Iceland"=>1, "Costa Rica"=>1, "Netherlands"=>2, "Sweden"=>1, "South Korea"=>1, "Austria"=>1, "China"=>1, "Poland"=>3, "Brazil"=>23, "Serbia and Montenegro"=>1, "France"=>5, "Chile"=>3, "Ecuador"=>1, "Colombia"=>3, "Argentina"=>2, "Hungary"=>2, "Uruguay"=>1, "Japan"=>1, "United Kingdom"=>15, "Switzerland"=>3, "Spain"=>9, "India"=>2, "New Zealand"=>3, "Canada"=>3, "Czech Republic"=>1, "Turkey"=>2, "Belgium"=>3, "Norway"=>2, "Finland"=>2, "Denmark"=>1, "Mexico"=>3, "Italy"=>3, "South Africa"=>1, "Israel"=>1, "Australia"=>1, "Germany"=>7}, "group_count"=>24}

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• {"id"=>"307836668902273024", "text"=>"& more @karlmeyer @Bxlx59xx @kaimatai http://t.co/ekUl5jE8e9 http://t.co/dWqkmoYdNk http://t.co/rUc2IKTB0z http://t.co/YAuUJBPePU #evolution", "created_at"=>"2013-03-02T12:55:55Z", "user"=>"ScientiaPercept", "user_name"=>"Scientia Perceptum", "user_profile_image"=>"http://a0.twimg.com/profile_images/1092002845/ScientiaPerceptumProfilePic_normal.jpg"}
• {"id"=>"494504690340884480", "text"=>"Evolution at 2 Levels: Genes & Form http://t.co/LC7R5aHBJG Reg evol likely for genes in mult tissues, w. pleiotropic coding SNPs & mult CRMs", "created_at"=>"2014-07-30T15:28:00Z", "user"=>"markgerstein", "user_name"=>"Mark Gerstein", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000232600610/b3683cc9f226a8173d08e6041cdee6ff_normal.jpeg"}
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• {"id"=>"494517965162053633", "text"=>"RT @markgerstein: Evolution at 2 Levels: Genes & Form http://t.co/LC7R5aHBJG Reg evol likely for genes in mult tissues, w. pleiotropic codi…", "created_at"=>"2014-07-30T16:20:45Z", "user"=>"drbachinsky", "user_name"=>"David R. Bachinsky", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1415439640/6822_1147392528923_1350846122_30401298_8082523_n_normal.jpg"}
• {"id"=>"494522712753451008", "text"=>"RT @markgerstein: Evolution at 2 Levels: Genes & Form http://t.co/LC7R5aHBJG Reg evol likely for genes in mult tissues, w. pleiotropic codi…", "created_at"=>"2014-07-30T16:39:37Z", "user"=>"b12unme", "user_name"=>"B12 unme", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2780871087/dbf2e33ea82e8b87677148bf52d6d213_normal.jpeg"}
• {"id"=>"494669053198209024", "text"=>"Evolution from genes or regulation? Unresolved. Proposed models remain simplistic neglecting high order interactions http://t.co/NTTAOM0VbZ", "created_at"=>"2014-07-31T02:21:07Z", "user"=>"LussierY", "user_name"=>"Prof. Yves Lussier", "user_profile_image"=>"http://pbs.twimg.com/profile_images/494365134945398786/kn6gdHKB_normal.jpeg"}

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• {"title"=>"한국창조과학회", "url"=>"http://ko.wikipedia.org/wiki/한국창조과학회", "timestamp"=>"2018-12-24T18:49:38Z"}

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Figshare

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• {"files"=>["https://ndownloader.figshare.com/files/962431"], "description"=>"<div><p>(A) Expression of the <i>yellow</i> pigmentation gene of Drosophila is controlled by several different cis-regulatory elements (red circles). Differences in the activity of selected elements (wing and wing spot) underlie differences in pigment patterns between species (Figure based on [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030245#pbio-0030245-b35\" target=\"_blank\">35</a>].)</p>\n <p>(B) Similarly, the expression of the <i>Pitx1</i> gene of vertebrates is inferred to be controlled by multiple elements (red circles). In pelvic-reduced stickleback fish, <i>Pitx1</i> expression is absent from the pelvic region. This is proposed to occur through of a selective loss of activity of the hindlimb regulatory element (cross through the red circle) (Figure based on [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030245#pbio-0030245-b33\" target=\"_blank\">33</a>].)</p></div>", "links"=>[], "tags"=>["modular", "cis-regulatory", "regions", "pleiotropic", "genes", "enables"], "article_id"=>632413, "categories"=>["Genetics", "Developmental Biology", "Evolutionary Biology"], "users"=>["Sean B Carroll"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030245.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Modular_Architecture_of_the_cis_Regulatory_Regions_of_Pleiotropic_Genes_Enables_the_Independent_Evolution_of_Gene_Expression_in_Different_Body_Parts_/632413", "title"=>"The Modular Architecture of the cis-Regulatory Regions of Pleiotropic Genes Enables the Independent Evolution of Gene Expression in Different Body Parts", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:04:20"}
• {"files"=>["https://ndownloader.figshare.com/files/962362"], "description"=>"<div><p>The function of a progenitor gene with the simple structure of one <i>cis</i>-regulatory element (red circle) and a pair of exons (black rectangles) can be expanded and diversified in several ways.</p>\n <p>(A) Gene duplication followed by mutations (asterisks) in either coding or regulatory sequences of the initially identical paralogs will produce genes that may be expressed in different ways or proteins with distinct functions, while the original function can be maintained.</p>\n <p>(B) An expansion in the number of <i>cis</i>-regulatory elements by any of a number of means (transposition, rearrangement, duplication, point mutation) can expand the number of tissues in which the gene is active, but preserves the original function.</p>\n <p>(C) The evolution of a new exon and splicing sites creates the potential for alternative forms of a protein to be made. Mutations in alternative exons (asterisks) need not affect the original function of the protein.</p></div>", "links"=>[], "tags"=>["modes"], "article_id"=>632359, "categories"=>["Genetics", "Developmental Biology", "Evolutionary Biology"], "users"=>["Sean B Carroll"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030245.g001", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_Modes_of_Gene_Evolution_Increase_the_Diversity_of_Gene_Function_and_Minimize_Pleiotropy_/632359", "title"=>"Different Modes of Gene Evolution Increase the Diversity of Gene Function and Minimize Pleiotropy", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:03:52"}

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Relative Metric

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F1000Prime