CiteULike | Further Information

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Mendeley | Further Information

{"title"=>"Two rounds of whole genome duplication in the ancestral vertebrate", "type"=>"journal", "authors"=>[{"first_name"=>"Paramvir", "last_name"=>"Dehal", "scopus_author_id"=>"6602411350"}, {"first_name"=>"Jeffrey L.", "last_name"=>"Boore", "scopus_author_id"=>"7006124496"}], "year"=>2005, "source"=>"PLoS Biology", "identifiers"=>{"issn"=>"15449173", "scopus"=>"2-s2.0-26444603772", "pmid"=>"16128622", "doi"=>"10.1371/journal.pbio.0030314", "isbn"=>"1545-7885 (Electronic)\\r1544-9173 (Linking)", "pui"=>"41437140", "sgr"=>"26444603772"}, "id"=>"b7fe595a-6000-37f5-ac15-fc990489c248", "abstract"=>"The hypothesis that the relatively large and complex vertebrate genome was created by two ancient, whole genome duplications has been hotly debated, but remains unresolved. We reconstructed the evolutionary relationships of all gene families from the complete gene sets of a tunicate, fish, mouse, and human, and then determined when each gene duplicated relative to the evolutionary tree of the organisms. We confirmed the results of earlier studies that there remains little signal of these events in numbers of duplicated genes, gene tree topology, or the number of genes per multigene family. However, when we plotted the genomic map positions of only the subset of paralogous genes that were duplicated prior to the fish-tetrapod split, their global physical organization provides unmistakable evidence of two distinct genome duplication events early in vertebrate evolution indicated by clear patterns of four-way paralogous regions covering a large part of the human genome. Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage.", "link"=>"http://www.mendeley.com/research/two-rounds-whole-genome-duplication-ancestral-vertebrate-1", "reader_count"=>574, "reader_count_by_academic_status"=>{"Unspecified"=>10, "Professor > Associate Professor"=>45, "Student > Doctoral Student"=>21, "Researcher"=>135, "Student > Ph. D. Student"=>173, "Student > Postgraduate"=>22, "Student > Master"=>55, "Other"=>12, "Student > Bachelor"=>67, "Lecturer"=>7, "Lecturer > Senior Lecturer"=>2, "Professor"=>25}, "reader_count_by_user_role"=>{"Unspecified"=>10, "Professor > Associate Professor"=>45, "Student > Doctoral Student"=>21, "Researcher"=>135, "Student > Ph. D. Student"=>173, "Student > Postgraduate"=>22, "Student > Master"=>55, "Other"=>12, "Student > Bachelor"=>67, "Lecturer"=>7, "Lecturer > Senior Lecturer"=>2, "Professor"=>25}, "reader_count_by_subject_area"=>{"Unspecified"=>19, "Agricultural and Biological Sciences"=>422, "Arts and Humanities"=>2, "Business, Management and Accounting"=>1, "Computer Science"=>9, "Earth and Planetary Sciences"=>3, "Economics, Econometrics and Finance"=>1, "Engineering"=>2, "Environmental Science"=>5, "Biochemistry, Genetics and Molecular Biology"=>81, "Mathematics"=>1, "Medicine and Dentistry"=>14, "Neuroscience"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>3, "Social Sciences"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>19}, "Environmental Science"=>{"Environmental Science"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>2}, "Engineering"=>{"Engineering"=>2}, "Neuroscience"=>{"Neuroscience"=>6}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>422}, "Computer Science"=>{"Computer Science"=>9}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>81}}, "reader_count_by_country"=>{"Republic of Singapore"=>1, "United States"=>17, "Portugal"=>2, "New Caledonia"=>1, "Sweden"=>4, "Netherlands"=>1, "South Korea"=>1, "China"=>1, "Serbia and Montenegro"=>1, "Brazil"=>5, "France"=>2, "Colombia"=>1, "Argentina"=>2, "Uruguay"=>1, "Japan"=>4, "United Kingdom"=>17, "Switzerland"=>2, "Spain"=>4, "Canada"=>2, "Belgium"=>1, "Norway"=>2, "Finland"=>1, "Denmark"=>1, "South Africa"=>2, "Mexico"=>1, "Israel"=>2, "Australia"=>3, "Germany"=>5}, "group_count"=>9}

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Scopus | Further Information

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ScienceSeeker | Further Information

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• {"id"=>"536123744960667648", "text"=>"@ban_postgate Here's an old paper on it:\nhttp://t.co/hEgEGvZGSm\nFascinating implications for the role of dosage balanced genes in evolution", "created_at"=>"2014-11-22T11:47:16Z", "user"=>"ProudPrimate1", "user_name"=>"ProudPrimate", "user_profile_image"=>"http://pbs.twimg.com/profile_images/498572104900427776/sYyoqC5f_normal.jpeg"}
• {"id"=>"548304936938008578", "text"=>"[Via @PLOSBiology ] http://t.co/JKhO6iXZ5U Fascinating implications for the role of dosage balanced genes in evolution", "created_at"=>"2014-12-26T02:30:58Z", "user"=>"SG_Calcio", "user_name"=>"Steve Graff", "user_profile_image"=>"http://pbs.twimg.com/profile_images/477124591567925248/Z9LzrO3a_normal.jpeg"}
• {"id"=>"701891345531580416", "text"=>".@Bulla_Adriano @tattoosandbones @steapot @SemiMooch\n1 ancient\nhttps://t.co/1KD1VkVAmf\n1 modern\nhttps://t.co/sfYhaUWJhY\nDuplication iscommon", "created_at"=>"2016-02-22T22:08:31Z", "user"=>"JaTapps", "user_name"=>"Vicomte John Tapps", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000709393693/8d97acf19b8194da39c85aca7106ad99_normal.jpeg"}

Wikipedia | Further Information

• {"title"=>"Euarchontoglires", "url"=>"http://en.wikipedia.org/wiki/Euarchontoglires", "timestamp"=>"2019-02-21T04:46:01Z"}
• {"title"=>"2R hypothesis", "url"=>"http://en.wikipedia.org/wiki/2R_hypothesis", "timestamp"=>"2019-02-11T15:14:12Z"}
• {"title"=>"Gene duplication", "url"=>"http://en.wikipedia.org/wiki/Gene_duplication", "timestamp"=>"2019-02-22T09:34:00Z"}
• {"title"=>"Osteichthyes", "url"=>"http://en.wikipedia.org/wiki/Osteichthyes", "timestamp"=>"2019-02-22T18:38:11Z"}
• {"title"=>"Perilipin-5", "url"=>"http://en.wikipedia.org/wiki/Perilipin-5", "timestamp"=>"2018-12-20T18:24:07Z"}
• {"title"=>"2R-Hypothese", "url"=>"http://de.wikipedia.org/wiki/2R-Hypothese", "timestamp"=>"2017-11-12T20:18:19Z"}
• {"title"=>"Chromosom", "url"=>"http://de.wikipedia.org/wiki/Chromosom", "timestamp"=>"2018-12-13T11:47:37Z"}
• {"title"=>"File:Patró de gens - Hipòtesi 2R.png", "url"=>"http://commons.wikimedia.org/wiki/File:Patró_de_gens_-_Hipòtesi_2R.png", "timestamp"=>"2018-10-18T22:33:11Z"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/962617"], "description"=>"<div><p>(A) Each circle represents a gene, labeled with the source genome according to the first letter of each taxon—C, M, H, and F for <i>Ciona,</i> mouse, human, and fugu, respectively—and further differentiated by numeral. BLASTP was first used to search all vertebrate genes for the one most similar to <i>Ciona'</i>s <i>C1</i> gene, in this case the mouse gene <i>M1.</i> Then other genes are recruited to the cluster if they have a higher similarity score to <i>M1</i> that that between <i>C1</i> and <i>M1,</i> indicated here by the red lines. The six genes shown on the right side of the diagram have some sequence similarity to those in the cluster, but less than that between <i>C1</i> and <i>M1,</i> so are not included. Because the vertebrates are more closely related to each other than any is to <i>Ciona,</i> each cluster will include those genes descended from a single gene in the common chordate ancestor, having arisen by either lineage splitting or gene duplication specific to one or more vertebrates. (See <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030314#s4\" target=\"_blank\">Materials and Methods</a> for more details.)</p>\n <p>(B) Evolutionary tree of the genes in this cluster show separate duplications for fugu and for human. Because the maximum likelihood method does not rely solely on sequence similarity, there is no significance to the mouse gene being most similar to <i>C1.</i> The mouse genome simply contained the most slowly evolving vertebrate gene in this multigene family; this can be from any vertebrate taxon with approximately equal likelihood.</p></div>", "links"=>[], "tags"=>["phylogenetic", "hypothetical"], "article_id"=>632603, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_the_Building_of_a_Gene_Cluster_and_Phylogenetic_Tree_Shown_by_a_Hypothetical_Example_/632603", "title"=>"Overview of the Building of a Gene Cluster and Phylogenetic Tree Shown by a Hypothetical Example", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:05:42"}
• {"files"=>["https://ndownloader.figshare.com/files/962777"], "description"=>"<p>This phylogenetic tree is based on 766 concatenated single copy protein sequences totaling 313,797 amino acid positions with branches proportional to the amount of change. Numerals in bold above the branches indicate the number of gene duplications occurring in each lineage; numerals below indicate branch lengths.</p>", "links"=>[], "tags"=>["chordates"], "article_id"=>632749, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_Analysis_of_the_Four_Chordates_with_Drosophila_as_an_Outgroup_/632749", "title"=>"Phylogenetic Analysis of the Four Chordates with <i>Drosophila</i> as an Outgroup", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:06:49"}
• {"files"=>["https://ndownloader.figshare.com/files/962679"], "description"=>"<p>Interior nodes are designated in lower case for those that simply result from lineage splitting and in upper case for gene duplications within a lineage. Although not shown, nodes are still scored if there is gene loss. Phylogenetic trees for each gene family can be viewed at <a href=\"http://phigs.org/\" target=\"_blank\">http://phigs.org/</a>, also providing a valuable tool for improving the inference of gene function. DBFTS, duplication before fish–tetrapod split; DBPRS, duplication before primate–rodent split; FD, fugu duplication; fts, fish–tetrapod split; HD, human duplication; MD, mouse duplication; prs, primate–rodent split.</p>", "links"=>[], "tags"=>["phylogenetic", "types", "relationships", "parsimoniously"], "article_id"=>632657, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hypothetical_Phylogenetic_Tree_Showing_All_Possible_Types_of_Gene_Relationships_and_How_They_Are_Most_Parsimoniously_Interpreted_/632657", "title"=>"Hypothetical Phylogenetic Tree Showing All Possible Types of Gene Relationships and How They Are Most Parsimoniously Interpreted", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:06:05"}
• {"files"=>["https://ndownloader.figshare.com/files/962450"], "description"=>"<div><p>(A) Representation of a hypothetical genome that has 22 genes shown as colored squares.</p>\n <p>(B) A genome duplication generates a complete set of paralogs in identical order.</p>\n <p>(C) Many paralogous genes suffer disabling mutations, become pseudogenes, and are then lost. One could imagine this condition being evidence of a single round of genome duplication followed by significant gene losses.</p>\n <p>(D) A second genome duplication recreates another set of paralogs in identical order, with multigene families that retained two copies now present in four, and those that had lost a member now present in two copies.</p>\n <p>(E) Again, many paralogous genes suffer disabling mutations, become pseudogenes, and are then lost. Of course, unrelated gene duplications and transpositions can occur. Even though this leaves only a few four-member gene families, the patterns of 2- and 3-fold gene families unite, in various combinations, all four genomic segments, revealing that the sequential duplications had been of very large regions, in this case all or nearly all of this hypothetical genome.</p></div>", "links"=>[], "tags"=>["locations", "paralogous", "genes", "genome"], "article_id"=>632434, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pattern_Predicted_for_the_Relative_Locations_of_Paralogous_Genes_from_Two_Genome_Duplications_/632434", "title"=>"Pattern Predicted for the Relative Locations of Paralogous Genes from Two Genome Duplications", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:04:30"}
• {"files"=>["https://ndownloader.figshare.com/files/962866"], "description"=>"<p>The queries shown here use Chromosomes 2, 4, 5, and 10, as indicated for the four panels. (The complete set can be seen in <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030314#sg002\" target=\"_blank\">Figure S2</a>.) On the <i>x-</i>axis is each chromosome arranged from p to q telomeres. On the <i>y-</i>axis is each of the 22 human autosomes plus the X and Y chromosomes. For each query gene on the <i>x-</i>axis, a “hit” is scored if the subject chromosome contains a paralog generated by a gene duplication prior to the fish–tetrapod split. The lower portion of each panel plots the <i>n-</i>fold redundancy along the query chromosome as defined by pairs of paralogs detected in a sliding window analysis. See the Material and Methods section for details, but briefly, for every human query gene, a window was considered of 50 genes to the left and 50 genes to the right, with a “hit” obtained for the subject chromosome if it includes the early-duplicated paralogs of genes on each side of the query. Four-fold (i.e., including the query) matching, as expected by the 2R hypothesis, is highlighted in a darker shade of blue.</p>", "links"=>[], "tags"=>["genomic", "positions", "paralogous", "pairs", "genes", "arose", "duplications", "predating"], "article_id"=>632830, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g005", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plot_of_the_Genomic_Positions_of_Paralogous_Pairs_of_Human_Genes_that_Arose_from_Duplications_Predating_the_Fish_8211_Tetrapod_Split_/632830", "title"=>"Plot of the Genomic Positions of Paralogous Pairs of Human Genes that Arose from Duplications Predating the Fish–Tetrapod Split", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:07:21"}
• {"files"=>["https://ndownloader.figshare.com/files/963030"], "description"=>"<div><p>(A) This is an example of the tetra-paralogous relationships of a subset of human genes that are all inferred, by gene trees, to have duplicated prior to the split of fish from tetrapods, but after the split of <i>Ciona</i> from vertebrates. These genes are on four chromosomes with their identities indicated outside of the circle. The complete set of tetra-paralogons can be viewed in <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030314#sg003\" target=\"_blank\">Figure S3</a>.</p>\n <p>(B) In contrast, paralogous human genes generated by duplications after the split of fish and tetrapods, as shown for this sample of the same four human chromosomes, do not form such tetra-paralogons. Their pattern appears to result from smaller-scale tandem duplications of individual genes or segments, followed by slow rearrangements. In addition to these apparently functional gene pairs shown in the figure for this portion of the human genome, we have identified eight pseudogene pairs that occur on different chromosomes; it is not clear whether these pseudogenes are the result of random retrotransposition (or other rearrangement mechanisms) rather than gene conversion events between older duplicates, which would make it appear as though these had duplicated later than they actually did, as has been observed in yeast [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030314#pbio-0030314-b29\" target=\"_blank\">29</a>].</p></div>", "links"=>[], "tags"=>["arbitrarily", "subset", "genome", "relationships", "paralogous"], "article_id"=>632987, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g007", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_An_Arbitrarily_Selected_Subset_of_the_Human_Genome_Showing_the_Physical_Relationships_Among_Paralogous_Genes_/632987", "title"=>"An Arbitrarily Selected Subset of the Human Genome Showing the Physical Relationships Among Paralogous Genes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:08:31"}
• {"files"=>["https://ndownloader.figshare.com/files/474523", "https://ndownloader.figshare.com/files/474557", "https://ndownloader.figshare.com/files/474758", "https://ndownloader.figshare.com/files/474782"], "description"=>"<div><p>The hypothesis that the relatively large and complex vertebrate genome was created by two ancient, whole genome duplications has been hotly debated, but remains unresolved. We reconstructed the evolutionary relationships of all gene families from the complete gene sets of a tunicate, fish, mouse, and human, and then determined when each gene duplicated relative to the evolutionary tree of the organisms. We confirmed the results of earlier studies that there remains little signal of these events in numbers of duplicated genes, gene tree topology, or the number of genes per multigene family. However, when we plotted the genomic map positions of only the subset of paralogous genes that were duplicated prior to the fish–tetrapod split, their global physical organization provides unmistakable evidence of two distinct genome duplication events early in vertebrate evolution indicated by clear patterns of four-way paralogous regions covering a large part of the human genome. Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage.</p> </div>", "links"=>[], "tags"=>["rounds", "genome", "duplication", "ancestral", "vertebrate"], "article_id"=>153534, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.0030314.sg001", "https://dx.doi.org/10.1371/journal.pbio.0030314.sg002", "https://dx.doi.org/10.1371/journal.pbio.0030314.sg003", "https://dx.doi.org/10.1371/journal.pbio.0030314.st001"], "stats"=>{"downloads"=>25, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Two_Rounds_of_Whole_Genome_Duplication_in_the_Ancestral_Vertebrate/153534", "title"=>"Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-20 13:36:56"}
• {"files"=>["https://ndownloader.figshare.com/files/962957"], "description"=>"<p>This histogram is generated by counting the depth of paralogon redundancy across all human chromosomes as shown in the lower part of <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030314#sg002\" target=\"_blank\">Figure S2</a> (and subsampled for <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030314#pbio-0030314-g005\" target=\"_blank\">Figure 5</a>). The peak at 4-fold coverage is consistent with the 2R hypothesis, and constitutes a lower bound estimate, because the sliding window examines only a small span of flanking genes and would be highly subject to effects of local gene rearrangements.</p>", "links"=>[], "tags"=>["bound", "redundancy"], "article_id"=>632917, "categories"=>["Biological Sciences", "Genetics", "Evolutionary Biology"], "users"=>["Paramvir Dehal", "Jeffrey L Boore"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030314.g006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histogram_Showing_the_Lower_Bound_Estimate_of_N_fold_Redundancy_Using_the_Analysis_Reported_in_Figure_5_/632917", "title"=>"Histogram Showing the Lower Bound Estimate of <i>N-</i>fold Redundancy Using the Analysis Reported in Figure 5", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:08:03"}

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Relative Metric

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F1000Prime | Further Information

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• {"year"=>2014, "month"=>12, "doi"=>"10.1371/journal.pbio.0030314", "f1000_id"=>"1028295", "url"=>"http://f1000.com/prime/1028295", "score"=>1, "classifications"=>["confirmation"], "updated_at"=>"2014-12-29T09:40:19Z"}
• {"year"=>2015, "month"=>1, "doi"=>"10.1371/journal.pbio.0030314", "f1000_id"=>"1028295", "url"=>"http://f1000.com/prime/1028295", "score"=>1, "classifications"=>["confirmation"], "updated_at"=>"2015-01-26T09:40:14Z"}
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• {"year"=>2015, "month"=>7, "doi"=>"10.1371/journal.pbio.0030314", "f1000_id"=>"1028295", "url"=>"http://f1000.com/prime/1028295", "score"=>1, "classifications"=>["confirmation"], "updated_at"=>"2015-07-27T08:40:12Z"}
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