CiteULike

Mendeley | Further Information

{"title"=>"Sex chromosome-specific regulation in the drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation", "type"=>"journal", "authors"=>[{"first_name"=>"Colin D.", "last_name"=>"Meiklejohn", "scopus_author_id"=>"6602672818"}, {"first_name"=>"Emily L.", "last_name"=>"Landeen", "scopus_author_id"=>"51161447500"}, {"first_name"=>"Jodi M.", "last_name"=>"Cook", "scopus_author_id"=>"51161090500"}, {"first_name"=>"Sarah B.", "last_name"=>"Kingan", "scopus_author_id"=>"8927855000"}, {"first_name"=>"Daven C.", "last_name"=>"Presgraves", "scopus_author_id"=>"6602188861"}], "year"=>2011, "source"=>"PLoS Biology", "identifiers"=>{"issn"=>"15449173", "scopus"=>"2-s2.0-80052324184", "pui"=>"362471731", "doi"=>"10.1371/journal.pbio.1001126", "isbn"=>"1545-7885 (Electronic)\\r1544-9173 (Linking)", "sgr"=>"80052324184", "pmid"=>"21857805"}, "id"=>"442772ff-5c3e-3f8e-9462-4c3ac0c8e42b", "abstract"=>"The evolution of heteromorphic sex chromosomes (e.g., XY in males or ZW in females) has repeatedly elicited the evolution of two kinds of chromosome-specific regulation: dosage compensation--the equalization of X chromosome gene expression in males and females--and meiotic sex chromosome inactivation (MSCI)--the transcriptional silencing and heterochromatinization of the X during meiosis in the male (or Z in the female) germline. How the X chromosome is regulated in the Drosophila melanogaster male germline is unclear. Here we report three new findings concerning gene expression from the X in Drosophila testes. First, X chromosome-wide dosage compensation appears to be absent from most of the Drosophila male germline. Second, microarray analysis provides no evidence for X chromosome-specific inactivation during meiosis. Third, we confirm the previous discovery that the expression of transgene reporters driven by autosomal spermatogenesis-specific promoters is strongly reduced when inserted on the X chromosome versus the autosomes; but we show that this chromosomal difference in expression is established in premeiotic cells and persists in meiotic cells. The magnitude of the X-autosome difference in transgene expression cannot be explained by the absence of dosage compensation, suggesting that a previously unrecognized mechanism limits expression from the X during spermatogenesis in Drosophila. These findings help to resolve several previously conflicting reports and have implications for patterns of genome evolution and speciation in Drosophila.", "link"=>"http://www.mendeley.com/research/sex-chromosomespecific-regulation-drosophila-male-germline-little-evidence-chromosomal-dosage-compen", "reader_count"=>70, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>8, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>28, "Student > Postgraduate"=>4, "Other"=>3, "Student > Master"=>6, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>8, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>28, "Student > Postgraduate"=>4, "Other"=>3, "Student > Master"=>6, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>10, "Agricultural and Biological Sciences"=>56, "Chemistry"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>56}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "Sweden"=>2, "Netherlands"=>1, "United States"=>4, "Japan"=>1, "Italy"=>1, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>2}

ORCID

CrossRef

• http://doi.org/10.1146/annurev-genet-120215-035429
• http://doi.org/10.1186/1471-2148-12-69
• http://doi.org/10.1371/journal.pgen.1003842
• http://doi.org/10.1111/j.1749-6632.2012.06748.x
• http://doi.org/10.1016/j.etap.2014.11.024
• http://doi.org/10.1371/journal.pone.0116829
• http://doi.org/10.1093/gbe/evt088
• http://doi.org/10.1371/journal.pgen.1007617
• http://doi.org/10.1534/genetics.112.148635
• http://doi.org/10.1093/gbe/evt145
• http://doi.org/10.1186/1741-7007-10-49
• http://doi.org/10.1186/1471-213X-13-7
• http://doi.org/10.1093/gbe/evv215
• http://doi.org/10.1098/rsob.140024
• http://doi.org/10.1534/genetics.114.169268
• http://doi.org/10.1093/gbe/evx154
• http://doi.org/10.1038/hdy.2017.12
• http://doi.org/10.1007/s00239-018-9849-5
• http://doi.org/10.1534/genetics.112.145102
• http://doi.org/10.1038/nrg3376
• http://doi.org/10.1093/gbe/evs093
• http://doi.org/10.1038/s41559-019-1009-9
• http://doi.org/10.1534/g3.113.008029
• http://doi.org/10.1111/jeb.12345
• http://doi.org/10.1371/journal.pbio.1002499
• http://doi.org/10.1371/journal.pone.0059826
• http://doi.org/10.1371/journal.pgen.1005015
• http://doi.org/10.1186/1741-7007-10-50
• http://doi.org/10.7717/peerj.771
• http://doi.org/10.1098/rstb.2011.0287
• http://doi.org/10.1111/evo.12500
• http://doi.org/10.1093/molbev/msx190
• http://doi.org/10.1016/j.semcdb.2013.05.002
• http://doi.org/10.1093/gbe/evx039
• http://doi.org/10.1038/s41598-019-51181-1
• http://doi.org/10.1093/molbev/mst239
• http://doi.org/10.1371/journal.pone.0055915
• http://doi.org/10.1093/gbe/evv115
• http://doi.org/10.1371/journal.pbio.1002315
• http://doi.org/10.1080/19336934.2015.1074786
• http://doi.org/10.1038/nrg3124
• http://doi.org/10.1093/molbev/msv227
• http://doi.org/10.1093/gbe/evu198
• http://doi.org/10.1534/genetics.116.186825
• http://doi.org/10.1016/j.cois.2014.12.003
• http://doi.org/10.4161/spmg.21748
• http://doi.org/10.1007/s00239-016-9735-y
• http://doi.org/10.1371/journal.pbio.1002078
• http://doi.org/10.1146/annurev-genet-111212-133301
• http://doi.org/10.1093/molbev/msu072
• http://doi.org/10.1093/gbe/evs077
• http://doi.org/10.3390/genes9050242
• http://doi.org/10.1007/s10577-013-9353-0
• http://doi.org/10.1534/g3.117.040089
• http://doi.org/10.1007/s10577-011-9255-y
• http://doi.org/10.1371/journal.pbio.3000094
• http://doi.org/10.1016/j.cub.2013.08.021
• http://doi.org/10.1101/gr.217216.116
• http://doi.org/10.1371/journal.pgen.1003690
• http://doi.org/10.1093/gbe/evr109
• http://doi.org/10.1371/journal.pone.0065171
• http://doi.org/10.1093/gbe/evv117
• http://doi.org/10.1093/gbe/evw043
• http://doi.org/10.1534/genetics.116.191130
• http://doi.org/10.1134/S0006297912110077
• http://doi.org/10.1007/s00412-011-0346-5
• http://doi.org/10.1155/2012/191495
• http://doi.org/10.1038/hdy.2013.86

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

{"UNIPROT"=>48}

PubMed Central

• 3446302
• 3602674
• 3428665
• 3532075
• 3396367
• 3530687
• 3975062
• 3391427
• 4400102
• 4686125
• 3391172
• 3391177
• 3512148
• 3584000
• 4196619
• 3509754
• 4281893
• 4437546
• 3738461
• 3798269
• 4334168
• 3260437
• 3463555
• 3567030
• 3602378
• 3677924
• 4366066
• 3995337
• 3242482
• 3490416
• 3514954
• 3698931
• 3814203
• 4202334
• 4524482
• 4524484
• 4700948
• 3401529
• 3483712
• 3907100
• 3469443
• 3887524
• 4043116
• 4338770
• 4105432

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80052324184"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80052324184?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052324184&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80052324184&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/80052324184", "dc:identifier"=>"SCOPUS_ID:80052324184", "eid"=>"2-s2.0-80052324184", "dc:title"=>"Sex chromosome-specific regulation in the drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation", "dc:creator"=>"Meiklejohn C.", "prism:publicationName"=>"PLoS Biology", "prism:issn"=>"15449173", "prism:eIssn"=>"15457885", "prism:volume"=>"9", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-08-01", "prism:coverDisplayDate"=>"August 2011", "prism:doi"=>"10.1371/journal.pbio.1001126", "citedby-count"=>"76", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Rochester", "affiliation-city"=>"Rochester", "affiliation-country"=>"United States"}], "pubmed-id"=>"21857805", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1001126", "source-id"=>"12977", "openaccess"=>"1", "openaccessFlag"=>true}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosbiology%2Farticle%3Fid%3D10.1371%252Fjournal.pbio.1001126", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

Research Blogging

ScienceSeeker | Further Information

Twitter

Wikipedia

Wordpress.com | Further Information

Counter

• {"month"=>"8", "year"=>"2011", "pdf_views"=>"173", "xml_views"=>"21", "html_views"=>"820"}
• {"month"=>"9", "year"=>"2011", "pdf_views"=>"144", "xml_views"=>"11", "html_views"=>"615"}
• {"month"=>"10", "year"=>"2011", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"180"}
• {"month"=>"11", "year"=>"2011", "pdf_views"=>"40", "xml_views"=>"5", "html_views"=>"183"}
• {"month"=>"12", "year"=>"2011", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"143"}
• {"month"=>"1", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"118"}
• {"month"=>"2", "year"=>"2012", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"124"}
• {"month"=>"3", "year"=>"2012", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"133"}
• {"month"=>"4", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"87"}
• {"month"=>"5", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"92"}
• {"month"=>"6", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"67"}
• {"month"=>"7", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"73"}
• {"month"=>"8", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"6", "html_views"=>"101"}
• {"month"=>"9", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"45"}
• {"month"=>"10", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"90"}
• {"month"=>"11", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"97"}
• {"month"=>"12", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"63"}
• {"month"=>"1", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"114"}
• {"month"=>"2", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"247"}
• {"month"=>"3", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"98"}
• {"month"=>"4", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"61"}
• {"month"=>"5", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"42"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"52"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"77"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"110"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"129"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"280"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"272"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"175"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"86"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"223"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"241"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"203"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"158"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"144"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"140"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"100"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"112"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"96"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"114"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"69"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"44"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"95"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"44"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"43"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"45"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"36"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"62"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"52"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"50"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"52"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"46"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"99"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"63"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"35"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"38"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"27"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"36"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"25"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"40"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"35"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"18"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"6"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"5", "html_views"=>"12"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"10"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"11"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"19"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"13"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"15"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"21"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"5"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"10"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"2"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/745375"], "description"=>"<p>Spermatogenic stage and chromosomal effects on the expression of <i>ocn</i> transgenes.</p>", "links"=>[], "tags"=>["chromosomal"], "article_id"=>415757, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.t005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spermatogenic_stage_and_chromosomal_effects_on_the_expression_of_ocn_transgenes_/415757", "title"=>"Spermatogenic stage and chromosomal effects on the expression of <i>ocn</i> transgenes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-16 01:35:57"}
• {"files"=>["https://ndownloader.figshare.com/files/745283"], "description"=>"<p>(A) Expression of <i>ocn:lacZ</i> transgenes is low or absent in females, and is significantly lower for <i>X</i>-linked inserts than autosomal inserts in males. Bars indicate the mean expression measured from 8 <i>X</i>-linked and 8 autosomal <i>WOL</i> inserts and 6 <i>X</i>-linked and 5 autosomal <i>YLZ</i> inserts. RNA was extracted from whole adult flies and expression from autosomal inserts was measured in both heterozygous and homozygous male and homozygous female genotypes. (B) The difference between <i>X-</i>linked and autosomal inserts persists from premeiotic to meiotic cells in the male germline. A subset of genotypes (two <i>X-</i>linked and one autosomal <i>WOL</i> and two <i>X-</i>linked and one autosomal <i>YLZ</i>) shown in panel A were used for dissections (see <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#s4\" target=\"_blank\">Materials and Methods</a> for details). In both panels, gene expression is measured relative to a <i>Rpl32</i> control probe and error bars indicate 95% confidence intervals.</p>", "links"=>[], "tags"=>["spermatogenic"], "article_id"=>415660, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.g005", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_chromosome_and_spermatogenic_stage_effects_on_the_expression_of_WOL_and_YLZ_transgenes_/415660", "title"=>"Sex, chromosome, and spermatogenic stage effects on the expression of <i>WOL</i> and <i>YLZ</i> transgenes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-16 01:34:20"}
• {"files"=>["https://ndownloader.figshare.com/files/745469"], "description"=>"a<p>Autosomal totals exclude genes on the 4th chromosome.</p>", "links"=>[], "tags"=>["log2", "changes", "stages"], "article_id"=>415846, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.t002", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_log2_magnitude_of_changes_in_expression_between_stages_of_spermatogenesis_/415846", "title"=>"Median log2 magnitude of changes in expression between stages of spermatogenesis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-16 01:37:26"}
• {"files"=>["https://ndownloader.figshare.com/files/375824", "https://ndownloader.figshare.com/files/375933", "https://ndownloader.figshare.com/files/376000", "https://ndownloader.figshare.com/files/376372", "https://ndownloader.figshare.com/files/376403", "https://ndownloader.figshare.com/files/376439", "https://ndownloader.figshare.com/files/376476", "https://ndownloader.figshare.com/files/376519", "https://ndownloader.figshare.com/files/376570", "https://ndownloader.figshare.com/files/376610"], "description"=>"<div><p>The evolution of heteromorphic sex chromosomes (e.g., <em>XY</em> in males or <em>ZW</em> in females) has repeatedly elicited the evolution of two kinds of chromosome-specific regulation: dosage compensation—the equalization of <em>X</em> chromosome gene expression in males and females— and meiotic sex chromosome inactivation (MSCI)—the transcriptional silencing and heterochromatinization of the <em>X</em> during meiosis in the male (or <em>Z</em> in the female) germline. How the <em>X</em> chromosome is regulated in the <em>Drosophila melanogaster</em> male germline is unclear. Here we report three new findings concerning gene expression from the <em>X</em> in <em>Drosophila</em> testes. First, <em>X</em> chromosome-wide dosage compensation appears to be absent from most of the <em>Drosophila</em> male germline. Second, microarray analysis provides no evidence for <em>X</em> chromosome-specific inactivation during meiosis. Third, we confirm the previous discovery that the expression of transgene reporters driven by autosomal spermatogenesis-specific promoters is strongly reduced when inserted on the <em>X</em> chromosome versus the autosomes; but we show that this chromosomal difference in expression is established in premeiotic cells and persists in meiotic cells. The magnitude of the <em>X</em>-autosome difference in transgene expression cannot be explained by the absence of dosage compensation, suggesting that a previously unrecognized mechanism limits expression from the <em>X</em> during spermatogenesis in <em>Drosophila</em>. These findings help to resolve several previously conflicting reports and have implications for patterns of genome evolution and speciation in <em>Drosophila</em>.</p> </div>", "links"=>[], "tags"=>["chromosome-specific", "germline", "chromosomal", "dosage", "meiotic", "inactivation"], "article_id"=>134237, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.1001126.s001", "https://dx.doi.org/10.1371/journal.pbio.1001126.s002", "https://dx.doi.org/10.1371/journal.pbio.1001126.s003", "https://dx.doi.org/10.1371/journal.pbio.1001126.s004", "https://dx.doi.org/10.1371/journal.pbio.1001126.s005", "https://dx.doi.org/10.1371/journal.pbio.1001126.s006", "https://dx.doi.org/10.1371/journal.pbio.1001126.s007", "https://dx.doi.org/10.1371/journal.pbio.1001126.s008", "https://dx.doi.org/10.1371/journal.pbio.1001126.s009", "https://dx.doi.org/10.1371/journal.pbio.1001126.s010"], "stats"=>{"downloads"=>10, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Sex_Chromosome_Specific_Regulation_in_the_Drosophila_Male_Germline_But_Little_Evidence_for_Chromosomal_Dosage_Compensation_or_Meiotic_Inactivation/134237", "title"=>"Sex Chromosome-Specific Regulation in the <em>Drosophila</em> Male Germline But Little Evidence for Chromosomal Dosage Compensation or Meiotic Inactivation", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-08-16 01:10:37"}
• {"files"=>["https://ndownloader.figshare.com/files/744836"], "description"=>"<p>(A) Autosome and <i>X</i> chromosome expression in cells in the male thorax and female thorax. (B) Autosome and <i>X</i> chromosome gene expression from control cells and from <i>SL2</i> cells in which dosage compensation has been knocked down by RNAi against <i>msl2 </i><a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#pbio.1001126-Hamada1\" target=\"_blank\">[43]</a>. (C–E) Autosome and <i>X</i> chromosome gene expression in the male germline. Premeiotic cells were dissected from the apical tip of the testes; meiotic cells were dissected from the proximal region of the testes. Data in (C) are from Agilent <i>Drosophila</i> gene expression microarrays; (D) shows previously published data <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#pbio.1001126-Vibranovski1\" target=\"_blank\">[41]</a> using Affymetrix GeneChips. (E) Previously published <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#pbio.1001126-Gan1\" target=\"_blank\">[48]</a> RNA-seq data from wild-type testes. *** <i>p</i><0.001 (Mann-Whitney test).</p>", "links"=>[], "tags"=>["chromosome", "autosomal", "dosage"], "article_id"=>415210, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_X_chromosome_and_autosomal_gene_expression_are_consistent_with_no_dosage_compensation_in_Drosophila_primary_spermatocytes_/415210", "title"=>"<i>X</i> chromosome and autosomal gene expression are consistent with no dosage compensation in <i>Drosophila</i> primary spermatocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-16 01:26:50"}
• {"files"=>["https://ndownloader.figshare.com/files/745501"], "description"=>"a<p>Autosomal totals exclude genes on the 4th chromosome.</p>", "links"=>[], "tags"=>["genes", "differences", "stages"], "article_id"=>415877, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.t001", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_genes_with_significant_differences_in_expression_between_stages_of_spermatogenesis_/415877", "title"=>"Number of genes with significant differences in expression between stages of spermatogenesis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-16 01:37:57"}
• {"files"=>["https://ndownloader.figshare.com/files/744937"], "description"=>"<p>(A) The distributions of expression differences between <i>msl2</i>-RNAi and control cells for <i>X</i> chromosome and autosomal probes <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#pbio.1001126-Hamada1\" target=\"_blank\">[43]</a>. (B) The distributions of expression differences between male germline cells and male thorax tissue for <i>X</i> and autosomal probes. Black lines indicate the median values of each distribution; the difference between the median log2 expression of autosomal and <i>X-</i>linked probes is 0.398 in (A) and 0.568 in (B).</p>", "links"=>[], "tags"=>["autosomal", "male-like", "cells", "dosage", "differences", "somatic", "germline"], "article_id"=>415301, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.g002", "stats"=>{"downloads"=>3, "page_views"=>38, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differences_in_X_linked_and_autosomal_gene_expression_between_male_like_SL2_cells_with_and_without_dosage_compensation_are_similar_to_the_differences_between_somatic_and_germline_cells_in_males_/415301", "title"=>"Differences in <i>X</i>-linked and autosomal gene expression between male-like <i>SL2</i> cells with and without dosage compensation are similar to the differences between somatic and germline cells in males.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-16 01:28:21"}
• {"files"=>["https://ndownloader.figshare.com/files/745167"], "description"=>"<p>RNA-seq data <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#pbio.1001126-Gan1\" target=\"_blank\">[48]</a> from wild-type ovaries, <i>bam</i> mutant ovaries, and <i>bam</i> mutant testes. * <i>p</i><0.05, *** <i>p</i><0.001 (Mann-Whitney test).</p>", "links"=>[], "tags"=>["chromosome", "autosome", "ovaries", "germline"], "article_id"=>415539, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.g003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_X_chromosome_and_autosome_expression_is_similar_in_ovaries_and_germline_stem_cells_/415539", "title"=>"<i>X</i> chromosome and autosome expression is similar in ovaries and germline stem cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-16 01:32:19"}
• {"files"=>["https://ndownloader.figshare.com/files/745404"], "description"=>"<p>Sex, transgene, and chromosomal effects on the expression of <i>ocn</i> transgenes.</p>", "links"=>[], "tags"=>["chromosomal"], "article_id"=>415782, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.t004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_transgene_and_chromosomal_effects_on_the_expression_of_ocn_transgenes_/415782", "title"=>"Sex, transgene, and chromosomal effects on the expression of <i>ocn</i> transgenes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-16 01:36:22"}
• {"files"=>["https://ndownloader.figshare.com/files/745228"], "description"=>"<p>(A & B) qRT-PCR results for 12 genes from premeiotic and meiotic dissections show good correspondence with previously published microarray results <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#pbio.1001126-Vibranovski1\" target=\"_blank\">[41]</a>. (C) Apical dissections (premeiotic cells) including the testis sheath show slight but detectable increases in the expression of <i>X</i>-linked genes relative to apical dissections from which the sheath has been removed. *** <i>p</i><0.001.</p>", "links"=>[], "tags"=>["indicates", "contaminating", "testis", "sheath", "detectable"], "article_id"=>415602, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qRT_PCR_analysis_indicates_the_contaminating_effect_of_testis_sheath_has_a_detectable_effect_on_gene_expression_/415602", "title"=>"qRT-PCR analysis indicates the contaminating effect of testis sheath has a detectable effect on gene expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-16 01:33:22"}
• {"files"=>["https://ndownloader.figshare.com/files/745443"], "description"=>"<p>Gene expression differences are log2 fold-change between the various dissections. qRT-PCR values were normalized by three control genes (see <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001126#s4\" target=\"_blank\">Materials and Methods</a>).</p>a<p>Premeiotic dissections with testis sheath included − meiotic dissections.</p>b<p>Premeiotic dissections with testis sheath included − premeiotic dissections with testis sheath removed.</p>c<p>Sheath effect is calculated as the ratio of (Ps−Pn)/(Ps−M) from qRT-PCR.</p>d<p><i>p-</i>value calculated from paired <i>t</i> tests between Ps and Pn.</p>", "links"=>[], "tags"=>["somatic", "testis", "sheath", "detectable", "changes", "stages"], "article_id"=>415807, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Colin D. Meiklejohn", "Emily L. Landeen", "Jodi M. Cook", "Sarah B. Kingan", "Daven C. Presgraves"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001126.t003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contamination_by_somatic_testis_sheath_has_detectable_effects_on_changes_in_gene_expression_between_stages_of_spermatogenesis_/415807", "title"=>"Contamination by somatic testis sheath has detectable effects on changes in gene expression between stages of spermatogenesis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-16 01:36:47"}

PMC Usage Stats | Further Information

• {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"33", "unique-ip"=>"30", "pdf"=>"19", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "year"=>"2011", "pdf"=>"11", "unique-ip"=>"19", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"45", "unique-ip"=>"39", "pdf"=>"19", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"12", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"47", "unique-ip"=>"22", "pdf"=>"20", "year"=>"2012", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"16", "pdf"=>"4", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "year"=>"2012", "pdf"=>"9", "unique-ip"=>"14", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"6", "unique-ip"=>"9", "pdf"=>"2", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
• {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
• {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
• {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
• {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"24", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"14", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"37", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"26", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"11", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"12", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"11", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"17", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"7", "full-text"=>"16", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 571, 709, 823, 937, 1038, 1133, 1216, 1298, 1370, 1447, 1518, 1588, 1656, 1725, 1790, 1856, 1926, 1992, 2054, 2118, 2182, 2242, 2301, 2363, 2425, 2484, 2544, 2602, 2662, 2716, 2776, 2841, 2901, 2960, 3016, 3071]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[301, 559, 686, 796, 908, 1013, 1103, 1196, 1281, 1355, 1431, 1507, 1579, 1648, 1711, 1778, 1841, 1910, 1967, 2034, 2087, 2141, 2202, 2261, 2320, 2386, 2444, 2502, 2566, 2632, 2691, 2755, 2812, 2873, 2929, 2997, 3047]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[296, 554, 686, 802, 910, 1014, 1104, 1195, 1277, 1349, 1419, 1483, 1551, 1620, 1690, 1757, 1820, 1888, 1957, 2017, 2081, 2140, 2202, 2259]}, {"subject_area"=>"/Medicine and health sciences/Clinical genetics", "average_usage"=>[327, 696, 837, 997, 1118, 1255, 1370, 1466, 1530, 1602, 1687, 1779, 1865, 1969, 2039, 2105, 2165, 2218, 2288, 2345, 2427, 2494, 2526, 2580, 2659, 2725, 2826, 2877, 2918, 2966, 3034, 3114, 3167, 3203, 3238, 3282, 3370]}]}

F1000Prime