CiteULike

Mendeley | Further Information

{"title"=>"Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection", "type"=>"journal", "authors"=>[{"first_name"=>"Ivan Lilyanov", "last_name"=>"Dzhagalov", "scopus_author_id"=>"8933859100"}, {"first_name"=>"Katherine Grace", "last_name"=>"Chen", "scopus_author_id"=>"55984008100"}, {"first_name"=>"Paul", "last_name"=>"Herzmark", "scopus_author_id"=>"6602248155"}, {"first_name"=>"Ellen A.", "last_name"=>"Robey", "scopus_author_id"=>"7005541821"}], "year"=>2013, "source"=>"PLoS Biology", "identifiers"=>{"sgr"=>"84878289907", "doi"=>"10.1371/journal.pbio.1001566", "pui"=>"369013928", "pmid"=>"23700386", "scopus"=>"2-s2.0-84878289907", "issn"=>"15449173", "isbn"=>"1545-7885"}, "id"=>"ca569eb2-a5db-3e30-ba75-bbbf2078236f", "abstract"=>"The elimination of autoreactive T cells occurs via thymocyte apoptosis and removal by thymic phagocytes, but the sequence of events in vivo, and the relationship between thymocyte death and phagocytic clearance, are unknown. Here we address these questions by following a synchronized cohort of thymocytes undergoing negative selection within a three-dimensional thymic tissue environment, from the initial encounter with a negative selecting ligand to thymocyte death and clearance. Encounter with cognate peptide-MHC complexes results in rapid calcium flux and migratory arrest in auto-reactive thymocytes over a broad range of peptide concentrations, followed by a lag period in which gene expression changes occurred, but there was little sign of thymocyte death. Caspase 3 activation and thymocyte loss were first detectable at 2 and 3 hours, respectively, and entry of individual thymocytes into the death program occurred asynchronously over the next 10 hours. Two-photon time-lapse imaging revealed that thymocyte death and phagocytosis occurred simultaneously, often with thymocytes engulfed prior to changes in chromatin and membrane permeability. Our data provide a timeline for negative selection and reveal close coupling between cell death and clearance in the thymus.", "link"=>"http://www.mendeley.com/research/elimination-selfreactive-t-cells-thymus-timeline-negative-selection", "reader_count"=>65, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>4, "Student > Master"=>7, "Student > Bachelor"=>5, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>4, "Student > Master"=>7, "Student > Bachelor"=>5, "Professor"=>5}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>4, "Mathematics"=>1, "Agricultural and Biological Sciences"=>36, "Medicine and Dentistry"=>4, "Chemistry"=>2, "Social Sciences"=>1, "Immunology and Microbiology"=>12}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>12}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>36}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Greece"=>1, "Belgium"=>1, "Brazil"=>1, "Denmark"=>1, "Israel"=>1, "Portugal"=>2}, "group_count"=>1}

ORCID | Further Information

CrossRef

• http://doi.org/10.4049/jimmunol.2000225
• http://doi.org/10.4049/jimmunol.1500361
• http://doi.org/10.1038/s41577-018-0083-6
• http://doi.org/10.1155/2018/4126106
• http://doi.org/10.1038/s41584-020-0455-8
• http://doi.org/10.1371/journal.pone.0071228
• http://doi.org/10.7554/eLife.03468
• http://doi.org/10.1371/journal.pone.0108941
• http://doi.org/10.1084/jem.20150178
• http://doi.org/10.1111/imr.12532
• http://doi.org/10.1084/jem.20161375
• http://doi.org/10.3389/fimmu.2015.00442
• http://doi.org/10.1016/j.devcel.2016.06.029
• http://doi.org/10.1038/s41590-020-0746-x
• http://doi.org/10.3390/ijms20174179
• http://doi.org/10.1111/imr.12398
• http://doi.org/10.1016/j.it.2017.10.007
• http://doi.org/10.1073/pnas.1408482111
• http://doi.org/10.1007/s10495-018-01511-x
• http://doi.org/10.3390/ijms21176200
• http://doi.org/10.7554/eLife.48097
• http://doi.org/10.4049/jimmunol.1700566
• http://doi.org/10.1084/jem.20200318
• http://doi.org/10.1038/s41467-019-09727-4
• http://doi.org/10.1371/journal.pcbi.1005417
• http://doi.org/10.1038/s41593-018-0192-3
• http://doi.org/10.1007/s00018-014-1607-2
• http://doi.org/10.4049/jimmunol.1900619
• http://doi.org/10.2217/imt.13.157
• http://doi.org/10.1093/intimm/dxv022
• http://doi.org/10.1126/scisignal.2004400
• http://doi.org/10.1146/annurev-cellbio-111315-125324
• http://doi.org/10.1038/s41385-020-0295-5
• http://doi.org/10.3389/fcell.2020.586807
• http://doi.org/10.1038/ni.2938
• http://doi.org/10.1016/j.intimp.2020.106262
• http://doi.org/10.1038/ni.2918
• http://doi.org/10.3389/fimmu.2018.00492

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations

PubMed Central

• 4078834
• 4078262
• 4095875
• 4348363
• 3738515
• 4182564
• 4612092
• 3756479
• 3912788
• 4564722
• 4171708

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84878289907"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84878289907?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878289907&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84878289907&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84878289907", "dc:identifier"=>"SCOPUS_ID:84878289907", "eid"=>"2-s2.0-84878289907", "dc:title"=>"Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection", "dc:creator"=>"Dzhagalov I.", "prism:publicationName"=>"PLoS Biology", "prism:issn"=>"15449173", "prism:eIssn"=>"15457885", "prism:volume"=>"11", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-06-03", "prism:coverDisplayDate"=>"2013", "prism:doi"=>"10.1371/journal.pbio.1001566", "citedby-count"=>"49", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of California, Berkeley", "affiliation-city"=>"Berkeley", "affiliation-country"=>"United States"}], "pubmed-id"=>"23700386", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1001566", "source-id"=>"12977", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosbiology%2Farticle%3Fid%3D10.1371%252Fjournal.pbio.1001566", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

Research Blogging

ScienceSeeker | Further Information

Twitter

• {"id"=>"337221002293551104", "text"=>"Watching how T cells are eliminated in the #thymus - #PLOSBiology paper http://t.co/OST3MOGsl6 synopsis http://t.co/5hqHkuCvSN", "created_at"=>"2013-05-22T14:58:46Z", "user"=>"PLOSBiology", "user_name"=>"PLOS Biology", "user_profile_image"=>"http://a0.twimg.com/profile_images/2432741784/7kk4r2cpabm7u2lqf17y_normal.jpeg"}
• {"id"=>"337260036898312192", "text"=>"#PLOSBiology: Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection http://t.co/grwr7pbWip", "created_at"=>"2013-05-22T17:33:53Z", "user"=>"drleemachado", "user_name"=>"Lee Machado", "user_profile_image"=>"http://a0.twimg.com/profile_images/3174100902/a2cfea440b53b3cde94acc3f41a107b2_normal.png"}
• {"id"=>"337363316584349696", "text"=>"Fun immunology stuff via @drleemachado: #PLOSBiology: Elimination of Self-Reactive T Cells in the Thymus A Timeline http://t.co/DTuVRuQBkB", "created_at"=>"2013-05-23T00:24:17Z", "user"=>"luddyka", "user_name"=>"Kim Luddy", "user_profile_image"=>"http://a0.twimg.com/profile_images/2741230006/1f2267e956ebf85cd3402dd5d9c5f406_normal.jpeg"}

Wikipedia | Further Information

• {"title"=>"File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s004.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s004.ogv", "timestamp"=>"2017-12-12T08:50:13Z"}
• {"title"=>"File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s005.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s005.ogv", "timestamp"=>"2017-12-12T08:50:13Z"}
• {"title"=>"File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s003.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s003.ogv", "timestamp"=>"2017-12-12T08:50:13Z"}
• {"title"=>"File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s002.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s002.ogv", "timestamp"=>"2017-12-12T08:50:13Z"}
• {"title"=>"File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s007.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s007.ogv", "timestamp"=>"2017-12-12T08:50:13Z"}
• {"title"=>"File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s006.ogv", "url"=>"http://commons.wikimedia.org/wiki/File:Elimination-of-Self-Reactive-T-Cells-in-the-Thymus-A-Timeline-for-Negative-Selection-pbio.1001566.s006.ogv", "timestamp"=>"2017-12-12T08:50:13Z"}

Wordpress.com | Further Information

Counter

• {"month"=>"5", "year"=>"2013", "pdf_views"=>"179", "xml_views"=>"16", "html_views"=>"1716"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"156", "xml_views"=>"26", "html_views"=>"2405"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"217"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"192"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"240"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"4", "html_views"=>"522"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"317"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"324"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"126"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"217"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"299"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"280"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"275"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"205"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"159"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"3", "html_views"=>"101"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"150"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"224"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"201"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"137"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"141"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"112"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"83", "xml_views"=>"0", "html_views"=>"151"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"137"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"128"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"86"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"133"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"103"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"184"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"117"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"121"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"68"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"108"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"80"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"94"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"125"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"77"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"81"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"61"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"45"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"108"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"263"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"110"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"104"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"110"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"199"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"272"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"249"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"206"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"185"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"252"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"178"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"259"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"389"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"233"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"183"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"169"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"65"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"112"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"67"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"66"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"48"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"6", "html_views"=>"62"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"42"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"75"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"6", "html_views"=>"88"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"68"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"33"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"54"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"43"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"81"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"60"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"69"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"64"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"38"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"51"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"1", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"34"}
• {"month"=>"2", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"36"}
• {"month"=>"3", "year"=>"2020", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"69"}
• {"month"=>"4", "year"=>"2020", "pdf_views"=>"54", "xml_views"=>"1", "html_views"=>"49"}
• {"month"=>"5", "year"=>"2020", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"6", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"7", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"8", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"9", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"10", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"11", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"24"}
• {"month"=>"12", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"1", "year"=>"2021", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"20"}
• {"month"=>"2", "year"=>"2021", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"26"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1065408", "https://ndownloader.figshare.com/files/1065410", "https://ndownloader.figshare.com/files/1065413", "https://ndownloader.figshare.com/files/1065414", "https://ndownloader.figshare.com/files/1065416", "https://ndownloader.figshare.com/files/1065417", "https://ndownloader.figshare.com/files/1065421"], "description"=>"<div><p>The elimination of autoreactive T cells occurs via thymocyte apoptosis and removal by thymic phagocytes, but the sequence of events <i>in vivo</i>, and the relationship between thymocyte death and phagocytic clearance, are unknown. Here we address these questions by following a synchronized cohort of thymocytes undergoing negative selection within a three-dimensional thymic tissue environment, from the initial encounter with a negative selecting ligand to thymocyte death and clearance. Encounter with cognate peptide–MHC complexes results in rapid calcium flux and migratory arrest in auto-reactive thymocytes over a broad range of peptide concentrations, followed by a lag period in which gene expression changes occurred, but there was little sign of thymocyte death. Caspase 3 activation and thymocyte loss were first detectable at 2 and 3 hours, respectively, and entry of individual thymocytes into the death program occurred asynchronously over the next 10 hours. Two-photon time-lapse imaging revealed that thymocyte death and phagocytosis occurred simultaneously, often with thymocytes engulfed prior to changes in chromatin and membrane permeability. Our data provide a timeline for negative selection and reveal close coupling between cell death and clearance in the thymus.</p></div>", "links"=>[], "tags"=>["immunology", "Immune cells", "t cells", "immunity", "Immune tolerance", "self-reactive", "cells", "timeline"], "article_id"=>705784, "categories"=>["Biological Sciences"], "users"=>["Ivan Lilyanov Dzhagalov", "Katherine Grace Chen", "Paul Herzmark", "Ellen A. Robey"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.1001566.s001", "https://dx.doi.org/10.1371/journal.pbio.1001566.s002", "https://dx.doi.org/10.1371/journal.pbio.1001566.s003", "https://dx.doi.org/10.1371/journal.pbio.1001566.s004", "https://dx.doi.org/10.1371/journal.pbio.1001566.s005", "https://dx.doi.org/10.1371/journal.pbio.1001566.s006", "https://dx.doi.org/10.1371/journal.pbio.1001566.s007"], "stats"=>{"downloads"=>13, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Elimination_of_Self_Reactive_T_Cells_in_the_Thymus_A_Timeline_for_Negative_Selection_/705784", "title"=>"Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-05-21 01:36:24"}

PMC Usage Stats | Further Information

• {"unique-ip"=>"28", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"41", "cited-by"=>"1", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"32", "full-text"=>"30", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
• {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"1", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"14", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"35", "full-text"=>"44", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"7", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"33", "full-text"=>"46", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"4", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"24", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"30", "full-text"=>"38", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"14", "full-text"=>"41", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"37", "full-text"=>"37", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"54", "full-text"=>"51", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"27", "full-text"=>"23", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"45", "full-text"=>"47", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"38", "full-text"=>"37", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"32", "full-text"=>"46", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"3", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"35", "full-text"=>"34", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"26", "full-text"=>"39", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"28", "full-text"=>"32", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"49", "full-text"=>"32", "pdf"=>"49", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"61", "full-text"=>"65", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"55", "full-text"=>"54", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"41", "full-text"=>"36", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"28", "full-text"=>"24", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"40", "full-text"=>"36", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"44", "full-text"=>"38", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"27", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"50", "full-text"=>"43", "pdf"=>"25", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"63", "full-text"=>"59", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"72", "full-text"=>"73", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"66", "full-text"=>"66", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"54", "full-text"=>"52", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"33", "full-text"=>"34", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"35", "full-text"=>"28", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"56", "full-text"=>"68", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"127", "full-text"=>"136", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"114", "full-text"=>"121", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"56", "full-text"=>"64", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
• {"unique-ip"=>"39", "full-text"=>"41", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}]}

F1000Prime | Further Information

• {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-05-26T08:35:32Z"}
• {"year"=>2014, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-06-30T08:35:25Z"}
• {"year"=>2014, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-07-28T08:35:35Z"}
• {"year"=>2014, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-08-25T08:35:34Z"}
• {"year"=>2014, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-09-29T08:35:37Z"}
• {"year"=>2014, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-10-27T08:35:17Z"}
• {"year"=>2014, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-11-24T09:33:26Z"}
• {"year"=>2014, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2014-12-29T09:43:15Z"}
• {"year"=>2015, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-01-26T09:41:06Z"}
• {"year"=>2015, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-02-23T09:41:06Z"}
• {"year"=>2015, "month"=>3, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-03-23T08:41:26Z"}
• {"year"=>2015, "month"=>4, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-04-27T08:41:15Z"}
• {"year"=>2015, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-05-25T08:41:05Z"}
• {"year"=>2015, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-06-29T08:41:09Z"}
• {"year"=>2015, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-07-27T08:41:01Z"}
• {"year"=>2015, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-08-31T08:41:13Z"}
• {"year"=>2015, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-09-28T08:41:00Z"}
• {"year"=>2015, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-10-26T08:41:19Z"}
• {"year"=>2015, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-11-30T09:41:20Z"}
• {"year"=>2015, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2015-12-28T09:41:23Z"}
• {"year"=>2016, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-01-25T09:41:23Z"}
• {"year"=>2016, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-02-29T09:40:57Z"}
• {"year"=>2016, "month"=>3, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-03-28T08:40:54Z"}
• {"year"=>2016, "month"=>4, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-04-25T08:41:04Z"}
• {"year"=>2016, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-05-16T08:41:02Z"}
• {"year"=>2016, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-06-27T08:40:59Z"}
• {"year"=>2016, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-07-25T08:40:57Z"}
• {"year"=>2016, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-08-29T08:40:50Z"}
• {"year"=>2016, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-09-26T08:40:56Z"}
• {"year"=>2016, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-10-31T08:40:55Z"}
• {"year"=>2016, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-11-28T09:40:58Z"}
• {"year"=>2016, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2016-12-26T09:41:11Z"}
• {"year"=>2017, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-01-30T09:41:05Z"}
• {"year"=>2017, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-02-27T09:41:10Z"}
• {"year"=>2017, "month"=>3, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-03-27T08:41:01Z"}
• {"year"=>2017, "month"=>4, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-04-24T08:41:03Z"}
• {"year"=>2017, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-05-29T08:41:02Z"}
• {"year"=>2017, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"http://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-06-26T08:41:08Z"}
• {"year"=>2017, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-07-31T08:41:02Z"}
• {"year"=>2017, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-08-28T08:41:07Z"}
• {"year"=>2017, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-09-25T08:41:10Z"}
• {"year"=>2017, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-10-30T08:41:32Z"}
• {"year"=>2017, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-11-27T09:41:13Z"}
• {"year"=>2017, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2017-12-25T09:41:02Z"}
• {"year"=>2018, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-01-29T09:40:48Z"}
• {"year"=>2018, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-02-26T09:40:51Z"}
• {"year"=>2018, "month"=>3, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-03-26T08:40:52Z"}
• {"year"=>2018, "month"=>4, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-04-30T08:40:49Z"}
• {"year"=>2018, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-05-28T08:40:51Z"}
• {"year"=>2018, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-06-25T08:40:51Z"}
• {"year"=>2018, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-07-30T08:40:58Z"}
• {"year"=>2018, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-08-27T08:41:04Z"}
• {"year"=>2018, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-09-24T08:40:59Z"}
• {"year"=>2018, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-10-29T08:41:02Z"}
• {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-11-26T09:40:57Z"}
• {"year"=>2018, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2018-12-31T09:41:09Z"}
• {"year"=>2019, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-01-28T09:40:55Z"}
• {"year"=>2019, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-02-25T09:40:58Z"}
• {"year"=>2019, "month"=>3, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-03-25T08:40:53Z"}
• {"year"=>2019, "month"=>4, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-04-29T08:41:02Z"}
• {"year"=>2019, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-05-27T08:41:07Z"}
• {"year"=>2019, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-06-24T08:41:00Z"}
• {"year"=>2019, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-07-29T08:41:16Z"}
• {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-08-26T08:41:07Z"}
• {"year"=>2019, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-09-30T08:41:08Z"}
• {"year"=>2019, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-10-28T08:41:07Z"}
• {"year"=>2019, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-11-25T09:41:10Z"}
• {"year"=>2019, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2019-12-30T09:41:25Z"}
• {"year"=>2020, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-01-27T09:41:02Z"}
• {"year"=>2020, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-02-24T09:41:08Z"}
• {"year"=>2020, "month"=>3, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-03-30T08:41:10Z"}
• {"year"=>2020, "month"=>4, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-04-27T08:41:05Z"}
• {"year"=>2020, "month"=>5, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-05-25T08:41:06Z"}
• {"year"=>2020, "month"=>6, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-06-29T08:41:08Z"}
• {"year"=>2020, "month"=>7, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-07-27T08:41:06Z"}
• {"year"=>2020, "month"=>8, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-08-31T08:41:13Z"}
• {"year"=>2020, "month"=>9, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-09-28T08:41:10Z"}
• {"year"=>2020, "month"=>10, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-10-26T08:41:07Z"}
• {"year"=>2020, "month"=>11, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-11-30T09:41:12Z"}
• {"year"=>2020, "month"=>12, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2020-12-28T09:41:11Z"}
• {"year"=>2021, "month"=>1, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2021-01-25T09:41:14Z"}
• {"year"=>2021, "month"=>2, "doi"=>"10.1371/journal.pbio.1001566", "f1000_id"=>"718113570", "url"=>"https://f1000.com/prime/718113570", "score"=>2, "classifications"=>["new_finding"], "updated_at"=>"2021-02-22T09:41:08Z"}