The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
- Publication Date
- June 24, 2014
- Journal
- PLOS Biology
- Authors
- Cendrine Tourette, Francesca Farina, Rafael P. Vazquez Manrique, Anne Marie Orfila, et al
- Volume
- 12
- Issue
- 6
- Pages
- e1001895
- DOI
- https://dx.plos.org/10.1371/journal.pbio.1001895
- Publisher URL
- http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1001895
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24960609
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068980
- Europe PMC
- http://europepmc.org/abstract/MED/24960609
- Web of Science
- 000337972900022
- Scopus
- 84903289274
- Mendeley
- http://www.mendeley.com/research/wnt-receptor-ryk-reduces-neuronal-cell-survival-capacity-repressing-foxo-activity-during-early-phase
Loading … 

Events
Loading … 

Mendeley | Further Information
{"title"=>"The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity", "type"=>"journal", "authors"=>[{"first_name"=>"Cendrine", "last_name"=>"Tourette", "scopus_author_id"=>"24448926000"}, {"first_name"=>"Francesca", "last_name"=>"Farina", "scopus_author_id"=>"57198007919"}, {"first_name"=>"Rafael P.", "last_name"=>"Vazquez-Manrique", "scopus_author_id"=>"8859803400"}, {"first_name"=>"Anne Marie", "last_name"=>"Orfila", "scopus_author_id"=>"54393966000"}, {"first_name"=>"Jessica", "last_name"=>"Voisin", "scopus_author_id"=>"56230146300"}, {"first_name"=>"Sonia", "last_name"=>"Hernandez", "scopus_author_id"=>"57196856392"}, {"first_name"=>"Nicolas", "last_name"=>"Offner", "scopus_author_id"=>"6506741808"}, {"first_name"=>"J. Alex", "last_name"=>"Parker", "scopus_author_id"=>"8872254300"}, {"first_name"=>"Sophie", "last_name"=>"Menet", "scopus_author_id"=>"55351380900"}, {"first_name"=>"Jinho", "last_name"=>"Kim", "scopus_author_id"=>"56156484200"}, {"first_name"=>"Jungmok", "last_name"=>"Lyu", "scopus_author_id"=>"56230141000"}, {"first_name"=>"Si Ho", "last_name"=>"Choi", "scopus_author_id"=>"56754392700"}, {"first_name"=>"Kerry", "last_name"=>"Cormier", "scopus_author_id"=>"8546174600"}, {"first_name"=>"Christina K.", "last_name"=>"Edgerly", "scopus_author_id"=>"35784367700"}, {"first_name"=>"Olivia L.", "last_name"=>"Bordiuk", "scopus_author_id"=>"36056028100"}, {"first_name"=>"Karen", "last_name"=>"Smith", "scopus_author_id"=>"7410185916"}, {"first_name"=>"Anne", "last_name"=>"Louise", "scopus_author_id"=>"6602951742"}, {"first_name"=>"Michael", "last_name"=>"Halford", "scopus_author_id"=>"6602542917"}, {"first_name"=>"Steven", "last_name"=>"Stacker", "scopus_author_id"=>"35444491800"}, {"first_name"=>"Jean Philippe", "last_name"=>"Vert", "scopus_author_id"=>"6603053445"}, {"first_name"=>"Robert J.", "last_name"=>"Ferrante", "scopus_author_id"=>"7004812342"}, {"first_name"=>"Wange", "last_name"=>"Lu", "scopus_author_id"=>"7404214890"}, {"first_name"=>"Christian", "last_name"=>"Neri", "scopus_author_id"=>"7007014997"}], "year"=>2014, "source"=>"PLoS Biology", "identifiers"=>{"scopus"=>"2-s2.0-84903289274", "sgr"=>"84903289274", "issn"=>"15457885", "doi"=>"10.1371/journal.pbio.1001895", "pmid"=>"24960609", "isbn"=>"1545-7885 (Electronic)\\r1544-9173 (Linking)", "pui"=>"373398345"}, "id"=>"63af7eba-6911-32e0-8f48-07b89bd1cadb", "abstract"=>"The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway may be neuroprotective, the role of Ryk in neurodegenerative disease remains unknown. We found that Ryk is up-regulated in neurons expressing mutant huntingtin (HTT) in several models of Huntington's disease (HD). Further investigation in Caenorhabditis elegans and mouse striatal cell models of HD provided a model in which the early-stage increase of Ryk promotes neuronal dysfunction by repressing the neuroprotective activity of the longevity-promoting factor FOXO through a noncanonical mechanism that implicates the Ryk-ICD fragment and its binding to the FOXO co-factor β-catenin. The Ryk-ICD fragment suppressed neuroprotection by lin-18/Ryk loss-of-function in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished β-catenin protection of mutant htt striatal cells against cell death vulnerability. Additionally, Ryk-ICD was increased in the nucleus of mutant htt cells, and reducing γ-secretase PS1 levels compensated for the cytotoxicity of full-length Ryk in these cells. These findings reveal that the Ryk-ICD pathway may impair FOXO protective activity in mutant polyglutamine neurons, suggesting that neurons are unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in HD.", "link"=>"http://www.mendeley.com/research/wnt-receptor-ryk-reduces-neuronal-cell-survival-capacity-repressing-foxo-activity-during-early-phase", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>8, "Mathematics"=>1, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>6, "Neuroscience"=>4, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}CrossRef
- http://doi.org/10.1093/brain/awz174
- http://doi.org/10.1016/j.pneurobio.2019.101645
- http://doi.org/10.1016/j.phrs.2020.105105
- http://doi.org/10.1111/nan.12514
- http://doi.org/10.1242/dev.162701
- http://doi.org/10.1016/j.arr.2017.06.001
- http://doi.org/10.3892/ijmm.2020.4515
- http://doi.org/10.1007/s12035-015-9138-x
- http://doi.org/10.1016/j.csbj.2016.02.001
- http://doi.org/10.1038/s41598-017-04256-w
- http://doi.org/10.2174/1574893614666190308160507
- http://doi.org/10.1089/ars.2017.7084
- http://doi.org/10.1177/0271678X17702669
- http://doi.org/10.1242/dev.195388
- http://doi.org/10.1016/j.jneumeth.2015.07.026
- http://doi.org/10.1016/j.neulet.2016.11.003
- http://doi.org/10.1016/j.tig.2017.10.002
- http://doi.org/10.1111/acel.13226
- http://doi.org/10.1016/j.stemcr.2015.11.005
- http://doi.org/10.1074/jbc.M114.612424
- http://doi.org/10.1371/journal.pone.0204438
- http://doi.org/10.1038/s41418-018-0270-9
- http://doi.org/10.1093/bioinformatics/btz514
- http://doi.org/10.1080/08977194.2018.1472089
- http://doi.org/10.1371/journal.pgen.1006137
- http://doi.org/10.1093/brain/awv384
- http://doi.org/10.1038/npjamd.2016.1
- http://doi.org/10.1093/hmg/ddv513
- http://doi.org/10.1371/journal.pone.0173644
- http://doi.org/10.3233/JAD-179932
Europe PMC Database Citations | Further Information
{"UNIPROT"=>13}Scopus | Further Information
{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84903289274"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84903289274?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903289274&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84903289274&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84903289274", "dc:identifier"=>"SCOPUS_ID:84903289274", "eid"=>"2-s2.0-84903289274", "dc:title"=>"The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity", "dc:creator"=>"Tourette C.", "prism:publicationName"=>"PLoS Biology", "prism:issn"=>"15449173", "prism:eIssn"=>"15457885", "prism:volume"=>"12", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-01-01", "prism:coverDisplayDate"=>"2014", "prism:doi"=>"10.1371/journal.pbio.1001895", "citedby-count"=>"32", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Adaptation biologique et vieillissement", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}, {"@_fa"=>"true", "affilname"=>"Hôpital Universitaire Charles Foix", "affiliation-city"=>"Ivry-sur-Seine", "affiliation-country"=>"France"}, {"@_fa"=>"true", "affilname"=>"Sorbonne Universite", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}, {"@_fa"=>"true", "affilname"=>"Inserm", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}], "pubmed-id"=>"24960609", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1001895", "source-id"=>"12977", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}- {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosbiology%2Farticle%3Fid%3D10.1371%252Fjournal.pbio.1001895", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}
- {"id"=>"482197040365965312", "text"=>"Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co/UeT0NEjwWJ", "created_at"=>"2014-06-26T16:21:47Z", "user"=>"PLOSBiology", "user_name"=>"PLOS Biology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2432741784/7kk4r2cpabm7u2lqf17y_normal.jpeg"}
- {"id"=>"482208319252099073", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-06-26T17:06:36Z", "user"=>"cryptanalytics", "user_name"=>"Cryptanalyst", "user_profile_image"=>"http://pbs.twimg.com/profile_images/481896860034932736/coUaUJgp_normal.jpeg"}
- {"id"=>"482233004346318848", "text"=>"Early event in HD http://t.co/ximsNSrtPa #ChesterBiomed", "created_at"=>"2014-06-26T18:44:42Z", "user"=>"ProfJHHW", "user_name"=>"Prof John Williams", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000486976187/f10e734bfc920ee419bb9ba38923970d_normal.jpeg"}
- {"id"=>"482236212288421889", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-06-26T18:57:27Z", "user"=>"Markusmicrobius", "user_name"=>"Prof Mark Fielder", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3371635456/0fc5932628abec8c1449026f1146e673_normal.jpeg"}
- {"id"=>"482340188056993792", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-06-27T01:50:36Z", "user"=>"JAlexParker", "user_name"=>"LX", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2213813311/image_normal.jpg"}
- {"id"=>"482369267770195970", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-06-27T03:46:10Z", "user"=>"eatsleepneuro", "user_name"=>"eat sleep neurology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/461865362594598912/RUfVywFb_normal.jpeg"}
- {"id"=>"482567164579569664", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-06-27T16:52:32Z", "user"=>"vfriendlylion", "user_name"=>"Heather Cassell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/772667837/mypictr_126x160_normal.jpg"}
- {"id"=>"484903613236789248", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-07-04T03:36:45Z", "user"=>"HDAwareness", "user_name"=>"HD Awareness", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000820645929/3825ca5ff72654f178a3b5266f94a2f7_normal.jpeg"}
- {"id"=>"493565289268002817", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-07-28T01:15:09Z", "user"=>"HDAwareness", "user_name"=>"HD Awareness", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000820645929/3825ca5ff72654f178a3b5266f94a2f7_normal.jpeg"}
- {"id"=>"493578962690646017", "text"=>"RT @PLOSBiology: Early problems in #HuntingtonsDisease make #neurons vulnerable to damage - #PLOSBiology http://t.co/5qyieQ9QsN http://t.co…", "created_at"=>"2014-07-28T02:09:29Z", "user"=>"TheDeemeister", "user_name"=>"Deanna Ryan-Meister", "user_profile_image"=>"http://pbs.twimg.com/profile_images/770238198/Dee_illustration_normal.jpg"}
Counter
- {"month"=>"6", "year"=>"2014", "pdf_views"=>"166", "xml_views"=>"22", "html_views"=>"1174"}
- {"month"=>"7", "year"=>"2014", "pdf_views"=>"154", "xml_views"=>"12", "html_views"=>"2098"}
- {"month"=>"8", "year"=>"2014", "pdf_views"=>"50", "xml_views"=>"5", "html_views"=>"534"}
- {"month"=>"9", "year"=>"2014", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"260"}
- {"month"=>"10", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"209"}
- {"month"=>"11", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"204"}
- {"month"=>"12", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"111"}
- {"month"=>"1", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"134"}
- {"month"=>"2", "year"=>"2015", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"97"}
- {"month"=>"3", "year"=>"2015", "pdf_views"=>"54", "xml_views"=>"0", "html_views"=>"101"}
- {"month"=>"4", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"99"}
- {"month"=>"5", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"84"}
- {"month"=>"6", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"51"}
- {"month"=>"7", "year"=>"2015", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"84"}
- {"month"=>"8", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"9", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"91"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"109"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"64"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"39"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"51"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"51"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"55"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"55"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"84"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"48"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"81"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"75"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"51"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"49"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"69"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"47"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"57"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"46"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"39"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"54"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"26"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"27"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"83"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"30"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"16"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"4", "html_views"=>"5"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"11"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"5"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"7", "html_views"=>"2"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"7"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"5", "html_views"=>"16"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"19"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"8"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"5"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"2"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"8"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"4"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"10"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"7"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"5", "html_views"=>"3"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"3", "html_views"=>"16"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"30", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"63", "full-text"=>"76", "pdf"=>"31", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"118", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"41", "full-text"=>"34", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"38", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"57", "full-text"=>"44", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"20", "cited-by"=>"3", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"64", "full-text"=>"45", "pdf"=>"23", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"24", "cited-by"=>"2", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"40", "full-text"=>"31", "pdf"=>"6", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"32", "full-text"=>"41", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"24", "full-text"=>"39", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"36", "full-text"=>"34", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"30", "full-text"=>"27", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"38", "full-text"=>"34", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"23", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"23", "full-text"=>"11", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"25", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
- {"unique-ip"=>"18", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"18", "full-text"=>"25", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"22", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"11", "full-text"=>"209", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"12", "full-text"=>"21", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"6", "full-text"=>"15", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"13", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"20", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
- {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
- {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"36", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
- {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
- {"unique-ip"=>"23", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
- {"unique-ip"=>"22", "full-text"=>"13", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
- {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
- {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
- {"unique-ip"=>"12", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
- {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
- {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
- {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
- {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
Relative Metric
{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Biology and life sciences/Toxicology", "average_usage"=>[266, 408]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}, {"subject_area"=>"/Medicine and health sciences/Clinical genetics", "average_usage"=>[306, 468]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}]}Loading … 

There are currently no alerts