Stimulus-Dependent State Transition between Synchronized Oscillation and Randomly Repetitive Burst in a Model Cerebellar Granular Layer
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Stimulus-dependent state transition between synchronized oscillation and randomly repetitive burst in a model cerebellar granular layer", "type"=>"journal", "authors"=>[{"first_name"=>"Takeru", "last_name"=>"Honda", "scopus_author_id"=>"36165230700"}, {"first_name"=>"Tadashi", "last_name"=>"Yamazaki", "scopus_author_id"=>"8325867200"}, {"first_name"=>"Shigeru", "last_name"=>"Tanaka", "scopus_author_id"=>"55509987200"}, {"first_name"=>"Soichi", "last_name"=>"Nagao", "scopus_author_id"=>"7202295031"}, {"first_name"=>"Tetsuro", "last_name"=>"Nishino", "scopus_author_id"=>"7402557530"}], "year"=>2011, "source"=>"PLoS Computational Biology", "identifiers"=>{"doi"=>"10.1371/journal.pcbi.1002087", "pmid"=>"21779155", "issn"=>"1553734X", "isbn"=>"1553-734X", "sgr"=>"79960963201", "scopus"=>"2-s2.0-79960963201", "pui"=>"362246938"}, "id"=>"ffc5abfe-c4da-36d6-848e-7a866d27637f", "abstract"=>"Information processing of the cerebellar granular layer composed of granule and Golgi cells is regarded as an important first step toward the cerebellar computation. Our previous theoretical studies have shown that granule cells can exhibit random alternation between burst and silent modes, which provides a basis of population representation of the passage-of-time (POT) from the onset of external input stimuli. On the other hand, another computational study has reported that granule cells can exhibit synchronized oscillation of activity, as consistent with observed oscillation in local field potential recorded from the granular layer while animals keep still. Here we have a question of whether an identical network model can explain these distinct dynamics. In the present study, we carried out computer simulations based on a spiking network model of the granular layer varying two parameters: the strength of a current injected to granule cells and the concentration of Mg²⁺ which controls the conductance of NMDA channels assumed on the Golgi cell dendrites. The simulations showed that cells in the granular layer can switch activity states between synchronized oscillation and random burst-silent alternation depending on the two parameters. For higher Mg²⁺ concentration and a weaker injected current, granule and Golgi cells elicited spikes synchronously (synchronized oscillation state). In contrast, for lower Mg²⁺ concentration and a stronger injected current, those cells showed the random burst-silent alternation (POT-representing state). It is suggested that NMDA channels on the Golgi cell dendrites play an important role for determining how the granular layer works in response to external input.", "link"=>"http://www.mendeley.com/research/stimulusdependent-state-transition-between-synchronized-oscillation-randomly-repetitive-burst-model", "reader_count"=>17, "reader_count_by_academic_status"=>{"Researcher"=>9, "Student > Ph. D. Student"=>4, "Other"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>9, "Student > Ph. D. Student"=>4, "Other"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Computer Science"=>{"Computer Science"=>2}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>2, "Japan"=>2, "Germany"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79960963201"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79960963201?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960963201&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79960963201&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79960963201", "dc:identifier"=>"SCOPUS_ID:79960963201", "eid"=>"2-s2.0-79960963201", "dc:title"=>"Stimulus-dependent state transition between synchronized oscillation and randomly repetitive burst in a model cerebellar granular layer", "dc:creator"=>"Honda T.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"7", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-07-01", "prism:coverDisplayDate"=>"July 2011", "prism:doi"=>"10.1371/journal.pcbi.1002087", "citedby-count"=>"16", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"The University of Electro-Communications", "affiliation-city"=>"Chofu", "affiliation-country"=>"Japan"}, {"@_fa"=>"true", "affilname"=>"RIKEN Center for Brain Science", "affiliation-city"=>"Wako", "affiliation-country"=>"Japan"}], "pubmed-id"=>"21779155", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1002087", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%252Fjournal.pcbi.1002087", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"61", "xml_views"=>"10", "html_views"=>"378"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"27", "xml_views"=>"6", "html_views"=>"311"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"6", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"344"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"11"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"2"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"21", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/380546", "https://ndownloader.figshare.com/files/380594", "https://ndownloader.figshare.com/files/380637", "https://ndownloader.figshare.com/files/380675"], "description"=>"<div><p>Information processing of the cerebellar granular layer composed of granule and Golgi cells is regarded as an important first step toward the cerebellar computation. Our previous theoretical studies have shown that granule cells can exhibit random alternation between burst and silent modes, which provides a basis of population representation of the passage-of-time (POT) from the onset of external input stimuli. On the other hand, another computational study has reported that granule cells can exhibit synchronized oscillation of activity, as consistent with observed oscillation in local field potential recorded from the granular layer while animals keep still. Here we have a question of whether an identical network model can explain these distinct dynamics. In the present study, we carried out computer simulations based on a spiking network model of the granular layer varying two parameters: the strength of a current injected to granule cells and the concentration of Mg<sup>2+</sup> which controls the conductance of NMDA channels assumed on the Golgi cell dendrites. The simulations showed that cells in the granular layer can switch activity states between synchronized oscillation and random burst-silent alternation depending on the two parameters. For higher Mg<sup>2+</sup> concentration and a weaker injected current, granule and Golgi cells elicited spikes synchronously (synchronized oscillation state). In contrast, for lower Mg<sup>2+</sup> concentration and a stronger injected current, those cells showed the random burst-silent alternation (POT-representing state). It is suggested that NMDA channels on the Golgi cell dendrites play an important role for determining how the granular layer works in response to external input.</p> </div>", "links"=>[], "tags"=>["stimulus-dependent", "synchronized", "oscillation", "randomly", "repetitive", "cerebellar", "granular"], "article_id"=>135172, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>["https://dx.doi.org/10.1371/journal.pcbi.1002087.s001", "https://dx.doi.org/10.1371/journal.pcbi.1002087.s002", "https://dx.doi.org/10.1371/journal.pcbi.1002087.s003", "https://dx.doi.org/10.1371/journal.pcbi.1002087.s004"], "stats"=>{"downloads"=>6, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Stimulus_Dependent_State_Transition_between_Synchronized_Oscillation_and_Randomly_Repetitive_Burst_in_a_Model_Cerebellar_Granular_Layer/135172", "title"=>"Stimulus-Dependent State Transition between Synchronized Oscillation and Randomly Repetitive Burst in a Model Cerebellar Granular Layer", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-07-14 01:26:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/756458"], "description"=>"<p><b><i>A</i></b>, <i>I</i><sub>MF</sub> dependence of <i>OI</i> and <i>PI</i>. High value of <i>OI</i> and <i>PI</i> tended to appear complementarily along the <i>I</i><sub>MF</sub> axis: <i>OI</i> was larger at a smaller current, whereas <i>PI</i> was larger at a larger current. <b><i>B</i></b>, <i>I</i><sub>MF</sub> dependence of average firing rate and oscillation frequency of grcs. The average firing rate increased monotonically as <i>I</i><sub>MF</sub> increased. The oscillation frequency linearly increased from 9 to 14 Hz as <i>I</i><sub>MF</sub> increased from 9.5 to 18 pA within the high <i>OI</i> domain.</p>", "links"=>[], "tags"=>["states", "amplitudes", "injected"], "article_id"=>426828, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g007", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dynamical_states_of_the_network_for_various_amplitudes_of_the_injected_current_at_Mg_2_8202_8202_1_2_mM_/426828", "title"=>"Dynamical states of the network for various amplitudes of the injected current at [Mg<sup>2+</sup>] = 1.2 mM.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:53:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/756551"], "description"=>"<p>The abscissa and ordinate represent [Mg<sup>2+</sup>] and <i>I</i><sub>MF</sub>, respectively. Values of <i>OI</i> are shown in the brightness of the green color, where the darkest shade indicates <i>OI</i> = 0 and brightest shade indicates <i>OI</i> = 1. Values of <i>PI</i> are shown by the brightness of the red color such that the darkest shade indicates <i>PI</i> = 0 and the brightest shade indicates <i>PI</i> = 1. Greenish or reddish domains indicate that the network exhibited synchronized oscillatory states or POT-representing states, respectively. Eight typical points are picked out from this parameter space. The white lines represent average firing rates of grcs of 1, 5, 10, 15, 20, 30 and 40 Hz.</p>", "links"=>[], "tags"=>["spanned"], "article_id"=>426927, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g008", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OI_and_PI_for_the_present_model_in_the_space_spanned_by_Mg_2_and_I_MF_/426927", "title"=>"<i>OI</i> and <i>PI</i> for the present model in the space spanned by [Mg<sup>2+</sup>] and <i>I</i><sub>MF</sub>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:55:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/756870"], "description"=>"<p>Parameter ranges mainly investigated in the present and previous research superimposed on the state map.</p>", "links"=>[], "tags"=>["ranges", "investigated", "superimposed"], "article_id"=>427250, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g011", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parameter_ranges_mainly_investigated_in_the_present_and_previous_research_superimposed_on_the_state_map_/427250", "title"=>"Parameter ranges mainly investigated in the present and previous research superimposed on the state map.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 02:00:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/756783"], "description"=>"<p><b><i>A</i></b>, Time evolution of membrane potential before conditioning. The abscissa indicates time from the CS onset. <b><i>B</i></b>, <b><i>C</i></b> and <b><i>D</i></b>, Time evolutions of membrane potential after conditioning in the cases where the US onset was set at 0.5, 0.75 and 1.0 s, respectively. The model PC learned to stop firing 100–200 ms earlier than the US onset for each conditioning.</p>", "links"=>[], "tags"=>["pc", "simulation", "eyelid"], "article_id"=>427157, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g010", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Membrane_potential_of_a_model_PC_in_the_simulation_of_delay_eyelid_conditioning_/427157", "title"=>"Membrane potential of a model PC in the simulation of delay eyelid conditioning.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:59:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/755986"], "description"=>"<p>Conventions are as in <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002087#pcbi-1002087-g002\" target=\"_blank\">Fig. 2</a>. <b><i>B</i></b> and <b><i>C</i></b> show that the grcs and Gocs elicited spikes synchronously and rhythmically during the small current injection, and that they generated spikes randomly during the large current injection. Even for the blockade of NMDA channels, the statistical features of the activity patterns of grcs during the small current injection (<b><i>D</i></b> and <b><i>F</i></b>) were the same as those shown in <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002087#pcbi-1002087-g002\" target=\"_blank\">Figs. 2<b><i>D</i></b> and <b><i>F</i></b></a>. When a large current was injected, the sufficiently small amplitude of oscillation in <i>NAC</i>(<i>τ</i>) shown in <b><i>E</i></b> indicates that grcs elicited spikes randomly, and the constant shown in <b><i>G</i></b> indicates that active grc populations were almost the same.</p>", "links"=>[], "tags"=>["grcs", "gocs", "nmda", "channels"], "article_id"=>426360, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g004", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Activities_of_model_grcs_and_Gocs_when_NMDA_channels_of_model_Gocs_were_blocked_/426360", "title"=>"Activities of model grcs and Gocs when NMDA channels of model Gocs were blocked.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:46:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/755813"], "description"=>"<p><b><i>A</i></b>, Temporal pattern of an injected current, in which a small current was injected for 0–2 and 4–6 s, whereas a large current was injected for 2–4 s. <b><i>B</i></b> and <b><i>C</i></b>, Spike patterns of 200 out of 1,024 grcs and 200 Gocs, respectively. During the injection of a small current, grcs and Gocs elicited spikes synchronously and rhythmically. During the injection of a large current, the populations of active grcs and Gocs exhibited random alternation between the burst and silent modes. <b><i>D</i></b> and <b><i>E</i></b>, Normalized autocorrelation functions, <i>NAC</i>(<i>τ</i>), during the injection of a small and a large currents, respectively. <b><i>F</i></b> and <b><i>G</i></b>, Similarity index functions, , of grcs are shown during small and large current injections, respectively. <i>NAC</i>(<i>τ</i>) indicates the oscillatory generation of spikes and shows that similar spike patterns were repeatedly generated, although the spike patterns gradually became different gradually with the separation of time during the small current injection. On the other hand, during the large current injection, <i>NAC</i>(τ) indicates the random spike generation and shows that the spike pattern changed gradually and that each pattern was only generated once.</p>", "links"=>[], "tags"=>["grcs", "gocs", "injected"], "article_id"=>426180, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Activities_of_grcs_and_Gocs_in_response_to_a_current_injected_to_model_grcs_/426180", "title"=>"Activities of grcs and Gocs in response to a current injected to model grcs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:43:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/755927"], "description"=>"<p>Reproducibility of spike patterns of grcs for injection of a large current.</p>", "links"=>[], "tags"=>["spike", "patterns", "grcs", "injection"], "article_id"=>426298, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reproducibility_of_spike_patterns_of_grcs_for_injection_of_a_large_current_/426298", "title"=>"Reproducibility of spike patterns of grcs for injection of a large current.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:44:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/756657"], "description"=>"<p>The average firing rate, <i>PI</i> and <i>OI</i> are each figure given for each point.</p>", "links"=>[], "tags"=>["indices", "normalized", "autocorrelation", "functions", "points"], "article_id"=>427023, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g009", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spike_patterns_similarity_indices_and_normalized_autocorrelation_functions_at_eight_points_as_in_Fig_8_/427023", "title"=>"Spike patterns, similarity indices and normalized autocorrelation functions at eight points as in <b>Fig. 8</b>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:57:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/755742"], "description"=>"<p><b><i>A</i></b>, A local circuit composed of a granule cell, a Golgi cell and mossy fibers with synaptic channels. AMPA and NMDA channels are assumed to exist on the Golgi cell dendrites, and GABA<sub>A</sub> channels are assumed to exist on the granule cell. <b><i>B</i></b>, 2-dimensional arrangement of granule cells, Golgi cells and parallel fibers in the model granular layer. Small dots and open circles indicate granule cells and Golgi cells, respectively. Horizontal lines indicate parallel fibers, which terminate on the Golgi cell dendrites shown by gray disks. <b><i>C</i></b>, During delay eyelid conditioning, an animal receives the repeated paired presentation of a sustained tonal conditioned stimulus (CS) and an airpuff that is a delayed unconditioned stimulus (US) inducing an eyeblink response. Mossy fibers convey CS signals to granule cells, which send excitation signals to Purkinje cells through parallel fibers, whereas climbing fibers convey US signals to Purkinje cells. Synaptic weights between parallel fibers and Purkinje cells undergo long-term depression (LTD) when the parallel fibers excite Purkinje cells at the timing of the signal input through climbing fibers. After conditioning, the animal elicits an eyeblink as a conditioned response (CR) to a CS around the timing of the airpuff.</p>", "links"=>[], "tags"=>["diagrams", "cerebellar", "stimuli", "eyelid"], "article_id"=>426108, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g001", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_diagrams_of_the_present_cerebellar_model_and_external_input_stimuli_in_delay_eyelid_conditioning_/426108", "title"=>"Schematic diagrams of the present cerebellar model and external input stimuli in delay eyelid conditioning.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:41:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/756159"], "description"=>"<p>Conventions are as in <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002087#pcbi-1002087-g002\" target=\"_blank\">Fig. 2</a>. When a small current was injected, the Gocs elicited spikes at high frequencies (<b><i>B</i></b>), which in turn strongly inhibited the grcs. Consequently, the generation of oscillatory spikes at grcs disappeared (<b><i>C</i></b>). The absence of the oscillation was demonstrated by the sharp peak of <i>NAC</i>(<i>τ</i>) at τ = 0 (<b><i>D</i></b>). The overlap of active grc populations decreased rapidly with the separation of time (<b><i>F</i></b>). When a large current was injected, the Gocs also fired at high frequencies, too (<b><i>B</i></b>). In this case, however, the populations of active grcs exhibited random alternation between the burst and silent modes although the grcs elicited spikes sparsely (<b><i>C</i></b>, compared with <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002087#pcbi-1002087-g002\" target=\"_blank\">Fig. 2<b><i>C</i></b></a>). This random spike pattern was demonstrated by the sharply localized peak of <i>NAC</i>(<i>τ</i>) at <i>τ</i> = 0 and otherwise, <i>NAC</i>(<i>τ</i>) ≈0, as shown in <b><i>E</i></b>. monotonically decreased as |τ| increased (<b><i>G</i></b>), indicating that the population of active grcs changed gradually to different populations with time without recurrence.</p>", "links"=>[], "tags"=>["grcs", "gocs", "nmda", "channels", "continually"], "article_id"=>426525, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g005", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Activities_of_grcs_and_Gocs_when_NMDA_channels_of_Gocs_were_continually_open_/426525", "title"=>"Activities of grcs and Gocs when NMDA channels of Gocs were continually open.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:48:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/756345"], "description"=>"<p><b><i>A</i></b>, Dependence of the oscillation index (<i>OI</i>) and POT representation index (<i>PI</i>) on the concentration of Mg<sup>2+</sup>. <i>OI</i> was large in two separate regions of Mg<sup>2+</sup> concentration, which are indicated by the vertical gray bands. In-between these gray bands, there is a domain in which <i>PI</i> was larger than 0.5. <b><i>B</i></b>, Average firing rate of grcs and frequency of oscillatory spike generation. The average firing rate increased monotonically as the Mg<sup>2+</sup> concentration increased. The oscillation frequency was around 7 Hz within the interval of 0.417–0.782 µM and around 20 Hz within the interval of 5.21–9.13 µM.</p>", "links"=>[], "tags"=>["states", "injection", "concentrations"], "article_id"=>426719, "categories"=>["Neuroscience"], "users"=>["Takeru Honda", "Tadashi Yamazaki", "Shigeru Tanaka", "Soichi Nagao", "Tetsuro Nishino"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002087.g006", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dynamical_states_of_the_network_during_a_current_injection_I_MF_8202_8202_22_7_pA_with_various_concentrations_of_Mg_2_/426719", "title"=>"Dynamical states of the network during a current injection (<i>I</i><sub>MF</sub> = 22.7 pA) with various concentrations of Mg<sup>2+</sup>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-14 01:51:59"}

PMC Usage Stats | Further Information

  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"10", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"5", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"10", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "unique-ip"=>"7", "pdf"=>"0", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"4", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"6", "unique-ip"=>"8", "pdf"=>"5", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"0", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[301, 558, 690, 806, 916, 1018, 1112, 1197, 1275, 1349, 1421, 1495, 1561, 1631, 1697, 1762, 1835, 1895, 1954, 2020, 2078, 2142, 2197, 2258, 2313, 2376, 2437, 2494, 2557, 2618, 2682, 2744, 2818, 2880, 2940, 3000, 3056]}, {"subject_area"=>"/Computer and information sciences", "average_usage"=>[355, 609, 735, 840, 944, 1029, 1109, 1193, 1255, 1320, 1391, 1469, 1540, 1608, 1683, 1753, 1824, 1905, 1967, 2042, 2117, 2189, 2240, 2300, 2392, 2452, 2509, 2569, 2635, 2710, 2772, 2846, 2882, 2956, 3014, 3086, 3139]}, {"subject_area"=>"/Computer and information sciences/Network analysis", "average_usage"=>[429, 735, 900, 1007, 1119, 1213, 1298, 1390, 1459, 1528, 1611, 1697, 1774, 1859, 1932, 2001, 2114, 2189, 2279, 2342, 2389, 2460, 2561, 2642, 2696, 2770, 2852, 2915, 2972, 3082, 3187, 3243, 3317, 3445, 3552, 3609, 3664]}, {"subject_area"=>"/Engineering and technology/Signal processing", "average_usage"=>[324, 555, 686, 779, 884, 954, 1015, 1088, 1148, 1205, 1279, 1317, 1377, 1433, 1490, 1539, 1605, 1662, 1716, 1758, 1824, 1885, 1952, 2004, 2055, 2112, 2178, 2232, 2280, 2305, 2348, 2385, 2442, 2486, 2554, 2628, 2641]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[303, 547, 667, 770, 875, 974, 1062, 1140, 1210, 1276, 1344, 1408, 1473, 1534, 1602, 1665, 1732, 1800, 1863, 1920, 1984, 2048, 2099, 2161, 2222, 2285, 2341, 2404, 2473, 2528, 2595, 2650, 2713, 2772, 2835, 2886, 2938]}]}
Loading … Spinner
There are currently no alerts