A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling
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{"title"=>"A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling", "type"=>"journal", "authors"=>[{"first_name"=>"Vijay", "last_name"=>"Vedula", "scopus_author_id"=>"55176997900"}, {"first_name"=>"Juhyun", "last_name"=>"Lee", "scopus_author_id"=>"55268939900"}, {"first_name"=>"Hao", "last_name"=>"Xu", "scopus_author_id"=>"57191264711"}, {"first_name"=>"C. C.Jay", "last_name"=>"Kuo", "scopus_author_id"=>"57022721100"}, {"first_name"=>"Tzung K.", "last_name"=>"Hsiai", "scopus_author_id"=>"6701525264"}, {"first_name"=>"Alison L.", "last_name"=>"Marsden", "scopus_author_id"=>"7006851741"}], "year"=>2017, "source"=>"PLoS Computational Biology", "identifiers"=>{"isbn"=>"1111111111", "sgr"=>"85032731434", "scopus"=>"2-s2.0-85032731434", "issn"=>"15537358", "pui"=>"619081511", "doi"=>"10.1371/journal.pcbi.1005828", "pmid"=>"29084212"}, "id"=>"161d4ea9-deb5-3f71-801a-f30d5f52ee51", "abstract"=>"Blood flow and mechanical forces in the ventricle are implicated in cardiac development and trabeculation. However, the mechanisms of mechanotransduction remain elusive. This is due in part to the challenges associated with accurately quantifying mechanical forces in the developing heart. We present a novel computational framework to simulate cardiac hemo-dynamics in developing zebrafish embryos by coupling 4-D light sheet imaging with a stabi-lized finite element flow solver, and extract time-dependent mechanical stimuli data. We employ deformable image registration methods to segment the motion of the ventricle from high resolution 4-D light sheet image data. This results in a robust and efficient workflow, as segmentation need only be performed at one cardiac phase, while wall position in the other cardiac phases is found by image registration. Ventricular hemodynamics are then quanti-fied by numerically solving the Navier-Stokes equations in the moving wall domain with our validated flow solver. We demonstrate the applicability of the workflow in wild type zebrafish and three treated fish types that disrupt trabeculation: (a) chemical treatment using AG1478, an ErbB2 signaling inhibitor that inhibits proliferation and differentiation of cardiac trabeculation; (b) injection of gata1a morpholino oligomer (gata1aMO) suppressing hemato-poiesis and resulting in attenuated trabeculation; (c) weak-atrium m58 mutant (wea) with", "link"=>"http://www.mendeley.com/research/method-quantify-mechanobiologic-forces-during-zebrafish-cardiac-development-using-4d-light-sheet-ima", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>5, "Other"=>1, "Professor"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>5, "Other"=>1, "Professor"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>5, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>2, "Chemical Engineering"=>1, "Chemistry"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>5}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "group_count"=>0}

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